Review
Chemistry, Inorganic & Nuclear
Samrah Kamal, Mohd Khalid, M. Shahnawaz Khan, M. Shahid
Summary: Fortification of the environment is necessary for ensuring safety. This review article discusses the development of advanced detection methods and sensory materials using coordination chemistry. Metal-organic frameworks (MOFs) have attracted significant attention due to their functional tunability and potential applications. The article focuses on the current trends, chemical nature, structural tunability, and sensing of hazardous substances related to tuning the MOF structure. The use of MOFs as fluorescent sensor materials for detecting explosives, hazardous metal ions, and anions is explored, as well as the tuning of MOFs for improved sensing ability, durability, and recyclability.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Organic
Qing Mao, Qian Zhao, Mu-Ze Li, Rui Qin, Meng-Lan Luo, Jing Xue, Ben-Hong Chen, Hai-Jun Leng, Cheng Peng, Gu Zhan, Bo Han
Summary: This study presents a tertiary amine-catalyzed [3 + 3]-benzannulation for the green synthesis of CF3-functionalized fully substituted benzonitriles, featuring exclusive chemo-selectivity, high atom-economy, and good step-economy. The rapid construction of unique triphenyl-substituted dicyanobenzoate products was demonstrated, along with successful scale-up synthesis to prove the practicality and reliability of the reaction. Mechanistic studies indicate that the [3 + 3]-benzannulation is initiated by an intermolecular Rauhut-Currier reaction.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Nathan P. Bowling, Erin D. Speetzen, Eric Bosch
Summary: The co-crystallization of a pyridyl-containing arylethynyl (AE) unit with 1,4-diiodotetrafluorobenzene resulted in the formation of figure-eight shaped helical motifs within the crystal lattice, with alternating left-handed (M) and right-handed (P) helices. The major driving forces for this assembly were found to be halogen bonding between the pyridyl nitrogen atoms and iodine substituents of the haloarene, as well as pi-pi stacking of the haloarenes. Additionally, calculations suggest that halogen bonding and pi-pi stacking interactions both enhance each other within the crystal structure.
Review
Materials Science, Multidisciplinary
Di Tian, Yulan Chen
Summary: This review focuses on the optical waveguides of polycyclic arene-based crystals, including molecular design, packing structures, crystal engineering, and corresponding photonic properties, as well as several proof-of-concept devices. It summarizes the current state of the rapidly expanding field of research in organic crystals for optical waveguiding, which has become a key exploration area.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chun-Hao Su, Meng-Jung Tsai, Wei-Kai Wang, Yi-Yun Li, Jing-Yun Wu
Summary: Through a dual-ligand synthetic approach, five isoreticular primitive cubic (pcu)-type pillared-layer metal-organic frameworks with microporous structures were engineered. The study revealed solvent-dependent fluorescence properties in some frameworks, which could be efficiently quenched by trace amounts of nitrobenzene.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Pinaki Nad, Arup Mukherjee
Summary: This study reviews the recent progress in C-H borylation and hydroboration reactions of indoles under metal-free conditions, discussing their scope and mechanistic studies.
Article
Chemistry, Organic
Zhi Zhang, Liansuo Zu
Summary: The study successfully synthesized a steroid-sterigmatocystin heterodimer using a concise method, including cascade dialdehyde cyclization, phenol-assisted reductive alkylation, and SNAr reaction. The research also explored a glycosylation-inspired method to provide the acetal linkage with ergosterol peroxide.
