期刊
OCULAR SURFACE
卷 20, 期 -, 页码 139-162出版社
ELSEVIER
DOI: 10.1016/j.jtos.2021.02.007
关键词
Aging; Immune cells; Tear film; T regulatory t cells; Lacrimal gland; Goblet cells
资金
- NIH [EY026893, EY030447, S10 OD025251]
- NIH/NEI [EY002520]
- P30 Cancer Center Support Grant [NCI-CA125123]
- Research to Prevent Blindness
- Hamill Foundation
- Sid Richardson Foundation
- ARVO Roche Collaborative Research Fellowship, Agencia Nacional de Promocion Cientifica y Tecnica de Argentina [PICT 2013-1436, 2015-0971, PICT 2018-02911]
- NIH Pathology Core [P30CA125123]
- Baylor Cytometry and Cell Sorting Core [CPRIT Core Facility Support Award] [CPRIT-RP180672]
- [NIH-RR024574]
As life expectancy increases, so does the prevalence of age-related diseases, including those affecting the eyes. Aging affects the mucosal immune response of the ocular surface, leading to a higher incidence of ocular surface diseases in the elderly.
Since the last century, advances in healthcare, housing, and education have led to an increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related diseases, such as cancer, autoimmunity, diabetes, and infection, and part of this increase in disease incidence relates to the significant changes that aging brings about in the immune system. The eye is not spared by aging either, presenting with age-related disorders of its own, and interestingly, many of these diseases have immune pathophysiology. Being delicate organs that must be exposed to the environment in order to capture light, the eyes are endowed with a mucosal environment that protects them, the so-called ocular surface. As in other mucosal sites, immune responses at the ocular surface need to be swift and potent to eliminate threats but are at the same time tightly controlled to prevent excessive inflammation and bystander damage. This review will detail how aging affects the mucosal immune response of the ocular surface as a whole and how this process relates to the higher incidence of ocular surface disease in the elderly.
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