Article
Clinical Neurology
Daniele Belvisi, Marco Canevelli, Matteo Costanzo, Margherita Giangrosso, Andrea Fabbrini, Andrea Borraccino, Giuseppe Bruno, Alfredo Berardelli, Giovanni Fabbrini
Summary: The study revealed that frailty in PD patients is associated with both motor and non-motor symptoms, with frail patients exhibiting more severe motor symptoms, higher global burden of non-motor symptoms, and pronounced cognitive deficits. The associations between frailty and symptom severity remained significant even after accounting for traditional predictors of PD severity.
JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Remi Morimoto, Mutsumi Iijima, Yasuyuki Okuma, Keisuke Suzuki, Fumihito Yoshii, Shigeru Nogawa, Takashi Osada, Kazuo Kitagawa
Summary: This study investigated the factors associated with non-motor symptoms (NMS) in patients with Parkinson's disease (PD). The results showed that NMS severity was higher in older adults, those with longer disease duration, subjective and objective motor function impairments, and rapid eye movement sleep behavior disorder (RBD). Sex-based differences were also observed, with higher levels of anxiety in female patients and higher levels of daytime sleepiness, urinary problems, and RBD in male patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Immunology
Yuanyuan Li, Yan Yang, Aonan Zhao, Ningdi Luo, Mengyue Niu, Wenyan Kang, Anmu Xie, Hong Lu, Lei Chen, Jun Liu
Summary: This study identified a correlation between a profile of four peripheral immune biomarkers and the development and progression of Parkinson's disease. The findings provide a basis for identifying Parkinson's disease patients with abnormal inflammatory profiles and providing timely therapeutic interventions.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Geriatrics & Gerontology
Qiu-Wan Liu, Cheng-Jie Mao, Zhao-Hui Lu, Rong-Fang Shi, Ying-Chun Zhang, Ping Zhao, Chun-Feng Liu
Summary: This study found that patients with Parkinson's disease are more likely to develop sarcopenia than healthy older adults, and fatigue and poor sleep quality are positively associated with sarcopenia. Further longitudinal studies are needed to clarify the causal relationships.
Article
Obstetrics & Gynecology
Oisin Fitzgerald, Silke Dyer, Fernando Zegers-Hochschild, Elena Keller, G. David Adamson, Georgina M. Chambers
Summary: The study explores the association between a country's level of gender equality and access to ART, and finds that ART utilization is associated with gender equality even after controlling for development level.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Bingbo Gao, Jianyu Yang, Ziyue Chen, George Sugihara, Manchun Li, Alfred Stein, Mei-Po Kwan, Jinfeng Wang
Summary: This paper presents a causal inference model based on cross-sectional Earth System data for revealing complex nonlinear causal associations. The model performs well in detecting weak to moderate causations between variables with insignificant correlations and limited temporal variations. It is also advantageous in identifying the primary causation direction and revealing bidirectional asymmetric causation.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Maurizio Bergamino, Elizabeth G. Keeling, Nicola J. Ray, Antonella Macerollo, Monty Silverdale, Ashley M. Stokes
Summary: This study analyzed the structural connectivity and white matter networks in patients with Parkinson's disease (PD) using diffusion MRI and graph theory. The results showed that PD patients had lower structural connectivity in certain brain areas compared to healthy controls. Altered connectivity between baseline and 36 months was also found. These findings suggest that studying structural and network metrics can provide insights into network reorganization in PD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Marina Picillo, David-Erick Lafontant, Susan Bressman, Chelsea Caspell-Garcia, Christopher Coffey, Hyunkeun Ryan Cho, Elliot L. Burghardt, Nabila Dahodwala, Rachel Saunders-Pullman, Caroline M. Tanner, Amy W. Amara
Summary: Men with early untreated Parkinson's disease (PD) showed greater longitudinal changes in motor and non-motor features compared to women. They also required higher dopaminergic medication dosages over time. However, there were no sex-related progression patterns observed in biological biomarkers.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Peikun He, Lin Shi, Yanyi Li, Qingrui Duan, Yihui Qiu, Shujun Feng, Yuyuan Gao, Yishan Luo, Guixian Ma, Yuhu Zhang, Lijuan Wang, Kun Nie