Article
Chemistry, Multidisciplinary
Vasily Sivchik, Aleksandr Kochetov, Toni Eskelinen, Kristina S. Kisel, Anastasia Solomatina, Elena Grachova, Sergey P. Tunik, Pipsa Hirva, Igor O. Koshevoy
Summary: The luminescent cyclometalated complexes decorated with cyanide ligand can serve as nucleophilic building blocks for halogen-bonded adducts, with noncovalent interactions playing a key role in their photoluminescent properties and excited states. The degree of aggregation via metal-metal interactions determines the optoelectronic properties and photoemissive characteristics of the crystalline materials.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Olesya V. Khoroshilova, Irina A. Boyarskaya, Aleksander V. Vasilyev
Summary: This study investigates the reaction of TMS ethers of CF3-benzyl alcohols and their heterocyclic analogues under the catalysis of strong acids, leading to the synthesis of alpha-(trifluoromethyl)styrenes and cis-/trans- 1,3-di(trifluoromethyl)indanes with high yields. The plausible reaction mechanisms, including the formation of CF3-benzyl carbocations as intermediates, are discussed.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Yingying Zhang, Yating Huang, Kewei Yu, Xiaoxiang Zhang, Wenhua Yu, Jiale Tang, Yiran Tian, Wanxing Wei, Zhuan Zhang, Taoyuan Liang
Summary: Herein, we report a novel iron and iodine cooperative catalytic system for the synthesis of diverse 2-amino-3-alkylindoles. The method exhibits good substrate and functional group compatibility, and the catalyst system and feedstocks are readily available, showing great potential for further exploration of biological activities.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Jia-Hui Chen, Zhi-Yu Jiang, Hai Xiao, Shuo Tong, Tan-Hao Shi, Jieping Zhu, Mei-Xiang Wang
Summary: We report a novel two-directional cyclization strategy for the synthesis of highly strained depth-expanded oxygen-doped chiral molecular belts. Starting from accessible resorcin[4]arenes, a remarkable cyclization cascade was developed to generate fused 2,3-dihydro-1H-phenalenes, which allowed the fabrication of expanded molecular belts. Through intramolecular nucleophilic aromatic substitution and ring-closing olefin metathesis reactions, highly strained O-doped C-2-symmetric belts were obtained. The enantiomers of the synthesized compounds exhibited excellent chiroptical properties, making them promising materials for various applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Ha Eun Kim, Jun-Ho Choi, Won-Jin Chung
Summary: This study successfully synthesized stable alpha-ketoimidoyl fluorides under mild conditions, demonstrating their high synthetic efficiency and practicality. The accelerating effect of the geminal fluorine substituent was also identified through density functional theory calculations.
Article
Chemistry, Organic
Linwei Huang, Wei Liu, Liang-Liang Zhao, Zengyu Zhang, Xiaoyu Yan
Summary: This study investigated the t-BuOK-catalyzed H/D exchange reaction of difluoromethylarenes in DMSO-d(6) solution, which showed excellent deuterium incorporation at the difluoromethyl group. Additionally, the impact of a trace amount of D2O in the DMSO-d(6) solution on the deuteration reaction was also examined.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Danish Ali, Nurabul Mondal, Anoop Kumar Panday, Lokman H. H. Choudhury
Summary: In this study, an efficient method for the synthesis of novel selenocyanates of amino pyrazole, amino uracil, and amino isoxazole derivatives is reported. The method involves the use of malononitrile and selenium dioxide in DMSO medium to generate triselenium dicyanide in situ. The method also demonstrates the synthesis of alkynyl selenides using selenocyanates of amino pyrazoles in the presence of CuI and Cs2CO3. The method offers advantages such as inexpensive starting materials, short reaction time, and good yields. It is also applicable for gram-scale synthesis.
