Cell morphology and mechanosensing can be decoupled in fibrous microenvironments and identified using artificial neural networks

Single-cell morphology encodes metastatic potential

(2020) Pei-Hsun Wu et al.   Science Advances

Identification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading

(2019) Joanna Y. Lee et al.   Scientific Reports

Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss

(2019) Edward D. Bonnevie et al.   Nature Biomedical Engineering

Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

(2019) Bailey V. Fearing et al.   FASEB JOURNAL

Mediating human stem cell behaviour via defined fibrous architectures by melt electrospinning writing

(2018) Kian F. Eichholz et al.   Acta Biomaterialia

Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate

(2018) Thomas C. von Erlach et al.   NATURE MATERIALS

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

Machine learning based methodology to identify cell shape phenotypes associated with microenvironmental cues

(2016) Desu Chen et al.   BIOMATERIALS

Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments

(2016) Steven R. Caliari et al.   BIOMATERIALS

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation

(2016) Claire M. McLeod et al.   Scientific Reports

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition

(2015) Michaël Ruff et al.   PLoS One

Multiparametric Classification Links Tumor Microenvironments with Tumor Cell Phenotype

(2014) Bojana Gligorijevic et al.   PLOS BIOLOGY

Quantitative shape analysis of chemoresistant colon cancer cells: Correlation between morphotype and phenotype

(2012) A. Pasqualato et al.   EXPERIMENTAL CELL RESEARCH

Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state

(2012) A.J. Michalek et al.   JOURNAL OF BIOMECHANICS

Re-establishment of cytoskeletal tensional homeostasis in lax tendons occurs through an actin-mediated cellular contraction of the extracellular matrix

(2012) Keri Gardner et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Evaluation of affine fiber kinematics in human supraspinatus tendon using quantitative projection plot analysis

(2011) Spencer P. Lake et al.   Biomechanics and Modeling in Mechanobiology

Diminished Type III Collagen Promotes Myofibroblast Differentiation and Increases Scar Deposition in Cutaneous Wound Healing

(2011) Susan W. Volk et al.   CELLS TISSUES ORGANS

A support vector machine classifier with rough set-based feature selection for breast cancer diagnosis

(2011) Hui-Ling Chen et al.   EXPERT SYSTEMS WITH APPLICATIONS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds

(2010) Ashwin S. Nathan et al.   Acta Biomaterialia

Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts

(2009) Angels Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Loss of Homeostatic Strain Alters Mechanostat “Set Point” of Tendon Cells In Vitro

(2008) Steven P. Arnoczky et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

(2008) Celeste M. Nelson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY