Article
Chemistry, Physical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Xihui Gao, Xinyuan Zhu, Bin Liu
Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.
CHEMISTRY OF MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Materials Science, Multidisciplinary
Ganesh Narayanan, Jialong Shen, Ishita Matai, Abhay Sachdev, Ramiz Boy, Alan E. Tonelli
Summary: Cyclodextrins are unique molecules obtained through degradation of starch, with abundant hydroxyl groups, and have a wide range of applications in nanotechnology, including serving as capping/reducing agents for metallic nanoparticles.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Abdallah Mohamed Ayoub, Bernd Gutberlet, Eduard Preis, Ahmed Mohamed Abdelsalam, Alice Abu Dayyih, Ayat Abdelkader, Amir Balash, Jens Schafer, Udo Bakowsky
Summary: Antimicrobial photodynamic therapy (aPDT) is an alternative therapeutic option that can effectively eliminate antibiotic-resistant bacteria with lower risks of resistance development and systemic toxicity. This study explored the complexation of Parietin (PTN) with (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD) to enhance its solubility, photophysical properties, and phototoxicity against bacteria. The complexation significantly increased the solubility and photostability of PTN, and the PTN/HP-beta-CD complexes showed a significant reduction in bacterial viability. This finding provides new opportunities for treating infections caused by multidrug-resistant bacteria.
Review
Polymer Science
Dong-Jin Lim
Summary: Methylene blue (MB) has been utilized in the textile industry and for pharmacological purposes. It has gained attention for its potential as a safe photosensitizer in photodynamic therapy (PDT), showing both anticancer and antibacterial activity. Challenges in creating MB-embedded nanoparticles or microparticles may affect the clinical efficacy of PDT.
Review
Nanoscience & Nanotechnology
Jianhua Zou, Ling Li, Zhen Yang, Xiaoyuan Chen
Summary: Phototherapy combined with immunotherapy enhances the immunostimulating response and has synergistic effects for cancer treatment. Photoimmunotherapy (PIT) is a potential win-win strategy to prevent tumor metastases and recurrence by inducing immunogenic cell death (ICD).
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Steven G. Turowski, Farukh A. Durrani, Walter A. Tabaczynski, Joseph Cacaccio, Joseph R. Missert, Leslie Curtin, Sandra Sexton, Ronald Alberico, Craig M. Hendler, Joseph A. Spernyak, Zachary Grossman, Ravindra K. Pandey
Summary: In this study, a tumor-avid chlorophyll a derivative, HPPH, currently undergoing clinical trials, was conjugated with Gd(III)tetraxetan (DOTA) moieties to create a conjugate with potential for both tumor imaging and photodynamic therapy (PDT). The conjugate showed tumor specificity and low organ toxicity in mice, indicating its potential as a cancer imaging and treatment agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Zhiwei Shi, Weiping Li, Azhu Wang, Yuzhe Wang, Huishi Pi, Huicong Liu, Haining Chen, Pei Li, Xiaoyu Jiang
Summary: A supra-photosensitizer based on the host-guest complexation of cyclodextrins and a bis-chalcone dye was prepared and characterized. The supra-photosensitizers exhibited higher fluorescence emission and longer fluorescence lifetime compared to conventional photo-sensitizers. The improved fluorescence coincided with improved photoinitiation efficiency and enhanced generation of volume grating. This supra-photosensitizer may open a new avenue for the design of high-performance photoinitiation systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Alex Vasilev, Roba Sofi, Stuart J. Smith, Ruman Rahman, Anja G. Teschemacher, Sergey Kasparov
Summary: One of the most challenging problems in treating glioblastoma (GBM) is its highly infiltrative nature. Researchers have found that using tetramethylrhodamine methyl ester (TMRM) as a photosensitizer in combination with photodynamic therapy (PDT) can target GBM cells, inducing mitochondrial damage and cell death, making it a potential direction for clinical translation.
Review
Pharmacology & Pharmacy
Marcin Olek, Agnieszka Machorowska-Pieniazek, Wojciech Stos, Janusz Kalukin, Dorota Bartusik-Aebisher, David Aebisher, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka
Summary: Treatment of malocclusions with fixed orthodontic appliances can hinder oral hygiene, leading to enamel demineralization and periodontal diseases. In addition to traditional methods, new approaches like photodynamic therapy are being explored for reducing plaque around brackets.
