期刊
ELIFE
卷 10, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.65998
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资金
- Biotechnology and Biological Sciences Research Council [BB/N019008/1, BB/P019560/1]
- BBSRC [BB/P019560/1, BB/N019008/1] Funding Source: UKRI
The study shows that optogenetic stimulation of septal cholinergic neurons affects different stages of memory formation, impairing memory formation when activated at the goal location, reducing sharp wave ripple incidence at the goal location, and decreasing SWR incidence while enhancing theta-gamma oscillations during sleep.
The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs, including the cholinergic input from the medial septum. Here, we used optogenetic stimulation of septal cholinergic neurons to understand how cholinergic activity affects different stages of spatial memory formation in a reward-based navigation task in mice. We found that optogenetic stimulation of septal cholinergic neurons (1) impaired memory formation when activated at goal location but not during navigation, (2) reduced sharp wave ripple (SWR) incidence at goal location, and (3) reduced SWR incidence and enhanced theta-gamma oscillations during sleep. These results underscore the importance of appropriate timing of cholinergic input in long-term memory formation, which might help explain the limited success of cholinesterase inhibitor drugs in treating memory impairment in Alzheimer's disease.
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