期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2021.659402
关键词
Alzheimer’ s disease; hydrogen sulfide; cysteine; redox; sulfhydration; persulfidation; transsulfuration
资金
- American Heart Association (AHA)/Paul Allen Frontiers Group [19PABH134580006]
The reverse transsulfuration pathway is a central hub integrating the metabolism of sulfur-containing amino acids and redox homeostasis, disruption of which may have deleterious consequences and is linked to Alzheimer's disease. Potential nodes of therapeutic intervention discussed in this review may pave the way for the development of novel treatments.
The reverse transsulfuration pathway has emerged as a central hub that integrates the metabolism of sulfur-containing amino acids and redox homeostasis. Transsulfuration involves the transfer of sulfur from homocysteine to cysteine. Cysteine serves as the precursor for several sulfur-containing molecules, which play diverse roles in cellular processes. Recent evidence shows that disruption of the flux through the pathway has deleterious consequences. In this review article, I will discuss the actions and regulation of the reverse transsulfuration pathway and its links to other metabolic pathways, which are disrupted in Alzheimer's disease (AD). The potential nodes of therapeutic intervention are also discussed, which may pave the way for the development of novel treatments.
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