Review
Chemistry, Analytical
Kefilwe V. Mokwebo, Samantha F. Douman, Onyinyechi V. Uhuo, Kaylin C. Januarie, Marlon Oranzie, Emmanuel I. Iwuoha
Summary: The HIV pandemic has led to the discovery and use of antiretroviral drugs for improving patient well-being and reducing the risk of perinatal transmission of HIV. Electroanalytical techniques, particularly voltammetry, have been widely used for ARV analysis due to their advantages of onsite monitoring and real-time analysis. This review discusses the development and recent advances in detection strategies for ARV drugs and focuses on different types of ARV drugs and their mechanisms.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sayed A. M. Marzouk, Aisha R. Alyammahi, Pablo Fanjul-Bolado
Summary: This paper describes three novel cells for electrochemical measurements, offering convenient electrical connection, excellent SPEC sealing, and versatility for various applications with different sample volumes. Additionally, a new experimental method is presented.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Tanja Vrabelj, Matjaz Finsgar
Summary: This review summarizes recent advances in the non-enzymatic electrochemical detection and quantification of pesticides, with a focus on the use of nanomaterial-based electrode modifiers and their analytical response. Carbon-based nanomaterials, metal, and metal oxide nanoparticles are commonly investigated for electrochemical analysis due to their high surface-to-volume ratio, large effective area, high conductivity, and (electro)chemical stability.
Article
Chemistry, Analytical
Soraya Hoefs, Valerie Jaut, Rudolf J. Schneider
Summary: The ergot alkaloids, a type of mycotoxin found in cereals, have caused numerous deaths. A portable and cost-effective test system for ergot alkaloid detection is essential for the food industry.
Article
Engineering, Electrical & Electronic
Nilesh S. Dumore, Mausumi Mukhopadhyay
Summary: A commercial graphene-amine (CGA) and synthesized selenium nanoparticle (SSeNP) nanocomposite coated on the surface of fluorine-doped tin oxide (SSeNPs-CGA-FTO) substrate was developed for H2O2 detection. The electrochemical sensors showed a linear response range from 0.1 mM to 20 mM with low detection limits of 0.1 mM and 0.05 mM for CGA-FTO and SSeNPs-CGA-FTO, respectively. The SSeNPs-CGA-FTO-based sensors also demonstrated higher selectivity towards H2O2.
JOURNAL OF ELECTRONIC MATERIALS
(2023)
Review
Food Science & Technology
Mohammad Reza Jalali Sarvestani, Zohreh Doroudi
Summary: This review paper summarizes various reports on the electroanalytical determination method of Carmoisine (CMS), compares different electrochemical sensors from various angles, and provides suggestions for future works to achieve the most suitable sensor with high sensitivity and commercialization potential.
FOOD ANALYTICAL METHODS
(2022)
Review
Chemistry, Analytical
S. Irem Kaya, Ahmet Cetinkaya, Sibel A. Ozkan
Summary: Nanotechnology and nanomaterials play a critical role in drug analysis. Carbon-based nanomaterials and electrochemical techniques are widely used for sensor development, aiming for rapid development, ease of use, and high sensitivity in drug analysis.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Florina Pogacean, Codruta Varodi, Lidia Magerusan, Stela Pruneanu
Summary: This article presents the development of an electrochemical sensor based on graphene/glassy carbon electrode for trace level detection of nitrite in water samples. The sensor exhibits remarkable enhanced sensing response towards nitrite compared to the bare electrode (three orders of magnitude higher). It also demonstrates excellent operational stability, repeatability, and interference capability, and shows excellent results in the practical application test in commercially available waters.
Review
Chemistry, Analytical
S. Irem Kaya, Sercan Yildirim, Ahmet Cetinkaya, Cem Erkmen, Bengi Uslu, Sibel A. Ozkan
Summary: This article discusses the issue of doping and its detection, focusing on WADA's regulations on prohibited substances and the application of electrochemical sensors in this area. Nanomaterials are used to enhance the performance of electrochemical sensors, making them a highly sensitive, selective, and rapid tool for detecting prohibited substances.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Tiago A. Matias, David L. O. Ramos, Lucas V. Faria, Abner de Siervo, Eduardo M. Richter, Rodrigo A. A. Munoz
Summary: A new electrochemical device is developed by combining 3D printing and laser-generated graphene sensors. The device utilizes 3D-printed cells and electrodes, as well as laser-induced graphene, to achieve excellent electrochemical sensing properties for the detection of atropine in beverages. The method shows a linear range, low detection limit, and satisfactory precision, making it a useful portable analytical tool for on-site applications in the forensic scenario.
