From Hydrogenation to Transfer Hydrogenation to Hydrogen Auto-Transfer in Enantioselective Metal-Catalyzed Carbonyl Reductive Coupling: Past, Present, and Future

Ethanol: Unlocking an Abundant Renewable C2‐Feedstock for Catalytic Enantioselective C‐C Coupling

(2021) Michael Joseph Krische et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereo- and Enantioselective Ruthenium-Catalyzed C-C Coupling of 1-Arylpropynes and Alcohols: Alkynes as Chiral Allylmetal Precursors in Carbonyl anti-(α-Aryl)allylation

(2021) Ming Xiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Enantioselective α-Alkenylation of N-Sulfonyl Amines: Modular Access to Chiral α-Branched Amines

(2021) Lun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Technology Trends of Catalysts in Hydrogenation Reactions: A Patent Landscape Analysis

(2020) Marius A. Stoffels et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Reductive Aldol and Mannich Reactions of Enone, Acrylate, and Vinyl Heteroaromatic Pronucleophiles

(2020) Cole C. Meyer et al.   CHEMICAL REVIEWS

Control of Absolute Stereochemistry in Transition‐Metal‐Catalyzed Hydrogen Borrowing Reactions

(2020) Timothy Kwok et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Total Synthesis of Exiguolide

(2020) Kengo Oka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent advances in asymmetric synthesis with CO2

(2020) Chuan-Kun Ran et al.   Science China-Chemistry

The Formosalides: Structure Determination by Total Synthesis

(2020) Alois Fürstner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formate‐Mediated Cross‐Electrophile Reductive Coupling of Aryl Iodides and Bromopyridines

(2020) Leyah A. Schwartz et al.   ISRAEL JOURNAL OF CHEMISTRY

Iron-Catalyzed Radical Intermolecular Addition of Unbiased Alkenes to Aldehydes

(2020) Mar Saladrigas et al.   ORGANIC LETTERS

Highly Productive α-Alkylation of Ketones with Alcohols Mediated by an Ir–Oxalamidato/Solid Base Catalyst System

(2020) Hideo Shimizu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Visible-Light-Driven Catalytic Reductive Carboxylation with CO2

(2020) Zhen Zhang et al.   ACS Catalysis

Successive Nucleophilic and Electrophilic Allylation for the Catalytic Enantioselective Synthesis of 2,4-Disubstituted Pyrrolidines

(2019) Guoshun Luo et al.   ORGANIC LETTERS

Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki–Hiyami–Kishi-Type Addition

(2019) Robert A. Swyka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclometalated Iridium–PhanePhos Complexes Are Active Catalysts in Enantioselective Allene–Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon Stereocenters

(2019) Leyah A. Schwartz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical syntheses and chemical genetics of carboxyl polyether ionophores: Recent highlights

(2019) Han Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Greening Organic Chemistry with Process Chemistry

(2019) Kai Rossen   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Clavosolide A via Asymmetric Alcohol-Mediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction

(2019) James M. Cabrera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Feedstock Reagents in Metal-Catalyzed Carbonyl Reductive Coupling: Minimizing Preactivation for Efficiency in Target-Oriented Synthesis

(2019) Rosalie S. Doerksen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of All‐Carbon Chiral Quaternary Centers via Cu(I)‐Catalyzed Enantioselective Reductive Hydroxymethylation of 1, 1‐Disubstituted Allenes with CO2

(2019) Kuiling Ding et al.   CHEMISTRY-A EUROPEAN JOURNAL

Vinyl Triflate–Aldehyde Reductive Coupling–Redox Isomerization Mediated by Formate: Rhodium‐Catalyzed Ketone Synthesis in the Absence of Stoichiometric Metals

(2019) William G. Shuler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Conversion of Primary Alcohols to 1,2-Amino Alcohols: Enantioselective Iridium-Catalyzed Carbonyl Reductive Coupling of Phthalimido-Allene via Hydrogen Auto-Transfer

(2019) Kim Spielmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inversion of Enantioselectivity in Allene Gas versus Allyl Acetate Reductive Aldehyde Allylation Guided by Metal-Centered Stereogenicity: An Experimental and Computational Study

