Article
Neurosciences
Na Cao, Atsushi Sasaki, Akiko Yuasa, Milos R. Popovic, Matija Milosevic, Kimitaka Nakazawa
Summary: This study investigates whether cortical stimulation can affect the corticospinal excitability induced by neuromuscular electrical stimulation (NMES). The results show that combined facilitatory priming and NMES can induce long-lasting facilitation in the corticospinal system, while either intervention alone has no effect.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Justine Magnuson, Mehmet A. A. Ozdemir, Elon Mathieson, Sofia Kirkman, Brice Passera, Sumientra Rampersad, Alyssa B. B. Dufour, Dana Brooks, Alvaro Pascual-Leone, Peter J. J. Fried, Mouhsin M. M. Shafi, Recep A. A. Ozdemir
Summary: This study comprehensively evaluated the neuromodulatory effects of various rTMS protocols on corticospinal excitability. The results showed that these protocols did not significantly modulate corticospinal excitability and had poor reproducibility. These findings question the effectiveness and reliability of widely used rTMS techniques in modulating corticospinal excitability.
Article
Biology
Jesus Perez-Ortega, Tzitzitlini Alejandre-Garcia, Rafael Yuste
Summary: Neuronal ensembles, identified as coactive groups of neurons in cortical activity, can last for weeks in the visual cortex of awake mice, with some ensembles maintaining activity for up to 46 days and displaying stronger functional connectivity.
Article
Neurosciences
Na Cao, Atsushi Sasaki, Akiko Yuasa, Milos R. Popovic, Matija Milosevic, Kimitaka Nakazawa
Summary: This study examined the optimal parameters for neuromodulation using combined rTMS and NMES. The results showed that corticospinal excitability was increased after the intervention with concurrent 50 Hz NMES and iTBS, but returned to baseline within 10 minutes. Short-duration concurrent and synchronized stimulation can effectively modulate corticospinal excitability.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Ryuichiro Kakizaki, Eichi Narimatsu, Takehiko Kasai, Kazuhito Nomura
Summary: Sepsis can modulate hippocampal synaptic plasticity, depressing excitatory synaptic transmissions and increasing somatic excitability, primarily due to septic oxygen superoxide.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Lingdi Fu, Lorenzo Rocchi, Ricci Hannah, Guizhi Xu, John C. Rothwell, Jaime Ibanez
Summary: The study highlights the importance of timing in inducing plastic changes in corticospinal excitability (CSE) by associating peripheral nerve stimulation with electromyogram (EMG) activity just before movement initiation. Furthermore, it demonstrates that background voluntary muscle activity can abolish the effect on CSE, suggesting that synapses inactive at rest but anticipating movement play a crucial role in plasticity induction.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Pasquale Cardellicchio, Elisa Dolfini, Alessandro D'Ausilio
Summary: Evidence suggests that human sensorimotor interaction requires mutual behavioral adaptation and shared cognitive task representations. It has been shown that the left dorsal premotor cortex plays a role in sculpting movements and modulating stopping performance in joint action coordination.
Article
Clinical Neurology
Andrea Guerra, Francesco Asci, Alessandro Zampogna, Valentina D'Onofrio, Alfredo Berardelli, Antonio Suppa
Summary: The study showed that the effects of transcranial alternating current stimulation (tACS) on long-term potentiation (LTP)-like plasticity of the primary motor cortex (M1) are significantly reduced in older adults compared to young adults.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Louisa Krile, Elnaz Ensafi, Jaeden Cole, Mah Noor, Andrea B. Protzner, Alexander McGirr
Summary: The combination of transcranial magnetic stimulation (TMS) and electroencephalography allows for direct interrogation of human cortical circuits. This study investigates the relationship between stimulus intensity and the amplitudes of TMS-evoked potential (TEP) components. The results show heterogeneous dose-response relationships among TEP components, with the N120 and P200 components exhibiting a dose-response relationship. Moreover, the study demonstrates that intermittent theta burst stimulation (iTBS) affects the dose-response relationship of the N120 component.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Yali Feng, Jack Jiaqi Zhang, Jiaqi Zhu, Xiaobing Tan, Sanyue Huang, Zhongfei Bai, Ying Yin
Summary: This study aimed to investigate the effects of intermittent theta burst stimulation (iTBS) on working memory performance in healthy adults, specifically focusing on the left dorsolateral prefrontal cortex (LDLPFC) and right dorsolateral prefrontal cortex (RDLPFC). The results showed significant time effects on overall accuracy in both 2-back and 3-back tasks, as well as on total reaction time in 3-back tasks. However, there were no significant interaction effects between time and group.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Lucero Aceves-Serrano, Jason L. Neva, Jonathan Munro, Martin Parent, Lara A. Boyd, Doris J. Doudet
Summary: The long-term therapeutic effects of TBS may be facilitated through the modulation of neurotransmission systems beyond the dopamine system.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Ling-Yi Liao, Yun-Juan Xie, Yi Chen, Qiang Gao
Summary: Intervention with cerebellar iTBS combined with physiotherapy has been shown to enhance balance and motor recovery in poststroke patients, providing a low-cost, rapid, and effective approach for stroke rehabilitation.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Clinical Neurology
Jaeden Cole, Ben Selby, Zahinoor Ismail, Alexander McGirr
Summary: In a randomized double-blind placebo-controlled crossover study, it was found that motor plasticity in patients with Major Depressive Disorder (MDD) is rescued and stabilized by the NMDA-R partial agonist D-cycloserine. The results indicate that D-cycloserine can regulate changes in motor plasticity in MDD patients.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
M. Wischnewski, M. Engelhardt, M. A. Salehinejad, D. J. L. G. Schutter, M-F Kuo, M. A. Nitsche
Article
Behavioral Sciences
Miles Wischnewski, Harold Bekkering, Dennis J. L. G. Schutter
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2018)
Article
Neurosciences
Adjmal M. E. Sarwary, Miles Wischnewski, Dennis J. L. G. Schutter, Luc P. J. Selen, W. Pieter Medendorp
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Psychology, Biological
Miles Wischnewski, Dennis J. L. G. Schutter
Review
Clinical Neurology
Miles Wischnewski, Dennis J. L. G. Schutter, Michael A. Nitsche
Article
Multidisciplinary Sciences
Mohammad Ali Salehinejad, Miles Wischnewski, Vahid Nejati, Carmelo M. Vicario, Michael A. Nitsche
Correction
Multidisciplinary Sciences
Mohammad Ali Salehinejad, Miles Wischnewski, Vahid Nejati, Carmelo M. Vicario, Michael A. Nitsche
Article
Neurosciences
Miles Wischnewski, Mie L. Joergensen, Boukje Compen, Dennis J. L. G. Schutter
Review
Neurosciences
Mohammad Ali Salehinejad, Vahid Nejati, Mohsen Mosayebi-Samani, Ali Mohammadi, Miles Wischnewski, Min-Fang Kuo, Alessio Avenanti, Carmelo M. Vicario, Michael A. Nitsche
NEUROSCIENCE BULLETIN
(2020)
Article
Neurosciences
Miles Wischnewski, Marius V. Peelen
Summary: There is a clear distinction between object and scene processing in the human high-level visual cortex, with evidence showing that TMS can selectively target and impair object recognition in the lateral occipital complex (LOC) and scene recognition in the occipital place area (OPA). These effects are stable over time and consistent across individual objects and scenes, supporting the distinction as an organizing principle of human high-level visual cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Mohammad Ali Salehinejad, Miles Wischnewski, Elham Ghanavati, Mohsen Mosayebi-Samani, Min-Fang Kuo, Michael A. Nitsche
Summary: Research shows that chronotype can modulate brain functions, with morning people outperforming in cognitive tasks. This advantage may be associated with enhanced cortical excitability and plasticity.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Miles Wischnewski, Marius Peelen
Summary: Objects can be recognized based on intrinsic features, but visibility may be limited in daily life. Object recognition is still accurate within typical scene contexts, supported by parallel processing and feedback mechanisms in the brain.
Review
Behavioral Sciences
Miles Wischnewski, Kathleen E. Mantell, Alexander Opitz
Summary: The study found that the electric field strength in the lower dorsolateral prefrontal cortex was most strongly related to improved working memory performance during tDCS stimulation of the left prefrontal cortex. A new tDCS montage was proposed to maximize the electric field strength in that brain region, which could benefit future studies aiming to affect working memory function.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Miles Wischnewski, Zachary J. Haigh, Sina Shirinpour, Ivan Alekseichuk, Alexander Opitz
Summary: The study utilized real-time targeting of mu and beta rhythms to non-invasively probe motor corticospinal excitability. Results showed significant phase-dependent modulation of cortico-spinal output by both mu and beta rhythms, with a double dissociation pattern observed. Mu power was positively correlated with corticospinal output, while power and phase effects did not interact, suggesting independence between these aspects of oscillations.
Review
Behavioral Sciences
Miles Wischnewski, Ivan Alekseichuk, Alexander Opitz
Summary: Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior, making it a potential tool for cognitive research and brain disorder therapies. It generates oscillating electric fields in the brain that can influence neural spike timing, local neural oscillatory power, and cross-frequency and cross-area coherence. tACS affects cognitive performance by modulating brain rhythms, synchronization, and metabolic activity. It also shows promising results in alleviating psychiatric and neurological symptoms by targeting abnormal neural oscillations. We summarize the mechanisms of tACS, its cognitive applications, and novel developments for personalized stimulation.
TRENDS IN COGNITIVE SCIENCES
(2023)
