Article
Rheumatology
Takamitsu Makino, Hironobu Ihn, Motoo Nakagawa, Misugi Urano, Ryuhei Okuyama, Norito Katoh, Chiharu Tateishi, Koji Masuda, Eisaku Ogawa, Emi Nishida, Shohei Nishimoto, Kenzo Muramoto, Daisuke Tsuruta, Akimichi Morita
Summary: This study examined axial involvement in PsA patients using MRI and evaluated the efficacy of 24-week adalimumab treatment in improving spondylitis and sacroiliitis. The results showed that spondylitis and sacroiliitis were common in PsA patients, and treatment with adalimumab for 24 weeks resulted in improvement in these conditions.
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Hanna Park, Ji Hyun Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park, Jennifer Jooha Lee
Summary: We aimed to clarify the clinical characteristics of psoriatic arthritis (PsA) in Korean patients, particularly focusing on PsA with axial involvement. Our study found that axial involvement is common in Korean PsA patients, and its characteristics can be distinct from those of ankylosing spondylitis (AS).
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Denis Poddubnyy
Summary: A significant number of PsA patients exhibit symptoms of inflammatory axial involvement, requiring clinical and laboratory evaluation as well as axial imaging. Treatment for confirmed axial PsA includes non-pharmacologic and pharmacologic methods such as non-steroidal anti-inflammatory drugs, tumor necrosis factor, interleukin 17, and Janus kinase inhibitors.
Review
Dermatology
Alice B. Gottlieb, Joseph F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that can lead to psoriatic arthritis, a heterogeneous musculoskeletal disease causing joint damage. Early detection and intervention by dermatologists is crucial in preventing permanent joint damage from psoriatic arthritis, which often manifests after skin symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Rheumatology
Victoria Furer, David Levartovsky, Jonathan Wollman, Irena Wigler, Daphna Paran, Ilana Kaufman, Ofir Elalouf, Sara Borok, Marina Anouk, Hagit Sarbagil-Maman, Mark Berman, Ari Polachek, Hagit Matz, Gideon Flusser, Ido Druckmann, Iris Eshed, Ori Elkayam
Summary: The study found that the prevalence of active sacroiliitis in a real-life sample of patients with PsA was 26%, with a lower prevalence of nonradiographic sacroiliitis (11%) compared to radiographic sacroiliitis (28.7%) in patients with longer disease duration. Inflammatory back pain was not a sensitive indicator for early-stage sacroiliitis.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Loredana Sabina Pascu, Nicolae Sarbu, Andrei Vlad Bradeanu, Daniela Jicman (Stan), Madalina Nicoleta Matei, Mihaela Ionela Sarbu, Doina Carina Voinescu, Aurel Nechita, Alin Laurentiu Tatu
Summary: Psoriatic arthritis is a clinically significant disease with a high prevalence and overlapping symptoms with other spondylarthritis disorders. Understanding the MRI manifestations and implementing a multidisciplinary strategy is crucial for effective management.
Review
Medicine, General & Internal
Ivan Giovannini, Alen Zabotti, Carmelo Ciccio, Matteo Salgarello, Lorenzo Cereser, Salvatore De Vita, Ilaria Tinazzi
Summary: The frequent involvement of the spine and sacroiliac joint in Psoriatic Arthritis (PsA) has led to its classification within the Spondyloarthritis group, although a clear distinction between PsA and Spondyloarthritis remains challenging. Axial involvement, ranging from 25 to 70% in PsA patients, must be taken into consideration alongside peripheral involvement for disease management. The lack of consensus in defining axial involvement in PsA has led to varying interpretations over the years, highlighting a need for improved clinical and radiological assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Walter P. Maksymowych, Mikkel Ostergaard
Summary: There is a renewed interest in defining the axial inflammation component of Psoriatic Arthritis (PsA), as recent studies suggest that this entity may respond differently to treatment compared to patients with axial spondyloarthritis. A workshop was conducted to review the literature on diagnosing PsA and to determine the most appropriate criteria. It was widely agreed that magnetic resonance imaging (MRI) plays an important role in defining axial inflammation in PsA, and it would be ideal to establish optimal MRI quantitative cut-offs for lesions in the sacroiliac joints and/or spine that reflect imaging typical of axial inflammation in PsA.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Rheumatology
Denis Poddubnyy, Deepak R. Jadon, Filip Van den Bosch, Philip J. Mease, Dafna D. Gladman
Summary: Psoriatic arthritis (PsA) is a chronic, inflammatory musculoskeletal disease with heterogeneous characteristics, and axial involvement can lead to complications in management and treatment decisions. The lack of agreed-upon classification and diagnostic criteria for axial PsA complicates the approach to this subset of patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Dafna D. Gladman
Summary: The prevalence of axial psoriatic arthritis (axPsA) is estimated at 40-50%, and recent studies suggest it has distinct features from ankylosing spondylitis. Due to the lack of a widely accepted definition of axPsA, designing therapeutic trials for this type of PsA has been challenging, but some recent trials indicate that treatments effective for peripheral arthritis may also be effective for axPsA.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Rheumatology
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemach, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Or Carmi, Yael Lahat, Tali Eviatar, Hagit Padova, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Ori Elkayam
Summary: This study found that ultrasound has a significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS. Patients with both PsA and FMS had significantly higher clinical composite indices scores, while their ultrasound scores were similar to those without FMS.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Mathematical & Computational Biology
Ying Wu, Richard J. Cook
Summary: This paper develops methods for assessing the predictive accuracy of a given event time model when the validation sample is comprised of interval-censored data, and empirically investigates their performance in the context of a rheumatology study.
