Review
Endocrinology & Metabolism
Yehan Bian, Heidi Hahn, Anja Uhmann
Summary: Hedgehog signaling plays essential roles in embryonic development, adult homeostasis, and tumorigenesis. Despite its close connection with pituitary embryonic development, the engagement of Hedgehog signaling in the pituitary gland has been underestimated. Dysfunction of this signaling pathway during pituitary development leads to gland malformation. Recent research also suggests a regulatory role of Hedgehog signaling in the adult pituitary, affecting homeostasis, hormone production, and possibly formation of neoplasms. Targeting this pathway with therapeutic strategies shows promise in treating pituitary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paz Cartas-Cejudo, Mercedes Lachen-Montes, Joaquin Fernandez-Irigoyen, Enrique Santamaria
Summary: Olfactory dysfunction is an early marker of neurodegenerative diseases, with changes in the olfactory bulb triggering molecular events across different neurological disorders. This study analyzed commonalities and differences in olfactory protein homeostasis, identifying disease-specific and commonly altered proteins across multiple neurological phenotypes. Bioinformatic analysis revealed potential disease-specific transcription factors and densely connected protein complexes targeted by various neurological diseases, offering new mechanistic insights at the olfactory level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Penglai Liu, Cheng Gao, Jing Wu, Tingting Wu, Ying Zhang, Changyu Liu, Changcheng Sun, Anan Li
Summary: This study investigates the role of the lateral entorhinal cortex (LEC) and the posterior piriform cortex (PPC) in aversive olfactory learning. The findings suggest that LEC is involved in the acquisition of negative odor value, while PPC is involved in the memory-retrieval phase. Inhibition of LEC CaMKIIa+ neurons affects fear encoding, fear memory recall, and PPC responses to a conditioned odor, providing evidence for the involvement of LEC CaMKIIa+ neurons in negative valence encoding.
Article
Oncology
Ramadevi Subramani, Adriana Estrada, Madeline Dixon, Maria Parada, Sheryl Rodriguez, Diego A. Pedroza, Matthew D. Ramirez, Alexa Clift, Lilia Garcia, Rajkumar Lakshmanaswamy
Summary: Early pregnancy reduces the lifetime risk of breast cancer by persistently altering the hypothalamic-pituitary hormonal axis, although the exact physiological mechanisms involved are not clear.
Review
Endocrinology & Metabolism
Pardis Mohammadzadeh, Gregory C. Amberg
Summary: AXL is a receptor tyrosine kinase that is commonly associated with various human cancers. It has been found to play a crucial role in neuroendocrine development and function, along with its ligand Gas6. AXL signaling, triggered by Gas6 binding, affects neuroendocrine structure and function in the brain, pituitary, and gonads. AXL has been identified as an upstream inhibitor of gonadotropin receptor hormone (GnRH) production during development and is also involved in the migration of GnRH neurons. It is implicated in reproductive diseases and spermatogenesis. The research on AXL/Gas6 signaling mechanisms provides valuable insights into neuroendocrine function in health and disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiujin Li, Bingjin Lin, Xumeng Zhang, Xu Shen, Hongjia Ouyang, Zhongping Wu, Yunbo Tian, Lingzhao Fang, Yunmao Huang
Summary: This study collected 175 high-quality RNA-seq samples from mammals and poultry to compare gene expression in the HPG axis, revealing significant differences between mammalian and avian species. Two key pathways, neuroactive ligand-receptor interaction and calcium signaling pathway, were identified to play important roles in animal reproduction.
Article
Biotechnology & Applied Microbiology
Xiujin Li, Bingjin Lin, Xumeng Zhang, Xu Shen, Hongjia Ouyang, Zhongping Wu, Yunbo Tian, Lingzhao Fang, Yunmao Huang
Summary: This study compares the gene expression in the hypothalamic-pituitary-gonad (HPG) axis between mammals and birds, revealing significant differences and identifying key pathways, such as neuroactive ligand-receptor interaction and calcium signaling pathway, that play important roles in animal reproduction.
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Svetlana Minakhina, Vanessa De Oliveira, Sun Young Kim, Haiyan Zheng, Fredric E. Wondisford
Summary: Fasting induces significant changes in the HPT axis, with THRB2 S101 phosphorylation playing a key role in the repression of the axis by TH and AMPK activation. CDK2 is proposed as a direct kinase phosphorylating THRB2 S101, suggesting a common mechanism for acute suppression of the HPT axis by nutritional deprivation and TH.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina Rother, Lynnette K. Nieman
Summary: The study revealed that abnormal thyroid function, likely mediated by subnormal nocturnal TSH levels, is prevalent in patients with Cushing syndrome. This abnormality can be reversed after cure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Joseph D. Zak, Nathan E. Schoppa
Summary: The study reveals the presence of various cell types within the olfactory bulb, which play crucial roles in processing and modulating olfactory information through different chemical synaptic connections, highlighting the importance of local circuits in shaping olfactory function.
