Article
Oncology
Shuohui Dong, Songhan Li, Xiaoyan Wang, Shuo Liang, Wenjie Zhang, Linchuan Li, Qian Xu, Bowen Shi, Zhiqiang Cheng, Xiang Zhang, Mingwei Zhong, Guangyong Zhang, Sanyuan Hu
Summary: This study found that the high expression of CD147 is associated with decreased chemosensitivity and unfavorable prognosis in colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). CD147 regulates glycolipid metabolism by upregulating HIF-1 alpha-mediated glycolysis and attenuating PPAR alpha-mediated fatty acid oxidation, resulting in 5-FU resistance in CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vilmante Zitkute, Egle Kukcinaviciute, Violeta Jonusiene, Vytaute Starkuviene, Ausra Sasnauskiene
Summary: Autophagy plays a crucial role in cancer cell chemoresistance, but the changes in autophagy in the case of acquired chemoresistance are poorly understood. This study reveals that 5-fluorouracil and oxaliplatin have different effects on autophagy in colorectal cancer cell lines and their chemoresistant sublines. Additionally, the protein levels of core-autophagy proteins are significantly modulated by these treatments.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Medical Laboratory Technology
Chaobin Li, Kemei Lu, Chenggang Yang, Wenfeng Du, Zhengkai Liang
Summary: This study aims to investigate the role of EIF3D in regulating resistance to 5-fluorouracil (5-Fu) in colorectal cancer (CRC). The results show that EIF3D promotes resistance to 5-Fu by upregulating the expression of RUVBL1 in CRC.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Rinad A. Algehani, Raefa Abou Khouzam, Gehan A. Hegazy, Aliaa A. Alamoudi, Ali M. El-Halawany, Riham S. El Dine, Ghada A. Ajabnoor, Fahad A. Al-Abbasi, Mohammed A. Baghdadi, Ibrahim Elsayed, Masao Hattori, Ahmed M. Al-Abd
Summary: A synergistic effect in terms of anticancer properties was observed when colossolactone-G was combined with 5-FU and GCB, influencing both apoptosis and autophagic cell death mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Shiekhah M. Alzahrani, Huda A. Al Doghaither, Ayat B. Al-Ghafari, Peter N. Pushparaj
Summary: Although 5-FU-based chemotherapy is widely used for colorectal cancer, it has limitations. Capecitabine, a prodrug of 5-FU, was developed to overcome these drawbacks and achieve more convenient therapy. This review compares the properties and efficacy of 5-FU therapy and capecitabine therapy, including drug metabolism, cellular mechanisms, safety, and tolerability. Future research should explore the combination of capecitabine with novel drugs to inhibit tumor initiation, progression, and metastasis.
Article
Biochemistry & Molecular Biology
Yong-Hwi Kang, Jin-Seok Lee, Nam-Hun Lee, Seung-Hyung Kim, Chang-Seob Seo, Chang-Gue Son
Summary: Colorectal cancer (CRC) is the third most common cancer worldwide among both men and women, with early detection and resection being the best treatment and chemotherapy a main treatment option. Coptidis Rhizoma extract (CRE) shows potential as an adjuvant agent against 5-FU-resistant colorectal cancers by reducing cell viability and inhibiting thymidylate synthase (TS) expression.
Article
Multidisciplinary Sciences
Tianyi Gao, Dan Yuan, Bangshun He, Yingdong Gao, Caidong Liu, Huilin Sun, Junjie Nie, Shukui Wang, Zhenlin Nie
Summary: HSPB8 plays a significant role in CRC 5-FU resistance by acting together with its co-chaperone BAG3 in autophagy-driven resistance. Additionally, the expression level of HSPB8 is significantly correlated with immune cell infiltration.
