Editorial Material
Obstetrics & Gynecology
Liron Bar-El, Amanda Chu, Karli Goldstein, Serin Seckin, Tamer Seckin
Summary: This article presents a case of endometriosis within an isthmocele membrane and diffuse peritoneal endometriosis after cesarean sections. A unique surgical repair technique is described, and a possible correlation between isthmocele formation and endometriosis is proposed.
FERTILITY AND STERILITY
(2022)
Article
Pharmacology & Pharmacy
Lidia Ferrer-Tasies, Hector Santana, Ingrid Cabrera-Puig, Elisabet Gonzalez-Mira, Lidia Ballell-Hosa, Carla Castellar-Alvarez, Alba Cordoba, Josep Merlo-Mas, Haydee Geronimo, Glay Chinea, Viviana Falcon, Evelyn Moreno-Calvo, Jan Skov Pedersen, Jessica Romero, Claudia Navarro-Requena, Calixto Valdes, Miladys Limonta, Jorge Berlanga, Santiago Sala, Eduardo Martinez, Jaume Veciana, Nora Ventosa
Summary: A method based on compressed CO2 was reported for obtaining nanoconjugates of recombinant human growth factor and nanovesicles called quatsomes, which show potential application in treating complex wounds.
ADVANCED THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Stavros Karampelas, Georges Salem Wehbe, Laurent de Landsheere, Dominique A. Badr, Linda Tebache, Michelle Nisolle
Summary: The study evaluated the effectiveness of laparoscopic isthmocele repair on symptoms and fertility-related problems, showing significant improvement in abnormal uterine bleeding, chronic pelvic pain, and secondary infertility. The results also demonstrated a significant increase in residual myometrial thickness after surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Hsin-Chung Tsai, Christine Sheng, Le-Shin Chang, Zhi-Hong Wen, Ching-Yin Ho, Chuan-Mu Chen
Summary: The study showed that wounds treated with rhEGF spray had the greatest size reduction by day 14 and promoted higher levels of mature Type I collagen synthesis, leading to regenerated tissue alignment with normal skin. The use of a new drug delivery technology, chitosan-rhEGF nanoparticles, overcame challenges associated with topical application of rhEGF, demonstrating the therapeutic potentials of this novel rhEGF topical spray solution.
JOURNAL OF WOUND CARE
(2021)
Article
Medicine, General & Internal
Egle Savukyne, Egle Machtejeviene, Saulius Paskauskas, Gitana Ramoniene, Ruta Jolanta Nadisauskiene
Summary: This study aimed to investigate the prevalence of Cesarean section (CS) scar niche during pregnancy using transvaginal ultrasound imaging. The study found that scar was visible in nearly 78% of women, with over 50% having a CS scar niche. Factors such as previous uterine curettage were associated with an increased risk for uterine niche formation in a subsequent pregnancy.
MEDICINA-LITHUANIA
(2021)
Article
Chemistry, Medicinal
Hyounggyoon Yoo, Seonghae Yoon, In-Jin Jang, Kyung-Sang Yu, Joon Young Hyon, Jungi Hwang, Inyoung Hwang, Jung Sunwoo, Jae-Yong Chung
Summary: This study evaluated the safety, tolerability, and pharmacokinetics of rhEGF eyedrops in healthy subjects. The results showed that rhEGF eyedrops were safe and well-tolerated, with mild and transient adverse reactions. Tear EGF concentrations rapidly increased and returned to baseline, while serum EGF levels remained unchanged after administration of rhEGF eyedrops.
Article
Medicine, General & Internal
Shuai Wei, Wei Wang, Li Li, Hao-Ye Meng, Chun-Zhen Feng, Yu-Ying Dong, Xi-Chi Fang, Qi-Qiang Dong, Wen Jiang, Hai-Li Xin, Zhan-Zhen Li, Xin Wang
Summary: The study found that an EGF concentration of 10 ng/ml and an action time of 10 min had optimal effects on cell proliferation and migration, and the V + E 10 min group promoted wound healing to the greatest extent and obtained the best histological score.
