Metabolic homeostasis via BDNF and its receptors

Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis

(2021) Jessica Houtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation

(2020) Brandon Podyma et al.   eLife

BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice

(2020) Alessandro Ieraci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

(2020) Gianluca Fulgenzi et al.   Nature Communications

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits

(2020) Juan Ji An et al.   Nature Communications

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities

(2020) Takuhiro Sonoyama et al.   Scientific Reports

BDNF influences neural cue-reactivity to food stimuli and food craving in obesity

(2020) Jan Malte Bumb et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding

(2019) Guey-Ying Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subpopulation of Bdnf-e1–expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control

(2019) He You et al.   Molecular Metabolism

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle

(2018) John Wood et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

(2018) Elena G. Bochukova et al.   Cell Reports

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

(2018) Gleb Kichaev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor

(2017) Khalil Saadipour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a Wiring Diagram Understanding of Appetite Control

(2017) Mark L. Andermann et al.   NEURON

Warm-Sensitive Neurons that Control Body Temperature

(2016) Chan Lek Tan et al.   CELL

Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion

(2016) Jessica Houtz et al.   DEVELOPMENTAL CELL

Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons

(2016) Haili Yang et al.   MOLECULAR ENDOCRINOLOGY

Neurotrophic factor control of satiety and body weight

(2016) Baoji Xu et al.   NATURE REVIEWS NEUROSCIENCE

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity

(2016) Bernat Baeza-Raja et al.   Cell Reports

BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice

(2016) M Madra et al.   Translational Psychiatry

Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure

(2015) Juan Ji An et al.   Cell Metabolism

Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment

(2015) Margarita Arango-Lievano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

(2015) Zongyang Mou et al.   Cell Reports

Structural basis of death domain signaling in the p75 neurotrophin receptor

(2015) Zhi Lin et al.   eLife

Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance

(2015) Ceren Ozek et al.   Molecular Metabolism

Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus

(2015) Guey-Ying Liao et al.   Molecular Metabolism

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

(2014) Danielle A. Simmons et al.   PLoS One

Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells

(2013) Thangiah Geetha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

BDNF and the central control of feeding: accidental bystander or essential player?

(2013) Maribel Rios   TRENDS IN NEUROSCIENCES

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

Prader-Willi syndrome

(2012) Suzanne B. Cassidy et al.   GENETICS IN MEDICINE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

RAI1 Transcription Factor Activity Is Impaired in Mutants Associated with Smith-Magenis Syndrome

(2012) Paulina Carmona-Mora et al.   PLoS One

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity

(2012) B. Baeza-Raja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome

(2010) Brooke Burns et al.   HUMAN MOLECULAR GENETICS

Lower Brain-Derived Neurotrophic Factor in Patients with Prader-Willi Syndrome Compared to Obese and Lean Control Subjects

(2010) Joan C. Han et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders

(2008) Josep Maria Mercader et al.   HUMAN MOLECULAR GENETICS

Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

(2008) Joan C. Han et al.   NEW ENGLAND JOURNAL OF MEDICINE

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

(2008) John C. Lin et al.   PLoS One

TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice

(2007) David Tsao et al.   ENDOCRINOLOGY

A DRD4/BDNF gene–gene interaction associated with maximum BMI in women with bulimia nervosa

(2007) Allan S. Kaplan et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS