Article
Biochemistry & Molecular Biology
Rajeev Shrestha, Shyam Kumar Mallik, Junmo Lim, Pallavi Gurung, Til Bahadur Thapa Magar, Yong-Wan Kim
Summary: Photodynamic therapy (PDT) can eliminate cancer cells and induce antitumor immune response by using Chlorin e6 (Ce6). Two efficient synthetic methods for preparing Ce6 from Spirulina platensis were described, and the phototoxic effect of Ce6 was investigated in vitro and its antitumor activity in vivo. The results showed that Ce6-PDT not only suppressed tumor growth at the injection site but also induced antitumor immunity through upregulating the expression of IFN-gamma, TNF-alpha, and IL-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Jenny Lou, Masato Aragaki, Nicholas Bernards, Tomonari Kinoshita, Jessica Mo, Yamoto Motooka, Tsukasa Ishiwata, Alexander Gregor, Tess Chee, Zhenchian Chen, Juan Chen, Kichizo Kaga, Satoru Wakasa, Gang Zheng, Kazuhiro Yasufuku
Summary: PLP-mediated PDT not only eradicates irradiated tumors but also induces regression of nonirradiated metastases. The treatment shows promise in improving the sensitivity of nonirradiated tumors to therapy.
Article
Medicine, Research & Experimental
Frank P. Vendetti, Pinakin Pandya, David A. Clump, Sandra Schamus-Haynes, Meysam Tavakoli, Maria diMayorca, Naveed M. Islam, Jina Chang, Greg M. Delgoffe, Jan H. Beumer, Christopher J. Bakkenist
Summary: Inhibitors of the ATR kinase can enhance the killing of tumor cells by DNA replication fork-targeting chemotherapies but also affect rapidly proliferating immune cells. Combining ATR inhibitor and radiotherapy can stimulate CD8+ T cell-dependent antitumor responses. The optimal schedule of ATR inhibitor and radiotherapy is determined by the duration of ATR inhibitor treatment, which affects the expansion of tumor antigen-specific CD8+ T cells.
Review
Immunology
Yue Lang, Yanan Lyu, Yehui Tan, Zheng Hu
Summary: Hematological malignancy is a serious disease that endangers human health and the research on its pathogenesis and therapies relies on the use of animal models. Recent studies have increasingly utilized mouse models hosting human hematological malignancy, which can better mimic human characteristics. Depending on the construction methods, these models can be categorized into different types with diverse characteristics and application values. Various strategies have also been developed to improve the engraftment and differentiation of human hematological malignant cells in vivo. Additionally, the humanized mouse model with both functional human immune system and autologous human hematological malignancy provides a unique tool for evaluating the efficacy of novel immunotherapeutic drugs/approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Stefanie Hiltbrunner, Laura Mannarino, Michaela B. Kirschner, Isabelle Opitz, Angelica Rigutto, Alexander Laure, Michela Lia, Paolo Nozza, Antonio Maconi, Sergio Marchini, Maurizio D'Incalci, Alessandra Curioni-Fontecedro, Federica Grosso
Summary: Malignant pleural mesothelioma is a rare and fatal disease linked to asbestos exposure, with limited therapeutic advancements. Standard treatments include platinum-based chemotherapy, pemetrexed, and surgery, but prognosis remains poor. The genomic landscape and potential therapeutic targets have been widely characterized, with emerging therapy approaches under evaluation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chidalu A. Edechi, Nnamdi M. Ikeogu, Gloria N. Akaluka, Lucas E. L. Terceiro, Mikayla Machado, Enitan S. Salako, Aida F. Barazandeh, Sam K. P. Kung, Jude E. Uzonna, Yvonne Myal
Summary: Studies suggest that PIP may have a dual effect in breast cancer, enhancing both antitumor immunity and promoting metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hong Kyu Lee, Hyeong-Jin Ji, Sang-Kyung Shin, Jihye Koo, Tae Hun Kim, Cho-Won Kim, Yeon Hee Seong, Jun-Eui Park, Kyung-Chul Choi
Summary: In this study, it was shown that inhibiting TGF-beta 2 can enhance T cell-mediated antitumor immunity and decrease the levels of regulatory T cells. These findings provide a new target for immunotherapeutic strategies in triple-negative breast cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Chengyue Wu, Angela M. Jarrett, Zijian Zhou, Nabil Elshafeey, Beatriz E. Adrada, Rosalind P. Candelaria, Rania M. M. Mohamed, Medine Boge, Lei Huo, Jason B. White, Debu Tripathy, Vicente Valero, Jennifer K. Litton, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov
Summary: This study successfully predicts the response of TNBC to neoadjuvant systemic therapy using MRI data and mathematical modeling, providing highly accurate predictions of therapeutic efficacy.
Review
Medicine, Research & Experimental
Yongmei Zhao, Tianqing Liu, Mengjiao Zhou
Summary: Exosomes secreted by immune cells play a significant role in cancer therapy due to their immunomodulatory characteristics and potential as drug delivery carriers. This review comprehensively outlines the biological and therapeutic characteristics of immune-cell-derived exosomes, summarizes their antitumor mechanism, and discusses their applications as nanocarriers for antitumor agents.
