Article
Chemistry, Medicinal
Di Zhang, Yafei Guo, Yingli Wang
Summary: A new ingredient group A4 was separated from Astragalus using membrane separation technique, and its immunoprotective effects and mechanisms on metabolic activity were studied through various experimental methods. The results showed that A4 could promote specific cell secretion and protect the spleen, alleviating immune dysfunction by modulating amino acid metabolism and energy metabolism.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Veterinary Sciences
Shaochuan Li, Renzhao Lin, Jiaxin Chen, Riaz Hussain, Shiwei Zhang, Yalin Su, Yanzi Chan, Abdul Ghaffar, Dayou Shi
Summary: Immunosuppression can alter the composition of the gut microbiota in animals, and Echinacea extract and Astragalus polysaccharide can alleviate the effects of immunosuppression on the gut microbiota. Both Echinacea extract and Astragalus polysaccharide mainly act by modulating the disrupted gut microbiota to counteract the effects of immunosuppression.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Clayton B. Hess, Tahseen H. Nasti, Vishal R. Dhere, Troy J. Kleber, Jeffrey M. Switchenko, Zachary S. Buchwald, William A. Stokes, Brent D. Weinberg, Nadine Rouphael, James P. Steinberg, Karen D. Godette, David J. Murphy, Rafi Ahmed, Walter J. Curran, Mohammad K. Khan
Summary: The study found that low-dose, whole-lung radiation therapy may improve disease outcomes for COVID-19 patients by immunomodulation. It showed promising results in some patients, indicating the need for larger prospective trials to confirm its efficacy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Nutrition & Dietetics
Lei Wang, Qing Tao, Zhiguo Wang, Jianfeng Shi, Wei Yan, Li Zhang, Yaoxiang Sun, Xiaoming Yao
Summary: This study found that green tea ingredients can reverse the molecular processes of COVID-19 and interact with SARS-CoV-2 proteins, suggesting their potential in treating COVID-19.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Yu Hu, Wenjuan Zhai, Duanling Tan, Haipeng Chen, Guiyu Zhang, Xuanjing Tan, Yuting Zheng, Wenhui Gao, Yijie Wei, Jinjun Wu, Xin Yang
Summary: Astragalus membranaceus, along with its active compounds formononetin and calycosin, exhibits anticarcinogenic effects against colon cancer by regulating multiple signaling pathways, inhibiting cell proliferation, promoting apoptosis, inhibiting migration, and targeting the ERK1/2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Ke-Gang Linghu, Qiushuo Ma, Shi-Hang Xiong, Mingming Zhao, Qiling Chen, Wen Xu, Meiwan Chen, Jian-Ye Zhang, Yuanjia Hu, Wei Xu, Hua Yu
Summary: The study extracted Astragali Radix (AR) and found that the whole ingredient extract (WIE) had a more complete chemical composition and higher content of active ingredients compared to the conventional water extraction (WAE). WIE demonstrated better therapeutic effects on ulcerative colitis (UC) in mice by improving immune function.
Article
Plant Sciences
Feng-xiang Zhang, Zi-ting Li, Xia Yang, Zhi-neng Xie, Ming-hao Chen, Zhi-hong Yao, Jian-xin Chen, Xin-sheng Yao, Yi Dai
Summary: Shuang-Huang-Lian preparation has significant therapeutic effects on upper respiratory tract infections. Through pharmacokinetic and network pharmacology analysis, the anti-flu substances and mechanism of SHL on H1N1 infected mice were revealed effectively.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Doo Jin Choi, Bo-Ram Choi, HaeJin Lee, Seong Cheol Kim, Dahye Yoon, Young-Seob Lee, Kyung-Sook Han, Sung-Bum Park, Geum-Soog Kim, Dae Young Lee
Summary: ALM16, a mixture of Astragalus membranaceus and Lithospermum erythrorhizon extracts, has significant anti-obesity effects in HFD-induced obese mice. It reduces body weight, improves lipid profile, and reduces liver damage.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Chi Teng Vong, Hisa Hui Ling Tseng, Peifen Yao, Hua Yu, Shengpeng Wang, Zhangfeng Zhong, Yitao Wan
Summary: The innate immune system, specifically the NLRP3 inflammasome, plays a crucial role in defending against danger signals and pathogens. The development of specific NLRP3 inhibitors has shown promise in treating inflammatory diseases.
