Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery-A Basic Review

The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.

Automated summary

This study focused on highlighting the main differences and similarities in degradation mechanisms between polymeric coatings and bulk coatings. It reviewed the properties of degradable polymers commonly used in drug delivery, factors affecting degradation mechanisms, and testing methods, while providing a retrospective on the evolution of controlled release of biodegradable polymeric coatings. Additionally, the study analyzed shortcomings in the degradation behavior of biopolymers in coating form and proposed potential solutions to existing problems.