C-O-Selective Cross-Coupling of Chlorinated Phenol Derivatives

Chemoselective cross-coupling of phenol derivatives is valuable for generating products that retain halides. Here we discuss recent developments in selective cross-couplings of chloroaryl phenol derivatives, with a particular focus on reactions of chloroaryl tosylates. The first example of a C-O-selective Ni-catalyzed Suzuki-Miyaura coupling of chloroaryl tosylates is discussed in detail.

Automated summary

The chemoselective cross-coupling of phenol derivatives is valuable for synthesizing products with retained halides. This review focuses on recent developments in selective cross-couplings of chloroaryl phenol derivatives, particularly reactions involving chloroaryl tosylates. A detailed discussion is provided on the first example of a C-O-selective Ni-catalyzed Suzuki-Miyaura coupling of chloroaryl tosylates.