Article
Electrochemistry
Palraj Kalimuthu, Tobias Kruse, Paul V. Bernhardt
Summary: The electrochemical nitrate biosensor utilizes nitrate reductase from Neurospora crassa, entrapped within a polymeric chitosan matrix on a glassy carbon electrode, with the electron mediator anthraquinone sulfonate. The sensor shows high sensitivity, selectivity, and long-term stability, and is successfully applied for nitrate detection in lake and river water samples.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Guzel Ziyatdinova, Ekaterina Guss, Elvira Yakupova
Summary: One sustainable trend in modern analytical chemistry is the design and fabrication of novel electrochemical sensors with high analytical and operational characteristics, focusing on sensors based on electropolymerized natural phenolic antioxidants. The combination of electropolymerized natural phenolic antioxidants and carbon nanomaterials as modifiers is of special interest for improving the performance of the sensors.
Review
Chemistry, Applied
Elis Marina Fonseca Almeida, Djenaine De Souza
Summary: Pesticides, when used inappropriately, can lead to contamination of the environment, soil, water, and foods. The accumulative effects of carbamates and dithiocarbamates pesticides in the human body can result in hormonal, neurological, and reproductive disorders, as well as carcinogenic or mutagenic effects. This review discusses the electroanalytical approach for detecting carbamates and dithiocarbamates, highlighting the advantages, disadvantages, and future prospects of voltammetric techniques in analyzing these pesticides in natural water and foods. It also emphasizes the importance of selecting appropriate materials for working electrodes in order to achieve sensitivity, selectivity, stability, and robustness in analytical applications.
Article
Chemistry, Multidisciplinary
Baomei Huang, Xi Luo, Qingmiao Pu, Junchun Guo, Xinyu Tong, Xiaoquan Lu
Summary: In this study, a electrochemical sensor was constructed with beta-CD-NH2-Fe3O4 magnetic nanomaterials modified electrode to detect toxic heavy metals (Pb2+, Cu2+) in river water. The modified electrode exhibited a larger active area and excellent electron transfer, resulting in a wider linear response range and lower detection limit compared to similar results reported in the literature.
Article
Chemistry, Analytical
Kamila Morawska, Witold Ciesielski, Sylwia Smarzewska
Summary: The research investigated the electrochemical behavior of the diacylhydrazine insecticide methoxyfenozide on a boron-doped diamond electrode and its interaction with double-stranded DNA, developing a sensitive SW voltammetric procedure for the determination of Met. The study demonstrated the intercalative binding mode between Met and dsDNA based on changes in electrochemical and spectroscopic behaviors.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Arash Ghoorchian, Mahdie Kamalabadi, Mahdi Moradi, Tayyebeh Madrakian, Abbas Afkhami, Hasan Bagheri, Mazaher Ahmadi, Hosein Khoshsafar
Summary: Here, a wearable potentiometric ion sensor for real-time monitoring of sodium ions in human sweat samples is presented. The sensor utilizes Na0.44MnO2 as the sensing material, and shows good analytical performance and detection range. The sensor is fully integrated into a headband textile for non-invasive analysis of sodium ions in sweat.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Saeid Ghavami, Mozhdeh Zamani, Mazaher Ahmadi, Mehran Erfani, Sanaz Dastghaib, Mahsa Darbandi, Sara Darbandi, Omid Vakili, Morvarid Siri, Beniamin Oskar Grabarek, Dariusz Boron, Maryam Zarghooni, Emilia Wiechec, Pooneh Mokarram
Summary: This article discusses the association between autophagy and epigenetics in gastrointestinal cancers (GICs), including their interplay, how epigenetic modifications affect cancer cell behavior, and how epigenetic drugs modulate autophagy to overcome chemoresistance in GICs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Pharmacology & Pharmacy
Mehdi Eshraghi, Mazaher Ahmadi, Saeid Afshar, Shahrokh Lorzadeh, Aida Adlimoghaddam, Nahid Rezvani Jalal, Ryan West, Sanaz Dastghaib, Somayeh Igder, Seyed Reza Naeimi Torshizi, Amir Mahmoodzadeh, Pooneh Mokarram, Tayyebeh Madrakian, Benedict C. Albensi, Marek J. Los, Saeid Ghavami, Stevan Pecic
Summary: Alzheimer's disease is a significant threat to global health due to an aging population. Current drugs for AD are not very effective, making the targeting of autophagy an attractive therapeutic approach. Drug repositioning is being considered as a time-efficient and cost-effective strategy for developing new therapies.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Nahid Rezvani Jalal, Tayyebeh Madrakian, Abbas Afkhami, Mazaher Ahmadi
Summary: In this study, an electrochemical sensor was developed by growing NiCo-BTC bimetallic MOFs on a glassy carbon electrode modified with conductive nitrogen-doped graphene oxide nanoribbons. The sensor showed promising results in detecting Doxorubicin.
