Article
Chemistry, Physical
Alessandra G. Ritacca, Luana Malacaria, Emilia Sicilia, Emilia Furia, Gloria Mazzone
Summary: This study investigates the ability of L-ascorbic acid to form complexes with Fe3+ and Cu2+ ions using potentiometric measurements and DFT computations, and identifies the most reliable complex structures.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Ana Belen Uceda, Josefa Donoso, Juan Frau, Bartolome Vilanova, Miquel Adrover
Summary: Frataxin is a mitochondrial protein crucial for regulating oxidative stress balance and protecting neurons. Research has shown that both human and yeast frataxins can inhibit the formation of reactive oxygen species and protect oxidation-prone proteins. This suggests that frataxins act as a shield against oxidation and could potentially be used to prevent neurological disorders associated with oxidative stress.
Review
Biochemistry & Molecular Biology
Andras Szarka, Tamas Lorincz, Peter Hajdinak
Summary: Iron, reactive oxygen species (ROS), and ascorbate play dual roles in cell fate decision, and their interactions have significant impacts on cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Horticulture
Chen Li, Jiaqi Tao, Zhaoxia Wu
Summary: Mechanical damage during processing can accelerate the senescence and deterioration of fresh-cut red pitaya. In this study, a low-concentration and long-term gaseous ozone treatment was found to delay the decline in fruit quality, enhance the antioxidant activities, and regulate reactive oxygen species (ROS) metabolism of fresh-cut red pitaya fruit. The ozone treatment improved the activity of antioxidant enzymes, maintained the redox balance, and delayed senescence.
SCIENTIA HORTICULTURAE
(2023)
Article
Biochemistry & Molecular Biology
Sanjay Kumar Rohaun, James A. Imlay
Summary: The study found that RSEs are resistant to hydrogen peroxide and superoxide in vitro. Viperin is gradually poisoned by molecular oxygen, while HemN is more sensitive to copper in the environment. These findings are important for understanding the function of RSEs and their response to environmental stresses.
Article
Engineering, Environmental
Zilong Zhang, Scott Weichenthal, Jeffrey C. Kwong, Richard T. Burnett, Marianne Hatzopoulou, Michael Jerrett, Aaron van Donkelaar, Li Bai, Randall Martin, Ray Copes, Hong Lu, Pascale Lakey, Manabu Shiraiwa, Hong Chen
Summary: This study found positive associations between long-term exposure to iron, copper, and ROS in PM2.5 and the risks of respiratory diseases. The impacts were more robust for COPD, pneumonia mortality, and respiratory mortality. The associations were stronger for ROS than for iron or copper.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Plant Sciences
Yu-Ying Sun, Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study found that nitric oxide (NO) can enhance thermotolerance in maize seedlings by triggering the LCD/H2S signaling pathway. Additionally, NO also improves the adaptability of maize seedlings to heat stress by regulating the activity of the ROS scavenging system.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Young-Saeng Kim, Seong-Im Park, Jin-Ju Kim, Sun-Young Shin, Sang-Soo Kwak, Choon-Hwan Lee, Hyang-Mi Park, Yul-Ho Kim, Il-Sup Kim, Ho-Sung Yoon
Summary: Abiotic stress can induce the generation of reactive oxygen species (ROS) in plants, leading to oxidative damage. In this study, we developed salt-tolerant transgenic rice plants that overexpressed the OsDHAR1 gene under the control of a stress-inducible promoter. These transgenic plants showed improved environmental adaptability and agronomic traits, including root development and grain yield. Knockdown of the OsDHAR2 gene in plants resulted in sensitivity to salt stress and reduced biomass and grain yield. Microarray analysis revealed the upregulation of genes related to cell growth, plant growth, senescence, and stress response in the transgenic plants. Our findings provide insights into the physiological processes underlying environmental adaptability and have implications for crop breeding and climate change adaptation.
Article
Limnology
Wytze K. Lenstra, Martijn Hermans, Marie J. M. Seguret, Rob Witbaard, Silke Severmann, Thilo Behrends, Caroline P. Slomp
Summary: The study found that in seasonally hypoxic areas of the Baltic Sea receiving high inputs of organic matter, there are high rates of benthic release of iron and manganese, which are sensitive to bottom water oxygen concentrations. Easily reducible iron and manganese oxides are key forms of particulate iron and manganese in suspended matter.