Article
Cell Biology
Feng Ye, Yuwen Xie, Mingdao Lin, Yang Liu, Yuan Fang, Keli Chen, Yaowei Zhang, Yi Ding
Summary: Colorectal cancer is the third most commonly diagnosed cancer worldwide. Chemotherapy resistance is a common problem in treating CRC patients. This study investigates the role of KIAA1549 in promoting tumor development and chemoresistance in colorectal cancer.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zhiwei Chen, Heyan Chen, Lihui Huang, Baiqun Duan, Sheng Dai, Wenjing Cai, Meng Sun, Zhikai Jiang, Ruijie Lu, Yiling Jiang, Xinyu Jiang, Hailun Zheng, Qing Yao, Kwonseop Kim, Guangyong Lin, Congying Xie, Maoping Chu, Ruijie Chen, Longfa Kou
Summary: Oxaliplatin resistance is a major obstacle in the chemotherapy of colorectal cancer. In this study, oxaliplatin/berbamine-co-loaded nanoparticles were designed to target SLC6A14 (ATB0,+) and inhibit cancer proliferation. The nanoparticles significantly inhibited the proliferation and decreased the drug resistance of resistant colorectal cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Vilmante Zitkute, Andrius Jasinevicius, Guoda Vaitiekaite, Egle Kukcinaviciute, Bernadeta Aleksandraviciute, Eigile Eidenaite, Lukas Sudeikis, Violeta Jonusiene, Ausra Sasnauskiene
Summary: The protein p62 plays a role in regulating cell survival and death in chemoresistant CRC cells. Its increased levels are associated with chemoresistance, while silencing p62 can increase sensitivity to chemotherapy drugs and reduce apoptosis levels and IL-8 protein levels.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Lan Jin, Yunhe Chen, Dan Cheng, Zhikai He, Xinyi Shi, Boyu Du, Xueyan Xi, Yujing Gao, Yang Guo
Summary: Colorectal cancer is a highly aggressive and lethal cancer, with autophagy playing a complex role in its pathobiology. The transcriptional coactivator YAP has been found to negatively regulate autophagy in CRC cells, promoting tumor progression by upregulating the apoptosis-inhibitory protein Bcl-2 through TEAD interaction, thereby suppressing autophagy-related cell death. Targeting the YAP/Bcl-2 pathway may hold promise as a potential therapeutic strategy against CRC.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Zihao Pan, Jun Zheng, Jiebin Zhang, Jiatong Lin, Jianguo Lai, Zejian Lyu, Huolun Feng, Junjiang Wang, Deqing Wu, Yong Li
Summary: This study identifies a circular RNA, circATG4B, that plays an important role in oxaliplatin resistance in colorectal cancer (CRC) cells. The results reveal that circATG4B induces oxaliplatin resistance by promoting autophagy and decreasing the sensitivity of CRC cells to chemotherapy.
Article
Oncology
Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma, Lingyu Zhao
Summary: This study demonstrates that MeCP2 confers 5-FU resistance in gastric cancer cells by upregulating the NOX4/PKM2 pathway. Knockdown of MeCP2 enhances the sensitivity of cells to 5-FU, and silencing NOX4 can rescue the inductive effect of MeCP2 overexpression on 5-FU sensitivity. In vivo experiments also show that MeCP2 knockdown enhances 5-FU sensitivity in tumors.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Erica Pranzini, Elisa Pardella, Livio Muccillo, Angela Leo, Ilaria Nesi, Alice Santi, Matteo Parri, Tong Zhang, Alejandro Huerta Uribe, Tiziano Lottini, Lina Sabatino, Anna Caselli, Annarosa Arcangeli, Giovanni Raugei, Vittorio Colantuoni, Paolo Cirri, Oliver D. K. Maddocks, Paola Chiarugi, Paolo Paoli, Maria Letizia Taddei
Summary: The study reveals that alterations in serine metabolism affect the sensitivity of colorectal cancer cells to 5-FU. Resistant cells become dependent on serine by increasing its synthesis or uptake. Mitochondrial compartmentalization of one-carbon metabolism supports purine biosynthesis and DNA damage response in resistant cells.
Article
Biochemistry & Molecular Biology
Sun Young Park, Ye Seo Chung, So Yeon Park, So Hee Kim
Summary: Resistance to oxaliplatin in colorectal cancer cells is associated with increased phosphorylation of AMPK, leading to cell survival. Inhibition of AMPK can induce autophagy and restore chemosensitivity to anticancer drugs.