Article
Multidisciplinary Sciences
Shuiqing Hu, Yan Fang, Xiang Chen, Tianlei Cheng, Miaoqing Zhao, Mingjian Du, Tuo Li, Minghao Li, Zhiqun Zeng, Yonglong Wei, Zhimin Gu, Conggang Zhang, Lijun Sun, Zhijian J. Chen
Summary: cGAS plays a crucial role in controlling the development of colitis-associated colon cancer by defending the integrity of the intestinal mucosa, suppressing inflammation, and promoting the proliferation of intestinal epithelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Lijun Dong, Jingwen Xie, Youyi Wang, Honglian Jiang, Kai Chen, Dantong Li, Jing Wang, Yunzhi Liu, Jia He, Jia Zhou, Liyun Zhang, Xiao Lu, Xiaoming Zou, Xiang-Yang Wang, Qingqing Wang, Zhengliang Chen, Daming Zuo
Summary: The study shows that mannose supplementation can alleviate symptoms of inflammatory bowel disease, including colitis. It improves intestinal barrier integrity, reduces the release of proteins, and prevents mitochondrial dysfunction. Mannose also synergizes with the conventional drug mesalamine in colitis treatment.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Article
Pharmacology & Pharmacy
Jiemei Chen, Mingchao Wang, Peng Zhang, Hui Li, Kai Qu, Ruiming Xu, Na Guo, Haibo Zhu
Summary: Cordycepin has been found to alleviate metabolic inflammation and improve obesity-related symptoms through regulating intestinal barrier function and intestinal flora.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jessica A. Canter, Sarah E. Ernst, Kristin M. Peters, Bradley A. Carlson, Noelle R. J. Thielman, Lara Grysczyk, Precious Udofe, Yunkai Yu, Liang Cao, Cindy D. Davis, Vadim N. Gladyshev, Dolph L. Hatfield, Petra A. Tsuji
Summary: The study suggests that Selenof may play a significant role in the development of colon tumors, affecting intestinal barrier integrity and the structural changes in glandular and mucin-producing goblet cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yujing Cui, Samuel Kumi Okyere, Pei Gao, Juan Wen, Suizhong Cao, Ya Wang, Junliang Deng, Yanchun Hu
Summary: The study demonstrated that Ageratina adenophora impaired intestinal function in rats by causing pathological changes and injury, reducing occludin levels, triggering an inflammation immune response, and leading to intestinal immune barrier dysfunction.
Article
Toxicology
Benuarda Toto, Alice Refosco, Maria O'Keeffe, Oyvind Halas Barkhald, Aurora Bronstad, Gulen Arslan Lied, Fekadu Yadetie, Anders Goksoyr, Tanja Kogel, Jutta Dierkes
Summary: This study investigated the effects of oral ingestion of polyamide and polyethylene particles in rats. The results showed that rats fed with microplastic particles had higher duodenal permeability, and the expression of the tight junction protein gene occludin was higher in the polyethylene group. However, there were no significant changes in the concentrations of tight junction proteins in the gut and plasma.
TOXICOLOGY LETTERS
(2022)
Article
Food Science & Technology
Xiaoyu Bao, Jianping Wu
Summary: Ovomucin hydrolysate has been shown to prevent pathogen adhesion to intestinal epithelial cells, and in this study, it was demonstrated to improve intestinal barrier integrity by inhibiting inflammatory responses induced by LPS.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agriculture, Dairy & Animal Science
Edith J. Mayorga, Erin A. Horst, Mohmmad Al-Qaisi, Brady M. Goetz, Megan A. Abeyta, Sonia Rodriguez-Jimenez, Samantha Lei, Jesus A. Acosta, John F. Patience, Mariana C. Rossoni Serao, Lance H. Baumgard
Summary: The study found that continuously infusing glucose or casein into the terminal ileum may stimulate a mild immune response, but has little to no effect on blood inflammatory markers, intestinal morphology, or key production parameters.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Sport Sciences
Harry A. Smith, Aaron Hengist, Drusus Johnson Bonson, Jean-Philippe Walhin, Robert Jones, Kostas Tsintzas, Gregg H. Afman, Javier T. Gonzalez, James A. Betts
Summary: The study found that ethanol ingestion did not affect muscle glycogen utilization during exercise, resulting in similar total whole-body carbohydrate oxidation rates. Ethanol ingestion had a slight impact on plasma lactate concentration, but there was no difference in the response during exercise.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Nutrition & Dietetics
Junrui Cheng, Emilio Balbuena, Baxter Miller, Abdulkerim Eroglu
Summary: The study found that beta-carotene can alleviate colonic inflammation and enhance tight junction proteins levels in an in vitro epithelial cell model, potentially improving barrier function.