LIMNOLOGY AND OCEANOGRAPHY
(2021)
Article
Geochemistry & Geophysics
Pooya Paydary, Alexandra E. P. Schellenger, Minerva Teli, Deb P. Jaisi, Annalisa Onnis-Hayden, Philip Larese-Casanova
Summary: This study found that reactive oxygen species such as ozone, hypochlorite, and hydrogen peroxide can completely or partially oxidize selenite to selenate within different time frames. Additionally, hydroxyl radicals generated by the photocatalytic decomposition of H2O2 can fully oxidize selenite within six hours.
Article
Chemistry, Physical
Chih-Huang Weng, Chong-Yi Liao, Jing-Hua Tzeng, Ying-Chen Chen, Jin Anotai, Yao-Tung Lin
Summary: Developing oxygen vacancies in nanomaterials is an effective method to enhance catalytic performance. In this study, a novel low-cost ternary iron-manganese-copper mixed oxide catalyst with abundant oxygen vacancies was successfully synthesized. Characterization analyses revealed the metal valence transformation, synergy structure, and role of oxygen vacancies in the catalyst, demonstrating its excellent catalytic oxidation performance. The stable and active structure of the catalyst after oxidizing ethylene suggests a redox cycle of catalytic mechanism. This work provides valuable insights into the development of high-performance and stable catalysts with abundant oxygen vacancies for VOCs elimination.
APPLIED SURFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Douglas Jardim-Messeder, Andreia Caverzan, Gabriel Afonso Bastos, Vanessa Galhego, Ygor de Souza-Vieira, Fernanda Lazzarotto, Esther Felix-Mendes, Lucas Lavaquial, Jose Nicomedes, Marcia Margis-Pinheiro, Gilberto Sachetto-Martins
Summary: In this study, APX genes were identified from various Poaceae species, and it was found that the APX gene family underwent duplication events and divergence. MitAPX, a unique type in Poaceae, is essential for rice plant growth, while sAPX and tAPX are responsible for regulating hydrogen peroxide levels in the cell and chloroplast, respectively.
GENETICS AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Plant Sciences
Conghui Li, Yadi Liu, Xiatong Liu, Keith Ka Ki Mai, Jiaxin Li, Xiaorui Guo, Chong Zhang, Hui Li, Byung-Ho Kang, Inhwan Hwang, Hai Lu
Summary: This study uncovered the process of chloroplast development in Populus tomentosa and identified the crucial role of PtotAPX in light-induced chloroplast development. These findings provide important insights into the mechanism of chloroplast development in woody plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Pharmacology & Pharmacy
David J. Merkler, Aidan J. Hawley, Betty A. Eipper, Richard E. Mains
Summary: Peptides play a crucial role in various physiological and neurobiological pathways, and amidation is a key step in the synthesis of bioactive peptides. Inhibiting the enzyme PAM, which is responsible for amidation, could be used for the treatment of cancer and psychiatric abnormalities. However, current inhibitor design has not fully utilized the structural and mechanistic details of PAM.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Svenja Offer, Elena Hartner, Sebastiano Di Bucchianico, Christoph Bisig, Stefanie Bauer, Jana Pantzke, Elias J. Zimmermann, Xin Cao, Stefanie Binder, Evelyn Kuhn, Anja Huber, Seongho Jeong, Uwe Kafer, Patrick Martens, Arunas Mesceriakovas, Jan Bendl, Ramona Brejcha, Angela Buchholz, Daniella Gat, Thorsten Hohaus, Narges Rastak, Gert Jakobi, Markus Kalberer, Tamara Kanashova, Yue Hu, Christoph Ogris, Annalisa Marsico, Fabian Theis, Michal Pardo, Thomas Groger, Sebastian Oeder, Jurgen Orasche, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Thomas Adam, Olli Sippula, Martin Sklorz, Jurgen Schnelle-Kreis, Hendryk Czech, Astrid Kiendler-Scharr, Yinon Rudich, Ralf Zimmermann
Summary: This study investigated the toxicological effects of aerosols generated by atmospheric aging on combustion soot particles (SPs) of gaseous biogenic or anthropogenic precursors in lung cell models. The researchers found that secondary organic aerosols (SOAs) had greater toxicity than primary SPs. Moreover, anthropogenic SOAs showed stronger toxic effects compared to biogenic SOAs.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Michal Pardo, Svenja Offer, Elena Hartner, Sebastiano Di Bucchianico, Christoph Bisig, Stefanie Bauer, Jana Pantzke, Elias J. Zimmermann, Xin Cao, Stephanie Binder, Evelyn Kuhn, Anja Huber, Seongho Jeong, Uwe Ka, Eric Schneider, Arunas Mesceriakovas, Jan Bendl, Ramona Brejcha, Angela Buchholz, Daniela Gat, Thorsten Hohaus, Narges Rastak, Erwin Karg, Gert Jakobi, Markus Kalberer, Tamara Kanashova, Yue Hu, Christoph Ogris, Annalisa Marsico, Fabian Theis, Tali Shalit, Thomas Gro, Christopher P. Rueger, Sebastian Oeder, Juergen Orasche, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Thomas Adam, Olli Sippula, Martin Sklorz, Juergen Schnelle-Kreis, Hendryk Czech, Astrid Kiendler-Scharr, Ralf Zimmermann, Yinon Rudich