(2019) Seung Wook Kim et al.   ACS Catalysis

Highly Selective and Catalytic Generation of Acyclic Quaternary Carbon Stereocenters via Functionalization of 1,3-Dienes with CO2

(2019) Xiao-Wang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes

(2018) James M. Cabrera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(0)-Catalyzed Cycloaddition of 1,2-Diols, Ketols, or Diones via Alcohol-Mediated Hydrogen Transfer

(2018) Hiroki Sato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intermolecular Metal-Catalyzed Reductive Coupling of Dienes, Allenes, and Enynes with Carbonyl Compounds and Imines

(2018) Michael Holmes et al.   CHEMICAL REVIEWS

Catalytic enantioselective aldol reactions

(2018) Yasuhiro Yamashita et al.   CHEMICAL SOCIETY REVIEWS

Catalytic nucleophilic ‘umpoled’ π-allyl reagents

(2018) Kim Spielmann et al.   CHEMICAL SOCIETY REVIEWS

Selection between Diastereomeric Kinetic vs Thermodynamic Carbonyl Binding Modes Enables Enantioselective Iridium-Catalyzed anti-(α-Aryl)allylation of Aqueous Fluoral Hydrate and Difluoroacetaldehyde Ethyl Hemiacetal

(2018) James M. Cabrera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From determination of enantiopurity to the construction of complex molecules: The Horeau principle and its application in synthesis

(2018) Andrew M. Harned   TETRAHEDRON

Hydroxoiridium-Catalyzed sp3 C−H Alkylation of Indoline Derivatives with Terminal Alkenes

(2018) Ikumi Nakamura et al.   Asian Journal of Organic Chemistry

Iridium-Catalyzed Direct Asymmetric Alkylation of Aniline Derivatives using 2-Norbornene

(2018) Tomohiko Shirai et al.   Asian Journal of Organic Chemistry

Catalytic Enantioselective Carbonyl Propargylation Beyond Preformed Carbanions: Reductive Coupling and Hydrogen Auto-Transfer

(2018) Brett R. Ambler et al.   ChemCatChem

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

(2018) Benjamin G. Reed-Berendt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iridium-Catalyzed Sequential sp 3 C−H Alkylation of an N -Methyl Group with Alkenes Towards the Synthesis of α-Substituted Amines

(2018) Hiroshi Hattori et al.   ADVANCED SYNTHESIS & CATALYSIS

Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes

(2018) Jeishla L. M. Matos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis

(2018) John D. Hayler et al.   ORGANOMETALLICS

Hydroamination and Hydroaminoalkylation of Alkenes by Group 3–5 Elements: Recent Developments and Comparison with Late Transition Metals

(2018) Jérôme Hannedouche et al.   ORGANOMETALLICS

Transition metal-catalyzed α-alkylation of amines by C(sp3)‒H bond activation

(2018) Laurine Gonnard et al.   TETRAHEDRON

Enantioselective Formation of CF3-Bearing All-Carbon Quaternary Stereocenters via C–H Functionalization of Methanol: Iridium Catalyzed Allene Hydrohydroxymethylation

(2017) Michael Holmes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Regio- and Enantioselective Copper-Catalyzed Reductive Hydroxymethylation of Styrenes and 1,3-Dienes with CO2

(2017) Yong-Yuan Gui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Allylation of Glycidols Mediated by Allyl Acetate via Iridium-Catalyzed Hydrogen Transfer

(2017) Seung Wook Kim et al.   ORGANIC LETTERS

Allenylation and Propargylation Reactions of Ketones, Aldehydes, Imines, and Iminium Ions Using Organoboronates and Related Derivatives

(2017) Christopher Hyland et al.   SYNTHESIS-STUTTGART

C -Propargylation Overrides O -Propargylation in Reactions of Propargyl Chloride with Primary Alcohols: Rhodium-Catalyzed Transfer Hydrogenation

(2016) Tao Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Hydrohydroxyalkylation of Styrene with Primary Alcohols or Aldehydes via Ruthenium-Catalyzed C−C Bond Forming Transfer Hydrogenation

