Article
Obstetrics & Gynecology
Yahong Li, Yun Sun, Xiaojuan Zhang, Xin Wang, Peiying Yang, Xianwei Guan, Yan Wang, Xiaoyan Zhou, Ping Hu, Tao Jiang, Zhengfeng Xu
Summary: In this study, there was no significant correlation found between the metabolic profile of amniotic fluid and fetal gender, maternal age, and gestational week in the second trimester of a normal pregnancy. However, a few metabolites showed differential expression.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Nutrition & Dietetics
Evelyn Jantscher-Krenn, Lara von Schirnding, Martin Troetzmueller, Harald Koefeler, Una Kurtovic, Herbert Fluhr, Andreas Mueller, Soyhan Bagci
Summary: This study found that human milk oligosaccharides (HMOs) are present in amniotic fluid throughout pregnancy, and their composition varies with gestational age. The early presence of HMOs in amniotic fluid suggests their potential role in fetal tissue development.
Article
Public, Environmental & Occupational Health
Kelly K. Ferguson, Sara Sammallahti, Emma Rosen, Michiel van den Dries, Anjoeka Pronk, Suzanne Spaan, Monica Guxens, Henning Tiemeier, Romy Gaillard, Vincent W. V. Jaddoe
Summary: This study identified three distinct fetal growth trajectories for weight among babies born small for gestational age (SGA). Children who were consistently small from mid-pregnancy had the worst neurodevelopmental outcomes at age 6, showing lower IQ and slightly more ADHD symptoms compared to non-SGA babies. The findings suggest that fetal growth trajectories may help identify SGA babies who are at risk for poor neurodevelopmental outcomes.
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aviad Rabinowich, Netanell Avisdris, Bossmat Yehuda, Ayala Zilberman, Tamir Graziani, Bar Neeman, Bella Specktor-Fadida, Dafna Link-Sourani, Yair Wexler, Jacky Herzlich, Karina Krajden Haratz, Leo Joskowicz, Liat Ben Sira, Liran Hiersch, Dafna Ben Bashat
Summary: Smaller, leaner fetuses are malnourished and will experience unfavorable outcomes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Nutrition & Dietetics
Laura E. Lach, Katherine E. Chetta, Amy L. Ruddy-Humphries, Myla D. Ebeling, Mathew J. Gregoski, Lakshmi D. Katikaneni
Summary: This study examined the growth and body composition of SGA and AGA VLBW infants, as well as their outpatient neurodevelopmental outcomes. The results showed significant differences in percentage of body fat, percentage of lean mass, and weight gain between SGA and AGA groups at the first ADP assessment. However, there was no difference in outpatient neurodevelopmental testing between the two groups. The study found that weight gain as catch-up body fat accrual is associated with normal neurodevelopment in SGA preterm infants compared to AGA preterm infants.
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Endocrinology & Metabolism
Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri
Summary: Babies with small for gestational age (SGA), defined as birthweight below the 10th percentile, may have a higher risk of neurodevelopmental abnormalities compared to babies with normal birthweight. Previous research has focused on studying the transport function of the placenta, while the role of placental hormones in fetal growth regulation remains largely unexplored. Using a mouse model, this study found that SGA fetuses had lower placental efficiency and reduced hormone production, leading to decreased brain weight and expression of certain genes related to development and metabolism. These findings highlight the importance of placental endocrine dysfunction in fetal growth and brain development in SGA babies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Erika Bonacina, Manel Mendoza, Alba Farras, Pablo Garcia-Manau, Berta Serrano, Ivan Hurtado, Raquel Ferrer-Oliveras, Lidia Illan, Mireia Armengol-Alsina, Elena Carreras
Summary: In early-onset SGA and FGR, the sFlt-1/PlGF values can predict the time to delivery and may be used for planning fetal surveillance by reducing ultrasound frequency in cases with sFlt-1/PlGF < 38 and providing closer follow-up in cases with sFlt-1/PlGF > 85.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Nutrition & Dietetics
Zainab Akhter, Nicola Heslehurst, Dries Ceulemans, Judith Rankin, Roger Ackroyd, Roland Devlieger
Summary: Prior bariatric surgery is a significant risk factor for delivering small for gestational age (SGA) babies, with factors such as gestational weight gain, receiving nutritional advice, and weight management playing significant roles in influencing the risk of SGA babies.