Summary: This study found that there is an association between glymphatic dysfunction and the progression of Parkinson's disease. Age, disease severity, and dyskinesia are negatively correlated with the glymphatic function. Further research indicated that glymphatic function is related to disease deterioration and cognitive decline, and may mediate the pathological role of toxic protein in cognitive decline.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Carla Silva-Batista, Daniel Boari Coelho, Renato Campos Freire Junior, Lorena Rosa Almeida, Adriana Guimaraes, Katia Cirilo Costa Nobrega, Hugo Machado Sanchez, Ana Raquel Rodrigues Lindquist, Vera Lucia Israel, Helcio Kanegusuku, Rachel Guimaraes, Nayanne Beckmann Bosaipo, Richelma Barbosa, Clynton Lourenco Correa, Maria Jose Finatto, Felipe Augusto dos Santos Mendes, Maria Elisa Pimentel Piemonte
Summary: Self-reported clinical worsening in people with Parkinson's disease living in Brazil during social distancing can be aggravated by the precarious e/tele-health system, with factors like decreased physical activity volume, impoverished daily routine, and fear of falling explaining the observed changes. A remote multi-professional support system is urgently needed to address the multifaceted worsening experienced by these individuals.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medical Informatics
Kristen A. Severson, Lana M. Chahine, Luba A. Smolensky, Murtaza Dhuliawala, Mark Frasier, Kenney Ng, Soumya Ghosh, Jianying Hu
Summary: The study developed a statistical progression model of early Parkinson's disease that accounts for intra-individual and inter-individual variability and medication effects. The predictive model discovered non-sequential, overlapping disease progression trajectories, supporting the use of non-deterministic disease progression models, and suggesting static subtype assignment might be ineffective at capturing the full spectrum of Parkinson's disease progression.
LANCET DIGITAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Yi-Chieh Chen, Rou-Shayn Chen, Yi-Hsin Weng, Ying-Zu Huang, Chiung Chu Chen, June Hung, Yi-Ying Lin
Summary: In Taiwanese PD patients, the severity of NMSs worsens with disease duration, and the increase in medication dosage is independent of the progression of NMSs.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Ruwei Ou, Yanbing Hou, Qianqian Wei, Junyu Lin, Kuncheng Liu, Lingyu Zhang, Zheng Jiang, Bei Cao, Bi Zhao, Wei Song, Huifang Shang
Summary: The study of global non-motor symptoms (NMS) in Chinese patients with Parkinson's disease (PD) showed an increase in the majority of NMS domains except for mood/apathy and sexual dysfunctions. The evolution of overall NMS in early PD was found to be mild and multidimensional, with a high NMS burden predicting faster motor progression of PD. This longitudinal study provides valuable insights into the progression of NMS in PD.
NPJ PARKINSONS DISEASE
(2021)
Article
Multidisciplinary Sciences
Andrea Kelemen, Laszlo Halasz, Lorand Eross, Gabor Rudas, Muthuraman Muthuraman, Denes Zadori, Bence Laczo, David Kis, Peter Klivenyi, Gabor Fekete, Laszlo Bognar, Daniel Bereczki, Gertrud Tamas
Summary: This study analyzed the combination of predictive clinical factors for balance impairment in Parkinson's disease patients treated with bilateral subthalamic stimulation. The duration of the disease, severity of motor symptoms, levodopa responsiveness, and additional sensory deficits were found to be important factors in predicting imbalance induced by subthalamic stimulation.
Article
Clinical Neurology
Hui Wang, Xiangdong Tang, Junying Zhou, Yanming Xu
Summary: This study found that the presence and severity of excessive daytime sleepiness (EDS) may be significantly associated with non-motor dysfunction in multiple system atrophy (MSA) patients, including fatigue, anxiety, depression, cognitive dysfunction, and sleep-related breathing disorder, but not with motor dysfunction.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
A. Alvarado-Bolanos, A. Cervantes-Arriaga, L. Zuazua-Vidal, O. Esquivel-Zapata, A. Alcocer-Salas, M. Rodriguez-Violante
Summary: This study aims to identify determinants of alexithymia and its association with quality of life in Parkinson's disease. The results show that lower education level and urinary symptoms are important factors contributing to difficulty identifying and describing feelings, and alexithymia independently affects the quality of life.
