Article
Medicine, General & Internal
Evan M. Murray, David J. Whellan, Haiying Chen, Alain G. Bertoni, Pamela Duncan, Amy M. Pastva, Dalane W. Kitzman, Robert J. Mentz
Summary: Diabetes status had minimal impact on the response to rehabilitation intervention in heart failure patients, with diabetic patients showing slightly less improvement in physical function compared to non-diabetic patients.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Geriatrics & Gerontology
Domenico Scrutinio, Pietro Guida, Roberta Ruggieri, Andrea Passantino
Summary: Summary: Poor functional status is common among older patients hospitalized for heart failure (HF) and is associated with worse prognosis. This study examined the prognostic value of 6-min walk test after transitional cardiac rehabilitation in older patients with HF. The results showed that increasing 6-min walk distance after rehabilitation was associated with a decreased risk of death, particularly in the subgroup with preserved EF.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Cardiac & Cardiovascular Systems
Anthony E. Peters, Dalane W. Kitzman, Haiying Chen, Benjamin Nelson, Amy M. Pastva, Pamela W. Duncan, Gordon R. Reeves, Bharathi Upadhya, David J. Whellan, Robert J. Mentz
Summary: The novel rehabilitation intervention in ADHF showed benefits for all BMI subgroups, with potentially greater improvements in physical function for obese patients compared to non-obese patients.
JACC-HEART FAILURE
(2022)
Article
Health Care Sciences & Services
Siddharth Jain, Paul R. Rosenbaum, Joseph G. Reiter, Omar Ramadan, Alexander S. Hill, Sean Hashemi, Rebecca T. Brown, Rachel R. Kelz, Lee A. Fleisher, Jeffrey H. Silber
Summary: The conventional definition of multimorbidity, which identifies patients with >= 2 comorbidities, labels almost all older patients as multimorbid, making it less useful. This study developed new medical condition-specific definitions, called Qualifying Comorbidity Sets (QCSs), for acute myocardial infarction (AMI), heart failure (HF), and pneumonia patients, which resulted in fewer patients being labeled as multimorbid but with a higher risk of death compared to the conventional definition.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hidehiro Kaneko, Hidetaka Itoh, Kentaro Kamiya, Kojiro Morita, Tadafumi Sugimoto, Masaaki Konishi, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Hideo Yasunaga, Issei Komuro
Summary: The study suggests a potential benefit of acute-phase initiation of cardiac rehabilitation for short-term clinical outcomes in hospitalized patients with acute heart failure, including lower in-hospital mortality, shorter hospital stay, and decreased incidence of 30-day readmission due to heart failure.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Domenico Scrutinio, Pietro Guida, Laura Adelaide Dalla Vecchia, Ugo Corra, Andrea Passantino
Summary: This study found that older female patients with heart failure undergoing cardiac rehabilitation had better prognosis compared to males. They also showed similar improvement in walking distance. However, females were more likely to achieve functional capacity levels predictive of improved survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Amy Attaway, Annette Bellar, Faty Dieye, Douglas Wajda, Nicole Welch, Srinivasan Dasarathy
Summary: The study revealed that in hospitalized patients with heart failure, older age was associated with a higher prevalence of muscle loss phenotype, leading to worse clinical outcomes for the patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Olivia N. Gilbert, Robert J. Mentz, Alain G. Bertoni, Dalane W. Kitzman, David J. Whellan, Gordon R. Reeves, Pamela W. Duncan, Michael Benjamin Nelson, Vanessa Blumer, Haiying Chen, Shelby D. Reed, Bharathi Upadhya, Christopher M. O'Connor, Amy M. Pastva
Summary: This study found that a 3-month rehabilitation intervention improved physical function and health-related quality of life in both older Black and White patients with acute decompensated heart failure, without significant differences between the two racial groups. However, the association between intervention and reduced all-cause rehospitalizations was stronger in White patients compared to Black patients, suggesting the need for further research.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Tan Van Nguyen, Huyen Thanh Dang, Mason Jenner Burns, Hiep H. H. Dao, Tu Ngoc Nguyen
Summary: The study aimed to investigate the prevalence of impairment of activities of daily living in older patients with heart failure, and found that ADL impairment was common and significantly increased the risk of readmission in this population.
Article
Geriatrics & Gerontology
Takuro Ohtsubo, Masafumi Nozoe, Masashi Kanai, Iori Yasumoto, Katsuhiro Ueno
Summary: Sarcopenia and physical activity were found to be independently associated with functional outcome in rehabilitation older inpatients, with lower levels of physical activity observed in sarcopenia patients compared to those without sarcopenia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mikhail N. Kosiborod, Christiane E. Angermann, Sean P. Collins, John R. Teerlink, Piotr Ponikowski, Jan Biegus, Josep Comin-Colet, Joao Pedro Ferreira, Robert J. Mentz, Michael E. Nassif, Mitchell A. Psotka, Jasper Tromp, Martina Brueckmann, Jonathan P. Blatchford, Afshin Salsali, Adriaan A. Voors
Summary: In patients hospitalized for acute heart failure, empagliflozin improved symptoms, physical limitations, and quality of life, with benefits seen as early as 15 days and maintained through 90 days. The study demonstrated clinical benefit of empagliflozin regardless of baseline symptomatic impairment.