(2016) Hongde Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes

(2016) Yan-Long Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic enantioselective OFF ↔ ON activation processes initiated by hydrogen transfer: concepts and challenges

(2016) Adrien Quintard et al.   CHEMICAL COMMUNICATIONS

Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

(2016) Nadine Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Osmium(0)-Catalyzed C–C Coupling of Ethylene and α-Olefins with Diols, Ketols, or Hydroxy Esters via Transfer Hydrogenation

(2016) Boyoung Y. Park et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Alcohol C–H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis

(2016) Jiajie Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C–C Bond Formation: Potency Does Not Confer Bryostatin-like Biology

(2016) John M. Ketcham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-BINAP Catalyzed Alcohol C–H tert-Prenylation via 1,3-Enyne Transfer Hydrogenation: Beyond Stoichiometric Carbanions in Enantioselective Carbonyl Propargylation

(2016) Khoa D. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Formation of All-Carbon Quaternary Centers via C–H Functionalization of Methanol: Iridium-Catalyzed Diene Hydrohydroxymethylation

(2016) Khoa D. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Swinholide A: An Exposition in Hydrogen-Mediated C–C Bond Formation

(2016) Inji Shin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydroxymethylation beyond Carbonylation: Enantioselective Iridium-Catalyzed Reductive Coupling of Formaldehyde with Allylic Acetates via Enantiotopic π-Facial Discrimination

(2016) Victoria J. Garza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-catalyzed reductive coupling of olefin-derived nucleophiles: Reinventing carbonyl addition

(2016) Khoa D. Nguyen et al.   SCIENCE

Recent Advances in the Asymmetric Nozaki–Hiyama–Kishi Reaction

(2016) Guozhu Zhang et al.   SYNTHESIS-STUTTGART

Homogeneous Ethanol to Butanol Catalysis—Guerbet Renewed

(2016) Hope Aitchison et al.   ACS Catalysis

Enantioselective sp3 C–H alkylation of γ-butyrolactam by a chiral Ir(i) catalyst for the synthesis of 4-substituted γ-amino acids

(2015) Yu-ki Tahara et al.   CHEMICAL COMMUNICATIONS

Substitution of alcohols by N-nucleophiles via transition metal-catalyzed dehydrogenation

(2015) Qin Yang et al.   CHEMICAL SOCIETY REVIEWS

Diastereo- and Enantioselective Iridium Catalyzed Carbonyl (α-Cyclopropyl)allylation via Transfer Hydrogenation

(2015) Ryosuke Tsutsumi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis, Stereochemical Revision, and Biological Reassessment of Mandelalide A: Chemical Mimicry of Intrafamily Relationships

(2015) Jens Willwacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium Catalyzed Diastereo- and Enantioselective Coupling of Propargyl Ethers with Alcohols: Siloxy-Crotylation via Hydride Shift Enabled Conversion of Alkynes to π-Allyls

(2015) Tao Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed C–C Coupling of a Simple Propargyl Ether with Primary Alcohols: Enantioselective Homoaldol Addition via Redox-Triggered (Z)-Siloxyallylation

(2015) Tao Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed C–C Coupling of Amino Alcohols with Dienes via Transfer Hydrogenation: Redox-Triggered Imine Addition and Related Hydroaminoalkylations

(2015) Te-Yu Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Ruthenium-Catalyzed Carbonyl Allylation via Alkyne–Alcohol C–C Bond-Forming Transfer Hydrogenation: Allene Hydrometalation vs Oxidative Coupling

(2015) Tao Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Asymmetric Hydrohydroxyalkylation of Butadiene: The Role of the Formyl Hydrogen Bond in Stereochemical Control

(2015) Matthew N. Grayson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereo- and Enantioselective Iridium Catalyzed Coupling of Vinyl Aziridines with Alcohols: Site-Selective Modification of Unprotected Diols and Synthesis of Substituted Piperidines

(2015) Gang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Generation of Triketide Stereopolyads via Merged Redox-Construction Events: Total Synthesis of (+)-Zincophorin Methyl Ester

