Article
Immunology
Changsheng Yan, Yuan Ma, He Li, Jitao Cui, Xiaoyu Guo, Gang Wang, Liang Ji
Summary: The study aimed to investigate the role of endoplasmic reticulum stress (ERS) in promoting caspase-1-dependent pancreatic acinar cell pyroptosis via the protein kinase R-like ER kinase (PERK) pathway to aggravate acute pancreatitis (AP). Findings showed that ERS enhances caspase-1-dependent pyroptosis and pyroptotic injury through the PERK pathway, exacerbating AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Duc-Vinh Pham, Prakash Shrestha, Thi-Kem Nguyen, Junhyeung Park, Mahesh Pandit, Jae-Hoon Chang, Soo Young Kim, Dong-Young Choi, Sung Soo Han, Inho Choi, Gyu Hwan Park, Jee-Heon Jeong, Pil-Hoon Park
Summary: MSC3D enhances the survival and functional capabilities of MSCs by decreasing the activation of NLRP3 inflammasomes through alleviation of ER stress in an autophagy-dependent manner. Downregulation of NLRP3 inflammasome signaling plays a critical role in the enhanced therapeutic efficacy of MSC spheroids.
Article
Biochemistry & Molecular Biology
Magdalena Kusaczuk, Rafal Kretowski, Monika Naumowicz, Anna Stypulkowska, Marzanna Cechowska-Pasko
Summary: The study investigated the interaction of dietary flavonoid quercetin with human glioblastoma cell lines. The results showed that quercetin induced apoptosis and cell death through activation of the intrinsic pathway of apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tuy An Trinh, Young Hye Seo, Sungyoul Choi, Jun Lee, Ki Sung Kang
Summary: Oxidative stress is a main cause of brain cell death in neurological disorders, while natural antioxidants can alleviate neurodegeneration. The study shows that osmundacetone from Elsholtzia ciliata has a neuroprotective effect against glutamate-induced oxidative toxicity and may be a potential agent for treating neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Zhaolin Gao, Min Li, Fei Yao, Xiaobo Xia, Tianqi Duan, Jingzhuo Meng, Yanxia Huang, Ye He, Adonira Saro, Jufang Huang
Summary: The study investigated the effects and underlying mechanisms of valdecoxib on retinal ischemia-reperfusion injury and oxygen-glucose deprivation/recovery injury. The results showed that valdecoxib protected R28 cells by reducing cell apoptosis and exerted a protective effect on retinas by inhibiting retinal ganglion cell apoptosis. In addition, valdecoxib reversed the expression of certain proteins induced by glaucomatous model and the reversal was mediated by the PERK-ATF4-CHOP pathway. These findings suggest that valdecoxib protects against glaucomatous injury by inhibiting ER stress-induced apoptosis via the PERK-ATF4-CHOP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ankang Hu, Jing Liu, Yonghui Wang, Maoyin Zhang, Yao Guo, Ying Qin, Tingya Liu, Yanjuan Men, Quangang Chen, Tingjun Liu
Summary: This study found that rafoxanide significantly inhibits the growth, invasion, and migration of non-small cell lung cancer cells by inducing apoptosis and cell cycle arrest. It also induces endoplasmic reticulum stress and activates the unfolded protein response. In vivo models showed that rafoxanide effectively inhibits tumor growth.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Juliana Gomez, Zammam Areeb, Sarah F. Stuart, Hong P. T. Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K. Montgomery, Hui K. Gan, Andrew M. Scott, Jordan Jones, Andrew H. Kaye, Andrew P. Morokoff, Rodney B. Luwor
Summary: EGFRvIII enhances survival of brain cancer cells under sub-optimal conditions by driving RCN1 expression, which blocks cell stress and death, allowing cells to survive and proliferate. This novel mechanism may lead to the development of drugs targeting EGFRvIII and RCN1 to induce brain cancer cell death.
Review
Engineering, Multidisciplinary
Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin
Summary: PHLDA1 is a multifaceted intracellular protein that belongs to the evolutionarily conserved pleckstrin homology-related domain family. It is associated with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence supports its role in endoplasmic reticulum stress signaling pathways, apoptosis, autophagy, and cell proliferation. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to a wide range of metabolic diseases.
