Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways

Kinase inhibitors in the treatment of obstructive pulmonary diseases

(2020) Amy E Defnet et al.   CURRENT OPINION IN PHARMACOLOGY

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

(2019) Mark Austin Hanson et al.   eLife

A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention

(2018) Ruben Prange et al.   Aging-US

New insights in neutrophilic asthma

(2018) Sven F. Seys et al.   CURRENT OPINION IN PULMONARY MEDICINE

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

(2016) Parisa Kakanj et al.   Nature Communications

Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic

(2016) Benjamin D. Levine et al.   Cell Reports

The Effects of Air Pollution and Temperature on COPD

(2015) Nadia N. Hansel et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila

(2015) J. A. Bosch et al.   DEVELOPMENT

The innate immune function of airway epithelial cells in inflammatory lung disease

(2015) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways

(2015) Kimberley Kallsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

Reduced FOXO1 Expression Accelerates Skin Wound Healing and Attenuates Scarring

(2014) Ryoichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis

(2014) Aleksander M Grabiec et al.   ANNALS OF THE RHEUMATIC DISEASES

Cystic fibrosis airway epithelium remodelling: involvement of inflammation

(2014) Damien Adam et al.   JOURNAL OF PATHOLOGY

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

Progenitor Outgrowth from the Niche in Drosophila Trachea Is Guided by FGF from Decaying Branches

(2014) F. Chen et al.   SCIENCE

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

The epithelium in idiopathic pulmonary fibrosis: breaking the barrier

(2014) Ana Camelo et al.   Frontiers in Pharmacology

Epithelial Injury and Repair in Airways Diseases

(2013) Christopher L. Grainge et al.   CHEST

FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress

(2013) Bhaskar Ponugoti et al.   JOURNAL OF CELL BIOLOGY

FOXO Transcription Factors Regulate Innate Immune Mechanisms in Respiratory Epithelial Cells

(2013) F. Seiler et al.   JOURNAL OF IMMUNOLOGY

Dermatophagoides pteronyssinus Major Allergen 1 Activates the Innate Immune Response of the Fruit Fly Drosophila melanogaster

(2012) C. Warmbold et al.   JOURNAL OF IMMUNOLOGY

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A

(2012) Shyamala Ganesan et al.   THORAX

Epithelial cells and airway diseases

(2011) David Proud et al.   IMMUNOLOGICAL REVIEWS

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Toll-8/Tollo Negatively Regulates Antimicrobial Response in the Drosophila Respiratory Epithelium

(2011) Idir Akhouayri et al.   PLoS Pathogens

Epithelial repair mechanisms in the lung

(2010) Lynn M. Crosby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Drosophilain Asthma Research

(2009) Thomas Roeder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Infection induces a survival program and local remodeling in the airway epithelium of the fly

(2009) Christina Wagner et al.   FASEB JOURNAL

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

(2009) J. R. DiAngelo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Factor-κB Activation in Airway Epithelium Induces Inflammation and Hyperresponsiveness

(2008) Cristen Pantano et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular architecture of the fruit fly's airway epithelial immune system

(2008) Christina Wagner et al.   BMC GENOMICS

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

(2008) David H. Broide   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IKK/NF-κB signaling in intestinal epithelial cells controls immune homeostasis in the gut

(2008) M Pasparakis   Mucosal Immunology