Review
Urology & Nephrology
Fadi Fakhouri, Nora Schwotzer, Gianfranca Cabiddu, Jonathan Barratt, Helene Legardeur, Vesna Garovic, Alejandra Orozco-Guillen, Jack Wetzels, Eric Daugas, Gabriella Moroni, Marina Noris, Vincent Audard, Manuel Praga, Elisa Llurba, Gregoire Wuerzner, Rossella Attini, David Desseauve, Elena Zakharova, Claudio Luders, Kate Wiles, Filomena Leone, Shilpanjali Jesudason, Nathalie Costedoat-Chalumeau, Andrea Kattah, Virgilia Soto-Abraham, Alexandre Karras, Jai Prakash, Liz Lightstone, Pierre Ronco, Claudio Ponticelli, Gerald Appel, Giuseppe Remuzzi, Vassilis Tsatsaris, Giorgina Barbara Piccoli
Summary: Our understanding of pregnancy in women with kidney diseases has improved, but there is little knowledge about specific kidney diseases. Glomerular diseases are a common cause of chronic kidney disease in young women and pose challenges in pregnancy due to immunologic diseases, hypertension, proteinuria, and kidney tissue damage. A review of current literature and expert opinions on glomerular diseases in pregnancy was conducted, providing practical information for nephrologists. This work highlights areas of uncertainty and the need for further collaborative studies to improve maternal and fetal health.
KIDNEY INTERNATIONAL
(2022)
Review
Neurosciences
Asher Ornoy, Gideon Koren
Summary: ADHD is a neurobehavioral condition affecting 5-10% of school-age children and 2-5% of adults. Stimulant medications like methylphenidate and amphetamines may have potential risks in pregnancy, while bupropion as an antidepressant seems to be safer. Limited data is available on the effects of ADHD medications on pregnancy and long-term neurodevelopment in children.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Miriam J. Haviland, Yael Nillni, Matthew P. Fox, David A. Savitz, Elizabeth E. Hatch, Kenneth J. Rothman, Michele R. Hacker, Tanran R. Wang, Lauren A. Wise
Summary: This study aimed to evaluate the association between psychotropic medication use during pregnancy and gestational age at delivery, while adjusting for depressive symptom and perceived stress severity. The results showed that women using psychotropic medications had a shorter gestational age at delivery, regardless of their depressive symptoms or perceived stress levels. The data suggest that this association is not confounded by indication.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guangyao Li, Ningli Wang, Yu Zhang, Wenbin Wei, Hai Lu, Suodi Zhai, Chao Zhang
Summary: This article discusses the widespread use of off-label drugs in ophthalmology in China and the safety issues associated with inappropriate use. To guide the use of these off-label drugs, the authors developed an evidence-based guideline using systematic reviews and meta-analyses to synthesize scientific evidence, and employed the GRADE approach to assess the quality of evidence and grade the strength of recommendations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Rishi Mittal, Rahul Krishnatry, Priyamvada Maitre, Vedang Murthy
Summary: This study proposed guidelines for inguinal CTV delineation in penile cancer, which were prospectively validated and found to be implementable and safe.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Psychiatry
Thomas Zandonai, Ana Maria Peiro, Francesca Fusina, Fabio Lugoboni, Lorenzo Zamboni
Summary: In recent years, there have been few studies focusing on the use and abuse of Benzodiazepines (BZDs) in sports. This article presents two clinical cases of elite endurance athletes who started using BZDs to address insomnia, recover faster, and manage muscle pain, highlighting that their sports doctors were unaware of the addictive properties of these drugs and failed to gradually reduce the dosage. The article aims to provide guidelines specifically for sports medicine physicians to manage situations involving BZD prescription, addiction recognition, and intervention strategies.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Sara T. Mustafa, Jane E. Harding, Clare R. Wall, Caroline A. Crowther
Summary: Adherence to dietary recommendations for women with GDM likely improves health outcomes, such as reducing medication use and adverse postpartum complications, and increasing breastfeeding.
