Article
Biochemistry & Molecular Biology
Nazarine Mokhtar, Marcin Drop, Florian Jacquot, Sylvain Lamoine, Eric Chapuy, Laetitia Prival, Youssef Aissouni, Vittorio Canale, Frederic Lamaty, Pawel Zajdel, Philippe Marin, Stephane Doly, Christine Courteix
Summary: Diabetic neuropathy can cause chronic pain and associated cognitive deficits. This study found that 5-HT6 receptor inverse agonists and rapamycin can alleviate mechanical hyperalgesia and cognitive deficits in a rat model of diabetic neuropathic pain. The 5-HT6 receptor ligands also showed efficacy in reducing tactile allodynia in other types of neuropathic pain. In addition, disrupting the interaction between 5-HT6 receptors and mTOR can alleviate both painful and cognitive symptoms in diabetic rats. Targeting the constitutive activity of 5-HT6 receptors or the 5-HT6 receptor-mTOR interaction could be valuable strategies for treating diabetic neuropathic pain and cognitive co-morbidities.
Article
Biology
Toshio Takahashi, Akira Shiraishi, Jun Murata, Shin Matsubara, Satsuki Nakaoka, Shinji Kirimoto, Masatake Osawa
Summary: Endogenous ACh affects the size of the intestinal stem niche through M3 signaling, impacting the growth and differentiation of intestinal epithelial cells. The EphB/ephrin-B and MAPK/ERK signaling cascade play a crucial role in maintaining the homeostasis of intestinal epithelial cell growth and differentiation.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Suting Liu, Hao Cheng, Liying Cui, Li Jin, Yunzi Li, Chao Zhu, Qing Ji, Jun Tang
Summary: Activation of astrocytes and changes in the levels of astrocytic glutamate transporter-1 (GLT-1) play critical roles in neuropathic pain development. P2Y1 purinergic receptor (P2Y1R) contributes to pain transduction by regulating glutamate release and synaptic transmission. In a rat model of spinal nerve ligation (SNL), up-regulated expression of P2Y1R and activation of A1 astrocytes were observed, while astrocyte-specific knockdown of P2Y1R alleviated SNL-induced nociceptive responses and enhanced GLT-1 expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Longfei Ma, Yangyuxin Huang, Fengjiang Zhang, Dave Schwinn Gao, Na Sun, Jinxuan Ren, Suyun Xia, Jia Li, Xinyi Peng, Lina Yu, Bao-Chun Jiang, Min Yan
Summary: Research has shown that nerve injury leads to upregulation of the MMP24 protein in the spinal cord, rather than Mmp24 mRNA; blocking this upregulation can alleviate neuronal sensitization and the development of neuropathic pain; additionally, m(6)A modification and FTO protein play important regulatory roles in this process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Changgeng Peng
Summary: Neuropathic pain caused by spinal cord injury is a long-term disturbance for patients, and the underlying mechanisms are still unclear. This study found that the abnormal expression of Nav1.7 in SDH is associated with NP. Pharmacological studies demonstrated that the blood-brain-barrier permeable Nav1.7 inhibitor GNE-0439 has a significant analgesic effect on NP in SCI mice.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Yanqiong Wu, Qiaochu Fu, Xiaoxia Huang, Yifan Luo, Shengjun Wan, Minjing Peng, Shanchun Su, Xueqin Xu, Yang Li, Xiaohui Li, Dongsheng Sun, Changbin Ke
Summary: Neuropathic pain is the most common symptom for which patients seek medical attention. Knockdown of the NWD1 gene can reverse the enhanced synaptic plasticity and development of neuropathic pain in experimental models. Additionally, knockdown of NWD1 can also inhibit dendritic growth and synaptogenesis.