MOLECULAR PHARMACEUTICS
(2022)
Article
Cell Biology
Ying Kai Chan, Sean K. Wang, Colin J. Chu, David A. Copland, Alexander J. Letizia, Helena Costa Verdera, Jessica J. Chiang, Meher Sethi, May K. Wang, William J. Neidermyer, Yingleong Chan, Elaine T. Lim, Amanda R. Graveline, Melinda Sanchez, Ryan F. Boyd, Thomas S. Vihtelic, Rolando Gian Carlo O. Inciong, Jared M. Slain, Priscilla J. Alphonse, Yunlu Xue, Lindsey R. Robinson-McCarthy, Jenny M. Tam, Maha H. Jabbar, Bhubanananda Sahu, Janelle F. Adeniran, Manish Muhuri, Phillip W. L. Tai, Jun Xie, Tyler B. Krause, Andyna Vernet, Matthew Pezone, Ru Xiao, Tina Liu, Wei Wang, Henry J. Kaplan, Guangping Gao, Andrew D. Dick, Federico Mingozzi, Maureen A. McCall, Constance L. Cepko, George M. Church
Summary: The study engineered AAV vectors by incorporating short DNA oligonucleotides to antagonize TLR9 activation, reducing innate immune responses and enhancing gene expression in clinically relevant animal models. The engineered vectors can avoid adverse reactions in some models, demonstrating a potential wider therapeutic window for AAV therapies.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yun Xing, Zhi-qiang Ren, Rui Jin, Liang Liu, Jin-peng Pei, Ker Yu
Summary: CD73 and TGF beta expression are associated with poor prognosis and tumor microenvironment changes in TNBC. Dual blockade of CD73 and TGF beta can inhibit cell migration, reverse EMT and fibrosis, induce tumor cell death, and modify the tumor microenvironment to have multifaceted inflammatory features.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Oncology
Wenwen Guo, Caiqin Zhang, Tianyun Qiao, Jumei Zhao, Changhong Shi
Summary: This article summarizes strategies for the development and use of HIS mice models in tumor immunotherapies, proposes a method of tumor identification and classification in HIS mice based on the tumor-infiltrating lymphocytes and PD-L1 expression, and suggests different combination treatment strategies to enhance the effect of immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shouqiang Zhang, Xin Han, Xinran Chen, Yuxin Liu, Jing Zhou
Summary: This study developed a triple tumor microenvironment (TME)-responsive nanoplatform by combining layered double-hydroxides (LDHs) and rare earth nanomaterials (Er@Lu). The nanoplatform exhibited multiple responses to TME, including cracking and releasing Ni2+ and chemotherapeutic drugs under acidic conditions, as well as recognizing and cutting peptide chains to restore fluorescence. Compared to a single TME response, the triple TME response nanoplatform showed better synergistic therapeutic effect.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Medicine, Research & Experimental
Shengcang Zhu, Feihong Yan, Lulu Yang, Bingyi Li, Ruxian Xue, Wenwen Yu, Yu Wang, Lu Huang, Lijun Wang, Rongcheng Han, Yuqiang Jiang
Summary: A novel strategy of radiodynamic therapy (RDT) using gold nanoclusters (AuNC@DHLA) has been developed, which can directly absorb low dose X-ray and generate high levels of reactive oxygen species (ROS) for efficient treatment of solid tumors. This approach not only improves therapeutic efficacy but also enhances anti-tumor immune response, with negligible systemic toxicity.
Review
Oncology
Lukasz Kuryk, Giulia Rodella, Monika Staniszewska, Katarzyna Wanda Pancer, Magdalena Wieczorek, Stefano Salmaso, Paolo Caliceti, Mariangela Garofalo
Summary: Malignant mesothelioma is a rare and aggressive cancer with no curative treatment for advanced disease. Recent advancements in understanding the interaction between the immune system and tumors have led to the development of immunotherapeutic approaches. This review provides an overview of new therapeutic options for mesothelioma with a focus on clinical trial results.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marc de Perrot, Licun Wu, Michael Cabanero, J. Yannis Perentes, Trevor D. McKee, Laura Donahoe, Penelope Bradbury, Mikihiro Kohno, Mei-Lin Chan, Junichi Murakami, Shaf Keshavjee, Ming-Sound Tsao, B. C. John Cho
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Editorial Material
Respiratory System
B. C. John Cho, Marc de Perrot
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Immunology
Mikihiro Kohno, Junichi Murakami, Licun Wu, Mei-Lin Chan, Zhihong Yun, B. C. John Cho, Marc de Perrot
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Yu Tian, Peiwei Li, Zhaohua Xiao, Jie Zhou, Xia Xue, Ning Jiang, Chuanliang Peng, Licun Wu, Hui Tian, Helmut Popper, Mau-Ern Poh, Fabrizio Marcucci, Chengke Zhang, Xiaogang Zhao
Summary: The study demonstrates that triptolide can reverse epithelial-mesenchymal transition in taxol-resistant lung adenocarcinoma cells and inhibit tumor growth by suppressing the p70S6K/GSK3/β-catenin pathway, suggesting its potential as a new therapeutic agent for taxol-resistant lung adenocarcinoma.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
K. Chiu, A. Hosni, S. H. Huang, L. Tong, W. Xu, L. Lu, A. Bayley, S. Bratman, J. Cho, M. Giuliani, J. Kim, J. Ringash, J. Waldron, A. Spreafico, J. Irish, R. Gilbert, P. Gullane, D. Goldstein, B. O'Sullivan, A. Hope
Summary: In oral cavity squamous cell cancer, extranodal extension (ENE) is an adverse feature in the current eighth edition head and neck TNM staging. Patients with pathological node-positive and ENE demonstrated worse outcomes in regional control, distant control, and overall survival compared to other cohorts.
