Review
Medicine, General & Internal
Sreedhar Subramanian, George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Eamon Laird, Richard Quinton, David Thickett, Jonathan M. Rhodes
Summary: Vitamin D deficiency is associated with an increased risk of COVID-19, especially in winter or among individuals with less sunlight exposure or darker skin pigmentation. Some studies have shown an association between vitamin D deficiency and increased severity of COVID-19, but the results of interventional studies are inconclusive.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Endocrinology & Metabolism
John P. Bilezikian, Neil Binkley, Hector F. De Luca, Angelo Fassio, Anna Maria Formenti, Ghada El-Hajj Fuleihan, Annemieke C. Heijboer, Andrea Giustina
Summary: This work reviews and discusses controversial topics regarding vitamin D, SARS-CoV-2 infection, and COVID-19. The International Conferences Controversies in Vitamin D are workshops that started in 2017 and feature international experts and leaders in the field. The fifth annual conference was held in Stresa, Italy, in September 2021.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Christian Mingiano, Tommaso Picchioni, Guido Cavati, Filippo Pirrotta, Marco Calabrese, Ranuccio Nuti, Stefano Gonnelli, Alberto Fortini, Bruno Frediani, Luigi Gennari, Daniela Merlotti
Summary: This study aimed to evaluate the relationship between 25-OH vitamin D (25OHD) levels and prognosis, mortality, mechanical ventilation, and orotracheal intubation in hospitalized COVID-19 patients. The study found a positive correlation between 25OHD levels and oxygenation levels, and significantly lower levels in patients requiring mechanical ventilation and intubation. Patients with severe 25OHD deficiency had longer hospital stays and higher mortality rates. Additionally, supplementation with calcifediol reduced hospitalization duration and mortality rates.
Article
Chemistry, Medicinal
Alexandra Povaliaeva, Viktor Bogdanov, Ekaterina Pigarova, Larisa Dzeranova, Nino Katamadze, Natalya Malysheva, Vitaliy Ioutsi, Larisa Nikankina, Liudmila Rozhinskaya, Natalia Mokrysheva
Summary: This study revealed that COVID-19 patients have low levels of vitamin D and increased production of active vitamin D metabolite, possibly to prevent hypocalcemia.
Article
Biochemistry & Molecular Biology
Marie Bicikova, Ludmila Macova, Martin Hill
Summary: Vitamin D plays an important role in immunomodulation, brain development, and functioning. Its potential immunoprotective role in COVID-19 has been discussed. This study found that individuals who took vitamin D had a significantly lower risk of COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sheng-Kang Chiu, Kuo-Wang Tsai, Chia-Chao Wu, Cai-Mei Zheng, Chung-Hsiang Yang, Wan-Chung Hu, Yi-Chou Hou, Kuo-Cheng Lu, You-Chen Chao
Summary: COVID-19 is characterized by significant immune dysfunction, requiring the development of effective treatments; various types of COVID-19 vaccines are under development and optimization, increasing public immunity may enhance vaccine effectiveness; Vitamin D supplementation may help mitigate the progression of COVID-19, but its role in vaccine efficacy remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Food Science & Technology
Alialdo Dantas Damascena, Laylla Mirella Galvao Azevedo, Tarcio de Almeida Oliveira, Jerusa da Mota Santana, Marcos Pereira
Summary: This article discusses the association between vitamin D deficiency and COVID-19, providing updated statistics. The study found that individuals with vitamin D deficiency had a higher chance of hospitalization and there was a certain relationship between vitamin D deficiency and mortality in COVID-19 patients. Vitamin D is associated with the severity of COVID-19.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Sieglinde Zelzer, Florian Prueller, Pero Curcic, Zdenka Sloup, Magdalena Holter, Markus Herrmann, Harald Mangge
Summary: This study aimed to investigate vitamin D status markers and degradation products in 148 hospitalized COVID-19 patients with different clinical courses. The results did not show a significant role of vitamin D in the course and outcome of COVID-19. Non-survivors were older, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently.
Review
Biochemistry & Molecular Biology
Alice Albergamo, Giulia Apprato, Francesca Silvagno
Summary: The genomic activity of vitamin D has significant effects on metabolism and physiological functions, particularly in relation to viral infections such as COVID-19. This review examines the correlation between vitamin D deficiency and increased risks of severe COVID-19 and respiratory distress syndrome. Clinical trials have tested vitamin D supplementation with promising results. Additionally, a biochemical analysis explores the antioxidant and anti-inflammatory functions of vitamin D and its influence on different biochemical pathways in the body's defense against viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Angela Feiner Solis, Ana Avedillo Salas, Maria Jose Luesma Bartolome, Sonia Santander Ballestin
Summary: This systematic review examines the impact of vitamin D supplementation on the disease course of COVID-19. The results suggest that regardless of initial vitamin D serum levels, patients benefit from vitamin D supplementation, although the outcomes are inconsistent and larger clinical trials are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Luigi Barrea, Ludovica Verde, William B. Grant, Evelyn Frias-Toral, Gerardo Sarno, Claudia Vetrani, Florencia Ceriani, Eloisa Garcia-Velasquez, Jose Contreras-Briceno, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: COVID-19 survivors are experiencing long COVID-19 with various health problems. Vitamin D deficiency is associated with the severity and mortality of COVID-19. Therefore, it is necessary to study the supplementation of vitamin D in COVID-19 patients.