ACS APPLIED NANO MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Rency Geevarghese, Seyedeh Sara Sajjadi, Andrzej Hudecki, Samad Sajjadi, Nahid Rezvani Jalal, Tayyebeh Madrakian, Mazaher Ahmadi, Malgorzata K. Wlodarczyk-Biegun, Saeid Ghavami, Wirginia Likus, Krzysztof Siemianowicz, Marek J. Los
Summary: Biomaterials for tissue scaffolds play a crucial role in tissue engineering and regenerative medicine. Choosing the right biomaterial and cells for implantation is essential for targeted reconstructive therapies. Modern biomaterials need to not only provide mechanical support for implanted cells and match the expected mechanical strength of artificial tissue, but also ensure cell survival and influence their desired differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Mojdeh Mohammadi, Sara Khosravi, Amir Nili-Ahmadabadi, Mahdie Kamalabadi, Vahid Ghasemzadeh-Mohammadi, Abbas Afkhami
Summary: In this research, a novel method combining ion mobility spectrometry (IMS) and dispersive liquid-liquid microextraction was developed and validated for the fast and quantitative analysis of Ampyra (AMP) in real samples. The method utilized silver nanoparticles as modifier agents and improved sensitivity through the delay of carrier gas flow after sample injection. Under the optimized conditions, AMP was detected in the linear range of 0.4-16 µmol L-1 with a detection limit of 0.12 µmol L-1. The developed method was successfully applied to quantify AMP in urine samples and validated against HPLC-UV/Vis. The proposed method opens up new possibilities for developing simple, fast, and effective analytical methods.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Applied
Zahra Hadian, Mahdie Kamalabadi, Yuthana Phimolsiripol, Balamuralikrishnan Balasubramanian, Jose Manuel Lorenzo Rodriguez, Amin Mousavi Khaneghah
Summary: The volatile and unstable Rosa damascena essential oil (REO) was improved by forming a host-guest complex with beta-cyclodextrin nanoparticles (8-CD). The encapsulated REO showed changed physicochemical characteristics and enhanced antioxidant activity. Additionally, beverages with the addition of 8-CD nanoparticle-loaded REO demonstrated higher overall acceptability.
Article
Electrochemistry
Samaneh Hashemi, Abbas Afkhami, Mahdie Kamalabadi, Tayyebeh Madrakian, Arash Ghoorchian, Vahid Ghasemzadeh-Mohammadi
Summary: We reported a novel electrochemical sensor for the indirect determination of cyanuric acid (CA) using the complex formation between CA and melamine (MEL) for the first time. The sensor utilized the electrochemical conversion of MEL to electroactive polymelamine, with the decline in current intensity upon the addition of CA serving as the sensor response. A calibration curve was constructed using square wave voltammetry, with a limit of detection of 80.28 mu mol L-1. The proposed method showed excellent recovery range (91.2-101.0%) for real sample analysis.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Mohadese Mahdian, Soheila Akbari Asrari, Mazaher Ahmadi, Tayyebeh Madrakian, Nahid Rezvani Jalal, Abbas Afkhami, Mohammadreza Moradi, Leila Gholami
Summary: We report on the synthesis and characterization of a dual stimuli-responsive hydrogel for pH and temperature-sensitive delivery of curcumin (CUR) anticancer drug. The release of CUR from the hydrogel was higher at acidic pH values, and the hydrogel remained stable at 37 degrees C. To enable thermal responsivity, polydopamine nanoparticles were embedded in the hydrogel. The GGPDNCs hydrogel is engineered to respond to both pH and temperature stimuli.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ali Fathi, Mazaher Ahmadi, Tayyebeh Madrakian, Abbas Afkhami, Sepideh Asadi
Summary: This study developed a multi-nebulizer-based aerosol-assisted system for scaling up the synthesis of magnetic nanoparticles from labs to industry. The system consists of a sprayer, an electric heater tunnel, and a rotating magnetic collector. The nanoparticles were successfully synthesized at lower temperatures with higher magnetization using this system.
