期刊
PROTEIN SCIENCE
卷 30, 期 8, 页码 1502-1520出版社
WILEY
DOI: 10.1002/pro.4098
关键词
computational chemistry; de novo design; protein design; protein synthesis
资金
- Fundacao para a Ciencia e a Tecnologia [SFRH/BD/138820/2018, UIDB/50011/2020, UIDP/50011/2020]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/138820/2018] Funding Source: FCT
Protein design, a vital aspect of synthetic biology, has made significant progress through computational advancements, enabling high-throughput screening and detailed design of novel proteins, particularly for small molecule targeting applications.
Protein design is the field of synthetic biology that aims at developing de novo custom-made proteins and peptides for specific applications. Despite exploring an ambitious goal, recent computational advances in both hardware and software technologies have paved the way to high-throughput screening and detailed design of novel folds and improved functionalities. Modern advances in the field of protein design for small molecule targeting are described in this review, organized in a step-by-step fashion: from the conception of a new or upgraded active binding site, to scaffold design, sequence optimization, and experimental expression of the custom protein. In each step, contemporary examples are described, and state-of-the-art software is briefly explored.
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