Article
Infectious Diseases
Maryam Nasiri, Javad Khodadadi, Sedigheh Molaei
Summary: This study found a significant association between vitamin D levels and hospital stay in COVID-19 patients, but no significant relationship with death rate or time to return to normal oxygen levels.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Food Science & Technology
Marcos Pereira, Alialdo Dantas Damascena, Laylla Mirella Galvao Azevedo, Tarcio de Almeida Oliveira, Jerusa da Mota Santana
Summary: This systematic review and meta-analysis found that vitamin D deficiency is associated with a higher prevalence in severe cases of COVID-19. Vitamin D insufficiency is also linked to increased hospitalization and mortality from COVID-19.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Neurosciences
Gilciane Ceolin, Giulia Pipolo Rodrigues Mano, Natalia Schmitt Hames, Luciana da Conceicao Antunes, Elisa Brietzke, Debora Kurrle Rieger, Julia Dubois Moreira
Summary: Studies have shown that vitamin D deficiency is associated with mental health problems and individual responses to stress. Maintaining adequate concentrations of serum vitamin D seems to have a protective effect. Vitamin D regulates serotonergic neurotransmission, gene expression, and enzyme activity, while also potentially affecting the development of depressive symptoms through its interaction with the biological clock.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Paul Dalla-Pozza, Maxime Hentzien, Clotilde Allavena, Anne Doe de Maindreville, Kevin Bouiller, Marc-Antoine Valantin, Emmanuel Lafont, Olivia Zaegel-Faucher, Antoine Cheret, Guillaume Martin-Blondel, Laurent Cotte, Firouze Bani-Sadr
Summary: This study highlights that factors other than low CD4(+) cell count and high HIV viral load may be associated with the occurrence of PML in people with HIV. Further studies are warranted to investigate in greater detail the immunologic characteristics of people with HIV who develop PML despite immune-virological control.
Article
Infectious Diseases
Colin Deschanvres, Jacques Reynes, Isabelle Lamaury, David Rey, Romain Palich, Firouze Bani-Sadr, Olivier Robineau, Claudine Duvivier, Laurent Hocqueloux, Lise Cuzin, Veronique Joly, Francois Raffil, Andre Cabie, Clotilde Allavena
Summary: Maintenance ART with dolutegravir-based dual regimens has shown efficacy in HIV-1infected subjects, but real-life data are limited. In this study, virological failure and resistance-associated mutations were assessed in dolutegravir maintenance regimens. Results indicated that careful virological screening is essential before switching to dolutegravir maintenance regimens in virologically suppressed patients.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Messaline Bermejo, Stephanie Mestrallet, Amelie Servettaz, Laure-Anne Pannet, Delphine Lebrun, Yohan N'Guyen, Laurent Andreoletti, Jean-Marc Reynes, Maxime Hentzien, Firouze Bani-Sadr
Summary: The study found that about one quarter of patients with HFRS had eosinophilia, which was associated with severe thrombocytopenia, high C-reactive protein levels, white blood cell count, and neutrophil count, and inversely associated with nephrotoxic drug intake. Elevated C-reactive protein concentrations were independently associated with eosinophilia, supporting the role of eosinophils in antiviral immunity against hantavirus infection.
INFECTIOUS DISEASES
(2022)
Review
Oncology
Marc-Antoine Valantin, Lena Royston, Maxime Hentzien, Aude Jary, Alain Makinson, Marianne Veyri, Sylvie Ronot-Bregigeon, Stephane Isnard, Romain Palich, Jean-Pierre Routy
Summary: Alternative systemic treatments are needed for patients with chemotherapy-refractory KS. Anti-angiogenic therapies and immune checkpoint blockade are potential therapeutic options to consider. In this review, potential therapeutic options for patients with recurrent or refractory KS are discussed, including systemic chemotherapies, immune checkpoint inhibitors, anti-herpesvirus agents, and anti-angiogenic drugs. Well-conducted clinical trials are urgently needed to evaluate the efficacy of targeted agents and immunomodulators in this patient population.