Article
Public, Environmental & Occupational Health
Inaki Galan, Cristina Ortiz, Monica Perez-Rios, Ana Ayuso-alvarez, Carmen Rodriguez-Blazquez, Javier Damian, Carlos Fernandez-Escobar, Esther Garcia-Esquinas, Teresa Lopez-Cuadrado
Summary: This study aims to assess the impact of light smoking on mortality. The results show that smokers have an increased risk of mortality compared to non-smokers. Therefore, it is necessary to conduct awareness-raising campaigns to increase people's awareness of the health hazards of light smoking.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Biology
Zoe Menczel Schrire, Christopher J. Gordon, Jake R. Palmer, Jade Murray, Ian Hickie, Naomi L. Rogers, Simon J. G. Lewis, Zoe Terpening, Jonathon E. Pye, Sharon L. Naismith, Camilla M. Hoyos
Summary: This study explored the association between clinical markers and circadian rhythms in older adults, finding that factors such as chronotype and light exposure were predictive of dim light melatonin onset (DLMO) time and phase angle. The use of clinical variables, such as actigraphy-derived light, as circadian markers in aging could be easily implemented into existing clinical practice and could potentially guide chronotherapeutic interventions.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Clinical Neurology
Jenny M. M. Norlin, Klas Kellerborg, Ulf Persson, Daniel Oudin Astrom, Peter Hagell, Pablo Martinez-Martin, Per Odin
Summary: This study found an association between the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) and health-related quality of life assessments. The findings suggest that CISI-PD could be used as a basis for defining health states in future health economic models and as outcomes in managed entry agreements.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Paul C. Donaghy, Claudia Carrarini, Daniel Ferreira, Annegret Habich, Dag Aarsland, Claudio Babiloni, Ece Bayram, Joseph P. M. Kane, Simon J. G. Lewis, Andrea Pilotto, Alan J. Thomas, Laura Bonanni
Summary: This study conducted a systematic review and meta-analysis of the diagnostic clinical features and biomarkers in MCI-LB, supporting the inclusion of current clinical features in the diagnostic criteria and finding promise in FDG-PET and quantitative EEG as diagnostic biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Valentina Leta, Daniel J. van Wamelen, Federico Aureli, Vinod Metta, Dhaval Trivedi, Pietro Cortelli, Carmen Rodriguez-Blazquez, Alexandra Rizos, K. Ray Chaudhuri
Summary: This study aimed to evaluate the long-term effects of opicapone and entacapone on non-motor symptoms (NMS) in levodopa-treated people with Parkinson's disease. The results showed that opicapone can stabilize NMS burden and sleep dysfunction, while entacapone leads to worsening of NMS burden and sleep scores over a 1-year follow-up.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Ambra Stefani, Claudia Trenkwalder, Isabelle Arnulf, Donald L. Bliwise, Bradley F. Boeve, Yuichi Inoue, Alejandro Iranzo, Simon J. G. Lewis, Federica Provini, Carlos Schenck, Gregor K. Wenning, Yun Wok Wing, Birgit Hogl, Aleksandar Videnovic
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Matthew J. J. Georgiades, James M. M. Shine, Moran Gilat, Jacqueline McMaster, Brian Owler, Neil Mahant, Simon J. G. Lewis
Summary: Patients with Parkinson's disease experience freezing of gait during cognitive tasks, and their subthalamic nucleus recordings show abnormal firing patterns at low frequencies, which may inform the development of deep brain stimulation protocols.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Priya Jagota, Shen-Yang Lim, Pramod Kumar Pal, Jee-Young Lee, Prashanth Lingappa Kukkle, Shinsuke Fujioka, Huifang Shang, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Norlinah Mohamed Ibrahim, Yoshikazu Ugawa, Zakiyah Aldaajani, Beomseok Jeon, Cid Diesta, Cholpon Shambetova, Chin-Hsien Lin
