4.7 Article Proceedings Paper

A composite coating with physical interlocking and chemical bonding on WE43 magnesium alloy for corrosion protection and cytocompatibility enhancement

期刊

SURFACE & COATINGS TECHNOLOGY
卷 412, 期 -, 页码 -

出版社

ELSEVIER SCIENCE SA
DOI: 10.1016/j.surfcoat.2021.127078

关键词

Biomedical magnesium alloys; Corrosion protection; Cytocompatibility; Composite coatings; Synergistic effects

资金

  1. Natural Science Foundation of Guangdong Province, China [2018030310352]
  2. Foundation of Jinan University [88019098]
  3. National Key Research and Development Program of China [2017YFB0305100]
  4. Science and Technology Planning Project of Guangzhou, China [201806040006]
  5. City University of Hong Kong Strategic Research Grant (SRG) [7005264]
  6. Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [CityU 11205617]
  7. Key Program of Guangdong Basic and Applied Basic Research Foundation [2020B1515120078]
  8. Natural Science Foundation of Hubei Province [2019CFB204]

向作者/读者索取更多资源

A composite coating composed of PLLA/APTES/hydroxide nanosheets was successfully prepared on magnesium alloy surface to enhance corrosion resistance and cytocompatibility. The coating structure design effectively retards the corrosion rate by increasing chemical bonding active sites and physical interlocking properties, demonstrating improved protection against corrosion of magnesium alloy.
Practical application of magnesium (Mg) alloys to bone fixation implants is hampered by the rapid degradation under the physiological conditions. Herein, a composite coating composed of poly(L-lactic acid) (PLLA) / (3-aminopropyl)triethoxysilane (APTES) / hydroxide nanosheets is produced on the Mg alloy by spin coating, immersion, and hydrothermal methods to enhance the corrosion resistance and cytocompatibility. The combination of the inner hydroxide nanosheets and middle APTES layer promotes the formation of strongly adhering and dense PLLA layer on the Mg alloy by increasing the active sites for chemical bonding and flexible physical interlocking. Electrochemical studies reveal decreased corrosion current densities from 1.3 +/- 0.4 x 10(-4) to 1.8 +/- 0.6 x 10(-9) A cm(-2) and increased pore resistance from 1.15 x 10(2) to 2.70 x 10(7) Omega cm(2) in the simulated body fluid (SBF). Propagation of corrosion along the horizontal (surface) and vertical (depth) directions after soaking in SBF for 7 days is retarded notably by the composite coating which is capable of mitigating dissolution of the Mg alloy by impeding electrolyte penetration and minimizing coating delamination. Furthermore, the attachment and viability of MC3T3-E1 pre-osteoblasts in vitro demonstrate the obviously enhanced cytocompatibility by the composite coating.

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