Review
Oncology
Ali Zarrabi, David Perrin, Mahboubeh Kavoosi, Micah Sommer, Serap Sezen, Parvaneh Mehrbod, Bhavya Bhushan, Filip Machaj, Jakub Rosik, Philip Kawalec, Saba Afifi, Seyed Mohammadreza Bolandi, Peiman Koleini, Mohsen Taheri, Tayyebeh Madrakian, Marek J. Los, Benjamin Lindsey, Nilufer Cakir, Atefeh Zarepour, Kiavash Hushmandi, Ali Fallah, Bahattin Koc, Arezoo Khosravi, Mazaher Ahmadi, Susan Logue, Gorka Orive, Stevan Pecic, Joseph W. Gordon, Saeid Ghavami
Summary: Rhabdomyosarcoma is a rare cancer that affects skeletal muscle, primarily in children and young adults. The treatment strategies for this disease include multi-agent chemotherapies following surgical resection and radiotherapy. This review provides a detailed clinical understanding of rhabdomyosarcoma, including its classification, diagnosis, and treatment strategies. The impact of apoptosis, macro-autophagy, and the unfolded protein response on chemotherapy response is discussed. Additionally, the use of in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models for screening future therapeutic approaches and promoting muscle regeneration is explored.
Article
Environmental Sciences
Amin Mousavi Khaneghah, Mahdie Kamalabadi, Ali Heshmati, Zahra Hadian
Summary: In this study, six potentially toxic elements (PTEs) were analyzed in domestic rice samples collected from Tehran. The concentrations of Cd, As, Cu, Pb, Cr, and Ni were measured using ICP-OES and the risks associated with PTE intake were assessed. The results showed potential non-carcinogenic risks for children and adults due to multiple PTE exposures from rice consumption, as well as a carcinogenic risk from Cr, Ni, As, and Cd exposure. The study highlights the importance of cumulative risk analysis and the need for environmental assessment and monitoring for public health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Analytical
Fatemeh Ghobadi Seresht, Mazaher Ahmadi, Sina Khalili, Mohsen Majidi
Summary: This paper describes the development of a low-cost yet efficient PEDD-based photometer. It utilizes a white LED as the emitter diode, an RGB LED as the detector diode (a novelty), and a multimeter for signal recording. The photometer was used to detect 2,4,6-trinitrotoluene (TNT) in soil samples by using a Meisenheimer complex of TNT with NaOH in acetonitrile as a probe. The method showed a linear calibration curve in the concentration range of 0.86 to 110 μg g(-1), with a detection limit of 0.27 μg g(-1) and a quantification limit of 0.81 μg g(-1). Analysis of soil samples from Iran Cinema and Television Town revealed trace residues of TNT.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Analytical
Mazaher Ahmadi, Samira Aghajani, Mohsen Majidi, Hesam Al-Din Hojjat Shamami
Summary: Wastewater treatment is a global concern, and the adsorption method has gained much attention for its low cost and easy recovery. Magnetic biosorbents show promise in the adsorption of organic and inorganic pollutants, but proper handling and disposal are crucial to avoid environmental pollution. This paper provides comprehensive information on the synthesis, magnetization, and application of magnetic biosorbents for wastewater treatment, aiming to pave the way for the development of new magnetic biosorbents from laboratories to the industry.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Analytical
Arash Ghoorchian, Mahdie Kamalabadi, Mahdi Moradi, Tayyebeh Madrakian, Abbas Afkhami, Hasan Bagheri, Mazaher Ahmadi, Hosein Khoshsafar
Summary: A wearable potentiometric ion sensor utilizing Na0.44MnO2 material is developed for real-time monitoring of sodium ions in human sweat samples, integrated into a headband textile for on-body sweat analysis. The sensor demonstrates good analytical performance, with a linear detection range suitable for physiological applications, serving as a potential tool for healthcare and disease diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).