Article
Rheumatology
Sahil Koppikar, Keith Colaco, Paula Harvey, Shadi Akhtari, Vinod Chandran, Dafna D. Gladman, Richard Cook, Lihi Eder
Summary: This study aimed to assess the incidence and risk factors for heart failure in patients with psoriatic disease and describe their electrocardiographic and echocardiographic findings. The results showed that heart failure was associated with a combination of known cardiovascular risk factors and measures of disease activity, particularly in nonischemic heart failure.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Samantha Sarabia, Chandra Farrer, Jensen Yeung, Dana Jerome, Richard J. Cook, Lihi Eder
Summary: Combining MSK-US with a screening questionnaire improves the triage of patients with suspected PsA.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Antonio Wong, Justine Y. Ye, Richard J. Cook, Dafna D. Gladman, Vinod Chandran
Summary: This study found that symptoms of anxiety/depression reduce the probability of achieving sustained MDA in PsA patients. Comprehensive management of PsA should include measures to address these comorbidities.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Statistics & Probability
Liqun Diao, Richard J. Cook
Summary: In this study, inference regarding exposure effects within subgroups of individuals and the effect-modifying role of certain covariates in stratified medicine research was discussed. The use of doubly inverse probability-weighted estimating equations and nested doubly robust estimating functions proved to yield efficient and robust estimators, especially in cases where auxiliary models are misspecified.
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE
(2022)
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: Compared with the general population, patients with immune-mediated inflammatory diseases (IMIDs) were more likely to be tested for SARS-CoV-2, but the infection rate was similar. The odds of SARS-CoV-2 infection varied across different IMID subgroups.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: The study found that patients with immune-mediated inflammatory diseases (IMIDs) have a higher risk of hospitalization with COVID-19, partly due to their comorbidities.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Statistics & Probability
Tugba Akkaya Hocagil, Louise M. Ryan, Richard J. Cook, Sandra W. Jacobson, Gale A. Richardson, Nancy L. Day, Claire D. Coles, Heather Carmichael Olson, Joseph L. Jacobson
Summary: Evidence from animal models and epidemiological studies suggests that prenatal alcohol exposure is associated with long-term cognitive and behavioral deficits. However, there is limited evidence regarding the specific nature and levels of exposure that increase the risk of clinically significant cognitive deficits. To address this, researchers have developed a hierarchical meta-analysis approach to synthesize data from multiple studies and estimate the effects of prenatal alcohol exposure on cognition.
Article
Mathematical & Computational Biology
Shu Jiang, Richard J. Cook
Summary: With the increasing importance of predictive modeling in health research, there is a need for rigorous methods to assess predictive accuracy. This paper addresses the problem of evaluating the accuracy of predictive models for nominal outcomes when outcome data are coarsened at random. Two scenarios are considered: multinomial response modeled by polytomous logistic regression, and a multistate disease process where class membership is unknown due to intermittent observation. The proposed extension to the polytomous discrimination index is used to evaluate the predictive accuracy in a study involving patients with arthritis.
STATISTICS IN MEDICINE
(2022)
Article
Clinical Neurology
Richard J. Cook, Ker-Ai Lee, Benjamin W. Y. Lo, R. Loch Macdonald
Summary: Classical regression can provide insights into causal mechanisms with careful consideration of variables and potential confounders, while predictive modeling focuses on prediction accuracy using alternative metrics to judge model adequacy.
WORLD NEUROSURGERY
(2022)
Article
Biology
Fangya Mao, Richard J. Cook
Summary: Modeling the spatial dependence of damage progression in chronic diseases can provide important scientific insights into their effects on multiple organ systems. This study focuses on modeling the spatial dependence of joint damage in psoriatic arthritis (PsA) and proposes new models and methods. By incorporating latent joint-specific indicators of susceptibility and adopting a Gaussian copula for dependence modeling, the authors develop likelihood and composite likelihoods for analyzing progression times subject to interval censoring. Simulation studies confirm the validity of the proposed methods, and the application to real data provides important insights for distinguishing PsA from other arthritic conditions.
Article
Statistics & Probability
Meaghan S. Cuerden, Liqun Diao, Cecilia A. Cotton, Richard J. Cook
Summary: We investigate causal inference for the effect modification of a biomarker in an observational study where the biomarker is only available for some individuals. We propose inverse probability weighted mean score estimating functions with two weights to account for confounding and missing data. An iterative approach is used to solve the equations and the large sample properties of the estimator are developed. Simulation studies compare the proposed method with other approaches, and an application to a rheumatology cohort illustrates the effect of a biologic therapy on inflammation.
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS
(2023)
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Richard J. Cook, Daniel Pereira, Vinod Chandran, Dafna D. Gladman
Summary: This study aimed to describe musculoskeletal (MSK) surgery in patients with psoriatic arthritis (PsA) and identify risk factors for undergoing first MSK surgery attributable to PsA. The results showed that markers of cumulative disease activity and damage were associated with a greater risk of needing surgery, while the effect of biologics did not reach statistical significance.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Mathematical & Computational Biology
Mao Fangya, Richard J. Cook
Summary: In this study, we focus on the design and analysis of two-phase studies to assess the relationship between a fixed marker (e.g., genetic) and event time under current status observation. We propose a design challenge of selecting a phase II sub-sample to maximize the precision of the marker effect, considering likelihood and weighted estimating functions for inference. Different design strategies are explored using registry data of patients with psoriatic arthritis to study the risk of diabetes as a comorbidity.
STATISTICS IN MEDICINE
(2023)
Article
Rheumatology
Stefan Perera, Richard Cook, Ker-Ai Lee, Patti Katz, Zahi Touma
Summary: Cognitive impairment is prevalent in SLE patients. This study examined cognitive changes in SLE patients over a 7-year period and found that most patients had relatively stable cognition. Older age and higher education levels were associated with improved cognition, while self-reported disease severity and depression were associated with cognitive decline.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