FRONTIERS IN NUTRITION
(2021)
Article
Oncology
Kun Wang, Yuhan Ding, Chang Xu, Mengdi Hao, Huimin Li, Lei Ding
Summary: In this study, the expression profile of Cldn-7 in inflammatory bowel disease and colitis-associated colorectal cancer was analyzed. Knockout of Cldn-7 gene resulted in intestinal abnormalities, increased susceptibility to colitis and colorectal cancer, disrupted epithelial barrier integrity, and promoted inflammatory cascade, leading to malignant transformation. These findings suggest a key role of Cldn-7 in maintaining intestinal homeostasis and preventing inflammatory bowel disease and consequent colorectal cancer.
Article
Fisheries
Rui Zhu, Xue-Qin Wu, Xue-Yuan Zhao, Zi-Hui Qu, Ya-Nan Quan, Ming-Hui Lu, Zong-Yu Liu, Li-Fang Wu
Summary: This study evaluated the protective effect of taurine on intestinal damage and growth inhibition induced by glycinin in juvenile Rhynchocypris lagowskii Dybowski. The results showed that taurine can partially alleviate the negative effects of glycinin on fish, improving growth performance and feed efficiency.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Felix Kwame Amevor, Zhifu Cui, Xiaxia Du, Zifan Ning, Xun Deng, Dan Xu, Gang Shu, Youhao Wu, Xueqing Cao, Wei Shuo, Yaofu Tian, Diyan Li, Yan Wang, Yao Zhang, Xiaohui Du, Qing Zhu, Xue Han, Xiaoling Zhao
Summary: This study investigated the effects of dietary combination of quercetin (Q) and vitamin E (VE) on the intestinal structure and barrier integrity in aged breeder chickens. The results showed that Q+VE had synergistic effects on intestinal morphology, reduced intestinal inflammatory damage, and increased the expression of tight junction proteins and anti-inflammatory genes. Q+VE also protected the small intestine from oxidative damage. These findings suggest that Q+VE can improve intestinal function in aged breeder hens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Rifat Nowshin Raka, Junsong Xiao, Hua Wu, Wenwen Lv, Zhiqian Ding, Yangping Cao, Xukai Li, Jinglong Sun, Kou Luan
Summary: Rosa rugosa cv. Plena, a 'drug homologous food' in China, has been widely used in the food industry as a popular additive. Pingyin rose essential oil (PREO), extracted from R. rugosa cv. Plena, has shown to alleviate and restore barrier integrity damages caused by dextran sodium sulfate (DSS). The study found that PREO treatment improved colitis symptoms, increased tight junction proteins expression and the enzyme activities of SOD and CAT, decreased production of NO, MDA, and MPO, and inhibited the expression of proinflammatory cytokines. Furthermore, PREO modulated the gut microbiota composition and improved intestinal barrier function through the TLR4-NF-kB signaling pathway.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Roberto C. Nava, Micah N. Zuhl, Terence A. Moriarty, Fabiano T. Amorim, Kelsey C. Bourbeau, Anna M. Welch, James J. McCormick, Kelli E. King, Christine M. Mermier
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2019)
Article
Rehabilitation
Neha P. Gothe, Kelsey Bourbeau
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2020)
Article
Rehabilitation
Markaela L. Bluhm, Kellie N. Hoehing, Rachael K. Nelson, Micah N. Zuhl
Summary: This study aimed to investigate the effect of cardiac rehabilitation on changes in functional capacity among patients with cardiovascular disease and a comorbidity of type 2 diabetes mellitus. The results of the study showed that patients with cardiovascular disease and type 2 diabetes mellitus experienced less improvement in functional capacity after cardiac rehabilitation compared to patients without type 2 diabetes mellitus.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Public, Environmental & Occupational Health
Rachael K. Nelson, Kristina Hasanaj, Gavin Connolly, Laramy Millen, Joshua Muench, Nicole S. C. Bidolli, Michael A. Preston, Alexander H. K. Montoye
Summary: According to this study, there is a discrepancy between step counts measured by wrist-worn activity monitors and hip-worn pedometers. The widely recommended 10,000 steps may not be accurate for all individuals. Having a more accurate indication of daily step count based on the type of device used could have positive effects on health.