Article
Biochemistry & Molecular Biology
Tae Woo Kim
Summary: Angelica gigas has a potent anti-tumor and anti-cancer effect. This study focused on the bioactive compound nodakenin and its effects on breast cancer. Nodakenin was found to inhibit breast cancer cell viability, decrease tumor volume in mice, and induce apoptosis. It also affected signaling pathways and calcium release. Additionally, nodakenin combined with radiation overcame radioresistance in breast cancer cells. These findings suggest nodakenin as a potential therapeutic strategy for breast cancer.
Article
Plant Sciences
Qun Zhao, Xinran Cheng, Wei Yu, Yun Bi, Jian Guo, Qingzhao Ma, Yingxia Gong, Li He, Xianjun Yu
Summary: Pristimerin exhibits potent antitumor activity against various cancers and can inhibit the proliferation of human OSCC cell lines by inducing apoptosis through endoplasmic reticulum stress activation and JNK signaling. Pri also suppresses tumor growth in OSCC xenografts, suggesting its potential therapeutic use for OSCC.
Article
Biochemistry & Molecular Biology
Jose Saura-Esteller, Ismael Sanchez-Vera, Sonia Nunez-Vazquez, Ana M. Cosialls, Pau Gama-Perez, Gauri Bhosale, Lorena Mendive-Tapia, Rodolfo Lavilla, Gabriel Pons, Pablo M. Garcia-Roves, Michael R. Duchen, Daniel Iglesias-Serret, Joan Gil
Summary: Fluorizoline induces ER stress and activation of the integrated stress response in HEK293T and U2OS cells, protecting against fluorizoline-induced apoptosis through eIF2α phosphorylation and increased protein levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Kuan-Wei Chiu, Hsuan-Ying Chen, Chiu-Liang Chen, Cheng-Pu Hsieh, Yi-Fu Huang
Summary: This study demonstrates that carvacrol inhibits the proliferation of osteosarcoma cells and induces apoptosis. It also induces ER stress and increases the levels of reactive oxygen species, contributing to apoptosis. The findings suggest that targeting ER stress might enhance the antitumor activity of carvacrol in osteosarcoma cells.
Article
Biochemistry & Molecular Biology
Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
Summary: This study revealed that HDACi suppresses the expression of GPX8, sensitizing HCC cells to ER stress and oxidative stress, leading to apoptosis.
Article
Biochemistry & Molecular Biology
Chengliang Yuan, Guoping Chen, Chengbao Jing, Mengxue Liu, Bo Liang, Guojin Gong, Mei Yu
Summary: Eriocitrin exhibits antiproliferative and proapoptotic effects by modulating STAT3/MAPKs signaling activation in MCF-7 cells, enhancing ROS generation, altering mitochondrial outer membrane potential, and inducing apoptotic morphological changes. Eriocitrin also suppresses STAT3 phosphorylation and activates JNK/p38 MAPK signaling, ultimately leading to apoptosis in MCF-7 cells. Overall, these findings suggest that Eriocitrin may be a potential novel chemotherapeutic agent for breast cancer treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenfeng Gou, Na Luo, Bing Yu, Hongying Wu, Shaohua Wu, Chen Tian, Jianghong Guo, Hongxin Ning, Changfen Bi, Huiqiang Wei, Wenbin Hou, Yiliang Li
Summary: UA232, a derivative of ursolic acid, demonstrates anti-tumor effects against breast and cervical cancer cells by inducing apoptosis and promoting autophagy. The compound exerts its pharmacological effects through triggering endoplasmic reticulum stress and lysosomal dysfunction, making it a promising candidate for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gan Rao, Gaolong Zhong, Ting Hu, Shaofeng Wu, Jiajia Tan, Xiaoyong Zhang, Riming Huang, Zhaoxin Tang, Lianmei Hu
Summary: In this study, ducks were used to mimic arsenic trioxide (ATO) exposure and investigate its mechanism of cardiac toxicity. The results showed that ATO inhibited body and organ growth, increased LDH levels, and caused deformity and ischemia infarction in ducks. Transmission electron microscopy revealed that ATO exacerbated mitochondrial swelling and cell nuclei contraction in the duck heart. ATO also induced oxidative stress and apoptosis, via the Nrf 2/Caspase 3 signaling pathway, by altering the expression levels of various genes and proteins related to apoptosis and oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Gan Rao, Gaolong Zhong, Ting Hu, Shaofeng Wu, Jiajia Tan, Xiaoyong Zhang, Riming Huang, Zhaoxin Tang, Lianmei Hu
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Microbiology
