Enantioselective Catalysis by Chiral Isothioureas

The influence of intramolecular sulfur–lone pair interactions on small-molecule drug design and receptor binding

(2016) B. M. Hudson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Silylations of Alcohols: Turning Simple Protecting-Group Strategies into Powerful Enantioselective Synthetic Methods

(2015) Li-Wen Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines

(2015) Siobhan R. Smith et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scales of Lewis Basicities toward C-Centered Lewis Acids (Carbocations)

(2015) Herbert Mayr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of “Shapeshifting” Properties

(2015) Tian Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Net Cycloaddition Approach to Optically Active 1,5-Benzothiazepines

(2015) Yukihiro Fukata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orthogonal tandem catalysis

(2015) Tracy L. Lohr et al.   Nature Chemistry

Atropselective syntheses of (−) and (+) rugulotrosin A utilizing point-to-axial chirality transfer

(2015) Tian Qin et al.   Nature Chemistry

Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones

(2015) Pei-Pei Yeh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Acylation of Acyclic Meso 1,3-Diols through Synergistic Isothiourea-Catalyzed Desymmetrization/Chiroablative Kinetic Resolution

(2015) Jérémy Merad et al.   ORGANIC LETTERS

Diastereoselective and Enantioselective Silylation of 2-Arylcyclohexanols

(2015) Li Wang et al.   ORGANIC LETTERS

Reactivity scales for quantifying polar organic reactivity: the benzhydrylium methodology

(2015) Herbert Mayr   TETRAHEDRON

Stereoselective Lewis base catalyzed formal 1,3-dipolar cycloaddition of azomethine imines with mixed anhydrides

(2015) Lena Hesping et al.   Chemical Science

Cycloaddition of cyclobutenone and azomethine imine enabled by chiral isothiourea organic catalysts

(2015) Bao-Sheng Li et al.   Chemical Science

Total Syntheses of Secalonic Acids A and D

(2014) Tian Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Organocatalytic Intramolecular Michael Addition/Lactonization for the Asymmetric Synthesis of Substituted Dihydrobenzofurans and Tetrahydrofurans

(2014) Dorine Belmessieri et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dual Catalysis Sees the Light: Combining Photoredox with Organo-, Acid, and Transition-Metal Catalysis

(2014) Matthew N. Hopkinson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Isothiourea-Catalyzed Asymmetric Synthesis of β-Lactams and β-Amino Esters from Arylacetic Acid Derivatives and N-Sulfonylaldimines

(2014) Siobhan R. Smith et al.   JOURNAL OF ORGANIC CHEMISTRY

Linear Free-Energy Relationship and Rate Study on a Silylation-Based Kinetic Resolution: Mechanistic Insights

(2014) Ravish K. Akhani et al.   JOURNAL OF ORGANIC CHEMISTRY

Isothiourea-Mediated Asymmetric Functionalization of 3-Alkenoic Acids

(2014) Louis C. Morrill et al.   JOURNAL OF ORGANIC CHEMISTRY

An Isothiourea-Catalyzed Asymmetric [2,3]-Rearrangement of Allylic Ammonium Ylides

(2014) Thomas H. West et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acylammonium Salts as Dienophiles in Diels–Alder/Lactonization Organocascades

(2014) Mikail E. Abbasov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents

(2014) Louis C. Morrill et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

α-Ketophosphonates as Ester Surrogates: Isothiourea-Catalyzed Asymmetric Diester and Lactone Synthesis

(2014) Siobhan R. Smith et al.   ORGANIC LETTERS

SYNTHESIS OF TERT-BUTYL (1S,2S)-2-METHYL-3-OXO-1-PHENYLPROPYLCARBAMATE BY ASYMMETRIC MANNICH REACTION

(2014)   ORGANIC SYNTHESES

Stereocontrol of All-Carbon Quaternary Centers through Enantioselective Desymmetrization ofMesoPrimary Diols by Organocatalyzed Acyl Transfer

(2013) Christèle Roux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic resolution of racemic α-hydroxyphosphonates by asymmetric esterification using achiral carboxylic acids with pivalic anhydride and a chiral acyl-transfer catalyst

(2013) Isamu Shiina et al.   CHEMICAL COMMUNICATIONS

Determination of Absolute Configuration of Secondary Alcohols Using Thin-Layer Chromatography

(2013) Alexander J. Wagner et al.   JOURNAL OF ORGANIC CHEMISTRY

Concise Synthesis of the Isothiourea Organocatalysts Homobenzotetramisole and Derivatives

(2013) Beatrice Ranieri et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid assembly of complex cyclopentanes employing chiral, α,β-unsaturated acylammonium intermediates

(2013) Gang Liu et al.   Nature Chemistry

Silylation-Based Kinetic Resolution of α-Hydroxy Lactones and Lactams

(2013) Robert W. Clark et al.   ORGANIC LETTERS

Telescoped Synthesis of Stereodefined Pyrrolidines

(2013) Dorine Belmessieri et al.   ORGANIC LETTERS

Kinetic Resolution of Racemic 2-Hydroxy-γ-butyrolactones by Asymmetric Esterification Using Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst

(2013) Kenya Nakata et al.   ORGANIC LETTERS

Kinetic Resolution of N-Acyl-Thiolactams via Catalytic Enantioselective Deacylation

(2013) Valentina D. Bumbu et al.   ORGANIC LETTERS

Anhydrides as α,β-unsaturated acyl ammonium precursors: isothiourea-promoted catalytic asymmetric annulation processes

(2013) Emily R. T. Robinson et al.   Chemical Science

Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study

(2013) Louis C. Morrill et al.   Chemical Science

Manifestation of Felkin-Anh Control in Enantioselective Acyl Transfer Catalysis: Kinetic Resolution of Carboxylic Acids

(2012) Xing Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dihydropyridones: Catalytic Asymmetric Synthesis, N- to C-Sulfonyl Transfer, and Derivatizations

(2012) Carmen Simal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Desymmetrisation of meso-diols mediated by non-enzymatic acyl transfer catalysts

(2012) Álvaro Enríquez-García et al.   CHEMICAL SOCIETY REVIEWS

Amidines, isothioureas, and guanidines as nucleophilic catalysts

(2012) James E. Taylor et al.   CHEMICAL SOCIETY REVIEWS

Combining transition metal catalysis and organocatalysis – an update

(2012) Zhenting Du et al.   CHEMICAL SOCIETY REVIEWS

Isothiourea-Mediated Asymmetric O- to C-Carboxyl Transfer of Oxazolyl Carbonates: Structure-Selectivity Profiles and Mechanistic Studies

(2012) Caroline Joannesse et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalyzed Enantioselective Desymmetrization of Diols in the Preparation of Chiral Building Blocks

(2012) María D. Díaz-de-Villegas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Kinetic Resolution of Racemic Secondary Benzylic Alcohols by the Enantioselective Esterification Using Pyridine-3-carboxylic Anhydride (3-PCA) with Chiral Acyl-Transfer Catalysts

(2012) Isamu Shiina et al.   HELVETICA CHIMICA ACTA

Kinetic Resolution of Secondary Alcohols Using Amidine-Based Catalysts

(2012) Ximin Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic, Enantioselective N-Acylation of Lactams and Thiolactams Using Amidine-Based Catalysts

(2012) Xing Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dyotropic Rearrangements of Fused Tricyclic β-Lactones: Application to the Synthesis of (−)-Curcumanolide A and (−)-Curcumalactone

(2012) Carolyn A. Leverett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Method for Production of Chiral 2-Aryl-2-fluoropropanoic Acids Using an Effective Kinetic Resolution of Racemic 2-Aryl-2-fluoropropanoic Acids

(2012) Atsushi Tengeiji et al.   MOLECULES

1,3-Dipolar cycloaddition of unstabilised azomethine ylides by Lewis base catalysis

(2012) Shveta Pandiancherri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Origin of Enantioselectivity in Benzotetramisole-Catalyzed Dynamic Kinetic Resolution of Azlactones

(2012) Peng Liu et al.   ORGANIC LETTERS

Catalytic asymmetric α-amination of carboxylic acids using isothioureas

(2012) Louis C. Morrill et al.   Chemical Science

Synergistic catalysis: A powerful synthetic strategy for new reaction development

(2012) Anna E. Allen et al.   Chemical Science

Non-enzymatic dynamic kinetic resolution of racemic α-arylalkanoic acids: an advanced asymmetric synthesis of chiral nonsteroidal anti-inflammatory drugs (NSAIDs)

(2012) Isamu Shiina et al.   Catalysis Science & Technology

Nonenzymatic Dynamic Kinetic Resolution of α-(Arylthio)- and α-(Alkylthio)alkanoic Acids

(2011) Xing Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Enantioselective Acyl Transfer onto Racemic as well as meso Alcohols, Amines, and Thiols

(2011) Christian E. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Resolution of Racemic 1-Heteroarylalkanols by Asymmetric Esterification Using Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-transfer Catalyst

(2011) Isamu Shiina et al.   CHEMISTRY LETTERS

Isothiourea-Catalysed Asymmetric C-Acylation of Silyl Ketene Acetals

(2011) Philip A. Woods et al.   CHEMISTRY-A EUROPEAN JOURNAL

Increasing the Reactivity of Nitrogen Catalysts

(2011) Nicolas De Rycke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Kinetic Resolution of α-Substituted Alkanoic Acids Promoted by Homobenzotetramisole

(2011) Xing Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Catalytic Properties of 4-Aryl-2,3-dihydro-4H-pyrimido[2,3-b]benzothiazoles for Asymmetric Acyl or Carboxyl Group Transfer Reactions

(2011) Baby Viswambharan et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophilicities and Lewis Basicities of Isothiourea Derivatives

