期刊
TALANTA
卷 227, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2021.122188
关键词
Surface-enhanced Raman spectroscopy (SERS); Aptamers; Nanoparticles (NPs); Nanostructure; Biosensors
资金
- National Natural Science Foundation of China [11635013]
- China Scholarship Council of China government
This review summarizes the general working strategies and different sensor designs of aptamer-based SERS biosensors, which include using aptamer conformational change or various extrinsic Raman reporters. The advantages, applications, and perspectives of these sensors are also discussed.
Surface-enhanced Raman spectroscopy, due to its high sensitivity, unique vibrational fingerprint identification of molecules and easy operation, has been extensively applied in different fields. Aptamers, being the unique single stranded DNA/RNA sequences that can specifically recognize and seize the target analytes, combined with Surface-enhanced Raman spectroscopy (SERS), can offer potent multiplex detection capacity with high specificity and sensitivity. In this review, we summarize and classify the general working strategies of different types of aptamer-based SERS biosensors with diversified protocols which either take aptamer conformational change as intrinsic reporter, or make use of various extrinsic Raman reporters in different sensor designs via on/off approach, sandwich-type and magnetic nanoparticles (NPs)-assisted approach, and catalytic reaction assisted approach with amplification of alternative Raman signals. The advantages, applications and perspectives of these aptamer-based SERS biosensors are also discussed.
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