Article
Chemistry, Multidisciplinary
Ying-Jie Liu, Liang Chen, Zhao-Yang Wang, Xi-Yan Dong, Ya-Ke Li, Shuang-Quan Zang
Summary: In this study, a charge donor/acceptor pair was designed to construct a light-harvesting system based on two chiral gold(I)-isocyanide complexes. By doping nonemissive S-AuI into blue-emitting S-AuCN, a tunable emission from blue to red was achieved. This large red-shifted emission was realized through the change in electronic properties and the resulting energy-transfer process between the S-AuCN dimer and red-emitting (S-AuCN)-(S-AuI) CT pair. Importantly, the energy-transfer process can be controlled by external stimuli, leading to high-contrast CPL switching properties. This study opens a new avenue for developing CPL switches using chiral organometallic complexes.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Hirokazu Enomoto, Nishant Mittal, Takayuki Inomata, Takuro Arimura, Tohru Izumi, Akinori Kimura, Keiichi Fukuda, Shinji Makino
Summary: This study identified that mutations in HSPD1 caused mitochondrial dysfunction, leading to mitophagy, increased ROS, and cardiac atrophy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Masaki Shimizu, Kenta Nishimura, Rika Hirakawa, Tsuneaki Sakurai
Summary: This study demonstrates the efficient ultraviolet (UV) fluorescence of 1,4-dialkenyl-2,5-dialkoxybenzenes and 1,4-dialkenyl-2,5-disiloxybenzenes in the solid state, with generally higher quantum yields than in solution. The adamantylidene-substituted benzenes showed particularly high UV fluorescence quantum yields in the solid state, and when doped into poly(methyl methacrylate) thin films, also exhibited UV emission with good efficiency. Density functional theory calculations provided insights into the optical excitation mechanisms of these compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Virology
Seiichi Kato, Hisatoshi Shida, Tomotaka Okamura, Xianfeng Zhang, Tomoyuki Miura, Tetsu Mukai, Makoto Inoue, Tsugumine Shu, Taeko K. Naruse, Akinori Kimura, Yasuhiro Yasutomi, Kazuhiro Matsuo
Summary: This study developed a urease-deficient bacillus Calmette-Guerin (BCG) and demonstrated its protective efficacy against SIV infection in Asian-origin cynomolgus monkeys. Strong immune responses were observed in some monkeys post-vaccination, leading to protection against SIV infection in a portion of the vaccinated animals.
JOURNAL OF VIROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Toshihiro Moriki, Toru Kubo, Kenta Sugiura, Yuri Ochi, Yuichi Baba, Takayoshi Hirota, Naohito Yamasaki, Akinori Kimura, Yoshinori L. Doi, Hiroaki Kitaoka
Summary: A study involving 209 Japanese HCM patients found that the Mayo Clinic HCM genotype predictor score is useful for predicting positive genetic test results. The study showed that there is an incremental increase in genetic testing yield with higher prediction scores.
CIRCULATION JOURNAL
(2021)
Article
Genetics & Heredity
Kousuke Tanimoto, Taeko K. Naruse, Tetsuro Matano, Akinori Kimura
Summary: A new high-throughput NGS-based genotyping method for MHC class I alleles in rhesus macaques and cynomolgus macaques was developed in this study. The method detected 95% and 100% of alleles identified by PCR cloning-based method in rhesus macaques and cynomolgus macaques, respectively, with high correlation to their expression levels. The simulation of new-allele detection using artificial alleles differing by a few nucleotide sequences from a known allele was accurate, and a real novel allele from a rhesus macaque sample was successfully detected, supporting the adaptability of the method for reducing cost and labor in NGS-based MHC genotyping for primate animal models such as macaques.
Article
Chemistry, Multidisciplinary
Masaki Shimizu
Summary: This article reviews the research on organic fluorophores and precious-metal-free phosphors, highlighting the prehistory of each project and the relationship between established molecular designs. It describes the design concepts, luminescence characteristics, and applications of various fluorophores, as well as the discovery, design, and luminescent properties of precious-metal-free compounds showing efficient room-temperature phosphorescence.
Review
Chemistry, Multidisciplinary
Masaki Shimizu, Tsuneaki Sakurai
Summary: Dual-fluorescent-phosphorescent compounds without precious metals have been studied for their potential applications in bio-imaging, data protection, luminescence sensing, and white-light emission. These compounds exhibit dual fluorescence and phosphorescence emission at room temperature, producing bimodal steady-state emission spectra in the solid state. The compounds are classified into six categories based on their chemical structures.