Review
Biochemistry & Molecular Biology
Shujin Lin, Chun Liu, Xiao Han, Haowei Zhong, Cui Cheng
Summary: Photodynamic therapy (PDT) is a promising treatment method due to its efficiency and accuracy, with viral nanoparticles (VNPs) showing great potential as delivery vehicles for PDT. VNPs have favorable properties and are being explored for applications in tumor cell treatment and antimicrobial therapy, with future prospects focusing on developing novel viral nanocarriers or improving existing viral vectors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Elzbieta Ostasnka, David Aebisher, Dorota Bartusik-Aebisher
Summary: Photodynamic Therapy (PDT) is a well-known alternative cancer treatment that relies on light activation of a photosensitizer in the presence of oxygen to induce cytotoxic effects in cancer cells. Proper light delivery and the selection of an appropriate photosensitizer are crucial for the effectiveness of PDT in treating cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas L. Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel R. Bravo, Abigail M. Elliot, Yi Feng, Marc Vendrell
Summary: The authors have developed a new family of photosensitizers that target pathogenic cells and retain metabolite function, enabling precise cell ablation through photodynamic therapy. By mimicking metabolic indicators of disease onset and progression, these photoactivatable probes can selectively kill pathogenic cells with high precision, offering a safer therapeutic approach that reduces potential side effects.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo, Christiani A. Amorim
Summary: Nanoemulsion, a stable system formed by blending two immiscible liquids and an emulsifying agent, has shown great potential in various fields. In photodynamic therapy, nanoemulsion-loaded photosensitizing agents can overcome limitations of common photosensitizers and provide an effective drug delivery technology.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Tristan Mangeolle, Ilya Yaltavets, Nicolas Lequeux, Thomas Pons, Lina Bezdetnaya, Frederic Marchal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2019)
Article
Oncology
Sophie Cortese, Erwan Kerrien, Ilya Yakavets, Rokia Meilender, Romina Mastronicola, Sophie Renard, Agnes Leroux, Lina Bezdetnaya, Gilles Dolivet
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2020)
Article
Pharmacology & Pharmacy
Marie Millard, Solene Posty, Max Piffoux, Jordane Jasniewski, Henri-Pierre Lassalle, Ilya Yakavets, Florence Gazeau, Claire Wilhelm, Amanda K. A. Silva, Lina Bezdetnaya
Article
Pharmacology & Pharmacy
Ilya Yakavets, Chloe Guereschi, Laureline Lamy, Irina Kravchenko, Henri-Pierre Lassalle, Vladimir Zorin, Lina Bezdetnaya
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Oncology
Ilya Yakavets, Aurelie Francois, Maelle Guiot, Nicolas Lequeux, Alexandra Fragola, Thomas Pons, Lina Bezdetnaya, Frederic Marchal
Article
Biochemistry & Molecular Biology
Claire Egloff-Juras, Ilya Yakavets, Victoria Scherrer, Aurelie Francois, Lina Bezdetnaya, Henri-Pierre Lassalle, Gilles Dolivet
Summary: This study developed a head and neck multicellular tumor spheroid model to evaluate cameras for NIR fluorescence-guided surgery protocols. The experiment showed that the fluorescence signal was significantly different at different depths for FaDu spheroids exposed to ICG in tissue-like phantoms, with a positive correlation between fluorescence intensity and spheroid size, and a negative correlation with depth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ilya Yakavets, Igor Yankovsky, Tatyana Zorina, Mikhail Belevtsev, Lina Bezdetnaya, Vladimir Zorin
Summary: Photodynamic therapy using temoporfin is a targeted cancer treatment. Co-administration of temoporfin with Me-β-CD can affect temoporfin distribution in blood, with a higher sensitivity in white blood cells. Me-β-CD can significantly increase cellular uptake of temoporfin in cancer cells, providing new options for modulating temoporfin biodistribution.
Article
Chemistry, Multidisciplinary
Anastasiya Navrotskaya, Darya Aleksandrova, Mahshid Chekini, Ilya Yakavets, Sina Kheiri, Elena Krivoshapkina, Eugenia Kumacheva
Summary: A nanostructured solvatochromic temperature indicator decorated with carbon dots has been developed to monitor temperature changes within a broad low-temperature range. The indicator covers a wide temperature range and possesses characteristics such as cost-efficiency, portability, photostability, and thermostability.
Article
Biophysics
Marie Millard, Yann Bernhard, Nadia Canilho, Stephanie Grandemange, Stephane Parant, Maxime Mourer, Henri-Pierre Lassalle, Andreea Pasc
Summary: This study successfully improved the photostability and cellular uptake efficiency of Indocyanine Green (ICG) mediated photothermal therapy by synthesizing nanosized ICG-loaded nanoparticles. The ICG-J/CX nanoparticles demonstrated significant potential for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Zhengkun Chen, Nancy Khuu, Fei Xu, Sina Kheiri, Ilya Yakavets, Faeze Rakhshani, Sofia Morozova, Eugenia Kumacheva
Summary: Fibrous biological tissues exhibit structural anisotropy due to fiber alignment, which affect cell proliferation, orientation, and mobility. In this study, a chemically crosslinked fibrous hydrogel was created by reacting aldehyde-modified cellulose nanofibers with gelatin. Structural anisotropy was induced by extruding the hydrogel precursor through different printheads, and the degree of anisotropy was controlled by ink composition and flow rate. The anisotropy of the hydrogel affected the orientation of dermal fibroblasts. This straightforward method for constructing fibrillar hydrogel scaffolds with structural anisotropy can be used to study the biological impact of tissue anisotropy.
Article
Chemistry, Physical
Busenur Aslanoglu, Ilya Yakavets, Vladimir Zorin, Henri-Pierre Lassalle, Francesca Ingrosso, Antonio Monari, Saron Catak
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Proceedings Paper
Optics
Ilya Yakavets, Henri-Pierre Lassalle, Vladimir Zorin, Lina Bezdetnaya
17TH INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS
(2019)
Proceedings Paper
Engineering, Biomedical
Dina Farrakhova, Yulia Maklygina, Igor Romanishkin, Anastasia Ryabova, Ilya Yakavets, Marie Millard, Lina Bolotine, Anna Plyutinskaya, Tatrna Karmakova, Andrey Pankratov, Victor Loschenov
SARATOV FALL MEETING 2018: OPTICAL AND NANO-TECHNOLOGIES FOR BIOLOGY AND MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
