期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2016, 期 35, 页码 5778-5798出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201600544
关键词
Total synthesis; Natural products; Antibiotics; Antitumor agents; Quinones; Structure elucidation
资金
- Department of Science and Technology (DST), New Delhi [SB/S1/OC-42/2013]
- Council of Scientific and Industrial Research (CSIR), New Delhi [02(0158)/13/EMR-II]
- Board of Research in Nuclear Sciences (Basic Sciences) [2013/37C/59/BRNS/2443]
- University Grants Commision (UGC), New Delhi
- CSIR
The dimeric pyranonaphthoquinones, bis versions of the naphtho[2,3-c]pyran-5,10-dione moiety, comprises a group of antibiotics that have been isolated from a variety of sources including plants, bacteria, fungi, and insects. This review discusses the known naturally occurring dimeric pyranonaphthoquinones, their isolation and bioactivity, and synthetic approaches towards them that have helped to confirm their structures, as well as to resolve structural uncertainties such as stereochemistry. The major focus has been on the synthetic approaches adopted to complete the challenging total synthesis of the natural isolates and analogues.
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