(2011) Biplab Maji et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Functionalization of Carboxylic Acids: Isothiourea-Catalyzed Asymmetric Intra- and Intermolecular Michael Addition−Lactonizations

(2011) Dorine Belmessieri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Resolution ofN-Acyl-β-Lactams via Benzotetramisole-Catalyzed Enantioselective Alcoholysis

(2011) Valentina D. Bumbu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigations of Cooperative Catalysis in the Enantioselective Fluorination of Epoxides

(2011) Julia A. Kalow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silylation-Based Kinetic Resolution of Monofunctional Secondary Alcohols

(2011) Cody I. Sheppard et al.   ORGANIC LETTERS

Kinetic Resolution of β-Lactams via Enantioselective N-Acylation

(2011) Xing Yang et al.   ORGANIC LETTERS

Determination of Absolute Configuration Using Kinetic Resolution Catalysts

(2011) Alexander J. Wagner et al.   ORGANIC LETTERS

A convenient method for the kinetic resolution of racemic 2-hydroxyalkanoates using diphenylacetic anhydride (DPHAA) and a chiral acyl-transfer catalyst

(2011) Kenya Nakata et al.   TETRAHEDRON-ASYMMETRY

Enantioselective, Organocatalyzed, Intramolecular Aldol Lactonizations with Keto Acids Leading to Bi- and Tricyclic β-Lactones and Topology-Morphing Transformations

(2010) Carolyn A. Leverett et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Ring Opening of Epoxides by Fluoride Anion Promoted by a Cooperative Dual-Catalyst System

(2010) Julia A. Kalow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Resolution of Racemic α-Arylalkanoic Acids with Achiral Alcohols via the Asymmetric Esterification Using Carboxylic Anhydrides and Acyl-Transfer Catalysts

(2010) Isamu Shiina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-enantioselectivity effects in 3,4-dihydropyrimido[2,1-b]benzothiazole-based isothioureas as enantioselective acylation catalysts

(2010) Dorine Belmessieri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Isothiourea-Mediated StereoselectiveC-Acylation of Silyl Ketene Acetals

(2010) Philip A. Woods et al.   ORGANIC LETTERS

Benzotetramisole-Catalyzed Dynamic Kinetic Resolution of Azlactones

(2010) Xing Yang et al.   ORGANIC LETTERS

Homobenzotetramisole-Catalyzed Kinetic Resolution of α-Aryl-, α-Aryloxy-, and α-Arylthioalkanoic Acids

(2009) Xing Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Effects of Methyl Substituents on the Activity and Enantioselectivity of Homobenzotetramisole-Based Catalysts in the Kinetic Resolution of Alcohols

(2009) Yuhua Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Isothiourea-Catalyzed Enantioselective Carboxy Group Transfer

(2009) Caroline Joannesse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combining transition metal catalysis and organocatalysis: a broad new concept for catalysis

(2009) Zhihui Shao et al.   CHEMICAL SOCIETY REVIEWS

Structural Analyses ofN-Acetylated 4-(Dimethylamino)pyridine (DMAP) Salts

(2009) Volker Lutz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Kinetic Resolution of the Racemic 2-Hydroxyalkanoates Using the Enantioselective Mixed-Anhydride Method with Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst

(2009) Isamu Shiina et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nonenzymatic kinetic resolution of racemic 2,2,2-trifluoro-1-aryl ethanol via enantioselective acylation

(2009) Qing Xu et al.   TETRAHEDRON

Lewis Base Catalysis in Organic Synthesis

(2008) Scott E. Denmark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Truncated Cinchona alkaloids as catalysts in enantioselective monobenzoylation of meso-1,2-diols

(2008) E. Peter Kündig et al.   CHEMICAL COMMUNICATIONS

Kinetic Resolution of Racemic Carboxylic Acids Using Achiral Alcohols by the Promotion of Benzoic Anhydrides and Tetramisole Derivatives: Production of Chiral Nonsteroidal Anti-Inflammatory Drugs and Their Esters

(2008) Isamu Shiina et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Concise Synthesis of Spirocyclic, Bridged γ-Butyrolactones via Stereospecific, Dyotropic Rearrangements of β-Lactones Involving 1,2-Acyl and δ-Lactone Migrations

(2008) Vikram C. Purohit et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AcOLeDMAP and BnOLeDMAP: Conformationally Restricted Nucleophilic Catalysts for Enantioselective Rearrangement of Indolyl Acetates and Carbonates

(2008) Trisha A. Duffey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amidine catalysed O- to C-carboxyl transfer of heterocyclic carbonate derivatives

(2008) Caroline Joannesse et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Homobenzotetramisole:  An Effective Catalyst for Kinetic Resolution of Aryl-Cycloalkanols

(2008) Vladimir B. Birman et al.   ORGANIC LETTERS

Kinetic resolution of 2,2-difluoro-3-hydroxy-3-aryl-propionates catalyzed by organocatalyst (R)-benzotetramisole

(2008) Hui Zhou et al.   TETRAHEDRON