Article
Neurosciences
Boateng Asamoah, Ahmad Khatoun, Myles Mc Laughlin
Summary: Through applying exogenous extracellular fields to modulate slow-wave neural oscillations in anesthetized rats, it has been demonstrated that these fields can modulate the amplitude of endogenous neural oscillations in a frequency-specific resonance pattern without affecting spike rate.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Alessandro Cruciani, Giovanni Pellegrino, Antonio Todisco, Francesco Motolese, Marco Sferruzzi, Davide Norata, Francesca Santoro, Gabriella Musumeci, Mariagrazia Rossi, Fabio Pilato, Vincenzo Di Lazzaro, Fioravante Capone
Summary: tACS is a technique that modulates brain activity through electrical current, and its effects can be precisely controlled by synchronizing with an individual's high-frequency oscillation frequency. This study provides initial evidence that tACS synchronized with an individual's high-frequency oscillation can specifically modulate thalamocortical activity, which may pave the way for innovative personalized neuromodulation methods for the somatosensory system.
Article
Neurosciences
Harry Tran, Sina Shirinpour, Alexander Opitz
Summary: Neural oscillations play a key role in information transfer in the brain, with transcranial alternating current stimulation (tACS) directly interacting with brain oscillatory activity. While tACS does not affect the firing rate of neurons in human studies, it can entrain the spiking activity of specific neuron types at lower field strengths. Understanding the impact of oscillating electric fields on single neuron activity highlights the importance of neuron morphology and biophysics in responsiveness to electrical stimulation.
Article
Neurosciences
Francois David, Melodie Borel, Suleman Ayub, Patrick Ruther, Luc J. Gentet
Summary: Neocortical interneurons play a crucial role in organizing brain oscillations for cognitive functions. This study reveals the layer-specific contribution of parvalbumin-expressing interneurons to neocortical oscillations in awake mice. The supragranular layer stimulation of PV neurons entrains gamma-frequency oscillations, while the infragranular layer stimulation is more effective at entraining delta and theta frequency oscillations. These findings provide insights into layer-based regulation of oscillations in the somatosensory cortex.
Article
Neurosciences
Emily B. J. Coffey, Isabelle Arseneau-Bruneau, Xiaochen Zhang, Sylvain Baillet, Robert J. Zatorre
Summary: There is ongoing debate about the presence and function of neural oscillatory mechanisms in the auditory system, with research suggesting that oscillatory entrainment may play a role in representing periodic sound throughout the auditory neuraxis. The study found significant oscillatory activity in auditory cortex and subcortical auditory nuclei, supporting the hypothesis of entrainment and highlighting the potential functional role of this mechanism in enhancing stability and reducing susceptibility to noise in real-life environments.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Stephen M. Town, Katarina C. Poole, Katherine C. Wood, Jennifer K. Bizley
Summary: The study found that the auditory cortex plays a role in processing sound features with mixed selectivity for spatial and nonspatial characteristics, contributing to various forms of hearing.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Mirtes Bruckmann, Karina Carlesso Pagliarin, Michele Vargas Garcia
Summary: This study found that mild hearing loss in older adults does not influence MMN, there is no significant correlation between MMN and cognitive tasks, but weak correlations with central auditory processing. Changes in CAP lead to longer durations in MMN.
Article
Psychology
Emily C. Cunningham, Ranxiao Frances Wang, Diane M. Beck
Summary: The study suggests that while performance on visual tasks synchronizes to a visual rhythm in the 8-12 Hz range, it does not synchronized to an auditory rhythm of the same frequency. However, adding an auditory rhythm to a visual rhythm may enhance the effects of the visual rhythm on performance. These observations suggest limitations to cross-modal entrainment.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE
(2022)
Article
Neurosciences
Jennifer Resnik, Daniel B. Polley
Summary: Correlational evidence in humans suggests that selective difficulties hearing in noisy, social settings may reflect premature auditory nerve degeneration. By inducing primary cochlear neural degeneration (CND) in adult mice, researchers found behavioral evidence for selective detection deficits in background noise. Tracking daily changes in auditory cortex neurons, they discovered distinct forms of plasticity induced by CND, resulting in hyperactivity, increased neural gain, and reduced adaptation to noise.
Article
Neurosciences
Xiao-Min Xu, Yuan Feng, Jian Wang, Richard Salvi, Xindao Yin, Jun Gao, Yu-Chen Chen
Summary: This study aimed to investigate the correlation between hearing loss-related central nervous system in rats and cognition. The study found a new model of auditory-limbic-cerebellum interactions explaining noise-induced hearing loss and cognitive impairments. The results revealed deficits in spatial learning/memory and body weight, and negative correlations between them. Functional and structural imaging techniques showed disrupted functional network and damaged fibers in certain brain regions.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Audiology & Speech-Language Pathology
Yi Fan Zhang, Anne Lasfargues-Delannoy, Isabelle Berry
Summary: Functional near-infrared spectroscopy (fNIRS) is a popular method in hearing research, and this study aims to identify efficient stimulation parameters for the auditory experimental design. The study found that cortical activity increases with longer stimulation durations, reaching a plateau at around 15 seconds. The nonlinearity of the hemodynamic responses is more pronounced with shorter durations (15s and 20s). The study suggests that a 15-second stimulation duration provides optimal signal quality for fNIRS research.