Article
Cardiac & Cardiovascular Systems
Kayoko Hirayama-Yamada, Natsuko Inagaki, Takeharu Hayashi, Akinori Kimura
Summary: Heart failure is a life-threatening disease often caused by cardiomyopathy, with dilated cardiomyopathy (DCM) being a common type characterized by ventricular enlargement and progressive heart failure. A novel pathogenic TTN truncation variant was discovered in familial DCM patients, and its functional changes were confirmed using a relatively simple cell model.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Virology
Katsutoshi Nagano, Chihiro Tani-Sassa, Yumi Iwasaki, Yuna Takatsuki, Sonoka Yuasa, Yuta Takahashi, Jun Nakajima, Kazunari Sonobe, Naoya Ichimura, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Shuji Tohda
Summary: This study conducted PCR testing on patients who visited the hospital between February and April 2021, revealing a rapid increase in cases with N501Y and E484K mutations from 8% to 46%, with these mutations being associated with R.1 lineage variants. However, there was no evidence of increased disease severity related to the R.1 variants.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biology
Hiroaki Kawano, Koichi Kawamura, Munetake Kanda, Mitsuaki Ishijima, Kuniko Abe, Tomayoshi Hayashi, Yuji Matsumoto, Akinori Kimura, Koji Maemura
Summary: Restrictive cardiomyopathy is a rare primary myocardial disease with unclear pathological features. A 65-year-old Japanese woman was diagnosed with MHY7 mutation-related RCM, with electron microscopy of a myocardial biopsy revealing specific features possibly associated with the pathogenesis of the disease.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Infectious Diseases
Hiromu Tanaka, Ho Lee, Atsuho Morita, Ho Namkoong, Shotaro Chubachi, Hiroki Kabata, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: This study conducted host genome analysis of hospitalized patients with COVID-19 in Japan and found a relatively high number of severe cases but a relatively low case fatality rate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Chihiro Tani-Sassa, Yumi Iwasaki, Naoya Ichimura, Katsutoshi Nagano, Yuna Takatsuki, Sonoka Yuasa, Yuta Takahashi, Jun Nakajima, Kazunari Sonobe, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Shuji Tohda
Summary: In the summer of 2021, the rapid spread of the Delta variant of the SARS-CoV-2 virus raised serious concerns globally. The Delta variant became the most prevalent in July and August, with infected patients in Tokyo being significantly younger, possibly due to vaccination of elderly individuals. Further research is needed to understand factors contributing to the increased infectivity of the Delta variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Sonoka Yuasa, Jun Nakajima, Yuna Takatsuki, Yuta Takahashi, Chihiro Tani-Sassa, Yumi Iwasaki, Katsutoshi Nagano, Kazunari Sonobe, Tomoyo Yoshimoto, Yoko Nukui, Hiroaki Takeuchi, Kousuke Tanimoto, Yukie Tanaka, Akinori Kimura, Naoya Ichimura, Shuji Tohda
Summary: The Omicron variant of COVID-19 has spread rapidly worldwide, surpassing the speed of the Delta variant. However, this increased transmissibility is not due to higher viral loads. The study suggests that factors such as increased affinity to cell receptors or immune escape may contribute to the enhanced infectivity of the Omicron variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Genetics & Heredity
Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Hisanori Kosuge, Shinji Suzuki, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura
Summary: This study identified a disease-causing gene, RBM20, associated with familial HCM, and confirmed that the p.Arg636His variant could be the causative factor for this particular HCM.
HUMAN GENOME VARIATION
(2022)
Review
Chemistry, Multidisciplinary
Masaki Shimizu, Tsuneaki Sakurai
Summary: This review covers organic small molecules and polymers that exhibit UV emission in the aggregated state and evaluates their potential as solid-state emitters based on their photoluminescence quantum yields and emission maxima.