(2015) Zachary A. Kasun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates

(2015) John Leonard et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Reductive cyclization of halo-ketones to form 3-hydroxy-2-oxindoles via palladium catalyzed hydrogenation: a hydrogen-mediated Grignard addition

(2015) Inji Shin et al.   TETRAHEDRON

Total synthesis and stereochemical assignment of cryptolatifolione

(2015) Luiz F. T. Novaes et al.   RSC Advances

Directed Ruthenium-Catalyzed C(sp3)H α-Alkylation of Cyclic Amines Using Dioxolane-Protected Alkenones

(2014) Artem A. Kulago et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective CH Functionalization of Alcohols by Redox-Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon

(2014) John M. Ketcham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst-Directed Diastereo- and Site-Selectivity in Successive Nucleophilic and Electrophilic Allylations of Chiral 1,3-Diols: Protecting-Group-Free Synthesis of Substituted Pyrans

(2014) Inji Shin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Redox-Triggered C–C Coupling of Alcohols and Vinyl Epoxides: Diastereo- and Enantioselective Formation of All-Carbon Quaternary Centers via tert-(Hydroxy)-Prenylation

(2014) Jiajie Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of seco-B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties

(2014) Ian P. Andrews et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

All-Carbon Quaternary Stereogenic Centers in Acyclic Systems through the Creation of Several C–C Bonds per Chemical Step

(2014) Ilan Marek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyketide construction via hydrohydroxyalkylation and related alcohol C–H functionalizations: reinventing the chemistry of carbonyl addition

(2014) Anne-Marie R. Dechert-Schmitt et al.   NATURAL PRODUCT REPORTS

Ruthenium(II)-Catalyzed C(sp3)–H α-Alkylation of Pyrrolidines

(2014) Marvin Schinkel et al.   ORGANIC LETTERS

Unique Regioselectivity in the C(sp3)–H α-Alkylation of Amines: The Benzoxazole Moiety as a Removable Directing Group

(2014) Günther Lahm et al.   ORGANIC LETTERS

Hydroaminoalkylation: Early-Transition-Metal-Catalyzed α-Alkylation of Amines

(2014) Laurel Schafer et al.   SYNTHESIS-STUTTGART

Catalytic asymmetric allylation of carbonyl compounds and imines with allylic boronates

(2014) Hua-Xing Huo et al.   Organic Chemistry Frontiers

Protecting-Group-Free Diastereoselective CC Coupling of 1,3-Glycols and Allyl Acetate through Site-Selective Primary Alcohol Dehydrogenation

(2013) Anne-Marie R. Dechert-Schmitt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Diastereoselective CC Coupling of α-Olefins and Styrenes to 3-Hydroxy-2-oxindoles by Ru-Catalyzed Hydrohydroxyalkylation

(2013) Eiji Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Cyanolide A in the Absence of Protecting Groups, Chiral Auxiliaries, or Premetalated Carbon Nucleophiles

(2013) Andrew R. Waldeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Impact of the Mukaiyama Aldol Reaction in Total Synthesis

(2013) S. B. Jennifer Kan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium catalyzed hydroaminoalkylation of isoprene via transfer hydrogenation: byproduct-free prenylation of hydantoins

(2013) Daniel C. Schmitt et al.   CHEMICAL COMMUNICATIONS

Total Synthesis of 6-Deoxyerythronolide B via C–C Bond-Forming Transfer Hydrogenation

(2013) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Photoredox Catalysis Enabled by Proton-Coupled Electron Transfer: Development of an Asymmetric Aza-Pinacol Cyclization

(2013) Lydia J. Rono et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-catalyzed asymmetric aldol reactions

(2013) Luiz C. Dias et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Diastereo- and Enantioselective Iridium-Catalyzed Carbonyl Propargylation from the Alcohol or Aldehyde Oxidation Level: 1,3-Enynes as Allenylmetal Equivalents

(2012) Laina M. Geary et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Carbonyl Propargylation by Iridium-Catalyzed Transfer Hydrogenative Coupling of Alcohols and Propargyl Chlorides

(2012) Sang Kook Woo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Consecutive iridium catalyzed C–C and C–H bond forming hydrogenations for the diastereo- and enantioselective synthesis of syn-3-fluoro-1-alcohols: C–H (2-fluoro)allylation of primary alcohols

