Article
Geriatrics & Gerontology
Hiroyo Yoshino, Yuanzhe Li, Kenya Nishioka, Kensuke Daida, Arisa Hayashida, Yuta Ishiguro, Daisuke Yamada, Nana Izawa, Katsunori Nishi, Noriko Nishikawa, Genko Oyama, Taku Hatano, Shinichiro Nakamura, Asako Yoritaka, Yumiko Motoi, Manabu Funayama, Nobutaka Hattori
Summary: This study investigated the prevalence and genotype-phenotype correlations of parkin RBR E3 ubiquitin protein ligase (PRKN) variants in Parkinson's disease (PD). The findings revealed that PRKN variants were associated with susceptibility to PD, and some of the variants were novel. Additionally, patients with two-allele had a younger age of onset, were more likely to have normal myocardial scintigraphy results, and showed exacerbation over the course of the disease.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Hirotaka Iwaki, Hampton L. Leonard, Mary B. Makarious, Matt Bookman, Barry Landin, David Vismer, Bradford Casey, J. Raphael Gibbs, Dena G. Hernandez, Cornelis Blauwendraat, Daniel Vitale, Yeajin Song, Dinesh Kumar, Clifton L. Dalgard, Mahdiar Sadeghi, Xianjun Dong, Leonie Misquitta, Sonja W. Scholz, Clemens R. Scherzer, Mike A. Nalls, Shameek Biswas, Andrew B. Singleton
Summary: The study describes the genetic component of the Accelerating Medicines Partnership Parkinson's Disease platform, providing a solution for democratizing data access and analysis for the Parkinson's disease research community.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Chun Yu Li, Ru Wei Ou, Yong Ping Chen, Xiao Jing Gu, Qian Qian Wei, Bei Cao, Ling Yu Zhang, Yan Bing Hou, Kun Cheng Liu, Xue Ping Chen, Wei Song, Bi Zhao, Ying Wu, Yi Liu, Hui Fang Shang
Summary: Functional and genetic studies have identified associations between several Zinc finger (ZNF) proteins and Parkinson's disease (PD). Rare variants in ZNF746 and ZNF219 were significantly associated with early-onset PD (EOPD), indicating a potential genetic link between these ZNF genes and PD. This study provides new insights into the genetic role of ZNFs in EOPD and expands the understanding of mutation spectrum in PD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Sumeet Kumar, Masoom M. Abbas, Shyla T. Govindappa, Uday B. Muthane, Madhuri Behari, Sanjay Pandey, Ramesh C. Juyal, B. K. Thelma
Summary: In this study, two compound heterozygous variants in the WASL gene were found in a familial form of Parkinson's disease, showing potential functional relevance in neurons. The novel findings suggest WASL as a strong candidate gene for autosomal recessive PD and encourage further exploration of its contribution in different populations.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Geriatrics & Gerontology
Xuanxiang Jin, Xiaoli Si, Xiaoguang Lei, Huifang Liu, Anwen Shao, Lingfei Li
Summary: This review discusses the selectivity of vestigial dopaminergic cells in Parkinson's disease for a sub-class of hypersensitive neurons. It describes the constitution of presynaptic vesicle related to dopamine homeostasis and the genetic and environmental evidence of presynaptic dysfunction that increases the risk of Parkinson's disease. Alterations in synaptic vesicular proteins may contribute to the vulnerability of certain dopamine neurons to neurodegenerative changes.
