期刊
SEMINARS IN CANCER BIOLOGY
卷 76, 期 -, 页码 143-155出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2021.04.009
关键词
Helicobacter pylori; Hydrogenase; Nickel; Urease; Virulence
类别
资金
- U.S. National Institutes of Health [NIH-R01GM069696]
- University of Bologna
- CIRMMP (Consorzio Interuniversitario di Risonanze Magnetiche di Metallo-Proteine)
Helicobacter pylori, a human pathogen causing peptic ulcers and classified as a Class I carcinogen, relies on nickel-urease and hydrogenase enzymes for survival and virulence. Nickel plays a crucial role in virulence, and proteins involved in nickel trafficking may be potential antibiotic targets.
Helicobacter pylori is a human bacterial pathogen that causes peptic ulcers and has been designated a Class I carcinogen by the International Agency for Research on Cancer (IARC). Its ability to survive in the acid environment of the stomach, to colonize the stomach mucosa, and to cause cancer, are linked to two enzymes that require nickel-urease and hydrogenase. Thus, nickel is an important virulence factor and the proteins involved in nickel trafficking are potential antibiotic targets. This review summarizes the nickel biochemistry of H. pylori with a focus on the roles of nickel in virulence, nickel homeostasis, maturation of urease and hydrogenase, and the unique nickel trafficking that occurs between the hydrogenase maturation pathway and urease nickel incorporation that is mediated by the metallochaperone HypA and its partner, HypB.
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