DRUG DISCOVERY TODAY
(2021)
Review
Cell Biology
Yan-yan Yan, Qiao-ru Guo, Feng-hua Wang, Rameshwar Adhikari, Zhuang-yan Zhu, Hai-yan Zhang, Wen-min Zhou, Hua Yu, Jing-quan Li, Jian-ye Zhang
Summary: Cell-free DNA plays a crucial role in cancer management and can be utilized for cancer screening, early diagnosis, therapeutic evaluation, monitoring disease progression, and determining disease prognosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Kaipei Luo, Yi Gao, Shaoping Yin, Yawen Yao, Hua Yu, Guangji Wang, Juan Li
Summary: Metastasis is a major cause of mortality in breast cancer patients, and the signal transducer and activator of transcription 3 (STAT3) is closely related to cancer metastasis. In this study, a multifunctional nanocomplex co-loaded with paclitaxel (PTX) and STAT3 siRNA was developed, showing superior efficacy in inhibiting tumor growth and suppressing metastasis by silencing STAT3 expression. The nanocomplex provides a promising platform for targeted treatment of metastatic cancer through chemo-gene combined therapy.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Applied
Wei Xiong, Shi Hang Xiong, Qi Ling Chen, Ke Gang Linghu, Guan Ding Zhao, John M. T. Chu, Gordon T. C. Wong, Juan Li, Yuan Jia Hu, Yi Tao Wang, Hua Yu
Summary: The study developed a strategy using BC-NP nanoparticles to enhance the oral bioavailability and therapeutic effect of BBR in diabetic kidney disease. The BC-NPs improved the intestinal permeability of BBR by regulating TJs and Pgp-mediated drug efflux, leading to significantly increased oral bioavailability and therapeutic potency of BBR.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Kaipei Luo, Feng Xu, Tianyi Yao, Jianping Zhu, Hua Yu, Guangji Wang, Juan Li
Summary: A dual-modified lipid albumin nanosystem was developed for targeted delivery of paclitaxel to treat multidrug-resistant cancer. The system showed improved intracellular accumulation of the drug and demonstrated excellent antitumor efficacy by inhibiting cell proliferation through controlled drug release within cells. In vivo studies confirmed elevated tumor accumulation and significant survival benefits in tumor-bearing mice, showcasing the potential of this system for targeted chemotherapy and overcoming multidrug resistance in cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Guanglan Ma, Xiao Du, Jianping Zhu, Feng Xu, Hua Yu, Juan Li
Summary: The study utilized poly(lactide) and hyaluronic acid co-modified dendrimers as an intelligent carrier to co-deliver paclitaxel and sorafenib for the treatment of liver cancer. The multifunctional micelle showed efficient drug release behavior under acidic conditions, demonstrating potential for targeted drug delivery in liver cancer therapy. The functionalized micelle exhibited superior antitumor and antimetastasis efficacy compared to free drugs, highlighting its potential as a biocompatible nano-carrier for delivering multiple anticancer drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Cell Biology
Xutao Zhang, Chunxiu Zhou, Lingchao Miao, Yi Tan, Yan Zhou, Meng Sam Cheong, Yu Huang, Yitao Wang, Hua Yu, Wai San Cheang
Summary: Both total saponin and ethanolic extract of Panax notoginseng showed significant protective effects on improving endothelial function in diabetes by alleviating endoplasmic reticulum stress and oxidative stress, providing new insights into the therapeutic potential of P. notoginseng extract against vascular diseases associated with metabolic disorders.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Engineering, Biomedical
Suleixin Yang, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen, Ka Hong Wong
Summary: In this study, a ferroptosis/apoptosis combinational therapy was achieved by depleting GSH and downregulating GPX4 to disrupt redox homeostasis and amplify ferroptosis-related oxidation effect. ROS-responsive serum-resistant nanoparticles were used to co-deliver shGPX4 and shMTHFD2 plasmids, leading to efficient transfection, lysosomal escape, and induction of ferroptosis and apoptosis in tumor cells.
