期刊
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
卷 87, 期 -, 页码 103-106出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2021.03.010
关键词
Sudden death; Epilepsy; SUDEP; Molecular autopsy; Genetic autopsy
资金
- CNPq (Brazilian Council for Scientific and Technologic Development, Brazil) PQ2 Research Fellowship [307861/2013-9]
- CNPq PQ1B Research Fellowship [306043/2011-4]
- Special visiting researcher - Fellowship in Brazil - Science Without Borders Program Project MEC/MCTI/CAPES/CNPq/FAPs from CAPES [88881.030478/2013-01]
- PRONEX Program (Programa de Nucleos de Excelencia - NENASC Project) of FAPESCCNPq-MS, Santa Catarina Brazil [56802/2010]
The article discusses the importance and correlation of sudden death in cardiology and epilepsy, and proposes an extended terminology for SUDEP classification, which may serve as a tool for better understanding the condition.
Sudden unexpected death in epilepsy (SUDEP) has been identified as one of the most prevalent causes of mortality in epilepsy, and SUDEP has consequently become an important topic of research. The causes appear multifactorial, including epilepsy-induced cardiac arrest. Current understanding of autopsy negative sudden unexplained death (SUD) in general population and its relation to sudden arrhythmic death syndrome (SADS) could shed some light in SUDEP. Mutual attention to the findings of sudden death in cardiology and epilepsy are discussed here. We performed a narrative review on SUDEP, epilepsy and molecular/genetic autopsy in this population. A proposal of an extended terminology for SUDEP classification is discussed in light of recent issues related to molecular autopsy and genetics. The extended classification might be a step forward in research protocols and a tool for better understanding SUDEP.
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