Article
Cardiac & Cardiovascular Systems
Jianqiu Pei, Lin Cai, Fang Wang, Chuansheng Xu, Shengqiang Pei, Hongwei Guo, Xiaogang Sun, Jerold Chun, Xiangfeng Cong, Weiquan Zhu, Zhe Zheng, Xi Chen
Summary: This study found that the level of lysophosphatidic acid (LPA) was increased in the peripheral blood of mice after myocardial infarction (MI), and the expression of its receptor LPA(2) was also increased in the heart. Deficiency of Lpar2 led to impaired heart function, increased scar size, and reduced vascular density. Mechanistic studies demonstrated that LPA-LPA(2) signaling promoted angiogenesis and maintained vascular homeostasis through multiple signaling pathways.
CIRCULATION RESEARCH
(2022)
Review
Chemistry, Medicinal
Zohreh Varasteh, Wolfgang A. Weber, Christoph Rischpler
Summary: Molecular imaging technologies play a vital role in the detection and treatment of cardiovascular disease, providing unique insights into pathobiological processes and enabling personalized therapy.
Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Naomi M. Hamburg, Mark A. Creager
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
Article
Cell Biology
Anais Moyon, Philippe Garrigue, Samantha Fernandez, Fabien Hubert, Laure Balasse, Pauline Brige, Guillaume Hache, Vincent Nail, Marcel Blot-Chabaud, Francoise Dignat-George, Francesca Rochais, Benjamin Guillet
Summary: The study found that Ga-68-sCD146 PET imaging showed higher AMOT expression after myocardial infarction, with significant correlations with heart perfusion, tissue fibrosis, and functional recovery.
Review
Cardiac & Cardiovascular Systems
Cristiano Spadaccio, Antonio Nenna, David Rose, Francesco Piccirillo, Annunziata Nusca, Francesco Grigioni, Massimo Chello, Gus J. Vlahakes
Summary: This review analyzes the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both coronary artery disease (CAD) and coronary revascularization, aiming to better understand their significance in the clinical arena and potential therapeutic use.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dong Im Cho, Min Joo Ahn, Hyang Hee Cho, Meeyoung Cho, Ju Hee Jun, Bo Gyeong Kang, Soo Yeon Lim, Soo Ji Yoo, Mi Ra Kim, Hyung-Seok Kim, Su-Jin Lee, Le Thanh Dat, Changho Lee, Yong Sook Kim, Youngkeun Ahn
Summary: Atherosclerosis is a vascular disease caused by chronic inflammation, and it is the leading cause of death. The protein ANGPTL4 has been shown to promote cardiac repair by suppressing pathological inflammation. In this study, it was found that ANGPTL4 protein can reduce the size of atherosclerotic plaques, decrease vascular inflammation, and improve plaque stability. This research provides a novel therapeutic strategy for preventing and treating atherosclerosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Barry R. Palmer, Melinda A. Paterson, Chris M. Frampton, Anna P. Pilbrow, Lorraine Skelton, Chris J. Pemberton, Robert N. Doughty, Chris J. Ellis, Richard W. Troughton, A. Mark Richards, Vicky A. Cameron
Summary: The study highlights the prognostic value of vascular endothelial growth factor (VEGF) as a biomarker in patients with coronary heart disease, and suggests that genetic variants in the VEGF-A gene may influence the formation of collateral circulation. The findings also indicate a close relationship between VEGF-A levels and factors such as patient baseline heart rate and collateral vessel perfusion.
Article
Cardiac & Cardiovascular Systems
Ofer Kobo, Tahmeed Contractor, Mohamed O. Mohamed, Purvi Parwani, Timir K. Paul, Raktim K. Ghosh, M. Chadi Alraes, Brijesh Patel, Mohammed Osman, Josef Ludwig, Ariel Roguin, Mamas A. Mamas
Summary: Patients with pre-existing vascular disease have worse outcomes after acute myocardial infarction (AMI), with an incremental increase in adverse outcomes as the number of diseased vascular beds increases, and differences in outcomes and utilization of invasive procedures based on sub-types of sites involved.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Chuiyu Kong, Dayin Lyu, Chang He, Rui Li, Qiulun Lu
Summary: Studies have shown that Dioscin significantly improves cardiac function in mouse models of myocardial infarction, reduces cardiac fibrosis and apoptosis, and promotes angiogenesis. Mechanistically, Dioscin enhances the proliferation and migration of hypoxic endothelial cells by up-regulating lncRNA MANTIS, leading to the induction of angiogenesis-related genes. This provides new insights into the cardioprotective effects of Dioscin and its impact on endothelial cell angiogenic activity.
Article
Neurosciences
James Hyun, Monica Lee, Jalees Rehman, Kostandin Pajcini, Asrar B. Malik
Summary: This study focused on investigating the potential pathways of Notch signalling in mediating vascular regeneration in mouse models. The researchers found that Notch signalling plays a crucial role in promoting well-ordered vascular regeneration through the downstream generation of guidance peptides such as SEM3g.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
James Hyun, