Review
Medicine, General & Internal
Phoebe Lin, Scott M. McClintic, Urooba Nadeem, Dimitra Skondra
Summary: The intestinal microbiota plays a crucial role in AMD pathogenesis, with growing evidence suggesting that environmental factors associated with AMD progression potentially work through the intestinal microbiota. There is a correlation between intestinal dysbiosis and AMD pathogenesis, while AREDS supplementation can reverse adverse intestinal microbial changes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jacek Dziedziak, Kaja Kasarello, Agnieszka Cudnoch-Jedrzejewska
Summary: Age-related macular degeneration (AMD) and glaucoma, both involving oxidative stress, are major causes of irreversible vision loss worldwide. Antioxidants play a crucial role in preventing these eye diseases, especially in individuals with diets rich in antioxidants. Numerous preclinical studies have demonstrated the efficacy of dietary antioxidants in combating neurodegeneration associated with AMD and glaucoma.
Article
Ophthalmology
Keean Nanji, Gurkaran S. Sarohia, Kevin Kennedy, Tiandra Ceyhan, Tyler McKechnie, Mark Phillips, Tahira Devji, Lehana Thabane, Peter Kaiser, David Sarraf, Sunir J. Garg, Sobha Sivaprasad, Charles C. Wykoff, Sophie J. Bakri, Tom Sheidow, Mohit Bhandari, Varun Chaudhary
Summary: This study used network meta-analysis to investigate the effect of anti-VEGF therapy on intraocular pressure. The results showed no clear difference in IOP increases between anti-VEGF agents and controls at 12 and 24 months after treatment initiation, but the findings were limited by imprecision.
Article
Food Science & Technology
Nguyen Dao, Thilini Thrimawithana, Terrence J. Piva, Danilla Grando, Huynh Tien
Summary: Age-related macular degeneration (AMD) is a chronic disease that causes blindness in older adults and has a significant economic impact on the healthcare system. Carotenoids from plants, such as lutein, zeaxanthin, and mesozeaxanthin, accumulate in the macula and protect against light exposure, oxidation, and inflammation, making them a potential preventative and therapeutic treatment for AMD. The dose and duration of treatment with carotenoids are important factors that influence their protective effects and can potentially improve visual outcomes in AMD patients. This review discusses the application of carotenoid supplementation as a non-invasive alternative for the prevention and treatment of AMD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Lisheng Chen, N. Dayanthi Perera, Athanasios J. Karoukis, Kecia L. Feathers, Robin R. Ali, Debra A. Thompson, Abigail T. Fahim
Summary: This study aimed to determine the differential apical and basolateral secretome of retinal pigment epithelium (RPE) cells and investigate the effects of oxidative stress on the directional secretion of proteins linked to age-related macular degeneration (AMD) and angiogenesis. The study found that oxidative stress altered the secretion of multiple factors related to AMD and neovascularization, promoting a pro-angiogenic microenvironment. Apical secretion was impacted more than basolateral, which may have implications for choroidal neovascularization.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Xiang Li, Roberta R. Holt, Carl L. Keen, Lawrence S. Morse, Glenn Yiu, Robert M. Hackman
Summary: Regular intake of Z-rich goji berries can increase MPOD and skin carotenoids in healthy middle-aged individuals, which may help prevent or delay the development of AMD.
Article
Materials Science, Multidisciplinary
Li-Jyuan Luo, Hong-Jyuan Jian, Scott G. Harroun, Jui-Yang Lai, Binesh Unnikrishnan, Chih-Ching Huang
Summary: The study demonstrated a potential nanocomposite for treating AMD through sustained drug release and targeted therapy. The findings suggest a great potential for clinical intervention in AMD treatment with the multifunctional nanocomposite.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Medicinal
Wataru Kikushima, Yoichi Sakurada, Yoshiko Fukuda, Mio Matsubara, Yumi Kotoda, Atsushi Sugiyama, Kenji Kashiwagi
Summary: This study aimed to investigate the effectiveness of a treat-and-extend regimen of intravitreal brolucizumab for eyes with exudative AMD refractory to aflibercept. The study found that after switching to brolucizumab, the follow-up interval significantly extended and 43% of the eyes achieved the desired treatment outcome at 12 months, but the best-corrected visual acuity did not improve.