Article
Neurosciences
Marco Toffoli, Harneek Chohan, Stephen Mullin, Aaron Jesuthasan, Selen Yalkic, Sofia Koletsi, Elisa Menozzi, Soraya Rahall, Naomi Limbachiya, Nadine Loefflad, Abigail Higgins, Jonathan Bestwick, Sara Lucas-Del-Pozo, Federico Fierli, Audrey Farbos, Roxana Mezabrovschi, Chiao Lee-Yin, Anette Schrag, David Moreno-Martinez, Derralynn Hughes, Alastair Noyce, Kevin Colclough, Aaron R. Jeffries, Christos Proukakis, Anthony H. V. Schapira
Summary: This study compared the motor and non-motor phenotypes of GBA1 carriers and non-carriers. The results showed that GBA1-positive PD patients had worse performance in visual cognitive tasks and olfaction compared to GBA1-negative PD patients. However, the study did not replicate previous findings of more frequent prodromal PD signs in non-affected GBA1 carriers.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jun Ogata, Kentaro Hirao, Kenya Nishioka, Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Soichiro Shimizu, Nobutaka Hattori, Yuzuru Imai
Summary: A novel LRRK2 variant-p.G2294R located in the WD40 domain was detected in a patient with familial Parkinson's disease through targeted gene-panel screening. This variant was found to be highly destabilized at the protein level. Experimental results showed upregulated expression of the LRRK2 p.G2294R protein in the patient's peripheral blood lymphocytes, while macrophages differentiated from the same blood sample exhibited decreased levels of LRRK2 protein. Additionally, reduced phagocytic activity was observed in pathogenic yeasts and alpha-synuclein fibrils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Maria Teresa Perinan, Pilar Gomez-Garre, Cornelis Blauwendraat, Pablo Mir, Sara Bandres-Ciga
Summary: Genetic variation within the mitochondrial pathway is considered to contribute to the risk of Parkinson's disease, with recent studies investigating the association between the RHOT1 and RHOT2 genes and PD etiology. However, analyses using large-scale genotyping and whole-genome sequencing data did not find evidence to support a role for RHOT1 and RHOT2 as disease-causing or modifying genes for PD risk or age at onset.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Manuela M. X. Tan, Michael A. Lawton, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Miriam Pollard, Leon Hubbard, Naveed Malek, Katherine A. Grosset, Sarah L. Marrinan, Nin Bajaj, Roger A. Barker, David J. Burn, Catherine Bresner, Thomas Foltynie, Nicholas W. Wood, Caroline H. Williams-Gray, John Hardy, Michael A. Nalls, Andrew B. Singleton, Nigel M. Williams, Yoav Ben-Shlomo, Michele T. M. Hu, Donald G. Grosset, Maryam Shoai, Huw R. Morris
Summary: The study found that genetic variants associated with Parkinson's disease risk are not linked to disease progression. The APOE epsilon 4 tagging variant was significantly associated with cognitive progression, while ATP8B2 gene showed a nominal association with motor progression. The new method shows promise in improving the measurement of symptom progression in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Elif Irem Sarihan, Eduardo Perez-Palma, Lisa-Marie Niestroj, Douglas Loesch, Miguel Inca-Martinez, Andrea R. V. R. Horimoto, Mario Cornejo-Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison Sarapura-Castro, Andrea Rivera-Valdivia, Elena Dieguez, Victor Raggio, Andres Lescano, Vitor Tumas, Vanderci Borges, Henrique B. Ferraz, Carlos R. Rieder, Artur F. Schumacher-Schuh, Bruno L. Santos-Lobato, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio, Francisco Lopera, Sonia Moreno, Pedro Chana-Cuevas, William Fernandez, Gonzalo Arboleda, Humberto Arboleda, Carlos E. Arboleda-Bustos, Dora Yearout, Cyrus P. Zabetian, Timothy A. Thornton, Timothy D. O'Connor, Dennis Lal, Ignacio F. Mata
Summary: Parkinson's disease patients from Latino descent show enrichment of copy number variants affecting known Parkinson's disease genes, with PRKN showing the strongest association. Additionally, 5.6% of early-onset patients carried a copy number variant on PRKN. This study provides insights into the genetic complexity of Parkinson's disease in this understudied population.
MOVEMENT DISORDERS
(2021)
Review
Cell Biology
Julie Lake, Catherine S. Storm, Mary B. Makarious, Sara Bandres-Ciga
Summary: Neurodegenerative diseases are complex and heterogeneous, making the discovery and validation of biomarkers challenging. Efforts to find genetic and transcriptomic indicators for disease diagnosis and treatment direction are ongoing and important. The next generation of biomarker studies show promise in implementing multi-modal approaches for large scale datasets, but require an open science framework for success.