Editorial Material
Infectious Diseases
Marius Troseid, Maxime Hentzien, Florence Ader, Sandra Wagner Cardoso, Jose R. Arribas, Jean-Michel Molina, Nicolas Mueller, Maya Hites, Fabrice Bonnet, Oriol Manuel, Dominique Costagliola, Beatriz Grinsztejn, Inge Christoffer Olsen, Yazdan Yazdapanah, Alexandra Calmy
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Editorial Material
Microbiology
Maxime Hentzien, Andrew Owen, Nathalie Strub-Wourgaft, Carmen Perez-Casas, Marius Troseid, Alexandra Calmy
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
M. Dupont, Claire Carlier, C. Gower-Rousseau, P. Barbier-Lider, D. Botsen, M. Brasseur, A. Burgevin, C. Chourbagi, R. D'Almeida, V Hautefeuille, M. Hentzien, A. Lambert, M. Lamuraglia, S. Lavau-Denes, A. Lopez, D. Parent, F. Slimano, M. Brugel, O. Bouche
Summary: This study found that patients treated in the French area with the highest incidence of Lyme disease are at a higher risk of CI-IRs, suggesting the need for increased attention to the risk of CI-IRs in these patients in those regions.
Letter
Immunology
Clemence Laurent, Maxime Hentzien, Simona Pavel, Kevin Didier, Messaline Bermejo, Yohan N'Guyen, Firouze Bani-Sadr
Article
Immunology
Romain Palich, Maxime Hentzien, Laurent Hocqueloux, Claudine Duvivier, Clotilde Allavena, Thomas Huleux, Pierre Delobel, Alain Makinson, David Rey, Lise Cuzin
Summary: This study aimed to describe factors associated with the choice of first antiretroviral therapy (ART) in persons with HIV (PWH) in France, including the country of birth, as well as the time to undetectable viral load and treatment discontinuation. The results showed that, regardless of HIV disease parameters, PWH born abroad were less likely to choose integrase strand transfer inhibitors (INSTI) as a first-line therapy compared to those born in France. Therefore, qualitative data are needed to better understand physicians' prescribing practices.
Letter
Biochemistry & Molecular Biology
Erica Telford, Beatriz Grinsztejn, Inge Christoffer Olsen, Nicolas Pulik, France Mentre, Skerdi Haviari, Maxime Hentzien, Olivier Segeral, Miquel B. Ekkelenkamp, Dimie Ogoina, Nathalie Strub-Wourgaft, Alpha Diallo, Yazdan Yazdanpanah, Alexandra Calmy
Article
Infectious Diseases
Maiwenn Petithomme-Nanrocki, Veronique Vernet-Garnier, Delphine Lebrun, Odile Bajolet, Morgane Bonnet, Maxime Hentzien, Xavier Ohl, Saidou Diallo, Firouze Bani-Sadr
Summary: This study evaluated the clinical outcomes of patients with bone and joint infection (BJI) associated with methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB) treated with early oral switch to oral antibiotics (before day 14) versus later or no switch. The results showed that among 79 patients with BJI associated with MSSAB, 50.6% had an early switch to oral antibiotics, with a median duration of intravenous antibiotics of 9 days. The overall cure rate was 81% with a follow-up of 6 months, and failure to control BJI did not differ between the two groups.
INFECTIOUS DISEASES NOW
(2023)
Meeting Abstract
Immunology
A. Saez-Cirion, A. -C. Mamez, V. Avettand-Fenoel, P. Thoueille, M. Nabergoj, M. Hentzien, E. Mereles Costa, M. Salgado, M. Nijhuis, A. Melard, E. Gardiennet, V. Monceaux, C. Passaes, A. Chapel, F. Perdomo-Celis, A. Wensing, J. Martinez-Picado, S. Yerly, M. Rougemont, A. Calmy
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Article
Medical Laboratory Technology
Maiwen Petithomme-Nanrocki, Aurelie Brunet, Kevin Didier, Maxime Hentzien, Thierry Tabary, Anne Doe de Maindreville, Firouze Bani-Sadr
Summary: There is a relationship between the disappearance of antithyroid antibodies from the CSF and a decrease in serum thyroid antibodies in a patient with Hashimoto's encephalopathy, which correlates with favorable clinical outcome.
ANNALES DE BIOLOGIE CLINIQUE
(2022)
Meeting Abstract
Immunology
M. Hentzien, J. Frossard, R. Kouyos, V. Prendki, J. Damas, E. Hofmann, D. Braun, P. Schmid, E. Bernasconi, S. Ragozzino, O. Efthimiou, C. Delpierre, C. Allavena, F. Bani-Sadr, A. Calmy
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Article
Medicine, General & Internal
Sophie Demotier, Anne Limelette, Alexandre Charmillon, Elisabeth Baux, Xavier Parent, Stephanie Mestrallet, Simona Pavel, Amelie Servettaz, Moustapha Drame, Anaelle Muggeo, Alain Wynckel, Claire Gozalo, Malak Abou Taam, Aurelie Fillion, Roland Jaussaud, Thierry Trenque, Lionel Piroth, Firouze Bani-Sadr, Maxime Hentzien
Summary: This study found that approximately one-quarter of patients treated with high-dose intravenous amoxicillin developed amoxicillin crystalluria (AC), which was highly predictive of acute kidney injury (AKI). Factors associated with the occurrence of AC included the concomitant use of angiotensin converting enzyme inhibitors and a decrease in urinary pH.