Article
Biochemistry & Molecular Biology
Licun Wu, Kosuke Yoshihara, Hana Yun, Saraf Karim, Nastaran Shokri, Fatemeh Zaeimi, H. S. Jeffrey Man, Amin Zia, Emanuela Felley-Bosco, Marc de Perrot
Summary: Malignant mesothelioma (MESO) has different subtypes and epithelial-mesenchymal transition (EMT) phenotypes. A panel of MESO EMT genes were found to be correlated with hypermethylation of epigenetic genes and loss of CDKN2A/B expression. The MESO EMT genes were associated with activation of TGF-beta, hedgehog, and IL-2-STAT5 signaling, and suppression of IFN-alpha and IFN-gamma response. Immune checkpoints were upregulated, while certain immune receptors were downregulated with the expression of MESO EMT genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Licun Wu, Mikihiro Kohno, Junichi Murakami, Amin Zia, Jonathan Allen, Hana Yun, Meilin Chan, Cristina Baciu, Mingyao Liu, Veronique Serre-Beinier, Michele De Palma, Emanuela Felley-Bosco, Jonathan Yeung, Trevor J. Pugh, Marc de Perrot
Summary: Defining the origin of tumor-associated macrophages (TAM) is crucial for developing targeted therapies for mesothelioma. Two distinct macrophage populations, small peritoneal/pleural macrophages (SPM) and large peritoneal/pleural macrophages (LPM), were identified in mice. SPM, which mainly consisted of M2-like TAM, rapidly increased in the tumor microenvironment and contributed to tumor development. On the other hand, LPM activated the IFN-gamma response and played a crucial role in the immune response, as confirmed by their depletion leading to loss of antitumoral memory immunity. The gene signature of SPM was observed in the pleural effusion and tumor of untreated mesothelioma patients, suggesting potential therapeutic targets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Zongjie Wang, Sharif Ahmed, Mahmoud Labib, Hansen Wang, Licun Wu, Fatemeh Bavaghar-Zaeimi, Nastaran Shokri, Soraly Blanco, Saraf Karim, Kasia Czarnecka-Kujawa, Edward H. Sargent, A. J. Robert McGray, Marc de Perrot, Shana O. Kelley
Summary: Potent circulating tumour-reactive lymphocytes (cTRLs) can be isolated from peripheral blood at high yield and purity via microfluidic immunomagnetic cell sorting, allowing for comprehensive downstream analyses of these rare cells. This method provides a solution to the clinical challenge of obtaining large and fresh tumour fractions for the use of tumour-infiltrating lymphocytes in solid tumour treatment.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Justin C. Y. Chan, H. S. Jeffrey Man, Usman M. Asghar, Karen Mcrae, Yidan Zhao, Laura L. Donahoe, Licun Wu, John Granton, Marc de Perrot
Summary: This study aimed to investigate the impact of sex on patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy. The results showed that female patients had a greater need for targeted PH medical therapy postoperatively, emphasizing the importance of early reassessment and long-term follow-up.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Licun Wu, Marc de Perrot
Summary: The SPARC gene is involved in extracellular matrix synthesis, cell shaping, tumor cell migration, invasion, metastasis, and the epithelial-mesenchymal transition process. It is associated with poor survival in MESO patients and correlates with an immunosuppressive tumor microenvironment. The gene may be targeted by microRNAs and is implicated in tumor angiogenesis.
Article
Medicine, General & Internal
Bill T. Duong, Licun Wu, Brenda J. Green, Fatemeh Bavaghar-Zaeimi, Zongjie Wang, Mahmoud Labib, Yuxiao Zhou, Fernando J. P. Cantu, Thurgaa Jeganathan, Sandra Popescu, Jennifer Pantea, Marc de Perrot, Shana O. Kelley
Review
Oncology
Licun Wu, Chengke Zhang, Xiaogang Zhao
Summary: The COVID-19 pandemic has significantly impacted lung cancer patients, who are believed to be at higher risk of infection and could see an increase in incidence and mortality. Vaccination is crucial for protecting lung cancer patients, and a better understanding of the SARS-CoV-2 virus could lead to the development of more effective vaccines in the future.
WORLD JOURNAL OF ONCOLOGY
(2021)