Article
Biology
Kieran A. Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C. Dickie, Andrew H. Cooper, Andrew M. Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I. Hughes, Gregory A. Weir, John S. Riddell, Andrew J. Todd
Summary: This study investigates the role of interneurons that continue to express neuropeptide Y (NPY-INs) in the adult mouse spinal cord. The findings suggest that activation of NPY-INs reduces acute pain and pruritogen-evoked itch, while silencing them causes exaggerated itch responses. Silencing another population of inhibitory interneurons also increases itch, but to a lesser extent.
Article
Neurosciences
De-Li Cao, Ling-Jie Ma, Bao-Chun Jiang, Qiang Gu, Yong-Jing Gao
Summary: CYP26A1 is upregulated in the spinal cord after spinal nerve ligation and its inhibition can alleviate neuropathic pain by promoting IL-10 expression and suppressing glial activation. CYP26A1 may be a potential therapeutic target for the treatment of neuropathic pain.
NEUROSCIENCE BULLETIN
(2023)
Article
Medicine, Research & Experimental
Yidan Zhang, Caihong Lin, Qingqing Yang, Yuanzeng Wang, Wen Zhao, Lei Li, Xiuhua Ren, Jianyuan Zhao, Weidong Zang, Jing Cao
Summary: This study found that electroacupuncture (EA) can relieve neuropathic pain by upregulating the expression of spinal SIRT3 protein and inhibiting the phosphorylation of spinal Ca/calmodulin-dependent protein kinase II (CaMKIIα). These findings provide insights into the mechanism underlying the therapeutic effect of EA on neuropathic pain.
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Meiling Han, Fan Zhang, Ying Wang, Yangyuxin Huang, Yanni He, Jinxuan Ren, Yu-Tao Deng, Yibo Gao, Xue Li, Lina Yu, Longfei Ma, Bao-Chun Jiang, Min Yan
Summary: Deregulated spinal cord proteins induced by nerve injury are crucial for neuropathic pain. Transcriptome and translatome analyses reveal that chromobox 2 (CBX2), an upregulated protein with unchanged mRNA level, plays a role in neuronal and astrocyte hyperactivities and pain hypersensitivities. The ERK pathway, CXCL13 upregulation in neurons, and further induction of astrocyte activation may be downstream signaling mechanisms of CBX2 in pain processing. Targeting CBX2 upregulation could be therapeutically beneficial.
NEUROSCIENCE LETTERS
(2023)
Article
Immunology
Hai-Ming Guo, Yu Zhang, Yan Zhang, Peng-Fei Jiao, Xiao-Chong Fan, Cun-Long Kong, Tao Wang, Xin-Xin Li, Hong-Wei Zhang, Li-Rong Zhang, Min-Yu Ma, Hui-Lian Bu
Summary: NINJ2 is involved in the development of nerve injury-induced neuropathic pain by activating neuroinflammation in the spinal cord via the NF-Kappa B pathway. The study suggests that reducing NINJ2 levels can partially block the development of pain in SNI rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Mustafa Umut Etli, Caner Sarikaya, Mehmet Resid Onen, Sait Naderi
Summary: This study found that neuropathic pain (NP) may occur in both pre-and postoperative periods in patients with spinal hemangioblastomas. The main factors affecting NP include the proximity of the tumor to the dorsal root entry zone, especially the presence of rostral syrinx.