Article
Cell Biology
Liliia Butiaeva, Tal Slutzki, Hannah E. Swick, Clement Bourguignon, Sarah C. Robins, Xiaohong Liu, Kai-Florian Storch, Maia Kokoeva
Summary: Studies have shown that LepR pericytes facilitate localized, paracellular blood-brain barrier leaks, enabling MBH LepR neurons to access circulating leptin. Disruption of LepR in pericytes leads to increased food intake, increased fat mass, and loss of leptin-dependent signaling in nearby LepR neurons.
Article
Endocrinology & Metabolism
Hongyuan Zhu, Luming Wu, Tingwei Su, Lei Jiang, Weiwei Zhou, Yiran Jiang, Cui Zhang, Xu Zhong, Weiqing Wang
Summary: This study investigated the association between radiological characteristics of benign adrenocortical tumors and the hypothalamus-pituitary-adrenal (HPA) axis in 494 patients. It was found that patients with mild autonomous cortisol secretion (MACS) had larger tumor diameter, thinner contralateral adrenal gland, and lower plasma ACTH and serum DHEAS levels compared to those with non-functional adrenocortical tumors (NFAT). ACTH was shown to mediate the effects of MACS on DHEAS and contralateral adrenal gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Bashair M. Mussa, Ankita Srivastava, Abdul Khader Mohammed, Anthony J. M. Verberne
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Article
Neurosciences
Yousef Al Zoubi, Bashair M. Mussa, Ankita Srivastava, Abdul Khader Mohammed, Elamin Abdelgadir, Alaaeldin Bashier, Fatheya Al Awadi, Salah Abusnana
Summary: Recurrent hypoglycemic episodes can lead to hypoglycemia unawareness. Research findings suggest that decreased TNF-alpha expression and increased expression of IL-1 beta, IL-6, and IFN-gamma in type 1 diabetes mellitus patients may indicate systemic inflammation as an underlying cause of HU.
Article
Genetics & Heredity
Md Rezanur Rahman, Tania Islam, Ferdinando Nicoletti, Maria Cristina Petralia, Rosella Ciurleo, Francesco Fisicaro, Manuela Pennisi, Alessia Bramanti, Talip Yasir Demirtas, Esra Gov, Md Rafiqul Islam, Bashair M. Mussa, Mohammad Ali Moni, Paolo Fagone
Summary: The study identified common molecular pathogenetic processes and pathways shared between schizophrenia and type 2 diabetes mellitus, including inflammatory-associated processes and membrane trafficking pathways. Transcription factors STAT1, RELA, NFKB1, and ERG were found to be involved in the expression of common differentially expressed genes in both SCZ and T2DM.
Article
Biochemistry & Molecular Biology
Bashair M. Mussa, Amir Ali Khan, Ankita Srivastava, Sallam Hasan Abdallah
Summary: This study focused on differentiating iMSCs into PDGFR alpha-positive cells, investigating the effects of NO on cell survival, and evaluating the impact of hyperglycemia on nNOS gene expression. The results showed that differentiation was successful, and NO had a significant effect on cell survival, while hyperglycemia increased nNOS expression. This novel model can help identify new therapeutic targets for treating DGP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Bashair M. Mussa, Ankita Srivastava, Abeer Al-Habshi, Abdul Khader Mohammed, Rabih Halwani, Salah Abusnana
Summary: The study revealed a significant increase in MCP-1 levels in T2DM patients with DNP, with IL-8 and TGF-beta strongly correlated with MCP-1 levels.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ankita Srivastava, Bashair M. Mussa
Summary: The COVID-19 pandemic has had a negative impact on millions of lives, and strict glycemic control is important for diabetic patients with COVID-19. Research has found that SARS-CoV-2 can invade the hypothalamus, which plays a central role in glucose regulation in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Tahra Al Ali, Alizeh Ashfaq, Narjes Saheb Sharif-Askari, Salah Abusnana, Bashair M. Mussa
Summary: This study aims to investigate the association between vitamin D deficiency and diabetic neuropathy in Emirati patients with type 2 diabetes mellitus (T2DM). The results showed that among the 600 patients, 50% had diabetic neuropathy and these patients had lower vitamin D levels compared to those without neuropathy. The study suggests a high prevalence of vitamin D deficiency in Emirati patients with T2DM and highlights the importance of addressing this issue.
Review
Medicine, General & Internal
Hala Zakaria, Salah Abusanana, Bashair M. Mussa, Ayesha S. Al Dhaheri, Lily Stojanovska, Maysm N. Mohamad, Sheima T. Saleh, Habiba I. Ali, Leila Cheikh Ismail
Summary: Gestational diabetes mellitus (GDM) is a common pregnancy-related endocrinopathy, affecting up to 25% of pregnancies globally. It increases the risk of complications during pregnancy and delivery, and also raises the chance of developing type 2 diabetes and cardiovascular diseases. This risk can be passed onto the next generation, creating a cycle of metabolic dysfunction. Recent studies have identified promising preventive measures for GDM, such as lifestyle interventions including physical activity and dietary changes. More research is needed to investigate the timing of lifestyle interventions and to personalize the approach based on individual risk factors.
MEDICINA-LITHUANIA
(2023)