PREVENTING CHRONIC DISEASE
(2022)
Editorial Material
Education, Scientific Disciplines
Steven J. Elmer, Cassandra R. Gohn, John J. Durocher, Naveen Sharma
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Obstetrics & Gynecology
Rachael K. Nelson, Selina M. Hafner, Alyssa C. Cook, Natalie J. Sterner, Erin L. Butler, Brooke E. Jakiemiec, William A. Saltarelli
Summary: This study investigated the attitudes, knowledge, and clinical practices of OB/GYNs regarding exercise during pregnancy. The results showed that the majority of surveyed physicians recognize the benefits of exercise during pregnancy and routinely advise their patients to exercise. However, only a small percentage of physicians have formal training in exercise physiology, and personalized exercise prescriptions are limited to a minority of patients.
WOMENS HEALTH REPORTS
(2022)
Review
Integrative & Complementary Medicine
Terence Moriarty, Kelsey Bourbeau, Micah Zuhl
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2020)
Review
Psychology, Multidisciplinary
Kelsey Bourbeau, Terence Moriarty, Akeisha Ayanniyi, Micah Zuhl
BEHAVIORAL SCIENCES
(2020)
Article
Psychology, Multidisciplinary
Terence Moriarty, Kelsey Bourbeau, Christine Mermier, Len Kravitz, Ann Gibson, Nicholas Beltz, Omar Negrete, Micah Zuhl
BEHAVIORAL SCIENCES
(2020)
Article
Cardiac & Cardiovascular Systems
Megan Mytinger, Rachael K. Nelson, Micah Zuhl
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2020)
Article
Medicine, General & Internal
Roberto Nava, Micah Zuhl, Kelsey Bourbeau, Terence Moriarty, Anna Welch, Christine Mermier
GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
(2019)
Article
Sport Sciences
Bryanne N. Bellovary, Kelli E. King, Tony P. Nunez, James J. McCormick, Andrew D. Wells, Kelsey C. Bourbeau, Zachary J. Fennel, Zidong Li, Kelly E. Johnson, Terence Moriarty, Christine M. Mermier
JOURNAL OF HUMAN SPORT AND EXERCISE
(2019)
Article
Cardiac & Cardiovascular Systems
Truman Haeny, Rachael Nelson, Jeremy Ducharme, Micah Zuhl
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2019)
Article
Psychology, Multidisciplinary
Terence Moriarty, Kelsey Bourbeau, Bryanne Bellovary, Micah N. Zuhl
BEHAVIORAL SCIENCES
(2019)
Article
Medicine, General & Internal
Kelsey C. Bourbeau, Mattina M. Rosinski, Taylor M. Szczygiel, Ryan Pettit-Mee, Jenna E. Sessions, Micah N. Zuhl
GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
(2019)