Summary: The increasing availability of molecular genetic testing has changed the landscape of both genetic research and clinical practice. These advancements lead to the awareness that some genetic movement disorders may cluster in certain ethnic populations and genetic pleiotropy may result in unique clinical presentations in specific ethnic groups. Recognition of a particular clinical phenotype, combined with information about the ethnic origin of patients could lead to early and correct diagnosis and assist the development of future personalized medicine for patients with these disorders.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Prashanth Lingappa Kukkle, Divyani Garg, Marcello Merello
Summary: Continuous subcutaneous apomorphine infusion (CSAI) is an advanced therapy for Parkinson's disease (PD), which can reduce OFF periods and improve motor symptoms in advanced cases of PD.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Sociology
Maria Falcon-Romero, Carmen Rodriguez-Blazquez, Maria Romay-Barja, Maria Joao Forjaz
Summary: The study explores the concerns and attitudes of the population towards the COVID-19 pandemic, and analyzes their acceptance and adherence to preventive measures, as well as their perception of risk and trust in information sources and institutions. The results show that attitudes are dynamic and influenced by both individual and contextual factors.
REVISTA ESPANOLA DE SOCIOLOGIA
(2023)
Article
Behavioral Sciences
Daniel Collerton, James Barnes, Nico J. Diederich, Rob Dudley, Dominic Ffytche, Karl Friston, Christopher G. Goetz, Jennifer G. Goldman, Renaud Jardri, Jaime Kulisevsky, Simon J. G. Lewis, Shigetoshi Naral, Claire O'Callaghan, Marco Onofrj, Javier Pagonabarraga, Thomas Parr, James M. Shine, Glenn Stebbins, John-Paul Taylor, Ichiro Tsuda, Rimona S. Weil
Summary: Despite years of research, it remains uncertain why people sometimes perceive things that aren't there. Eight models of complex visual hallucinations have been proposed since 2000, each based on different understandings of brain organization. To address this variability, researchers established an integrated Visual Hallucination Framework that aligns with current theories of veridical and hallucinatory vision, enabling a systematic investigation of the relationship between hallucination phenomenology and cognitive structures. The episodic nature of hallucinations suggests a complex relationship between state and trait markers, highlighting new avenues for research and potential approaches to treating distressing hallucinations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Amin Cervantes-Arriaga, David J. Garcia-Romero, Marco Munuzuri-Camacho, Oscar Esquivel-Zapata, David Davila-Ortiz de Montelano, Leticia Martinez-Ruano, Ana J. Hernandez-Medrano, Maria A. Ruiz-Mafud, Gloria I. Cerda-Hernandez, Arturo Abundes-Corona, Mayela Rodriguez-Violante
Summary: This study aimed to identify factors contributing to the delayed diagnosis of Huntington's disease (HD). A cross-sectional study was conducted on HD patients, collecting variables such as CAG repeats, age of onset, primary symptom, age of molecular diagnosis, and time-to-diagnosis. Results showed that out of 107 patients (50.5% female) with a mean age of 49 years, delayed diagnosis was associated with neuropsychiatric symptoms and early onset of the disease. Linear regression analysis confirmed neuropsychiatric symptoms and early onset as independent risk factors for delayed diagnosis.
REVISTA MEXICANA DE NEUROCIENCIA
(2023)
Article
Clinical Neurology
Amin Cervantes-Arriaga, Oscar Esquivel-Zapata, Emmanuel Escobar-Valdivia, David Garcia-Romero, Marco Munuzuri-Camacho, Ana J. Hernandez-Medrano, Arturo Abundes-Corona, Mayela Rodriguez-Violante
Summary: This study aims to determine whether type 2 diabetes mellitus impacts the age of Parkinson's disease onset. The results showed that Parkinson's disease patients with type 2 diabetes mellitus had an older age at disease onset, suggesting a potential role of type 2 diabetes mellitus in delaying the age of disease onset.
REVISTA MEXICANA DE NEUROCIENCIA
(2023)