ACTA BIOMATERIALIA
(2022)
Article
Food Science & Technology
Mingming Zhao, Ke-Gang Linghu, Linxuan Xiao, Tianyi Hua, Guanding Zhao, Qiling Chen, Shihang Xiong, Liyu Shen, Jinyu Yu, Xiaotao Hou, Erwei Hao, Zhengcai Du, Jiagang Deng, Gang Bai, Xiaojia Chen, Ling Li, Peng Li, Hua Yu
Summary: In this study, the similarity and difference between Camellia nitidissima Chi (CC), C. euphlebia Merr. ex Sealy (CE), and C. insularis (CI) were comprehensively compared in terms of chemistry and pharmacology. A statistical model combining untargeted metabolomics and fingerprint analyses was developed for chemical pattern recognition and discrimination of the three yellow camellias species. The results showed that CC, CE, and CI could be distinguished based on specific chemical combinations and that they exhibited differences in anti-inflammation/anti-oxidation activities.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Integrative & Complementary Medicine
Ke-Gang Linghu, Qiushuo Ma, Shi-Hang Xiong, Mingming Zhao, Qiling Chen, Wen Xu, Meiwan Chen, Jian-Ye Zhang, Yuanjia Hu, Wei Xu, Hua Yu
Summary: The study extracted Astragali Radix (AR) and found that the whole ingredient extract (WIE) had a more complete chemical composition and higher content of active ingredients compared to the conventional water extraction (WAE). WIE demonstrated better therapeutic effects on ulcerative colitis (UC) in mice by improving immune function.
Article
Pharmacology & Pharmacy
Mingming Zhao, Linxuan Xiao, Ke-Gang Linghu, Guanding Zhao, Qiling Chen, Liyu Shen, Parsa Dar, Meiwan Chen, Yuan Hu, Jinming Zhang, Hua Yu
Summary: The anti-inflammatory effects and chemical compositions of Bupleuri chinense DC. (Beichaihu, BCH) and B. scorzonerifolium Willd. (Nanchiahu, NCH) were compared in this study. It was found that NCH exhibited stronger anti-inflammatory effects and had different chemical compositions compared to BCH. Metabolomics and chemometric approaches were used to identify chemical markers for the species discrimination of BCH and NCH.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ke-Gang Linghu, Guan-Ding Zhao, Dai-Yan Zhang, Shi-Hang Xiong, Guo-Ping Wu, Li-Yu Shen, Wen-Qing Cui, Tian Zhang, Yuan-Jia Hu, Bing Guo, Xiang-Chun Shen, Hua Yu
Summary: This study demonstrates that leocarpinolide B (LB), a compound extracted from Sigesbeckia Herba, has therapeutic effects on rheumatoid arthritis (RA) by inhibiting the DNA binding activity of NF-kappa B, thereby reducing inflammation.
Article
Integrative & Complementary Medicine
Dai-yan Zhang, Wen-qing Cui, Ling Hou, Jing Yang, Li-yang Lyu, Ze-yu Wang, Ke-Gang Linghu, Wen-bin He, Hua Yu, Yuan-jia Hu
Summary: This study aims to expand potential targets and verify drug-herb interactions using the node2vec algorithm. The results show that node2vec algorithm performs the best among all algorithms and successfully identifies potential interactions between 32 herbal chemicals and drug targets.
Article
Integrative & Complementary Medicine
Hua Luo, Chi Teng Vong, Dechao Tan, Jinming Zhang, Hua Yu, Lin Yang, Chen Zhang, Chun Luo, Zhangfeng Zhong, Yitao Wang
Summary: Panax notoginseng saponins (PNS) exhibit significant anti-inflammatory effects by downregulating MAPK and NF-κB signaling pathways, which helps reduce inflammatory responses, alleviate tissue damage, and maintain intestinal integrity and functionality.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