WORLD NEUROSURGERY
(2021)
Article
Immunology
Jaesung Lee, Giljae Lee, Gwangpyo Ko, Sung Joong Lee
Summary: This study highlights the impact of the gut microbiota on glial cell growth and maturation through the gut-brain axis. Depletion of the gut microbiota using antibiotics prevented nerve injury-induced pain in mice, and recolonization of the gut microbiota resulted in the relapse of pain. The diversity and composition of the gut microbiome were altered by nerve injury, and probiotic treatment before nerve injury alleviated pain sensitization.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
You-You Lv, Han Wang, Hai-Ting Fan, Ting Xu, Wen-Jun Xin, Rui-Xian Guo
Summary: The present study found that SUMOylation of spinal Kir7.1 may contribute to the development of mechanical allodynia in neuropathic pain by decreasing the surface expression of Kir7.1.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Anesthesiology
Huayuan Song, Yuan Han, Cailong Pan, Xueting Deng, Wenling Dai, Liang Hu, Chunyi Jiang, Yanjing Yang, Zhixiang Cheng, Fei Li, Guangqin Zhang, Xuefeng Wu, Wentao Liu
Article
Anesthesiology
Su Liu, Yue-Peng Liu, Zhi-Jiang Huang, Yan-Kai Zhang, Angela A. Song, Ping-Chuan Ma, Xue-Jun Song
Article
Neurosciences
Ni Xu, Ming-Zheng Wu, Xue-Ting Deng, Ping-Chuan Ma, Ze-Hua Li, Lei Liang, Meng-Fan Xia, Dong Cui, Duan-Duan He, Yuan Zong, Zhong Xie, Xue-Jun Song
JOURNAL OF NEUROSCIENCE
(2016)
Article
Anesthesiology
Jiajie Li, Lujie Xu, Xueting Deng, Chunyi Jiang, Cailong Pan, Lu Chen, Yuan Han, Wenling Dai, Liang Hu, Guangqin Zhang, Zhixiang Cheng, Wentao Liu
Article
Anesthesiology
Xue-Ting Deng, Yuan Han, Wen-Tao Liu, Xue-Jun Song
Article
Cell Biology
Xue-Ting Deng, Si-Min Tang, Pei-Yao Wu, Quan-Peng Li, Xian-Xiu Ge, Bo-Ming Xu, Hui-Shan Wang, Lin Miao
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Anesthesiology
Mingzheng Wu, Zehua Li, Lei Liang, Pingchuan Ma, Dong Cui, Peng Chen, Genhao Wu, Xue-Jun Song
Article
Biochemistry & Molecular Biology
Nicole Y. Lai, Melissa A. Musser, Felipe A. Pinho-Ribeiro, Pankaj Baral, Amanda Jacobson, Pingchuan Ma, David E. Potts, Zuojia Chen, Donggi Paik, Salima Soualhi, Yiqing Yan, Aditya Misra, Kaitlin Goldstein, Valentina N. Lagomarsino, Anja Nordstrom, Kisha N. Sivanathan, Antonia Wallrapp, Vijay K. Kuchroo, Roni Nowarski, Michael N. Starnbach, Hailian Shi, Neeraj K. Surana, Dingding An, Chuan Wu, Jun R. Huh, Meenakshi Rao, Isaac M. Chiu
Article
Anesthesiology
Pingchuan Ma, Peng Chen, Zhao-Lin Zhou, Ru-Fan Mo, Mingzheng Wu, Xue-Jun Song
Article
Anesthesiology
Dong Cui, Ze-Hua Li, Cheng Li, Chengjie Qiu, Pingchuan Ma, Mingzheng Wu, Xue-Jun Song
Summary: The study suggests that spinal A beta 1-42 acts as an endogenous analgesic peptide by regulating cytokines and Wnt pathways. This may offer a potential target for the development of novel analgesic peptides.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Geriatrics & Gerontology
Xueting Deng, Pingchuan Ma, Mingzheng Wu, Huabao Liao, Xue-Jun Song
Summary: The study reveals that gelatinases MMP-9 and MMP-2 play critical roles in the pathogenesis of diabetic neuropathy, with MMP-9 promoting DNP and MMP-2 potentially serving as a negative regulator. Additionally, the findings suggest that alpha-lipoic acid may suppress STZ-induced mechanical allodynia by inhibiting MMP-9 and rescuing MMP-2 activity, providing a potential target for the development of novel analgesic and anti-inflammatory drugs.
Review
Surgery
Sangeeta S. Chavan, Pingchuan Ma, Isaac M. Chiu
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)