(2012) Abbas Hassan et al.   CHEMICAL COMMUNICATIONS

Asymmetric homogeneous hydrogenations at scale

(2012) David J. Ager et al.   CHEMICAL SOCIETY REVIEWS

Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs

(2012) Pablo Etayo et al.   CHEMICAL SOCIETY REVIEWS

The Role of the Alcohol and Carboxylic Acid in Directed Ruthenium-Catalyzed C(sp3)H α-Alkylation of Cyclic Amines

(2012) Sheba D. Bergman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Conversion of Primary Alcohols to α-exo-Methylene γ-Butyrolactones via Iridium-Catalyzed C–C Bond-Forming Transfer Hydrogenation: 2-(Alkoxycarbonyl)allylation

(2012) T. Patrick Montgomery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs

(2012) Yu Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral-Anion-Dependent Inversion of Diastereo- and Enantioselectivity in Carbonyl Crotylation via Ruthenium-Catalyzed Butadiene Hydrohydroxyalkylation

(2012) Emma L. McInturff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Allylation of Chiral β-Stereogenic Alcohols: Bypassing Discrete Formation of Epimerizable Aldehydes

(2012) Daniel C. Schmitt et al.   ORGANIC LETTERS

Formation of C–C bonds via ruthenium-catalyzed transfer hydrogenation

(2012) Joseph Moran et al.   PURE AND APPLIED CHEMISTRY

Enantioselective C-H Crotylation of Primary Alcohols via Hydrohydroxyalkylation of Butadiene

(2012) J. R. Zbieg et al.   SCIENCE

Cationic iridium-catalyzed enantioselective activation of secondary sp3 C–H bond adjacent to nitrogen atom

(2012) Shiguang Pan et al.   TETRAHEDRON

Iridium-Catalyzed anti-Diastereo- and Enantioselective Carbonyl (α-Trifluoromethyl)allylation from the Alcohol or Aldehyde Oxidation Level

(2011) Xin Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Iridium-Catalyzed Vinylogous Reformatsky-Aldol Reaction from the Alcohol Oxidation Level: Linear Regioselectivity by Way of Carbon-Bound Enolates

(2011) Abbas Hassan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Catalytic Amination of Alcohols

(2011) Sebastian Bähn et al.   ChemCatChem

Catalytic enantioselective Grignard Nozaki–Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability

(2011) Abbas Hassan et al.   CHEMICAL COMMUNICATIONS

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Propargylation

(2011) Chang-Hua Ding et al.   CHEMICAL REVIEWS

Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines

(2011) Miguel Yus et al.   CHEMICAL REVIEWS

Enhanced anti-Diastereo- and Enantioselectivity in Alcohol-Mediated Carbonyl Crotylation Using an Isolable Single Component Iridium Catalyst

(2011) Xin Gao et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Generation of Acyclic Polypropionate StereopolyadsviaDouble Diastereo- and Enantioselective Iridium-Catalyzed Crotylation of 1,3-Diols: Beyond Stepwise Carbonyl Addition in Polyketide Construction

(2011) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Bryostatin 7viaC–C Bond-Forming Hydrogenation

(2011) Yu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polarity Inversion of Donor–Acceptor Cyclopropanes: Disubstituted δ-Lactones via Enantioselective Iridium Catalysis

(2011) Joseph Moran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereo- and Enantioselective Ruthenium-Catalyzed Hydrohydroxyalkylation of 2-Silyl-butadienes: Carbonylsyn-Crotylation from the Alcohol Oxidation Level

(2011) Jason R. Zbieg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concise Formal Synthesis of (+)-Neopeltolide

(2011) Zhen Yang et al.   ORGANIC LETTERS

Ir(I)-Catalyzed Enantioselective Secondary sp3C–H Bond Activation of 2-(Alkylamino)pyridines with Alkenes

(2011) Shiguang Pan et al.   ORGANIC LETTERS

Use of an Iridium-Catalyzed Redox-Neutral Alcohol-Amine Coupling on Kilogram Scale for the Synthesis of a GlyT1 Inhibitor