Article
Nutrition & Dietetics
Sophia Neidlein, Rainer Wirth, Maryam Pourhassan
Summary: The study found that iron deficiency is an independent risk factor for fatigue and poor functional recovery among older hospitalized patients. Iron supplementation seems to be capable of improving functional performance.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Robert J. Mentz, David J. Whellan, Gordon R. Reeves, Amy M. Pastva, Pamela Duncan, Bharathi Upadhya, M. Benjamin Nelson, Haiying Chen, Shelby D. Reed, Paul B. Rosenberg, Alain G. Bertoni, Christopher M. O'Connor, Dalane W. Kitzman
Summary: Older patients with heart failure with preserved ejection fraction (HFpEF) had significantly worse impairments at baseline compared to those with heart failure with reduced ejection fraction (HFrEF), and may derive greater benefits from the intervention.
JACC-HEART FAILURE
(2021)
Article
Psychology, Multidisciplinary
Lidia Gazzi, Laura Comini, Simonetta Scalvini, Irene Taccolini, Michele Vitacca
Summary: This study tested the feasibility of telepsychology support for patients with severe cardiorespiratory disease and their caregivers, and explored the relationships between patients' and caregivers' clinical measures. The results showed that telepsychology support was feasible and satisfying, and could improve the quality of life for both patients and caregivers.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Akio Shimizu, Keisuke Maeda, Tatsuro Inoue, Naoharu Mori, Ryo Momosaki
Summary: This study found that early physical rehabilitation intervention can effectively reduce adverse outcomes, including 30-day mortality and readmission rates, in frail older patients with community-acquired pneumonia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Amit Saha, Kershaw Patel, Colby Ayers, Christie M. Ballantyne, Adolfo Correa, Christopher Defilippi, Michael E. Hall, Robert J. Mentz, Stephen L. Seliger, Wondwosen Yimer, Javed Butler, Jarett D. Berry, James A. De Lemos, Ambarish Pandey
Summary: Among Black adults, persistent or worsening levels of cardiac troponin I (hs-cTnI) are associated with an increased risk of heart failure (HF). Participants with incident, stable or improved, or worsened hs-cTnI elevation had higher HF risk compared to those without elevated hs-cTnI.
JOURNAL OF CARDIAC FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Theresa M. Coles, L. Lin, Kevin Weinfurt, Bryce B. Reeve, John A. Spertus, Robert J. Mentz, Ileana L. Pin, Fraser d. Bocell, Michelle e. Tarver, Debra m. Henke, Anindita Saha, Brittany Caldwell, Silver Spring
Summary: Women diagnosed with heart failure report worse quality of life than men on PRO measures. The assumption that women and men interpret quality of life questions the same way is crucial for valid comparison and combining outcomes by subgroups in heart failure. This issue not only affects clinical trials, but also has important implications for addressing health inequities. The validity of PRO measures is key to interpreting differences in heart failure outcomes.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Ambarish Pandey, Dalane W. W. Kitzman, M. Benjamin Nelson, Amy M. M. Pastva, Pamela Duncan, David J. J. Whellan, Robert J. J. Mentz, Haiying Chen, Bharathi Upadhya, Gordon R. R. Reeves
Summary: Frailty is common among older patients with ADHF and is associated with worse QOL and higher risk of clinical events. The REHAB-HF trial showed that a 3-month tailored physical rehabilitation intervention improved physical function and QOL for these patients. This analysis found that patients with worse baseline frailty had a more significant improvement in physical function with the intervention compared to those who were prefrail.
Article
Cardiac & Cardiovascular Systems
Stephen J. Greene, Eric J. Velazquez, Kevin M. Anstrom, Robert A. Clare, Tracy A. DeWald, Mitchell P. Psotka, Andrew R. Ambrosy, Gerin J. Stevens, John Rommel, Tamas Alexy, Fassil Ketema, Dong-Yun Kim, Patrice Desvigne-Nickens, Bertram L. Pitt, Eric J. Eisenstein, Robert Mentz, TRANSFORM-HF Investigators
Summary: The TRANSFORM-HF trial compared the effects of torsemide and furosemide on patient-reported outcomes among patients with heart failure. The study found that there was no significant difference in improving symptoms or quality of life between torsemide and furosemide over a period of 12 months.
