期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 250, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2020.119363
关键词
Graphitic carbon nitride; Photodynamic therapy; Reactive oxygen species; Visible-light; Photosensitizer
类别
资金
- National Natural Science Foundation of China [21874023]
The addition of nitrogen-rich triazole group into the g-C3N4 motif significantly enhances the light absorption of g-C3N5 NSs, leading to higher efficiency of visible-light utilization. In vitro anticancer studies demonstrate the potential of g-C3N5 NSs as a low-toxic and biocompatible high-efficient photosensitizer for PDT.
Graphitic carbon nitride (g-C3N4) has been shown as a promising visible-light photosensitizer for photodynamic therapy (PDT) application. Nevertheless, its therapeutic efficiency is limited by the low efficiency of visible-light utilization. To overcome this issue, 3-amino-1,2,4-triazole-derived graphitic carbon nitride nanosheets (g-C3N5 NSs) are prepared for PDT application. The addition of nitrogen-rich triazole group into the g-C3N4 motif significantly makes the light absorption of g-C3N5 NSs red-shift with the band gap down to 1.95 eV, corresponding to a absorption edge at a wavelength of 636 nm. g-C3N5 NSs generate superoxide anion radicals (O-2(center dot-)) and singlet oxygen (O-1(2)) under the irradiation of a low-intensity white light emitting diode. Owing to the high efficiency of visible-light utilization, g-C3N5 NSs show about 9.5 fold photocatalytic activity of g-C3N4 NSs. In vitro anticancer studies based on the results of CCK-8 assay, Calcein-AM/PI cell-survival assay and photo-induced intracellular ROS level analysis in living HeLa cells demonstrate the potential of g-C3N5 NSs as a low-toxic and biocompatible high-efficient photosensitizer for PDT. (C) 2020 Elsevier B.V. All rights reserved.
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