Article
Infectious Diseases
Qian Liu, Sanwang Li, Feifan Xie
Summary: This study aimed to provide a population PK analysis of linezolid in patients undergoing renal replacement therapy (RRT), and evaluate the target attainment of linezolid standard dosing. The results showed that standard linezolid dosing is adequate for anuric RRT patients with MIC <= 2 mg/L. The probability of target attainment was low for RRT patients with preserved renal function.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Mei Yang, Libo Zhao, Xiaohui Wang, Chen Sun, Hengmiao Gao, Xiaoling Wang, Suyun Qian
Summary: This study evaluated the population pharmacokinetic properties of linezolid in critically ill children and established an optimal dosage regimen based on developmental PopPK/PD model and simulation. Factors such as body weight and AST levels were found to significantly affect the variability in linezolid pharmacokinetics in the pediatric population. Dosage adjustment according to AST levels was deemed necessary for treatment success.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Sebastian G. Wicha, Andrea Mair, Ute Chiriac, Otto R. Frey, Thomas Fuchs, Max Gaasch, Stefan Hagel, Daniel C. Richter, Jason A. Roberts, Anka C. Roehr, Markus A. Weigand, Alexander Brinkmann
Summary: This study described the pharmacokinetic characteristics of continuous infusion of linezolid in critically ill patients and established the relationship between linezolid exposure and platelet count over time. It suggested that optimizing linezolid dosing based on creatinine clearance and body weight can maximize therapeutic exposures and that therapeutic drug monitoring may be necessary due to high variability in individual doses.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Lu Shi, Ying Zhang, Lufen Duan, Lifeng Huang, Jingjing Li, Jian Lu, Zhiwei Zhuang, Yunlong Yuan, Zongtai Feng, Jiantong Sun, Xin Liu, Qin Zhou, Hongzhi Xue, Jinhui Xu, Lian Tang
Summary: This study evaluated the effect of clinical pharmacist-mediated optimisation of a linezolid regimen using a population pharmacokinetic (PPK) model. The results showed that interventions by clinical pharmacists reduced the incidence of linezolid-induced thrombocytopenia (LIT) and other adverse drug reactions (ADRs). Furthermore, implementation of model-informed precision dosing (MIPD) for linezolid markedly increased the proportion of patients with target trough concentration (Cmin) and area under the concentration-time curve/MIC ratio (AUC24/MIC).
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Pharmacology & Pharmacy
Danhong Liang, Zhi Liang, Guoliang Deng, Anfen Cen, Dandan Luo, Chen Zhang, Suiqin Ni
Summary: The use of Polymyxin B is increasing due to the global spread of multidrug-resistant gram-negative bacteria. However, unsatisfactory therapeutic effects have been observed in critically ill patients. This study aims to determine the pharmacokinetic characteristics of polymyxin B, identify influencing factors, and optimize dosing regimens for clinical effectiveness.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chao-Yang Chen, Min Xie, Jun Gong, Ning Yu, Ran Wei, Li-Li Lei, Si-Miao Zhao, Ruo-Ming Li, Xiu Dong, Xiang-Lin Zhang, Ying Zhou, Shuang-Ling Li, Yi-Min Cui
Summary: This study aimed to investigate the population pharmacokinetics (PPK) characteristics of teicoplanin in adult sepsis patients and provide recommendations for optimal teicoplanin dosing regimens. The study found that current standard doses may result in undertherapeutic concentrations and area under the curve (AUC), and a single dose of at least 12 mg/kg may be needed. Model-based simulations revealed the optimal dosing regimens for different renal functions. The importance of monitoring teicoplanin trough concentrations and AUC was emphasized.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nan Yang, Jing Wang, Yueliang Xie, Junjie Ding, Cuifang Wu, Jingjing Liu, Qi Pei
Summary: This study evaluated the adequacy and predictive capabilities of various meropenem models on routine data, showing that Bayesian forecasting outperformed a priori prediction in predictability.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Manuel Mena, Julio-Cesar Garcia, Rosa-Helena Bustos
Summary: In individualized therapy, the Bayesian approach integrated with population pharmacokinetic models (PopPK) and therapeutic drug monitoring (TDM) is useful for optimizing the efficacy and safety of vancomycin in critically ill patients. A Shiny app with R was developed and validated using different PopPK models for individualized therapy. The Llopis model showed better accuracy but greater bias, while the Goti model had the lowest root mean square error (RMSE). Further research and implementation of PopPK models, MIPD and TDM in real time are needed for clinical application.