MILITARY MEDICAL RESEARCH
(2021)
Editorial Material
Obstetrics & Gynecology
Ruben Alvero
Summary: Nontubal ectopic pregnancy and cesarean section scar pregnancy are relatively uncommon but dangerous events. Early diagnosis and treatment by reproductive endocrinologists are crucial.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Huihui Chen, Yizhi Wang, Hui Zhang, Xipeng Wang
Summary: This study aims to compare hysteroscopic findings with myometrial thickness and post-surgical outcomes in patients with Cesarean section scar defects (CSDs). The study found that CSDs can be categorized into different phenotypes based on hysteroscopic observations, including pale mucosae, cyst lesions, increased local vascularization, polypoid lesions, and serrated niches. However, these phenotypes were not correlated with the outcome of repair for CSDs.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Integrative & Complementary Medicine
Shih-Chao Lin, Xiang Zhang, Shiow-Yi Chen, Chi-Chien Lin, Yen-Shuo Chiu
Summary: The study shows that utilizing microencapsulation technology to encapsulate recombinant human epidermal growth factor is more effective in relieving osteoarthritis compared to individual use of hyaluronic acid or rhEGF. This treatment significantly reduces cartilage destruction, inhibits inflammation, and has a significant effect on restoring damaged joint structure.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Dermatology
Maria Teresa Cacua Sanchez, Luis Fernando Giraldo, Jhon Alejandro Diaz
Summary: This study compared the efficacy of recombinant human epidermal growth factor (rhEGF) plus compression therapy with standard care in 48 patients with venous ulcers from chronic venous insufficiency. The results showed that rhEGF significantly reduced healing time and achieved better wound closure outcomes, indicating its potential as a beneficial therapy for patients with limited treatment options.
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2021)
Article
Dermatology
Dong Hyo Kim, Ji Hoon Yang, Soo Ick Cho, Ji Young Yoon, Ji Won Kim, Sungjun Choi, Dae Hun Suh
Summary: The clinical efficacy of epidermal growth factor ointment (EGFO) on acne and acne scars was evaluated in this study. The results indicated that EGFO significantly improved acne lesions and scars. Treatment with EGFO altered the expression of various factors related to acne and scarring.
Article
Obstetrics & Gynecology
Ammar Al Naimi, Niki Mouzakiti, Bartosch Wolnicki, Frank Louwen, Franz Bahlmann
Summary: The study assessed lateral uterine wall ruptures in women with a history of cesarean section using OmniView technology, revealing a lower incidence of lateral ruptures. The research indicated that RMT on the coronal plane was more intact than that on the sagittal plane, suggesting a potential explanation for the lower incidence of lateral ruptures.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Microbiology
Xing Yang, Xinyi Pan, Manchao Li, Zhi Zeng, Yanxian Guo, Panyu Chen, Xiaoyan Liang, Peigen Chen, Guihua Liu
Summary: This study revealed the adverse effects of potentially harmful microbes on the host endometrium in Cesarean section scar diverticulum (CSD). The mechanism of these effects includes inhibition of beneficial bacteria activity such as lactobacilli, consumption of protective endometrium metabolites, and production of harmful metabolites. From the perspectives of microbial, metabolic, and host responses, this study provides important insights to design preventive and therapeutic strategies for CSD.
MICROBIOLOGY SPECTRUM
(2022)
Article
Acoustics
A. Banerjee, Z. Al-Dabbach, F. E. Bredaki, D. Casagrandi, A. Tetteh, N. Greenwold, M. Ivan, D. Jurkovic, A. L. David, R. Napolitano
Summary: This study aimed to assess the reproducibility of a standardized method for measuring Cesarean section scars and niches using transvaginal ultrasound. The results showed that both 2D and 3D ultrasound imaging can be used to assess the position and characteristics of the scars and niches with high reproducibility. The distance from the scar to the internal cervical os was the most reproducible measurement parameter.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)