Article
Obstetrics & Gynecology
Daisy Leon-Martinez, Lisbet S. Lundsberg, Jennifer Culhane, Jun Zhang, Moeun Son, Uma M. Reddy
Summary: In this large cohort study, Hadlock, recent fetal growth nomograms, and a local population-derived fetal growth reference performed comparably in predicting small for gestational age and neonatal composite outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Health Care Sciences & Services
Lok Hin Lee, Elizabeth Bradburn, Rachel Craik, Mohammad Yaqub, Shane A. A. Norris, Leila Cheikh Ismail, Eric O. O. Ohuma, Fernando C. C. Barros, Ann Lambert, Maria Carvalho, Yasmin A. A. Jaffer, Michael Gravett, Manorama Purwar, Qingqing Wu, Enrico Bertino, Shama Munim, Aung Myat Min, Zulfiqar Bhutta, Jose Villar, Stephen H. H. Kennedy, J. Alison Noble, Aris T. T. Papageorghiou
Summary: Accurate estimation of gestational age is crucial for obstetric care. Ultrasound measurement of fetal size is the best method, but its accuracy decreases in the later stages of pregnancy. This study presents a machine learning-based model that estimates gestational age using only ultrasound images. The model outperforms current ultrasound-based methods, even in cases of intrauterine growth restriction.
NPJ DIGITAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Xinyu Shu, Na Chen, Yan Zhang, Juan Juan, Yingdong Zheng, Huixia Yang
Summary: This study aimed to explore fetal growth trajectories of large-for-gestational-age and small-for-gestational-age infants in twin pregnancies to provide strategies for fetal growth management. The study found that the growth patterns of large-for-gestational-age and small-for-gestational-age twin fetuses diverged from 26 weeks of gestation and continued to increase until delivery. Therefore, closer monitoring is suggested from 26 weeks of gestation for those carrying small fetuses.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Paige A. Bommarito, David E. Cantonwine, Danielle R. Stevens, Barrett M. Welch, Angel D. Davalos, Shanshan Zhao, Thomas F. McElrath, Kelly K. Ferguson
Summary: This study characterized different profiles of fetal growth using ultrasound measurements, which is important for distinguishing between pathological fetal growth restriction and constitutional smallness.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Liyue Shen, Jimmy Zheng, Edward H. Lee, Katie Shpanskaya, Emily S. McKenna, Mahesh G. Atluri, Dinko Plasto, Courtney Mitchell, Lillian M. Lai, Carolina Guimaraes, Hisham Dahmoush, Jane Chueh, Safwan S. Halabi, John M. Pauly, Lei Xing, Quin Lu, Ozgur Oztekin, Beth M. Kline-Fath, Kristen W. Yeom
Summary: Magnetic resonance imaging provides unparalleled visualization of the fetal brain, but accurately determining age-appropriate neural development has been challenging. This study presents a deep learning model that predicts gestational age with high accuracy and minimal error. The model demonstrates good performance and generalizability across different institutions.
SCIENTIFIC REPORTS
(2022)
Review
Pediatrics
Tatjana Tamara Koenig, Alexander Heimann, Swantje Scharenberg, Susi Kriemler, Oliver Muensterer, Jannos Siaplaouras
Summary: Background Physical education and sports participation are important for children and adolescents. A differentiated school sports exemption (DSE) allows individualized sports participation. In an online survey, physicians and physical education teachers were asked about their opinions on DSE. Results showed that DSE was well accepted but rarely used. Most exemptions were due to lack of sports gear, common colds, or acute injuries. Chronic diseases or disabilities were less common reasons for exemption. Teachers felt unprepared to handle students with chronic diseases or disabilities in PE class.