Review
Clinical Neurology
Manuel Toledo, Barbara Mostacci, Magdalena Bosak, Joanna Jedrzejzak, Rhys H. Thomas, Javier Salas-Puig, Arnaud Biraben, Bettina Schmitz
Summary: Valproate, a broad-spectrum antiepileptic drug, is particularly effective in certain types of epilepsy syndromes. The European Medicines Agency introduced new restrictions on its use in females of childbearing potential, leading to controversy and debate. Limited information on the teratogenic potential of alternative treatments presents challenges in the clinical management of pregnant women and women of childbearing age.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Stacey A. Cohen, Minetta C. C. Liu, Alexey Aleshin
Summary: The continuous improvement in cancer care over the past decade has led to a gradual decrease in cancer-related deaths. This is largely attributed to improved treatment and disease management strategies. Early detection of recurrence using blood-based biomarkers such as circulating tumour DNA (ctDNA) is being increasingly used in clinical practice.
Article
Pharmacology & Pharmacy
Min Meng, Qi Zhou, Wenjuan Lei, Min Tian, Ping Wang, Yunlan Liu, Yajia Sun, Yaolong Chen, Qiu Li
Summary: This study systematically analyzed the supporting evidence, drug information, and type of off-label drug use in pediatric guidelines, finding gaps in reporting and evidence of off-label drug use recommendations that could expose children to medical risks.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Microbiology
Agata Misera, Igor Loniewski, Joanna Palma, Monika Kulaszynska, Wiktoria Czarnecka, Mariusz Kaczmarczyk, Pawel Liskiewicz, Jerzy Samochowiec, Karolina Skonieczna-Zydecka
Summary: The relationship between drugs and microbiota is two-way. The proper composition and function of microbiota are key factors for some medications used in modern medicine. On the other hand, pharmacotherapeutic agents can significantly modify the microbiota, which in turn affects its function. A recent study revealed that nearly 25% of drugs administered to humans have antimicrobial effects. Multiple antidepressants have antimicrobial properties, and there are antibiotics with proven antidepressant effects. Additionally, antibiotics can cause mental phenotype changes, and some antibiotics have adverse effects including neurological and psychological symptoms, supporting the hypothesis that intestinal microbiota may affect the function of the central nervous system. We have comprehensively collected data on psychiatric drugs and their antimicrobial properties, which we believe has strong implications for the treatment of psychiatric entities. However, our study also highlights the need for more well-designed trials to analyze the function of gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Alexander J. Kieturakis, Rifat A. Wahab, Charmi Vijapura, Mary C. Mahoney
Summary: During pregnancy and lactation, the breast undergoes unique physiological changes which can be identified with appropriate imaging modalities. Discussing the safety of breast imaging with patients can improve management outcomes. Additionally, this article provides information on the safety of various imaging modalities, screening guidelines, and recommendations for diagnostic evaluation during this period.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Gregor Lichtner, Brian S. Alper, Carlo Jurth, Claudia Spies, Martin Boeker, Joerg J. Meerpohl, Falk von Dincklage
Summary: This study proposes a FHIR-based format that uses computer-interpretable representations of knowledge artifacts to directly generate evidence-based recommendations. An information model and corresponding representation based on FHIR resources were developed, allowing for the transparent evaluation of evidence and the facilitation of computer-interpretable guideline recommendations.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Geriatrics & Gerontology
Yingyang Zhang, Hao Luo, Gloria H. Y. Wong, Mei Zhao, Xiaozhen Lv, Terry Y. S. Lum, Celine S. L. Chui, Xin Yu, Ian C. K. Wong, Huali Wang
Summary: This study examined prescribing rates of dementia medication in China and found that the prescription rate of antidementia drugs was higher, while the rate of coprescription of psychotropic and antidementia drugs was lower than in Western studies. The prescription of dementia medication in China was generally consistent with clinical guidelines and depended on patients' clinical symptoms.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Medicine, General & Internal
Matteo Lambertini, Claudia Massarotti, Julie Havas, Barbara Pistilli, Anne-Laure Martin, Alexandra Jacquet, Charles Coutant, Florence Coussy, Asma Dhaini Merimeche, Florence Lerebours, Christine Rousset-Jablonski, Christelle Jouannaud, Olivier Rigal, Marion Fournier, Patrick Soulie, Maria Alice Franzoi, Lucia Del Mastro, Ann H. Partridge, Fabrice Andre, Ines Vaz-Luis, Antonio Di Meglio
Summary: As life expectancy increases for cancer patients, survivorship has become a crucial aspect of breast cancer care. Adequate contraceptive counseling is important for premenopausal breast cancer patients who do not wish to become pregnant. This study examined contraceptive use and methods in early breast cancer patients and identified factors associated with contraceptive use over time. The findings highlight the importance of raising awareness and providing targeted contraceptive counseling for premenopausal women with early breast cancer.