Article
Chemistry, Multidisciplinary
Shuting Xu, Kaixuan Cui, Kaiqi Long, Jia Li, Ni Fan, Wai-Ching Lam, Xiaoling Liang, Weiping Wang
Summary: This study reports a novel approach for combined anti-angiogenic and photodynamic therapy of wet age-related macular degeneration (wAMD) by intravenous administration of a photoactivatable nanosystem. The nanosystem, composed of a reactive oxygen species (ROS)-sensitive drug and a photosensitizer, showed promising therapeutic efficacy against CNV with minimized systemic toxicity.
Article
Nutrition & Dietetics
Zhaofang Li, Yajing Li, Yijing Hou, Yahui Fan, Hong Jiang, Baoyu Li, Hailu Zhu, Yaning Liu, Lei Zhang, Jie Zhang, Min Wu, Tianyou Ma, Tong Zhao, Le Ma
Summary: This study aimed to assess the association between LCAT DNA methylation and the risk of AMD, and found that higher LCAT DNA methylation was associated with increased risk of AMD. Furthermore, higher concentrations of plasma retinol and β-cryptoxanthin were associated with decreased levels of LCAT DNA methylation. These findings highlight the importance of comprehensively assessing LCAT DNA methylation and increasing vitamin and carotenoid status for the prevention of AMD.
Article
Medicine, General & Internal
Gauthier Kielwasser, Laurent Kodjikian, Corinne Dot, Carole Burillon, Philippe Denis, Thibaud Mathis
Summary: This study demonstrates the value of the Odysight(R) application in detecting exudative recurrences in patients with macular edema in addition to a conventional follow-up regimen. Although the sensitivity and positive predictive value of the application are low, its use alongside regular follow-up can detect early recurrences in certain cases, allowing for timely treatment adjustments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Jiangbo Ren, Anli Ren, Xizhi Deng, Zhengrong Huang, Ziyu Jiang, Zhi Li, Yan Gong
Summary: This review summarizes the regulatory effects of long-chain polyunsaturated fatty acids (LCPUFA) on inflammation in age-related macular degeneration (AMD) and discusses their possible clinical applications.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Ophthalmology
Geoffrey K. Broadhead, Elvira Agron, David Peprah, Tiarnan D. L. Keenan, Thomas P. Lawler, Julie Mares, Emily Y. Chew
Summary: This cohort study found an association between dietary nitrate intake and the progression of age-related macular degeneration (AMD). However, this association was not replicated in other cohorts or adjusted for dietary patterns. Therefore, the results are insufficient to support new clinical recommendations.
JAMA OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nagashree Shamarao, Mukunda Chethankumar
Summary: In this study, lutein oxidized products (LOPs) that can inhibit adipogenesis were synthesized and characterized. The results showed that LOPs effectively inhibited pancreatic lipase activity and had good binding capability with the key regulator PPAR-γ. In addition, the pharmacokinetic properties of LOPs were superior to lutein alone. Histological examination revealed that LOPs alleviated the pathological changes in the liver and adipose tissue. Therefore, LOPs may offer a novel approach for the treatment of obesity.
Article
Biochemistry & Molecular Biology
Binxing Li, Preejith Vachali, Fu-Yen Chang, Aruna Gorusupudi, Ranganathan Arunkumar, Linjia Shi, Gregory T. Rognon, Jeanne M. Frederick, Paul S. Bernstein
Summary: This study found that HDL serves as the primary transporter for macular carotenoids, and ApoA-I may be involved in the selective delivery of these carotenoids to the retinal pigment epithelium.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Chemistry, Applied
Azucena Rodriguez-Mena, Luz Araceli Ochoa-Martinez, Silvia Marina Gonzalez-Herrera, Olga Miriam Rutiaga-Quinones, Ruben Francisco Gonzalez-Laredo, Begona Olmedilla-Alonso
Summary: This article discusses the latest technologies and applications of plant-derived pigments such as carotenoids, anthocyanins, and betalains. Advanced extraction and encapsulation techniques improve the efficiency of pigment utilization in food, making it more attractive. The application of natural pigments provides health benefits and reduces the risk of various diseases.