KLINISCHE PADIATRIE
(2023)
Article
Pediatrics
Unn Inger Moinichen, Audun Mikkelsen, Ragnhild Gunderson, Thomas Johan Kibsgard, Lars Morkrid, Hanneke IJsselstijn, Ragnhild Emblem
Summary: This study investigated the impact of scoliosis and musculoskeletal abnormalities on adolescents with esophageal atresia (EA). The results showed that 12% of patients had significant scoliosis, 18% had vertebral anomalies, and musculoskeletal abnormalities were detected in 22-78% of the patients. Scoliosis was associated with reduced physical activity, while musculoskeletal abnormalities were related to decreased physical activity and impaired motor skills.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Haitao Feng, Jochem Koenig, Tatjana Koenig, Oliver Muensterer
Summary: Magnetic acupuncture (MA) has beneficial effects on postoperative pain in children undergoing laparoscopic appendectomy (LA) and reduces the need for analgesics. MA is safe, simple, and effective, and further studies are warranted.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Audun Mikkelsen, Unn Inger Moinichen, Henrik Mikael Reims, Krzysztof Grzyb, Lars Aabakken, Lars Morkrid, Hanneke IJsselstijn, Ragnhild Emblem
Summary: This study found that questionnaires and interviews alone were not reliable screening tools, but combining dysphagia scores from interviews with non-invasive test results can predict the risk of esophageal metaplasia.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Chantal A. ten Kate, Nadine M. Teunissen, Joost van Rosmalen, Lieke S. Kamphuis, Michiel P. van Wijk, Maja Joosten, E. Sofie van Tuyll van Serooskerken, Rene Wijnen, Hanneke IJsselstijn, Andre B. Rietman, Manon C. W. Spaander
Summary: This study developed and validated a specific questionnaire (SQEA) to assess health-related quality of life in adults with esophageal atresia. The questionnaire showed good feasibility, reliability, and validity. It is able to discriminate disease burden and serves as an interesting signaling tool for clinicians to identify more severely affected patients.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Biochemistry & Molecular Biology
Daniel P. de Bruyn, Michiel Bongaerts, Ramon Bonte, Jolanda Vaarwater, Magda A. Meester-Smoor, Robert M. Verdijk, Dion Paridaens, Nicole C. Naus, Annelies de Klein, George J. G. Ruijter, Emine Kilic, Erwin Brosens
Summary: Using untargeted metabolomics, we identified differential metabolite patterns in UM patients compared to controls. The random forest classifier and leave-one-out cross-validation confirmed the discriminatory ability of these metabolite patterns in distinguishing UM patients from controls, but not in differentiating high-risk and low-risk UM patients. Dysregulation of metabolite patterns may be associated with processes related to malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Hanna E. Klaeger, Benjamin Nast-Kolb, Lea Reuter, Florian Hoffmann, Sabrina Juranek, Christoph Bidlingmaier, Nicole Fabri, Nils K. T. Schoenberg, Johanna Wagner, Florian Heinen, Oliver Muensterer, Christiane Zeller, Anne-Sophie Holler, Alexandra Froeba-Pohl, Michaela V. V. Bonfert
Summary: The Bavarian government declared a full lockdown related to COVID-19 pandemic on March 16, 2020. This study aimed to investigate the impact of the lockdown on pediatric mild traumatic brain injury (mTBI). A retrospective chart review found that the number of mTBI cases decreased by half during the lockdown. Falls at home accounted for a significantly higher proportion of mTBI, and there were higher rates of hospital admissions, intensive care unit admissions, longer hospital stays, and intracranial pathologies on neuroimaging during the lockdown.
Article
Pediatrics
Isabel I. Sreeram, Johannes M. Schnater, Joost van Rosmalen, Suzan C. M. Cochius-den Otter, Nina C. J. Peters, Robbert J. Rottier, Saskia J. Gischler, Rene M. H. Wijnen, Hanneke IJsselstijn, Andre B. Rietman
Summary: This study longitudinally assessed the self-reported health status and quality of life in 8- and 12-year-old survivors of congenital diaphragmatic hernia (CDH). It was found that boys' self-reported health status declined between the ages of 8 and 12, while quality of life remained stable. These findings highlight the importance of ongoing somatic and psychological assessments for CDH survivors in adolescence and adulthood.