Zihui Chen, Si Li, Zhiying Liu, Zuwang Sun, Li Mo, Minru Bao, Zonghe Yu, Xiaoyong Zhang
Summary: The diversity and distribution of culturable fouling bacteria in different mariculture zones in Daya Bay were studied. A total of 129 isolates of fouling bacteria belonging to 37 species in 25 genera were identified. The dominant genera in fouling bacterial community were Pseudomonas, Arcobacter, and Curtobacterium. Furthermore, the ratios of biofilm-forming bacteria in mariculture zones were higher in shellfish and fish than in non-mariculture zones.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keyue Wu, Yiyang Li, Yuqi Lin, Baojun Xu, Jiajia Yang, Li Mo, Riming Huang, Xiaoyong Zhang
Summary: This study isolated and characterized a sulfated exopolysaccharide, AVP141-A, from the broth of marine-derived fungus. AVP141-A exhibited potential as an immune activator by significantly enhancing the activity of inflammation factors and activating specific signaling pathways in macrophages. These findings suggest that AVP141-A has the potential for further development as a marine fungal-derived therapeutic compound.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Maosheng Li, Hongyu Li, Xiaoyong Zhang, Xianhong Wang, Youhua Tao
Summary: Exploiting non-covalent interactions to catalyze ionic polymerizations is still in its early stages. A recent study demonstrated non-covalent anion-binding catalysis for living cationic polymerization of vinyl ethers. This study further investigates the structure-reactivity relationships and roles of anion-binding interactions in the catalytic process. The findings provide insights into the mechanism of anion-binding catalytic polymerization and offer guidance for future catalyst design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Metallurgy & Metallurgical Engineering
Hong-duo Wang, Zhi-yong Zhou, Kuai-she Wang, Wen Wang, Peng Han, Cheng-wen Zhang, Yong-xin Lu, Guang Li, Yi-di Lu, Xiao Li, Yan-ming Liu, Xiao-yong Zhang
Summary: Friction stir welding (FSW) was used to prepare Q235 low-carbon steel joint and the microstructure of different zones of the joint was characterized. The corrosion behavior of different macroscopic zones of the joint was evaluated in a NaCl solution. The corrosion resistance varied among different microzones, with the HAZ(RS) and HAZ(AS) showing the highest resistance to corrosion while TMAZ(RS), SZ, and TMAZ(AS) showed a lower resistance.
JOURNAL OF IRON AND STEEL RESEARCH INTERNATIONAL
(2023)
Article
Materials Science, Characterization & Testing
Yongxin Lu, Binhua Zhang, Pengjun Wen, Yuwei Zhou, Hongfeng Feng, Hongduo Wang, Xueli Xu, Xiao Li, Xiaoyong Zhang
Summary: The optimization of welding parameters for TC4 titanium alloys/304 stainless steel (TC4/304 SS) using friction stir lap welding (FSLW) was investigated based on orthogonal test. The results showed that when the rotating speed was constant, the high temperature zone area and peak temperature decreased with the increase of the traversing speed. Similarly, when the traversing speed was constant, the high temperature zone area and peak temperature increased with the increasing rotating speed. Under different heat input conditions, the formation of brittle and hard intermetallic compounds at the interface varied.
Article
Chemistry, Physical
Yue Hou, Xiao-Yong Zhang, Chang Liu, Chengri Yin, Zhenxing Yin
Summary: In this study, CuO nanomaterials were used to construct electrical devices based on starfish-like particles and nanowires. The difference in carrier concentration between wet and dry regions was utilized to generate electrical signals. The relationship between CuO microstructure and performance was examined, and the effect of different reaction conditions on device output performance was explored.
Article
Construction & Building Technology
Anchi Shi, Mowen Xie, Liuyuan Zhao, Xiaoyong Zhang, Zhixiang Wu, Simiao Wu
Summary: This paper proposes a method to identify the dynamic characteristics of a dangerous rock mass based on constant micromotion. By analyzing the dynamic parameters and characteristics of the rock mass, it is possible to determine the degree of surface damage. Integration of vibration mechanics theory and elastic wave scattering theory is found to be more effective in analyzing the damage of the structure of the rock mass.