Article
Cell Biology
Yu-Chien Hung, Kuan-Lin Huang, Po-Lin Chen, Jeng-Lin Li, Serena Huei-An Lu, Jui-Chih Chang, Han-Yi Lin, Wen-Chun Lo, Shu-Yi Huang, Tai-Ting Lee, Tai-Yi Lin, Yuzuru Imai, Nobutaka Hattori, Chin-San Liu, Su-Yi Tsai, Chun-Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan
Summary: Human ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) plays a role in regulating cyt-c-induced apoptosis, as demonstrated by the fruit fly model. Knockdown of UQCRC1 in neurons leads to Parkinson's disease-like symptoms, which can be rescued by UQCRC1 expression. This study provides new insights into the pathogenic mechanisms of familial parkinsonism associated with UQCRC1 mutations.
Article
Biochemistry & Molecular Biology
Rosie Bell, Rebecca J. Thrush, Marta Castellana-Cruz, Marc Oeller, Roxine Staats, Aishwarya Nene, Patrick Flagmeier, Catherine K. Xu, Sandeep Satapathy, Celine Galvagnion, Mark R. Wilson, Christopher M. Dobson, Janet R. Kumita, Michele Vendruscolo
Summary: The N-terminal acetylation of alpha-synuclein alters its aggregation behavior, reducing its rate of aggregation and affecting the structural properties of its fibrillar aggregates.
Review
Geriatrics & Gerontology
Tingting Du, Le Wang, Weijin Liu, Guanyu Zhu, Yingchuan Chen, Jianguo Zhang
Summary: Parkinson's disease is a progressive neurodegenerative disorder with specific neuropathology and early symptoms. Early diagnosis and monitoring disease progression are crucial for patient outcomes. Understanding biomarkers for PD can help guide clinical applications.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Sophia R. L. Vieira, Anthony H. V. Schapira
Summary: The discovery of GBA1 mutations as the greatest genetic risk factor for Parkinson's disease has led to a paradigm shift in research. GBA1-associated Parkinson's disease exhibits subtle differences in phenotype compared to idiopathic cases, and targeted therapies for GBA1 are being developed and investigated.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Review
Clinical Neurology
Maria Teresa Perinan, Kajsa Brolin, Sara Bandres-Ciga, Cornelis Blauwendraat, Christine Klein, Ziv Gan-Or, Andrew Singleton, Pilar Gomez-Garre, Maria Swanberg, Pablo Mir, Alastair Noyce
Summary: Parkinson's disease is a complex neurodegenerative condition caused by interactions between genetic and environmental factors. This article provides insights into the environmental modifiers of Parkinson's disease, discusses precedents from other neurological conditions, outlines genetic and environmental factors contributing to the disease, and reviews potential environmental modifiers affecting its severity.
ANNALS OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Kimberley J. Billingsley, Pilar Alvarez Jerez, Francis P. Grenn, Sara Bandres-Ciga, Laksh Malik, Dena Hernandez, Ali Torkamani, Mina Ryten, John Hardy, Sonja W. Scholz, Bryan J. Traynor, Clifton L. Dalgard, Debra J. Ehrlich, Toshiko Tanaka, Luigi Ferrucci, Thomas G. Beach, Geidy E. Serrano, Jinhui Ding, J. Raphael Gibbs, Cornelis Blauwendraat, Andrew B. Singleton
MOVEMENT DISORDERS
(2022)
Editorial Material
Clinical Neurology
Bashayer Al-Mubarak, Mohamed Ahmed Nour, Artur Schumacher-Schuh, Sara Bandres-Ciga
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Konstantin Senkevich, Cornelia E. Zorca, Aliza Dworkind, Uladzislau Rudakou, Emma Somerville, Eric Yu, Alexey Ermolaev, Daria Nikanorova, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Da Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupre, Lior Greenbaum, Sharon Hassin-Baer, Francis P. Grenn, Ming Sum Ruby Chiang, S. Pablo Sardi, Benoit Vanderperre, Cornelis Blauwendraat, Jean-Francois Trempe, Edward A. Fon, Thomas M. Durcan, Roy N. Alcalay, Ziv Gan-Or
Summary: Senkevich et al. provide evidence that GALC is the gene associated with Parkinson's disease at the chromosome 14 locus and suggest that the association of variants at the GALC locus may be driven by their effect of increasing galactosylceramidase expression and activity. The study highlights the role of lysosome in Parkinson's disease pathogenesis.
Article
Clinical Neurology
Bernabe Bustos, Kimberley Billingsley, Cornelis Blauwendraat, J. Raphael Gibbs, Ziv Gan-Or, Dimitri Krainc, Andrew B. Singleton, Steven J. Lubbe
Summary: Bustos et al. conducted the first genome-wide meta-analysis of common short tandem repeats (STRs) in Parkinson's disease and identified four new independent risk factors. They found that STRs contribute to the heritability of Parkinson's disease and that STR-associated genes are enriched in Parkinson's disease-relevant tissues and pathways.
Article
Clinical Neurology
Sitki Cem Parlar, Francis P. P. Grenn, Jonggeol Jeffrey Kim, Cornelis Baluwendraat, Ziv Gan-Or
Summary: This review aims to generate and share a comprehensive database for GBA1 variants reported in Parkinson's disease (PD) to support future research and clinical trials. A total of 371 GBA1 variants in PD were found and a browser containing up-to-date information on these variants was created. The classification and browser presented in this work will inform and support basic, translational, and clinical research on GBA1-PD.
MOVEMENT DISORDERS
(2023)
Article
Biochemical Research Methods
Jordi Martorell-Marugan, Marco Chierici, Sara Bandres-Ciga, Giuseppe Jurman, Pedro Carmona-Saez
Summary: This study aims to conduct a comprehensive systematic review of studies applying machine learning to Parkinson's disease data. It summarizes the main advances in using machine learning methodologies for Parkinson's disease research and highlights the increasing interest in this area within the research community.
CURRENT BIOINFORMATICS
(2023)
Article
Clinical Neurology
Konstantin Senkevich, Paria Alipour, Ekaterina Chernyavskaya, Eric Yu, Alastair J. Noyce, Ziv Gan-Or
Summary: This study used genetic and epidemiological methods and found a potential genetic link between type 1 diabetes (T1D) and Parkinson's disease (PD), suggesting a potentially protective role of T1D in PD risk and progression.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Yuri L. Sosero, Ziv Gan-Or
Summary: LRRK2 variants are associated with both familial and sporadic PD. LRRK2-PD presents with benign clinical features and variable pathology, including inconsistent presence of Lewy bodies and significant Alzheimer's disease pathology. The mechanisms of LRRK2-PD are still unclear, but inflammation, vesicle trafficking, lysosomal homeostasis, and ciliogenesis have been suggested. Understanding the role and function of LRRK2 in PD is important as novel therapies targeting LRRK2 are being developed.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Pilar Alvarez Jerez, Jose Luis Alcantud, Lucia de los Reyes-Ramirez, Anni Moore, Clara Ruz, Francisco Vives Montero, Noela Rodriguez-Losada, Prabhjyot Saini, Ziv Gan-Or, Chelsea X. Alvarado, Mary B. Makarious, Kimberley J. Billingsley, Cornelis Blauwendraat, Alastair J. Noyce, Andrew B. Singleton, Raquel Duran, Sara Bandres-Ciga
Summary: This study aimed to explore the genetic and genomic connection between neurodegeneration with brain iron accumulation (NBIA) and Parkinson's Disease (PD). Screening for known and rare pathogenic mutations in genes linked to NBIA in PD cases and controls, four NBIA variants were associated with PD risk. However, no enrichment of heterozygous variants in NBIA-related genes risk was identified in PD cases versus controls. Overall, the study suggests that NBIA and PD may be separate molecular entities.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Hampton L. Leonard, Ruqaya Murtadha, Alejandro Martinez-Carrasco, Alina Jama, Amica Corda Mueller-Nedebock, Ana-Luisa Gil-Martinez, Anastasia Illarionova, Anni Moore, Bernabe I. Bustos, Bharati Jadhav, Brook Huxford, Catherine Storm, Clodagh Towns, Dan Vitale, Devina Chetty, Eric Yu, Francis P. Grenn, Gabriela Salazar, Geoffrey Rateau, Hirotaka Iwaki, Inas Elsayed, Isabelle Francesca Foote, Zune Jansen van Rensburg, Jonggeol Jeff Kim, Jie Yuan, Julie Lake, Kajsa Brolin, Konstantin Senkevich, Lesley Wu, Manuela M. X. Tan, Maria Teresa Perinan, Mary B. Makarious, Michael Ta, Nikita Simone Pillay, Oswaldo Lorenzo Betancor, Paula R. Reyes-Perez, Pilar Alvarez Jerez, Prabhjyot Saini, Rami al-Ouran, Ramiya Sivakumar, Raquel Real, Regina H. Reynolds, Ruifneg Hu, Shameemah Abrahams, Shilpa C. Rao, Tarek Antar, Thiago Peixoto Leal, Vassilena Iankova, William J. Scotton, Yeajin Song, Andrew Singleton, Mike A. Nalls, Sumit Dey, Sara Bandres-Ciga, Cornelis Blauwendraat, Alastair J. Noyce
Summary: Open science and collaboration are essential for Parkinson's disease (PD) research progress. Hackathons bring together people with diverse skills and backgrounds to generate resources and creative solutions. A virtual 3-day hackathon was organized, involving 49 early-career scientists from 12 countries who built PD-focused tools and pipelines. The goal was to provide scientists with access to necessary code and tools, accelerating their research. Hackathons inspire creative thinking, supplement data science training, and foster collaboration, benefiting early-career researchers. The generated resources can accelerate PD genetics research.
NPJ PARKINSONS DISEASE
(2023)
Letter
Clinical Neurology
Miriam Ostrozovicova, Yasser Mecheri, Bashayer R. Al-Mubarak, Nada Al-Tassan, Mary B. Makarious, Maria Teresa Perinan, Sara Bandres-Ciga
Article
Clinical Neurology
Thiago P. Leal, Shilpa C. Rao, Jennifer N. French-Kwawu, Mateus H. Gouveia, Victor Borda, Sara Bandres-Ciga, Miguel Inca-Martinez, Emily A. Mason, Andrea R. V. R. Horimoto, Douglas P. Loesch, Elif Sarihan, Mario R. Cornejo-Olivas, Luis Torres, Pilar E. Mazzetti-Soler, Carlos Cosentino, Elison H. Sarapura-Castro, Andrea Rivera-Valdivia, Angel C. Medina, Elena M. Dieguez, Victor E. Raggio, Andres Lescano, Vitor Tumas, Vanderci Borges, Henrique B. Ferraz, Carlos R. Rieder, Artur Schumacher Schuh, Bruno L. Santos-Lobato, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio, Francisco Lopera, Sonia Moreno, Pedro Chana-Cuevas, William Fernandez, Gonzalo Arboleda, Humberto Arboleda, Carlos Arboleda E. Bustos, Dora Yearout, Maria F. Lima-Costa, Eduardo Tarazona-Santos, Cyrus P. Zabetian, Timothy A. Thornton, Timothy D. O'Connor, Ignacio F. Mata
Summary: This study conducted the first X-chromosome-wide association study for PD risk in a Latin American cohort, identifying eight linkage disequilibrium regions associated with PD. One of these regions (rs5525496) is associated with multiple expression quantitative trait loci in brain and non-brain tissues, but colocalization analysis suggests that it may not mediate risk through the expression of these genes. The study also replicated a previous finding from an X-chromosome-wide association study, showing an association between rs28602900 and PD in non-European populations.
MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
