FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance

Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure

(2019) Magdalene Ameka et al.   Scientific Reports

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

(2019) Steven A. Kliewer et al.   Cell Metabolism

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Heterogeneity of adipose tissue in development and metabolic function

(2018) Theresa Schoettl et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Ageing-related receptors resolved

(2018) Makoto Kuro-o   NATURE

Inactivating hepatic follistatin alleviates hyperglycemia

(2018) Rongya Tao et al.   NATURE MEDICINE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion

(2018) Abdelfattah El Ouaamari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

(2017) Harald Staiger et al.   ENDOCRINE REVIEWS

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

(2016) Lucas D. BonDurant et al.   Annual Review of Nutrition

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Association Between Serum Fibroblast Growth Factor 21 and Mortality Among Patients With Coronary Artery Disease

(2016) Qing Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes

(2016) TingYu Liu et al.   Scientific Reports

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Naringenin Prevents Obesity, Hepatic Steatosis, and Glucose Intolerance in Male Mice Independent of Fibroblast Growth Factor 21

(2015) Julia M. Assini et al.   ENDOCRINOLOGY

Serum Adropin Level in Patients with Stable Coronary Artery Disease

(2015) Liang-Ping Zhao et al.   Heart Lung and Circulation

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic insulin resistance and increased hepatic glucose production in mice lackingFgf21

(2015) João Paulo G Camporez et al.   JOURNAL OF ENDOCRINOLOGY

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

(2015) Jakob Schiøler Hansen et al.   Molecular Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Interplay between FGF21 and insulin action in the liver regulates metabolism

(2014) Brice Emanuelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown fat fuel utilization and thermogenesis

(2014) Kristy L. Townsend et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

(2013) João Paulo G. Camporez et al.   ENDOCRINOLOGY

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

(2012) Joel T. Haas et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

Genome-wide analysis of FoxO1 binding in hepatic chromatin: Potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis

(2012) Dong-Ju Shin et al.   NUCLEIC ACIDS RESEARCH

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

(2012) Yukari Ido-Kitamura et al.   PLoS One

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

(2012) Andrew C. Adams et al.   Molecular Metabolism

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

(2011) Fredirick L. Mashili et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Serum Selenoprotein P Levels in Patients with Type 2 Diabetes and Prediabetes: Implications for Insulin Resistance, Inflammation, and Atherosclerosis

(2011) S. J. Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unknown

(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Hepatic FoxO1 Ablation Exacerbates Lipid Abnormalities during Hyperglycemia

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

(2009) S. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA)

(2008) Erin D. Michos et al.   ATHEROSCLEROSIS

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE