期刊
NEURON
卷 109, 期 9, 页码 1554-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2021.03.003
关键词
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资金
- Della Martin Postdoctoral Fellowship
- Human Frontiers Science Program CrossDisciplinary Postdoctoral Fellowship [LT000637/2016]
- UCLACaltech MSTP [NIGMS T32 GM008042]
- National Institute of Health BRAIN Initiative [U01NS099724]
- T&C Chen Brainmachine Interface Center
- Boswell Foundation
- Heritage Medical Research Institute
This study demonstrates the use of functional ultrasound neuroimaging to detect the neural correlates of movement planning in the brain, providing a critical advancement towards the development of less invasive, high resolution, and scalable neuro-recording and brain interface tools.
New technologies are key to understanding the dynamic activity of neural circuits and systems in the brain. Here, we show that a minimally invasive approach based on ultrasound can be used to detect the neural correlates of movement planning, including directions and effectors. While non-human primates (NHPs) performed memory-guided movements, we used functional ultrasound (fUS) neuroimaging to record changes in cerebral blood volume with 100 mm resolution. We recorded from outside the dura above the posterior parietal cortex, a brain area important for spatial perception, multisensory integration, and movement planning. We then used fUS signals from the delay period before movement to decode the animals' intended direction and effector. Single-trial decoding is a prerequisite to brain-machine interfaces, a key application that could benefit from this technology. These results are a critical step in the development of neuro-recording and brain interface tools that are less invasive, high resolution, and scalable.
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