(2011) Martin A. Berliner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Unlocking Hydrogenation for C–C Bond Formation: A Brief Overview of Enantioselective Methods

(2011) Abbas Hassan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The direct catalytic asymmetric aldol reaction

(2010) Barry M. Trost et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Carbonyl Allylation, Crotylation, andtert-Prenylation of Furan Methanols and Furfurals via Iridium-Catalyzed Transfer Hydrogenation

(2010) Benjamin Bechem et al.   JOURNAL OF ORGANIC CHEMISTRY

Iridium-Catalyzedanti-Diastereo- and Enantioselective Carbonyl (Trimethylsilyl)allylation from the Alcohol or Aldehyde Oxidation Level

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Roxaticin via C−C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries, and Premetalated Nucleophiles in Polyketide Construction

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

anti-Diastereo- and Enantioselective Carbonyl (Hydroxymethyl)allylation from the Alcohol or Aldehyde Oxidation Level: Allyl Carbonates as Allylmetal Surrogates

(2010) Yong Jian Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereo- and Enantioselectiveanti-Alkoxyallylation Employing Allylicgem-Dicarboxylates as Allyl Donors via Iridium-Catalyzed Transfer Hydrogenation

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic synthesis of amines and N-containing heterocycles: Amidate complexes for selective C–N and C–C bond-forming reactions

(2010) Patrick Eisenberger et al.   PURE AND APPLIED CHEMISTRY

Enantioselective Allylation, Crotylation, and Reverse Prenylation of Substituted Isatins: Iridium-Catalyzed CC Bond-Forming Transfer Hydrogenation

(2009) Junji Itoh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1,n-Glycols as Dialdehyde Equivalents in Iridium-Catalyzed Enantioselective Carbonyl Allylation and Iterative Two-Directional Assembly of 1,3-Polyols

(2009) Yu Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Hydroaminoalkylation

(2009) Peter W. Roesky   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

(2009) Graham E. Dobereiner et al.   CHEMICAL REVIEWS

ESI-MS, DFT, and Synthetic Studies on the H2-Mediated Coupling of Acetylene: Insertion of C═X Bonds into Rhodacyclopentadienes and Brønsted Acid Cocatalyzed Hydrogenolysis of Organorhodium Intermediates

(2009) Vanessa M. Williams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Carbonyl Reverse Prenylation from the Alcohol or Aldehyde Oxidation Level Employing 1,1-Dimethylallene as the Prenyl Donor

(2009) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

anti-Diastereo- and Enantioselective Carbonyl Crotylation from the Alcohol or Aldehyde Oxidation Level Employing a Cyclometallated Iridium Catalyst: α-Methyl Allyl Acetate as a Surrogate to Preformed Crotylmetal Reagents

(2009) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elongation of 1,3-Polyols via Iterative Catalyst-Directed Carbonyl Allylation from the Alcohol Oxidation Level

(2009) Abbas Hassan et al.   ORGANIC LETTERS

Cationic Ir(I)-Catalyzed sp3C−H Bond Alkenylation of Amides with Alkynes

(2009) Kyoji Tsuchikama et al.   ORGANIC LETTERS

Highly Stereoselective Aldol Reactions in the Total Syntheses of Complex Natural Products

(2009) Markus Kalesse et al.   SYNLETT

Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones:  Design of Effective Monodentate TADDOL-Like Phosphonite Ligands

(2008) Cisco Bee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level Using Allyl Acetate as an Allyl Metal Surrogate

(2008) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level via Transfer Hydrogenative Coupling of Allyl Acetate: Departure from Chirally Modified Allyl Metal Reagents in Carbonyl Addition

(2008) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Branch-Selective Reductive Coupling of 2-Vinyl Pyridines and IminesviaRhodium Catalyzed C−C Bond Forming Hydrogenation

(2008) Venukrishnan Komanduri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalyst-Directed Diastereoselectivity in Hydrogenative Couplings of Acetylene to α-Chiral Aldehydes: Formal Synthesis of All Eightl-Hexoses

(2008) Soo Bong Han et al.   ORGANIC LETTERS