Article
Psychiatry
Line Philipsen, Nanna Wurtz, Christoffer Polcwiartek, Kristian Hay Kragholm, Christian Torp-Pedersen, Rene Ernst Nielsen, Svend Eggert Jensen, Rubina Attar
Summary: This study analyzed the time trends in coronary procedures, guideline-based drugs, and mortality following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD). The results showed that patients with BD and ACS received fewer coronary angiography and redeemed fewer prescriptions of guideline-based drugs compared to the control group. The treatment gap remained unchanged for PCI and CABG, and the mortality risk ratio for patients with BD experiencing ACS remained constant over the study period.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Mathilde Frahm Laursen, Christoph U. Correll, Rasmus W. Licht, Maria Rodrigo-Domingo, Anne Katrine Pagsberg, Rene Ernst Nielsen
Summary: This study aims to describe the symptoms before and at the time of register-diagnosis in children and adolescents. A random sample from a Danish nationwide cohort of patients was selected for chart-review. The results showed that frequently reported symptoms before diagnosis include anhedonia, irritability, hyperactivity, decreased energy, and psychotic symptoms. In addition, symptoms of ADHD, anxiety, suicide attempts, cutting, and criminal activity were also reported before incident BD diagnosis.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Oncology
Cathrine F. F. Hjorth, Per Damkier, Tore B. B. Stage, Soren Feddersen, Stephen Hamilton-Dutoit, Bent Ejlertsen, Timothy L. L. Lash, Henrik Boggild, Henrik T. T. Sorensen, Deirdre Cronin-Fenton
Summary: This study found that single nucleotide polymorphisms may influence return-to-work and stable labor market attachment after breast cancer treatment, but overall, the SNPs examined did not have a significant impact on these outcomes in premenopausal women with breast cancer.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Julie Rudbech Krumborg, Nicolaj Mikkelsen, Per Damkier, Zandra Nymand Ennis, Daniel Pilsgaard Henriksen, Mads Lillevang-Johansen, Sidsel Arnspang Pedersen, Troels K. Bergmann
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Otorhinolaryngology
Per Damkier, Brian Cleary, Jesper Hallas, Jesper H. H. Schmidt, Louise Ladebo, Peter B. B. Jensen, Lars Christian Lund
Summary: This study compared the occurrence of sudden sensorineural hearing loss after immunization with BNT162b2 (Comirnaty; Pfizer BioNTech) or mRNA-1273 (Spikevax; Moderna) vaccines to unvaccinated individuals. The results showed that there was no association between these vaccines and the occurrence of sudden sensorineural hearing loss, but there was a slightly increased risk of receiving moderate to high-dose prednisolone treatment after visiting an ear-nose-throat specialist.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Letter
Public, Environmental & Occupational Health
Per Damkier
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
C. L. Petersen, M. R. Hansen, T. Ohlenschlaeger, P. Damkier
Summary: This study investigated the quality of evidence and expected clinical value of treatments recommended by the Danish Medicines Council (DMC). The results showed that most recommendations by the DMC were based on low or very low-quality evidence according to GRADE ratings, and no recommendations were based on high-quality evidence. The added clinical value of the treatments was often not documented and rarely large.