Article
Multidisciplinary Sciences
Hiroomi Tatsumi, Masayuki Akatsuka, Hiromitsu S. Kuroda, Satoshi S. Kazuma, Shintaro S. Suzuki, Yoshiki S. Masuda
Summary: In this study, we investigated the effect of Linezolid on platelet counts in critically ill patients with thrombocytopenia during their stay in the ICU. The results showed that platelet count increased significantly after the initiation of Linezolid therapy, and the frequency of platelet transfusion decreased. These findings suggest that Linezolid may be considered as a treatment option for methicillin-resistant Staphylococcus aureus in critically ill patients in the ICU.
Article
Pharmacology & Pharmacy
Xiangru Luo, Shiyi Wang, Dong Li, Jun Wen, Na Sun, Guangjun Fan
Summary: The study aimed to develop a pharmacokinetic model for tigecycline in critically ill patients and optimize dosing regimens. Results showed that APACHEII score and age significantly influenced the drug's clearance and distribution volume. The standard dose regimen often failed to achieve satisfactory therapeutic effects for critically ill patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Tobias Hueppe, Katharina M. Goetz, Andreas Meiser, Andrea de Faria Fernandes, Felix Maurer, Heinrich V. Groesdonk, Thomas Volk, Thorsten Lehr, Sascha Kreuer
Summary: This study investigated the pharmacokinetics of multiple-dose intravenous fosfomycin in critically ill patients undergoing continuous venovenous hemodialysis. The study found that dosing should be adjusted based on renal clearance and CVVHD.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Parisa Ghasemiyeh, Afsaneh Vazin, Farid Zand, Elham Haem, Iman Karimzadeh, Amir Azadi, Mansoor Masjedi, Golnar Sabetian, Reza Nikandish, Soliman Mohammadi-Samani
Summary: This study included 53 critically ill patients with a total of 212 blood samples from June 2019 to June 2021. The AUC-based monitoring approach for vancomycin administration was found to be superior in predicting nephrotoxicity occurrence. Trough concentration and AUC tau values should be maintained below the cut-off points to avoid vancomycin-induced AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Cristina Sanches, Geisa C. S. Alves, Andras Farkas, Samuel Dutra da Silva, Whocely Victor de Castro, Farah Maria Drummond Chequer, Francisco Beraldi-Magalhaes, Igor Rafael dos Santos Magalhaes, Andre de Oliveira Baldoni, Mark D. Chatfield, Jeffrey Lipman, Jason A. Roberts, Suzanne L. Parker
Summary: This study developed a population pharmacokinetic model for piperacillin in critically ill Brazilian patients and described interethnic variation using external validation. The results showed that the pharmacokinetic parameters obtained from critically ill Brazilian patients were similar to those observed in studies performed in critically ill patients of other ethnicities. Therefore, dose adjustment based on creatinine clearance is required in Brazilian patients.