Article
Ophthalmology
Claudia Farinha, Patricia Barreto, Rita Coimbra, Maria Luz Cachulo, Joana Barbosa Melo, Jose Cunha-Vaz, Yara Lechanteur, Carel B. Hoyng, Rufino Silva
Summary: This study found that both common and rare genetic variants are associated with AMD, with a rare CFH variant conferring the highest risk of the disease. However, the allele frequency of three major risk variants is lower than expected in the population studied.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Joao Pedro Marques, Rosa Pinheiro, Ana Luisa Carvalho, Miguel Raimundo, Mario Soares, Pedro Melo, Joaquim Murta, Jorge Saraiva, Rufino Silva
Summary: This study describes the genetic spectrum, retinal phenotypes, and pRNFL thickness in a cohort of Caucasian RPGR-mutation heterozygotes. The results show that clinically severe phenotypes are not uncommon among female carriers, and provide novel insights into pRNFL changes observed in RPGR heterozygotes that mimic what has been reported in male patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
B. Arias-Peso, S. Mendez-Martinez, M. Puzo, L. Castro Roger, N. Pardinas, N. Pardinas Baron, O. Ruiz-Moreno
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2023)
Article
Genetics & Heredity
Joao Pedro Marques, Ricardo Machado Soares, Silvia Simao, Rebhi Abuzaitoun, Chris Andrews, C. Henrique Alves, Antonio Francisco Ambrosio, Joaquim Murta, Rufino Silva, Maria Fernanda Abalem, K. Thiran Jayasundera
Summary: The purpose of this study was to evaluate the self-reported visual function and psychosocial impact of visual loss in patients with EYS-associated retinal degeneration. Two patient-reported outcome measures, the MRDQ and MVAQ, were used. The results showed a correlation between the PRO measures and the clinician-reported outcomes.
OPHTHALMIC GENETICS
(2023)
Editorial Material
Nutrition & Dietetics
Begona Olmedilla-Alonso
Article
Genetics & Heredity
Sara Geada, Francisco Teixeira-Marques, Bruno Teixeira, Ana Luisa Carvalho, Nuno Lousan, Jorge Saraiva, Joaquim Murta, Rufino Silva, Xavier Zanlonghi, Sabine Defoort-Dhellemmes, Vasily Smirnov, Claire-Marie Dhaenens, Catherine Blanchet, Isabelle Meunier, Joao Pedro Marques
Summary: This study reported the molecular spectrum and ocular and olfactory phenotypes of a multiethnic cohort with CNGB1-related RP. The study found that while widespread retinal degeneration was present in most patients, with delayed diagnosis in adulthood, relatively preserved visual acuity was observed. Only a few patients had preserved olfactory function, all of whom carried at least one missense variant.
Review
Ophthalmology
Audrey Cougnard-Gregoire, Benedicte M. J. Merle, Tariq Aslam, Johanna M. Seddon, Isabelle Aknin, Caroline C. W. Klaver, Gerhard Garhoefer, Alfredo Garcia Layana, Angelo Maria Minnella, Rufino Silva, Cecile Delcourt
Summary: Exposure to blue light from LED lights and digital devices raises concerns about its potential deleterious effects on eye health. This review discusses the ocular effects of blue light and the effectiveness of protection and prevention methods against potential blue light-induced ocular injury.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Ricardo Machado Soares, Ana Luisa Carvalho, Silvia Simao, Celia Azevedo Soares, Miguel Raimundo, C. Henrique Alves, Antonio Francisco Ambrosio, Joaquim Murta, Jorge Saraiva, Rufino Silva, Joao Pedro Marques
Summary: This study aims to provide detailed information about the natural history, genetic landscape, and phenotypic spectrum of EYS-associated retinal degeneration (EYS-RD). The study identified 8 novel EYS variants and found a high frequency of atypical phenotypes. Patients with atypical RP had better best-corrected visual acuity (BCVA) and larger ellipsoid zone widths, indicating a better prognosis.