Summary: This study investigates the toxicities of secondary organic aerosols (SOAs) derived from different precursor compounds. It shows that SOAs derived from a typical anthropogenic precursor have higher toxicological potency and activate different cellular mechanisms compared to those derived from a typical biogenic precursor.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Engineering, Environmental
Steven J. Campbell, Kate Wolfer, Peter J. Gallimore, Chiara Giorio, Daniel Haussinger, Marc-Aurele Boillat, Markus Kalberer
Summary: The ozonolysis of alkenes is responsible for the formation of significant amounts of Criegee intermediates (CIs), but their contributions to aerosol particle chemistry remain uncertain. In this study, a novel methodology using spin traps was used to simultaneously quantify CIs produced from the ozonolysis of volatile organic compounds in the gas and particle phases. The results showed that only the smallest CI with one carbon atom was detected in the gas phase, while multiple particle-bound CIs were observed in the secondary organic aerosol (SOA). Furthermore, it was found that CIs have a longer lifetime in highly viscous SOA particles compared to the gas phase.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Edwige Moyroud, Chiara A. Airoldi, Jordan Ferria, Chiara Giorio, Sarah S. Steimer, Paula J. Rudall, Christina J. Prychid, Shannon Halliwell, Joseph F. Walker, Sarah Robinson, Markus Kalberer, Beverley J. Glover
Summary: Plants use both chemical and structural means to appear colorful. In this study, we investigate the formation of diffraction gratings on the petal surface by studying a novel model system, Hibiscus trionum, and different species of Hibiscus. We find that the chemical composition of the cuticle plays a crucial role in restricting the formation of diffraction gratings to the pigmented region of the petal.
Article
Engineering, Environmental
Shunyao Wang, Peter J. Gallimore, Carolyn Liu-Kang, Kirsten Yeung, Steven J. Campbell, Battist Utinger, Tengyu Liu, Hui Peng, Markus Kalberer, Arthur W. H. Chan, Jonathan P. D. Abbatt
Summary: This study reports the unique chemical and toxicological metrics of biomass burning organic aerosols (BBOA) from pine wood smoldering during multiphase aging by gas-phase hydroxyl radicals (OH). Both the fresh and OH-aged BBOA show activity relevant to adverse health outcomes. Short-term aging initiated by OH radicals can produce biomass burning particles with a higher particle-bound reactive oxygen species (ROS) generation capacity, posing a greater exposure hazard for residents in large population centers close to wildfire regions than previously studied fresh biomass burning emissions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Stavros Stagakis, Christian Feigenwinter, Roland Vogt, Markus Kalberer
Summary: This study develops a high-resolution bottom-up model that provides hourly maps of urban surface CO2 fluxes, including contributions from buildings, traffic, human respiration, soil respiration, plant respiration, and plant photosynthetic uptake. The model is designed to be simple and flexible, using commonly available data as input, making it transferable to different locations. Applied to Basel, Switzerland, the model captures the dynamic spatiotemporal variability of urban CO2 fluxes and estimates lower emissions from buildings and traffic compared to the local inventory.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Chemical
Michal Pardo, Hendryk Czech, Svenja Offer, Martin Sklorz, Sebastiano Di Bucchianico, Elena Hartner, Jana Pantzke, Evelyn Kuhn, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Gert Jakobi, Stefanie Bauer, Anja Huber, Elias J. J. Zimmermann, Narges Rastak, Stephanie Binder, Ramona Brejcha, Eric Schneider, Jurgen Orasche, Christopher P. P. Rueger, Thomas Groeger, Sebastian Oeder, Jurgen Schnelle-Kreis, Thorsten Hohaus, Markus Kalberer, Olli Sippula, Astrid Kiendler-Scharr, Ralf Zimmermann, Yinon Rudich
Summary: Soot particles (SP) are common components of atmospheric particulate matter and can cause adverse health effects. We investigated the biological responses of lung epithelial cells following exposure to fresh- and photochemically aged-SP at the air-liquid interface. Our results showed that aging of SP increased toxicity through surface modifications, leading to oxidative stress, inflammation, and DNA damage.