Article
Cardiac & Cardiovascular Systems
Anthony E. Peters, Robert M. Clare, Karen Chiswell, G. Michael Felker, Anita Kelsey, Robert Mentz, Adam D. DeVore
Summary: Heart failure guidelines recommend assessment of left ventricular ejection fraction (LVEF) to classify patients. However, LVEF alone may be insufficient to characterize patients with mildly reduced or preserved LVEF. Recommendations on additional testing are lacking, and there are limited data on use of echocardiographic features beyond LVEF in these patients.
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Anthony E. Peters, Angie Wu, Karen Chiswell, Paul Hofmann, Richard Nkulikiyinka, Wilfried Dinh, Jonathan P. Piccini, Robert J. Mentz, Marat Fudim
Summary: Continuous monitoring of heart rate variability (HRV) in 225 patients with cardiac defibrillators or cardiac resynchronization devices showed modest changes over a 2-year period. Low baseline HRV, indicative of low parasympathetic tone and/or increased sympathetic tone, was associated with worse clinical outcomes in terms of all-cause hospitalization. However, changes in HRV observed over a 6-month follow-up period did not predict subsequent outcomes.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ersilia M. Defilippis, Robert J. Mentz, Anuradha Lala
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert J. Mentz, Jonathan H. Ward, Adrian F. Hernandez, Serge Lepage, David A. Morrow, Samiha Sarwat, Kavita Sharma, Scott D. Solomon, Randall C. Starling, Eric J. Velazquez, Kristin Williamson, Shelley Zieroth, Eugene Braunwald
Summary: The PARAGON-HF trial evaluated the effects of Sac/Val compared to Val on clinical outcomes in patients with HFpEF or HFmrEF. The PARAGLIDE-HF trial further investigated the use of Sac/Val in patients with recent worsening HF events and in specific populations not well represented in the PARAGON-HF trial, including those with de novo HF, severe obesity, and Black patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Hiroyuki Tsutsui, Nancy M. Albert, Andrew J. S. Coats, Stefan D. Anker, Antoni Bayes-Genis, Javed Butler, Ovidiu Chioncel, Christopher R. Defilippi, Mark H. Drazner, G. Michael Felker, Gerasimos Filippatos, Mona Fiuzat, Tomomi Ide, James L. Januzzi Jr, Koichiro Kinugawa, Koichiro Kuwahara, Yuya Matsue, Robertj Mentz, Marco Metra, Ambarish Pandey, Giuseppe Rosano, Yoshihiko Saito, Yasushi Sakata, Naoki Sato, Petar M. Seferovic, John Teerlink, Kazuhiro Yamamoto, Michihiro Yoshimura
Summary: Natriuretic peptides, brain (B-type) natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP), are important markers for the diagnosis and risk stratification of heart failure (HF). This article is the result of a collaboration among three heart failure societies and provides a comprehensive perspective on the use of natriuretic peptides in the diagnosis and management of HF.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Arsalan Hamid, Wondwosen K. Yimer, Adebamike A. Oshunbade, Daisuke Kamimura III, Donald Clark, Ervin R. Fox, Yuan- Min, Paul Muntner, Daichi Shimbo, Ambarish Pandey, Amil M. Shah, Robert J. Mentz, Daniel W. Jones, Alain G. Bertoni, John E. Hall, Adolfo Correa, Javed Butler, Michael E. Hall
Summary: This study aimed to assess the independent effects of diabetes and hypertension on left ventricular (LV) remodeling in Black adults. Through a cross-sectional analysis of Black adults, it was found that diabetes was only associated with changes in LV structure and function when accompanied by hypertension. These findings suggest that hypertension is the main contributor to cardiac structural and functional changes in Black adults with diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nursing
Margory A. Molloy, Margaret Bowers, Amy M. Pastva, Jacqueline Vaughn
Summary: This project engaged healthcare students in a creative interprofessional activity to solve a healthcare problem by designing a program to increase awareness of automated external defibrillators device locations on campus. Engaging students in such interdisciplinary projects promotes skills, teamwork, and communication that are essential for their future careers in healthcare.
TEACHING AND LEARNING IN NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Olivia N. Gilbert, Robert J. Mentz, Alain G. Bertoni, Dalane W. Kitzman, David J. Whellan, Gordon R. Reeves, Pamela W. Duncan, Michael Benjamin Nelson, Vanessa Blumer, Haiying Chen, Shelby D. Reed, Bharathi Upadhya, Christopher M. O'Connor, Amy M. Pastva
Summary: This study found that a 3-month rehabilitation intervention improved physical function and health-related quality of life in both older Black and White patients with acute decompensated heart failure, without significant differences between the two racial groups. However, the association between intervention and reduced all-cause rehospitalizations was stronger in White patients compared to Black patients, suggesting the need for further research.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Robert J. Mentz, Veraprapas Kittipibul, Anita Deswal
JACC-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Robert J. Mentz, Stephen A. Brunton, Janani Rangaswami
CARDIOVASCULAR DIABETOLOGY
(2023)