Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease

Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule

(2020) Pablo Cabrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Improved Method for Measuring Absolute Metabolite Concentrations in Small Biofluid or Tissue Samples

(2019) Tharindu Fernando et al.   JOURNAL OF PROTEOME RESEARCH

Three-dimensional architecture of pericardial nephrocytes in Drosophila melanogaster revealed by FIB/SEM tomography

(2019) Yuto Kawasaki et al.   CELL AND TISSUE RESEARCH

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

(2019) Charles P. Najt et al.   MOLECULAR CELL

Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A

(2019) Valentina Marchesin et al.   Cell Reports

The assembly of lipid droplets and their roles in challenged cells

(2018) W Mike Henne et al.   EMBO JOURNAL

Mitochondrial dysfunction in diabetic kidney disease

(2018) Josephine M. Forbes et al.   Nature Reviews Nephrology

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

(2018) Hans-Joachim Anders et al.   Nature Reviews Nephrology

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atgldeficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage

(2017) Wen Chen et al.   FEBS Journal

High-performance serial block-face SEM of nonconductive biological samples enabled by focal gas injection-based charge compensation

(2017) T.J. DEERINCK et al.   JOURNAL OF MICROSCOPY

Immunologic and endocrine functions of adipose tissue: implications for kidney disease

(2017) Qingzhang Zhu et al.   Nature Reviews Nephrology

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease

(2017) Chee-Hoe Ng et al.   NEUROBIOLOGY OF AGING

Developmental diet regulates Drosophila lifespan via lipid autotoxins

(2017) M. Irina Stefana et al.   Nature Communications

Drosophilatools and assays for the study of human diseases

(2016) Berrak Ugur et al.   Disease Models & Mechanisms

3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy

(2016) Matthew R. G. Russell et al.   JOURNAL OF CELL SCIENCE

Modeling Monogenic Human Nephrotic Syndrome in theDrosophilaGarland Cell Nephrocyte

(2016) Tobias Hermle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis

(2016) Vivette D. D'Agati et al.   Nature Reviews Nephrology

MiniCORVET is a Vps8-containing early endosomal tether in Drosophila

(2016) Péter Lőrincz et al.   eLife

spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster

(2015) Eric M. Merzetti et al.   BMC NEUROSCIENCE

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle

(2015) Matthew A. Sanders et al.   Cell Metabolism

DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling

(2015) Thomas Oliver Eichmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenously Tagged Rab Proteins: A Resource to Study Membrane Trafficking in Drosophila

(2015) Sebastian Dunst et al.   DEVELOPMENTAL CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease

(2015) S. Kuwahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase

(2015) Soda Balla Diop et al.   Cell Reports

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals

(2015) Jianbo Na et al.   Cell Reports

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Balancing the fat: lipid droplets and human disease

(2013) Natalie Krahmer et al.   EMBO Molecular Medicine

The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage

(2013) K. Thiel et al.   JOURNAL OF CELL SCIENCE

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

The Drosophila Nephrocyte: Back on Stage

(2013) J. Na et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes

(2013) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Cubilin and Amnionless Mediate Protein Reabsorption in Drosophila Nephrocytes

(2012) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

TrakEM2 Software for Neural Circuit Reconstruction

(2012) Albert Cardona et al.   PLoS One

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

(2012) Wilhelm Palm et al.   PLoS Genetics

A software complement to AMDIS for processing GC-MS metabolomic data

(2011) Volker Behrends et al.   ANALYTICAL BIOCHEMISTRY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Lipoprotein Particles Cross the Blood-Brain Barrier in Drosophila

(2010) M. Brankatschk et al.   JOURNAL OF NEUROSCIENCE

Bringing together components of the fly renal system

(2009) Barry Denholm et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes

(2009) S. Zhuang et al.   DEVELOPMENT

The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling

(2009) Stefanie K Tiefenböck et al.   EMBO JOURNAL

Nutrition Controls Mitochondrial Biogenesis in the Drosophila Adipose Tissue through Delg and Cyclin D/Cdk4

(2009) Claudia Baltzer et al.   PLoS One

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

(2008) Helen Weavers et al.   NATURE