AEROSOL SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Environmental
Steven J. Campbell, Battist Utinger, Alexandre Barth, Suzanne E. Paulson, Markus Kalberer
Summary: This study presents a novel approach using two online instruments to quantitatively measure the oxidative potential (OP) of particulate matter. It investigates the influence of Fe(II) and Cu(II) on secondary organic aerosol (SOA) and reveals a range of synergistic and antagonistic interactions. The results provide new insights into the influence of metal and SOA interactions on particle OP.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Stavros Stagakis, Christian Feigenwinter, Roland Vogt, Dominik Brunner, Markus Kalberer
Summary: This study develops a novel approach that combines urban eddy covariance (EC) tower observations of CO2 flux with an advanced urban bottom-up (BU) surface flux model within a Bayesian inversion framework. The methodology provides optimized gridded CO2 flux information for each urban surface flux component at high spatial and temporal resolution. The results show improved estimations of flux variabilities and reductions in anthropogenic emissions, with traffic emissions having the greatest confidence among the flux components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Julian Resch, Kate Wolfer, Alexandre Barth, Markus Kalberer
Summary: In order to understand the sources and processes of organic aerosol particles, it is necessary to characterize their chemical composition. This study used liquid chromatography-mass spectrometry to analyze the effects of storage conditions and time on the composition of secondary organic aerosol. The results showed that low temperature storage conditions preserved the chemical composition, while storage at room temperature led to significant time-dependent changes.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Article
Meteorology & Atmospheric Sciences
Battist Utinger, Steven John Campbell, Nicolas Bukowiecki, Alexandre Barth, Benjamin Gfeller, Ray Freshwater, Hans-Rudolf Ruegg, Markus Kalberer
Summary: Large-scale epidemiological studies consistently show that exposure to ambient particulate matter (PM) has adverse health effects, but the specific properties of particles responsible for the effects and the underlying mechanisms remain uncertain. The oxidative potential (OP) of aerosol particles, the ability to produce reactive oxidative species (ROSs) and deplete antioxidants, is believed to be a key metric for particle toxicity. Traditional methods for measuring OP are labor-intensive and time-consuming. To address this, a portable online instrument was developed to directly measure particle OP under physiological conditions, providing continuous and accurate measurements with high time resolution.
ATMOSPHERIC MEASUREMENT TECHNIQUES
(2023)
Article
Engineering, Environmental
Steven J. Campbell, Battist Utinger, Alexandre Barth, Suzanne E. Paulson, Markus Kalberer
Summary: The oxidative potential (OP) of particulate matter is a key metric for assessing atmospheric particle toxicity. This study used two novel online instruments to quantify particle OP and investigated the influence of Fe(II) and Cu(II) on the OP of secondary organic aerosol (SOA). Synergistic and antagonistic interactions were observed when Fe(II) and Cu(II) were mixed with representative biogenic and anthropogenic SOA. A kinetic model revealed important reactions among SOA components, transition metals, and ascorbate, impacting the OP.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Zhi-Hui Zhang, Elena Hartner, Battist Utinger, Benjamin Gfeller, Andreas Paul, Martin Sklorz, Hendryk Czech, Bin Xia Yang, Xin Yi Su, Gert Jakobi, Jurgen Orasche, Juergen Schnelle-Kreis, Seongho Jeong, Thomas Groeger, Michal Pardo, Thorsten Hohaus, Thomas Adam, Astrid Kiendler-Scharr, Yinon Rudich, Ralf Zimmermann, Markus Kalberer
Summary: This study comprehensively characterized and compared the formation of particle-bound reactive oxygen species (ROS) in secondary organic aerosols (SOAs) generated from different sources. The results suggest that quantifying particle-bound ROS could be a feasible method for predicting aerosol particle toxicity and adverse health effects.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2022)