Review
Medicine, General & Internal
Hai Wang, Zhifeng Xi, Lu Deng, Yixiao Pan, Kang He, Qiang Xia
Summary: Liver ischemia-reperfusion injury is a hot research topic in recent years, related to liver surgery and transplantation. Macrophages play a crucial role in triggering and maintaining liver IRI.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Immunology
Wei Ding, Yunfei Duan, Zhen Qu, Jiawei Feng, Rongsheng Zhang, Xiaodong Li, Donglin Sun, Xiaoying Zhang, Yunjie Lu
Summary: Exacerbated by an acidic microenvironment, HIRI was alleviated by NaHCO3 through neutralizing acid, however, its protection was compromised by liposome-mediated macrophage depletion. The acidic microenvironment promoted M1 polarization while suppressing M2 polarization of macrophages, and PPAR-gamma activation could reduce HIRI by inhibiting M1 polarization under acidic conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qi Chen, Yating Song, Ningli Yang, Xiaoming Ai, Liyong Pu, Lianbao Kong
Summary: This study found that aging worsened ischemia/reperfusion injury and suppressed TRIB1 protein expression and anti-inflammatory function in macrophages. Restoring TRIB1 can alleviate liver damage by activating M2 polarization and anti-inflammatory response.
Article
Immunology
Xin Xu, Weiwei Gao, Lei Li, Jiheng Hao, Bin Yang, Tao Wang, Long Li, Xuesong Bai, Fanjian Li, Honglei Ren, Meng Zhang, Liyong Zhang, Jiyue Wang, Dong Wang, Jianning Zhang, Liqun Jiao
Summary: The study suggests that Annexin A1 (ANXA1) may modulate cerebral ischemia-reperfusion (I/R) injury by regulating microglia/macrophage polarization and inflammation. Ac2-26, a peptide of ANXA1, can shift microglia/macrophage polarization towards an anti-inflammatory phenotype, improving outcomes in a mouse model of transient middle cerebral artery occlusion/reperfusion (tMCAO/R). The protective effect is mediated through the FPR2/ALX-dependent AMPK-mTOR pathway and may have potential clinical implications for AIS patients receiving EVT therapy. Plasma ANXA1 levels may serve as a potential biomarker for predicting clinical outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Shang-Lin Li, Zhi-Min Wang, Cong Xu, Fu-Heng Che, Xiao-Fan Hu, Rui Cao, Ya-Nan Xie, Yang Qiu, Hui-Bo Shi, Bin Liu, Chen Dai, Jun Yang
Summary: Liraglutide can protect the liver from ischemia-reperfusion injury by inhibiting macrophage polarization towards an inflammatory phenotype.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenyu Zhao, Mingxing Sui, Rui Chen, Hanlan Lu, Youhua Zhu, Lei Zhang, Li Zeng
Summary: The study revealed that SIRT3 protects against kidney damage from IRI by modulating the DRP1 pathway to induce mitochondrial autophagy.
Article
Cell Biology
Yuan Jiang, Xingxuan He, Calogera M. Simonaro, Bin Yi, Edward H. Schuchman
Summary: The study demonstrates that recombinant acid ceramidase has therapeutic potential in hepatic ischemia reperfusion injury in mice, reducing damage and decreasing oxidative stress and inflammation. Changes in sphingolipid metabolism play a crucial role in the injury, and administration of acid ceramidase can alter sphingolipid levels and other pathologic changes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Long Liu, Fei Xiao, Jie Sun, Qi Wang, Aidong Wang, Fabiao Zhang, Zhu Li, Xuequan Wang, Zheping Fang, Yingli Qiao
Summary: Ischemia reperfusion injury is a major barrier to liver transplantation. This study identified extracellular vesicles as a major cause of hepatic inflammation and tissue damage in liver ischemia reperfusion injury. Hepatocyte-derived exosomal miR-122-5p was found to mediate liver ischemia reperfusion injury by polarizing Kupffer cell, and inhibiting miR-122-5p showed a protective effect against liver ischemia reperfusion injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jin Zhao, Xiao-Dong Chen, Zheng-Zheng Yan, Wen-Fang Huang, Ke-Xuan Liu, Cai Li
Summary: This study found that gut-derived exosomes contribute to liver injury induced by intestinal ischemia/reperfusion by promoting the polarization of hepatic macrophages.
Article
Genetics & Heredity
Jing Zheng, Ni Yang, Yingying Wan, Wenjing Cheng, Gan Zhang, Shi Yu, Baoye Yang, Xinyu Liu, Xingyan Chen, Xueliang Ding, Ling Wu, Xiang Yu
Summary: Drug-induced liver injury (DILI) is a major concern, and the development of protective medications is urgently needed. In this study, a Cel-loaded biomimetic nanodrug based on erythrocyte membrane vesicles (EMV) was developed to protect the liver from acetaminophen (APAP)-induced liver injury. The Cel-loaded EMV (C-EMV) showed sustained release and excellent liver accumulation, and it could alleviate liver injury by regulating macrophage polarization. The protective effect of C-EMV on APAP-induced liver injury depended on hepatic macrophages.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Immunology
Tong Wu, Cheng Zhang, Tianfeng Shao, Jianzhong Chen, Diyu Chen
Summary: Ischemia-reperfusion injury (IRI) is a crucial factor in liver transplantation, and the activation of hepatic macrophages, especially NLRP3 inflammasome, plays a significant role in the progression of IRI. The NLRP3 inflammasome pathway in hepatic macrophages is highly expressed and may lead to liver IRI, making it a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xinyu Ge, Qingshu Meng, Lu Wei, Jing Liu, Mimi Li, Xiaoting Liang, Fang Lin, Yuhui Zhang, Yinzhen Li, Zhongmin Liu, Huimin Fan, Xiaohui Zhou
Summary: The study revealed that EVs released by the heart during ischemia-reperfusion exacerbate heart injury, while inhibiting EVs with GW4869 can reduce the damage. It was further demonstrated that IR-EVs promote M1-like polarization of macrophages and increase the expression of inflammatory cytokines.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Plant Sciences
Xin Dong, Jialin Jiang, Zhijun Lin, Ruijia Wen, Ling Zou, Tong Luo, Zhuoji Guan, Xuan Li, Linhai Wang, Lu Lu, Huan Li, Yusheng Huang, Zhongqi Yang, Junyan Wang, Xiaohan Ye, Xiaohua Hong, Lingjun Wang, Shaoxiang Xian, Zixin Chen
Summary: This study demonstrated that Nuanxinkang (NXK) has a protective effect on ischemia/reperfusion (IR)-induced heart failure (HF). NXK modulates the ratio of proinflammatory and anti-inflammatory macrophages, reducing inflammation and improving cardiac function. The results suggest that NXK could be a natural strategy for the anti-inflammatory treatment of HF.
Article
Biotechnology & Applied Microbiology
Shengjie Tang, Xiangcheng Xie, Ming Wang, Lili Yang, Wei Wei
Summary: Asiaticoside has a protective effect on renal ischemia-reperfusion injury (IRI) by inhibiting inflammatory mediators and promoting macrophage polarization.
Article
Immunology
Lin Li, Haiyan Gan, Huaqian Jin, Yan Fang, Yan Yang, Jianping Zhang, Xiaowei Hu, Lisheng Chu
Summary: The study demonstrated that AS-IV can improve long-term brain injury after cerebral ischemia/reperfusion by promoting the polarization of microglia/macrophages and increasing the expression of PPAR-γ, leading to enhanced neurogenesis and angiogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)