Article
Neurosciences
Joshua D. Downer, James Bigelow, Melissa J. Runfeldt, Brian J. Malone
Summary: Population responses to amplitude modulation (AM) in the primary auditory cortex (A1) have been modeled and evaluated, showing that a simple population-based decoding model involving unweighted convergence of neuronal responses can accurately classify AM frequencies. This suggests that dynamic rate coding in auditory cortex is influenced by shared modulation phase preferences among cortical neurons. These findings emphasize the importance of population-based synchrony in sensory coding.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Amanda Henton, Yanjun Zhao, Thanos Tzounopoulos
Summary: Damage to sensory organs triggers compensatory plasticity mechanisms in sensory cortices, resulting in restored cortical responses and recovery of perceptual detection thresholds. In this study, the authors investigated the changes in intrinsic properties and biophysical mechanisms following noise-induced peripheral damage. They found a specific reduction in the intrinsic excitability of parvalbumin-expressing neurons in the auditory cortex, associated with an increase in KCNQ potassium channel activity. These findings provide insights into the cell type and channel-specific plasticity mechanisms involved in hearing loss and related disorders.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Wenlu Pan, Jing Pan, Yan Zhao, Hongzheng Zhang, Jie Tang
Summary: This study found that the knockout of SERT gene in mice resulted in reduced dendritic length and spine density of auditory cortex neurons, disrupted frequency-tonotopic organization, and abnormal frequency tuning in auditory neurons. These findings suggest that SERT plays a key role in the development and maintenance of auditory cortical neurons.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Brandon T. Paul, Munir Demir Bajin, Mila Uzelac, Joseph Chen, Trung Le, Vincent Lin, Andrew Dimitrijevic
Summary: Deaf individuals who use a cochlear implant (CI) have different outcomes for auditory speech communication. Previous research viewed visual crossmodal plasticity as harmful, but this study suggests that plasticity related to visual language may be beneficial for speech recovery. Crossmodal reorganization in CI users does not necessarily predict poor speech outcomes, and differences in crossmodal activation during lip reading may be related to communication strategies used by users.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Zubeyir Bayraktaroglu, Tuba Akturk, Gorsev Yener, Tom A. de Graaf, Lutfu Hanoglu, Ebru Yildirim, Duygu Hunerli Gunduz, Ilayda Kiyi, Alexander T. Sack, Claudio Babiloni, Bahar Guntekin
Summary: Parkinson's disease patients with mild cognitive impairment exhibit abnormal neurophysiological oscillatory mechanisms, primarily driven by delta frequencies, during cognitive tasks.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Editorial Material
Psychiatry
Chih-Sung Liang, Po-Han Chou, Shao-Cheng Wang, Alexander T. Sack, Kuan-Pin Su
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Clinical
Mathilde Kennis, Felix Duecker, Els Elaut, Guy T'Sjoen, Tom Loeys, Alexander T. Sack, Marieke Dewitte
Summary: Multiple surveys have shown that transgender individuals have lower sexual well-being compared to cisgender individuals. However, previous studies have limitations in terms of ecological validity and memory bias. In this diary study, transgender and cisgender individuals reported on their sexual behavior, sexual esteem, and body image for three weeks. The findings suggest that intimacy predicts sexual esteem in transgender individuals, while sexual openness predicts sexual esteem and body image. Transgender individuals scored lower on daily sexual esteem and body image than cisgender individuals, but there were no differences in daily sexual behavior. Clinicians should consider sexuality more broadly and address sexual esteem when discussing sexuality with transgender patients.
JOURNAL OF SEX RESEARCH
(2023)
Article
Clinical Neurology
Marom Bikson, Ana Ganho- Avila, Abhishek Datta, Morten Goertz Joensson, Bernadette Gillick, Sungjin Kim, Jinuk Kim, Adam Kirton, Kiwon Lee, Timothy Marjenin, Balder Onarheim, Erik M. Rehn, Alexander T. Sack, Gozde Unal
Summary: The objective of the LOTES-2023 guidance is to update the previous LOTES-2017 guidance and provide a transparent framework for the design of limited output transcranial electrical stimulation devices. This updated guidance aligns with international standards and regulations and emphasizes the responsibility of manufacturers in conducting device-specific risk management within a constrained dose range. The warnings and precautions have been updated to align with current biomedical evidence and applications.