Article
Microbiology
J. M. Boonstra, K. C. van der Elst, J. G. Zijlstra, T. S. van der Werf, J. W. C. Alffenaar, D. J. Touw
Summary: This study developed a population pharmacokinetic model to assess micafungin drug exposure in critically ill patients, with optimal sampling strategies for determining AUC. The model provides the opportunity for quick optimization of micafungin exposure from a single blood sample using Bayesian software, which may assist in guiding early dose decision-making.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Rasha M. El-Gaml, Noha M. El-Khodary, Rania R. Abozahra, Ayman A. El-Tayar, Soha M. El-Masry
Summary: In critically ill patients, continuous infusion with a loading dose of Linezolid is superior to continuous infusion without a loading dose or intermittent infusion, as it improves the drug concentration and AUC/MIC values, while reducing mortality rate.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Qing-Rui Wu, Dan-Lin Zheng, Pei-Ming Liu, Hui Yang, Lu-An Li, Su-Juan Kuang, Ying-Yu Lai, Fang Rao, Yu-Mei Xue, Ji-Jin Lin, Shuang-Xin Liu, Chun-Bo Chen, Chun-Yu Deng
Summary: Mitochondrial dysfunction and impaired Ca2+ handling play crucial roles in the development of diabetic cardiomyopathy. Inhibiting Drp1 and Orai1 activity can alleviate cardiomyocyte hypertrophy and dysfunction induced by high glucose.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Huifang Wang, Chunbo Chen, Binfei Li, Zhou Cheng, Zeng Wang, Xiangwei Huang, Minghai Xian, Jian Zhuang, Jimei Chen, Chengbin Zhou, Yiyu Deng
Summary: This study developed a nomogram model to predict the survival of RCS patients that received VA-ECMO, using variables like pre-ECMO cardiogenic arrest, lactate, inotropic score, and mNUTRIC score. The nomogram showed good discrimination in both the development and validation cohorts, providing improved benefits for RCS patients as shown in decision and clinical impact curves.
POSTGRADUATE MEDICINE
(2022)
Article
Urology & Nephrology
Jianchao Ma, Yujun Deng, Haiyan Lao, Xin Ouyang, Silin Liang, Yifan Wang, Fen Yao, Yiyu Deng, Chunbo Chen
Summary: Combining serum cystatin C and urinary N-acetyl-beta-D-glucosaminidase with routine clinical factors may improve the prediction precision of AKI in septic patients in the ICU. The nomogram showed fair discrimination and good calibration in the validation cohort, with good clinical utility according to decision curve analysis.
Review
Nutrition & Dietetics
Xin Ouyang, Rong Qu, Bei Hu, Yifan Wang, Fen Yao, Bo Lv, Cheng Sun, Yiyu Deng, Chunbo Chen
Summary: The study found that in some cases, metoclopramide can facilitate the successful placement of nasoenteric tubes postpylorically, however overall evidence is still insufficient to prove its benefits in this process. More high-quality, large-sample RCTs are needed to elucidate the effects of metoclopramide.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Hematology
Zhonglin Feng, Xipei Wang, Li Zhang, Rizvangul Apaer, Lixia Xu, Jianchao Ma, Xinyi Li, Huimin Che, Bin Tang, Yuwang Xiong, Yubin Xia, Jie Xiao, Xiaoyan Su, Yamei Wang, Xianrui Dou, Jinzhong Chen, Lifan Mei, Zhiqiang Xue, Yuanyuan Kong, Sijia Li, Hong Zhang, Ting Lin, Feng Wen, Xia Fu, Yiming Tao, Lei Fu, Zhuo Li, Renwei Huang, Zhiming Ye, Chaosheng He, Wei Shi, Xinling Liang, Guibao Ke, Shuangxin Liu
Summary: The study showed that SAC/VAL was safe and effective in improving left ventricular ejection fraction in HD patients with HFrEF or HFmrEF. The concentrations of LBQ657 and VAL remained within safe ranges during treatment with SAC/VAL 100 mg BID.