ADVANCES IN CIVIL ENGINEERING
(2023)
Article
Construction & Building Technology
Xiaoyong Zhang, Mowen Xie, Zhengjun Huang, Yan Du, Lei Zhang, Zhixiang Wu, Zhuang Fan
Summary: In mountainous areas, the instability of dangerous rock mass poses a threat to human life and property safety. This study analyzed the dynamic characteristics of dangerous rock mass under constant micromotion, proposing that the center frequency of high-frequency components of elastic waves can reflect the damage degree of the dangerous rock mass. The research provides a new idea for the prevention and control of dangerous rock masses.
ADVANCES IN CIVIL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Shixia Cheng, Rensa Lv, Fei Cheng, Bin Han, Anqing Fu, Xiaoyong Zhang, Jianxun Zhang, Yaorong Feng, Huilin Gao
Summary: This paper introduces a kind of X100 pipeline steel with a multiphase structure of bainite and fine M/A constituent, which has high strength, toughness, and excellent plasticity. The Heating on-line partitioning (HOP) process is used to achieve the multiphase structure by diffusing carbon atoms from bainite to austenite, improving austenite stability and increasing the volume fraction of retained austenite. The widening of bainite laths and the decrease in dislocation density increase the plasticity, while carbides precipitation and martensite formation provide the steel with high strength.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Christian P. Hettich, Xiaoyong Zhang, David Kemper, Ruoqi Zhao, Shaoyuan Zhou, Yangyi Lu, Jiali Gao, Jun Zhang, Meiyi Liu
Summary: A multistate energy decomposition analysis (MS-EDA) method is introduced to analyze the energy components in molecular complexes in excited states. It partitions the total binding energy of an excimer or an exciplex into a ground-state term and excited-state contributions, providing quantitative insights into physical concepts such as exciton delocalization and superexchange charge-transfer effects. Based on the analysis, molecular complexes in excited states can be categorized into encounter excited-state complex, charge-transfer exciplex, and intimate excimer or exciplex. MS-EDA can serve as a useful tool for understanding photochemical and photobiological processes.
Article
Materials Science, Multidisciplinary
Yongxin Lu, Yuwei Zhou, Pengjun Wen, Fan Luo, Jian Cao, Youwei Xu, Shiqing Wang, Xiao Li, Xiaoyong Zhang, Wenya Li
Summary: This paper investigates the influence of laser power on the properties of K418 alloy prepared by selective laser melting. The results show that an optimal laser power can lead to the best mechanical properties, including the smallest grain size, more small-angle grain boundaries, and maximum elongation.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Chemistry, Inorganic & Nuclear
Dan Liu, Xuefeng Guo, Xiaoyong Zhang, Abdullah A. Al-Kahtani, Liviu F. Chibotaru
Summary: In this study, the single-molecule magnet (SMM) behavior of a series of lanthanide ions (Tb3+, Dy3+, Ho3+, Er3+, Tm3+ and Yb3+) encapsulated in zigzag carbon nanotubes (CNTs) of different diameters was investigated ab initio. The results showed that, except for Er3+ encapsulated in the (7,0) CNT, none of the investigated systems exhibited any blocking behavior. This can be attributed to the strong competition between axial and equatorial contributions to the crystal field of the encapsulated ions, resulting in weak or lack of magnetic axiality. These results provide useful theoretical guidance for the design of high-performance SMMs via modulating the crystal field of the ligand environment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Jun Zhang, Zhen Tang, Xiaoyong Zhang, Hong Zhu, Ruoqi Zhao, Yangyi Lu, Jiali Gao
Summary: A flexible self-consistent field method called target state optimization (TSO) is introduced for exploring electronic excited configurations and localized diabatic states. The method partitions molecular orbitals into different subspaces based on the excitation or localization pattern for a target state, avoid mixing of orbitals belonging to different subspaces. The TSO method can be applied in both Hartree-Fock theory and Kohn-Sham density functional theory (DFT). Comparisons with time-dependent density functional theory (TD-DFT) calculations show that TSO-DFT provides similar quality results for valence excited states of organic compounds with average errors of 0.5 and 0.4 eV, respectively, and superior performance for core excitation, doubly excited states, and charge-transfer states.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