OPHTHALMOLOGY RETINA
(2023)
Article
Cell Biology
Xikun Han, Ines Lains, Jun Li, Jinglun Li, Yiheng Chen, Bing Yu, Qibin Qi, Eric Boerwinkle, Robert Kaplan, Bharat Thyagarajan, Martha Daviglus, Charlotte E. Joslin, Jianwen Cai, Marta Guasch-Ferre, Deirdre K. Tobias, Eric Rimm, Alberto Ascherio, Karen Costenbader, Elizabeth Karlson, Lorelei Mucci, A. Heather Eliassen, Oana Zeleznik, John Miller, Demetrios G. Vavvas, Ivana K. Kim, Rufino Silva, Joan Miller, Frank Hu, Walter Willett, Jessica Lasky-Su, Peter Kraft, J. Brent Richards, Stuart MacGregor, Deeba Husain, Liming Liang
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. In this study, we investigated the genetic components shared between metabolites and AMD, using multi-ethnic genetic and metabolomic data. Through our analysis, we identified 108 potential causal relationships between plasma metabolites and advanced AMD, particularly in lipid-related pathways. This study provides valuable insights into the understanding of AMD pathogenesis and its risk factors.
CELL REPORTS MEDICINE
(2023)
Article
Medicine, General & Internal
Arshad M. Khanani, Sunil S. Patel, Giovanni Staurenghi, Ramin Tadayoni, Carl J. Danzig, David A. Eichenbaum, Jason Hsu, Charles C. Wykoff, Jeffrey S. Heier, David R. Lally, Jordi Mones, Jared S. Nielsen, Veeral S. Sheth, Peter K. Kaiser, Julie Clark, Liansheng Zhu, Hersh Patel, Justin Tang, Dhaval Desai, Glenn J. Jaffe
Summary: The study assessed the efficacy and safety of avacincaptad pegol 2 mg in reducing geographic atrophy lesion growth. The results showed that avacincaptad pegol 2 mg significantly slowed down the growth of geographic atrophy compared to sham treatment, with good tolerability.
Article
Nutrition & Dietetics
Carlos Heriberto Garcia-Lithgow, Madeline Duran-Cabral, Alexandra Winter-Matos, Kilsaris Garcia-Estrella, Julen Garcia-Duran, Estefania Di-Sanzo, Nicole Martinez-De-La-Cruz, Julia Rodriguez-Abreu, Begona Olmedilla-Alonso
Summary: This study evaluated the 24-hour urinary sodium and potassium excretion and estimated the salt intake in normotensive and hypertensive Dominican adults. The results showed no significant correlation between urinary sodium and potassium excretion and blood pressure, except for a correlation between potassium and systolic blood pressure in the normotensive group. The sodium-to-potassium ratio was higher in younger subjects and was associated with blood pressure in the hypertensive and older groups. Age, sex, body mass index, and sodium-to-potassium ratio were determinants of blood pressure.
Article
Ophthalmology
Patricia Barreto, Claudia Farinha, Rita Coimbra, Maria Luz Cachulo, Joana Barbosa Melo, Yara Lechanteur, Carel B. Hoyng, Jose Cunha-Vaz, Rufino Silva
Summary: This study aims to assess the interaction between genetic risk and adherence to the Mediterranean diet in age-related macular degeneration (AMD). By examining and surveying 612 participants, it was found that high adherence to the Mediterranean diet reduced the risk of AMD by 60%. In individuals with low genetic risk and high adherence to the Mediterranean diet, the risk of AMD was reduced by 5-fold. The results suggest that there is a protective interaction between genetics and diet in preventing AMD.
Article
Ophthalmology
Galadriel Gimenez-Calvo, Francisco de Asis Bartol-Puyal, Irene Altemir, Silvia Mendez-Martinez, Cristina Almenara, Diana Soriano-Pina, Ane Murueta-Goyena, Jose Manuel Larrosa
Summary: This study assessed the influence of biometric measurements on the defocus curve after implantation of an enlarged depth-of-focus (EDoF) intraocular lens (IOL). The results showed that biometric measurements such as corneal keratometry, axial length, and pupil size had an impact on visual acuity after surgery. These parameters could be used to predict the performance of EDoF IOLs.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jose Maria Ruiz-Moreno, Alfredo Adan, Maria Lafuente, Monica Asencio Duran, Luis Arias Barquet, Alfredo Garcia Layana, Javier Araiz Iribarren
Summary: This study assessed the effectiveness and safety of intravitreal fluocinolone-acetonide implant (FAc-i) in patients with chronic diabetic macular edema (DME) who did not sufficiently respond to previous therapies. The results showed that FAc-i was associated with improved visual and anatomic outcomes in these patients, with no unexpected adverse events.
INTERNATIONAL OPHTHALMOLOGY
(2023)