BLOOD PURIFICATION
(2022)
Article
Chemistry, Medicinal
Jinhua Lan, Zheng Wu, Xipei Wang, Yifan Wang, Fen Yao, Bo-xin Zhao, Yirong Wang, Jingchun Chen, Chunbo Chen
Summary: The study developed a population pharmacokinetic model for optimizing the dosing regimens of meropenem in critically ill patients with pulmonary infection. The findings suggest that frequent administration or continuous intravenous infusion of meropenem is required to achieve optimal therapeutic outcomes.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Urology & Nephrology
Linhui Hu, Lu Gao, Danqing Zhang, Yating Hou, Lin Ling He, Huidan Zhang, Yufan Liang, Jing Xu, Chunbo Chen
Summary: In a study of 383 critically ill patients undergoing emergency surgery, postoperative reoperation, postoperative APACHE II score, and postoperative serum lactic acid were identified as independent risk factors for postoperative AKI, with higher mortality rates and costs in the AKI group.
Article
Microbiology
Zheng Wu, Jinhua Lan, Xipei Wang, Yijin Wu, Fen Yao, Yifan Wang, Bo-Xin Zhao, Yirong Wang, Jingchun Chen, Chunbo Chen
Summary: This study investigated the population pharmacokinetics of caspofungin in heart transplant (HTx) and non-HTx patients. The findings showed that HTx did not affect the pharmacokinetics of caspofungin, but dosing adjustments should be made in patients with decreased albumin levels.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Danna Lin, Lihua Yu, Dewei Shang, Lulu Huang, Li Wu, Xu Liao, Yajie Zhang, Juan Zi, Jingxin Zhang, Yinghua Zeng, Xipei Wang, Lihua Yang
Summary: This study aimed to investigate the effect of food on the pharmacokinetics of posaconazole suspension in pediatric patients with acute leukaemia and to recommend optimal dosing strategies. The study found that the recommended dosage of posaconazole for pediatric patients can be predicted by considering bodyweight and diet type.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiao-lin Li, Shan-qing Huang, Tao Xiao, Xi-pei Wang, Wan Kong, Shu-jing Liu, Zi Zhang, Ye Yang, Shan-shan Huang, Xiao-jia Ni, Hao-yang Lu, Ming Zhang, Yu-guan Wen, De-wei Shang
Summary: This study developed a population pharmacokinetic model for paroxetine in Chinese patients and investigated the effects of dose, formulation, and sex on its pharmacokinetic parameters. The results showed that dose and formulation significantly influenced the pharmacokinetics of paroxetine, while there was no genetic influence of CYP2D6 enzymes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Gongjie Guo, Yonglin Wu, Yingjian Liu, Zixian Wang, Guifeng Xu, Xipei Wang, Feiqing Liang, Weihua Lai, Xiao Xiao, Qian Zhu, Shilong Zhong
Summary: This study used a two-sample Mendelian randomization analysis to investigate the potential causal relationships between gut microbial taxa and serum lipid levels. The results showed several associations between specific gut microbial taxa and LDL-C, TC, and TG levels.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Analytical
Yirong Wang, Jingchun Chen, Jinpan Du, Liming Lei, Boxin Zhao, Yunpeng Bai, Dong Chen, Xipei Wang, Chunbo Chen
Summary: A simple, economical, and efficient HPLC-MS/MS method was developed and validated to determine polymyxin B1 (PB1), polymyxin B1-Ile (PB1-I), polymyxin B2 (PB2), and polymyxin B3 (PB3) in human plasma for the treatment of multidrug-resistant gram-negative bacteria. The method was successfully applied to the pharmacokinetics of PB in critically ill patients.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zhanzhang Wang, Lu Li, Shanqing Huang, Xipei Wang, Shujing Liu, Xiaolin Li, Wan Kong, Xiaojia Ni, Ming Zhang, Shanshan Huang, Yaqian Tan, Yuguan Wen, Dewei Shang
Summary: This study successfully developed a joint population pharmacokinetic model to characterize the concentrations of Venlafaxine (VEN) and O-desmethyl venlafaxine (ODV), identifying important clinical variables that affect their clearance. This model may contribute to precision medication in clinical practice and serve as a reference for other drugs with pre-system metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)