Editorial Material
Clinical Neurology
Chris Baeken, Martijn Arns, Jerome Brunelin, Lorena Chanes, Igor Filipcic, Ana Ganho-Avila, Marco Hirnstein, Fady Rachid, Alexander T. Sack, Jacinta O'shea, Giordano D'urso, Andrea Antal
Article
Psychology, Clinical
Priya T. Gajadien, Tjardo S. Postma, Iris van Oostrom, Karel W. F. Scheepstra, Hanneke van Dijk, Alexander T. Sack, Odile A. van den Heuvel, Martijn Arns
Summary: Sleep problems can predict the response of treatment resistant OCD patients to repetitive transcranial magnetic stimulation (rTMS). The PSQI items of subjective sleep quality, sleep latency, and daytime dysfunction, as well as the HSDQ-insomnia scale, were found to predict treatment response.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Georgios Mikellides, Panayiota Michael, Lilia Psalta, Artemis Stefani, Teresa Schuhmann, Alexander T. Sack
Summary: The study investigated the long-term effects of accelerated intermittent theta burst stimulation (aiTBS) in smoking cessation, showing that the positive effects on nicotine dependence and tobacco craving lasted for at least one month after treatment, but dissipated after six months. No significant differences were found between the three groups.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Letter
Clinical Neurology
Amourie Prentice, Ylka Kolken, Christina Tuttle, Joris van Neijenhof, Richard Pitch, Iris van Oostrom, Vera Kruiver, Jonathan Downar, Alexander T. Sack, Martijn Arns, Nikita van der Vinne
Article
Neurosciences
Amourie Prentice, Ana Rita Barreiros, Nikita van der Vinne, Sven Stuiver, Hanneke van Dijk, Jeroen Antonius van Waarde, Mayuresh Korgaonkar, Alexander T. Sack, Martijn Arns
Summary: This study found an association between high rostral anterior cingulate cortex (rACC) theta activity and treatment resistance, suggesting potential improvement in the usefulness of rACC-theta biomarker in treatment selection and prognosis.
NEUROPSYCHOBIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Dimo Ivanov, Federico De Martino, Elia Formisano, Francisco J. Fritz, Rainer Goebel, Laurentius Huber, Sriranga Kashyap, Valentin G. Kemper, Denizhan Kurban, Alard Roebroeck, Shubharthi Sengupta, Bettina Sorger, Desmond H. Y. Tse, Kamil Uludag, Christopher J. Wiggins, Benedikt A. Poser
Summary: This article reviews the 9.4 T work done in Maastricht, including functional and anatomical imaging experiments. By utilizing specific techniques and optimized coils, the researchers were able to obtain high-quality imaging results and highlight the technical challenges and practical issues associated with ultra-high field MRI.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Steve Bates, Serge O. Dumoulin, Paul J. M. Folkers, Elia Formisano, Rainer Goebel, Aidin Haghnejad, Rick C. Helmich, Dennis Klomp, Anja G. van der Kolk, Yi Li, Aart Nederveen, David G. Norris, Natalia Petridou, Stefan Roell, Tom W. J. Scheenen, Menno M. Schoonheim, Ingmar Voogt, Andrew Webb
Summary: We propose a vision for a 14 Tesla MR system, which includes a novel whole-body magnet design using high temperature superconductor, a console and associated electronic equipment, an optimized radiofrequency coil setup for proton measurement in the brain, and a high-performance gradient set. This system has significant applications in neuroscience and medical research, allowing for fine-grained observation of neural activity and structural abnormalities.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Lauren Zwienenberg, Hanneke van Dijk, Stefanie Enriquez-Geppert, Nikita van der Vinne, Richard Gevirtz, Evian Gordon, Alexander T. Sack, Martijn Arns
Summary: Currently, major depressive disorder (MDD) treatment plans are based on trial-and-error, and remission rates remain low. A strategy to replace trial-and-error and increase remission rates could be treatment stratification using the heartbeat-evoked potential (HEP) as a biomarker. The study found that using HEP as a stratification biomarker can enhance treatment outcome prediction for venlafaxine and rTMS.
NEUROPSYCHOBIOLOGY
(2023)
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)
Article
Neurosciences
Aline M. Dantas, Alexander T. Sack, Elisabeth Bruggen, Peiran Jiao, Teresa Schuhmann
Summary: This study investigated the functional relevance of frontal theta-band activity in decision-making using transcranial alternating current stimulation (tACS) over right or left dorsolateral prefrontal cortex (DLPFC). The results showed that risk-taking behavior increased after left DLPFC stimulation and decreased after right DLPFC stimulation. Furthermore, stimulation intensity had an effect on behavioral responses.
Review
Behavioral Sciences
Ting Wang, Tom de Graaf, Joshua Williams, Zhihao Wang, Teresa Schuhmann, Felix Duecker, Alexander T. Sack
Summary: Spatial attention control involves specialized functions in both hemispheres of the brain, leading to hemispheric asymmetries. Neuropsychological models explain this lateralization mainly based on patient studies of hemineglect. Our meta-analysis assessed inhibitory TMS effects on PPC during visual detection tasks across ten studies (1994-2022). These results call for a re-evaluation of current theoretical models of attention and their application to novel brain stimulation-based therapeutic interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)