Article
Medicine, General & Internal
Casper M. Kersten, Sergei M. Hermelijn, Louis W. J. Dossche, Nagarajan Muthialu, Paul D. Losty, Maarten Schurink, Andre B. Rietman, Marten J. Poley, Joost van Rosmalen, Tabitha P. L. Zanen van den Adel, Pierluigi Ciet, Jan von der Thusen, Erwin Brosens, Hanneke Ijsselstijn, Harm A. W. M. Tiddens, Rene M. H. Wijnen, J. Marco Schnater
Summary: The CONNECT consortium has established a core outcome set for the management of asymptomatic CPAM, which includes respiratory insufficiency, surgical complications, mass effect, and multifocal disease. The CONNECT trial aims to compare conservative and surgical management to develop evidence-based practice.
Article
Pediatrics
Loes F. M. van der Zanden, Sander Groen in't Woud, Iris A. L. M. van Rooij, Josine S. L. T. Quaedackers, Martijn Steffens, Liesbeth L. L. de Wall, Michiel F. Schreuder, Wout F. J. Feitz, Nel Roeleveld
Summary: By investigating maternal risk factors, we found that posterior urethral valves (PUV) is a multifactorial disorder caused by both genetic and environmental factors. Family history, maternal age, and hypertension were associated with PUV development, while higher maternal age and gestational hypertension seemed to decrease the risk. The role of assisted reproductive techniques in PUV development needs further research.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Kathrin Guerlich, Bernadeta Patro-Golab, Alex Barnacle, Ulrich Baumann, Andreas G. Eicken, Alan Fraser, Dariusz A. Gruszfeld, Nikolaus H. Haas, Anneliene Jonker, Michael Kammermeier, Damien Kenny, Sanja Kolacek, Risto Lapatto, Ian Maconochie, Silke Mader, Gearoid McGauran, Tom Melvin, Oliver Muensterer, Paul Piscoi, Alberto K. Romano, Amulya T. Saxena, Dominik A. Schneider, Mark Turner, Johan Vande Walle, Berthold Koletzko, European Acad Paediat
Summary: Due to increased requirements and costs for device certification, several high-risk medical devices for children have become unavailable in the EU. The CORE-MD project, funded by the EU, held workshops and meetings to develop recommendations for investigating and certifying these devices, based on expert opinions and scoping review results on clinical trials.
Article
Pediatrics
Jakob Muehling, Alexandra Froeba-Pohl, Oliver J. Muensterer, Dietrich von Schweinitz, Roland Kappler
Summary: This study aimed to determine the expression level of the BCL-2 gene in neuroblastoma patients and its correlation with clinical parameters. The results showed that BCL-2 was expressed in all tumor samples, and its expression level was associated with gender, disease staging, metastasis, and presurgical chemotherapy. However, it was not associated with overall survival and MYCN amplification. These findings suggest the potential for targeted therapy with BCL-2 inhibitors in lower-stage neuroblastoma and highlight the need for further research on concomitant genetic alterations to better understand the impact of BCL-2 in pediatric tumors.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2023)
Letter
Oncology
Danmei Zhang, Oliver Muensterer, Jens Neumann, Klara Dorman, Mark Rassner, Irene Schmid, Volker Heinemann
PEDIATRIC BLOOD & CANCER
(2023)
Article
Medicine, General & Internal
Federica Pederiva, Steven S. Rothenberg, Nigel Hall, Hanneke Ijsselstijn, Kenneth K. Y. Wong, Jan von der Thuesen, Pierluigi Ciet, Reuven Achiron, Adamo Pio d'Adamo, J. Marco Schnater
Summary: This article introduces the etiology, diagnosis, and treatment of congenital lung malformations (CLMs), and focuses on the impact of this disease on patients' quality of life.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Ophthalmology
Annechien E. G. Haarman, Caroline C. W. Klaver, Milly S. Tedja, Susanne Roosing, Galuh Astuti, Christian Gilissen, Lies H. Hoefsloot, Marianne van Tienhoven, Tom Brands, Frank J. Magielsen, Bert H. J. F. M. M. Eussen, Annelies de Klein, Erwin Brosens, Virginie J. M. Verhoeven
Summary: In this study, rare genetic variation in patients with high myopia was investigated using whole genome sequencing (WGS). The study found different contributions of common and rare variants in high myopia and identified some candidate genes that could explain the high myopia phenotype in some patients.
OPHTHALMOLOGY SCIENCE
(2023)