Article
Public, Environmental & Occupational Health
A. Juel, A. Erlangsen, L. L. Berring, E. R. Larsen, N. Buus
Summary: This study explores how parents reconstruct and negotiate their parental identity after realizing that their offspring is suicidal. Through interviews with 21 Danish parents, it is found that parents' perspectives on their parental identity can be conceptualized as a moral career consisting of three distinct stages. These stages are negotiated through social interaction and play a crucial role in the re-construction of parental identity and sense of agency.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Pharmacology & Pharmacy
R. L. Bromley, M. Bickle Graz, M. Bluett-Duncan, C. Chambers, P. Damkier, K. Dietrich, H. Dolk, K. Grant, S. Mattson, K. J. Meador, H. Nordeng, T. F. Oberlander, A. Ornoy, A. Revet, J. Richardson, J. Rovet, L. Schuler-Faccini, E. Smearman, V. Simms, C. Vorhees, K. Wide, A. Wood, L. Yates, E. Ystrom, T. A. Supraja, J. Adams
Summary: The study aims to achieve consensus on the core neurodevelopmental outcomes, optimize methodologies, and overcome barriers in conducting pregnancy pharmacovigilance studies with neurodevelopmental outcomes. The vision is to establish a comprehensive understanding of neurodevelopmental outcomes in pregnancy pharmacovigilance through a complementary set of studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
N. H. Paulsen, P. Pfeiffer, M. Ewertz, S. Feddersen, H. S. Holm, T. K. Bergmann, C. Qvortrup, P. Damkier
Summary: The study aimed to compare the frequency of grade >3 FP-TOX before and after the implementation of DPYD genotyping. The results showed that the overall frequency of grade >3 FP-TOX was 27% in the DPYD genotype-guided group compared to 24% in the historical cohort. DPYD genotyping reduced the frequency of FP-related hospitalization from 19% to 0% in DPYD variant carriers. In wild-type patients, those with uracil >16 ng/mL had a higher frequency of FP-TOX than those with uracil <16 ng/mL.
Article
Health Care Sciences & Services
Anette Juel, Lene L. Berring, Annette Erlangsen, Erik R. Larsen, Niels Buus
Summary: This study explores how participants develop and display feelings of ownership during a collaborative process to design a website. The findings reveal that participants' sense of ownership goes through two distinct and overlapping phases. In the first phase, only researchers and the website designer display a sense of ownership, facilitated by the research context. In the second phase, service users gradually develop a sense of ownership through workshop design activities, enabling them to control the process and gain intimate knowledge of the outcome. The sense of ownership is displayed in their statements about the website.
HEALTH EXPECTATIONS
(2023)
Editorial Material
Psychiatry
Rene Ernst Nielsen, Rasmus W. Licht
Summary: Lithium is the primary choice for preventing bipolar disorder relapses, with data supporting its effectiveness in managing symptoms and preventing relapse.
Article
Pediatrics
Nana Brandborg Sorensen, Rene Ernst Nielsen, Ann-Eva Christensen, Mikkel Kristian Kjeldsen, Charlotte Ulrikka Rask, Jakob Christensen, Anne Sofie Hansen
Summary: This study examined the treatment and collaboration among 334 Danish children and adolescents diagnosed with functional seizures. The most commonly used treatment modalities were psychoeducation and outpatient follow-up. Only a few patients received the recommended combination of psychoeducation, outpatient follow-up, and psychotherapy. Implementing a multidisciplinary treatment approach should be explored to improve the treatment for this group.
Review
Health Care Sciences & Services
Sanne T. Kristiansen, Poul Videbech, Mette Kragh, Karen R. Sigaard, Cecilie N. Lyhne, Erik R. Larsen, Merete Bjerrum
Summary: The objective of this review is to identify and synthesize evidence on how adult patients experience living with depression-related insomnia. It will examine experiences related to pharmacological and non-pharmacological interventions to improve sleep.
JBI EVIDENCE SYNTHESIS
(2023)
Article
Andrology
Ken Lund, Olav Sivertsen Garvik, Signe Marie Aagaard, Line Riis Jolving, Michael Due Larsen, Per Damkier, Bente Mertz Norgard
Summary: The study investigated the association between paternal use of non-steroid anti-inflammatory drugs and opioids before conception and adverse birth outcomes. Weak associations were found for paternal exposure to these medications and preterm birth/small for gestational age, but not for low Apgar score or major congenital malformations. The effect sizes were small and less likely to be clinically relevant.
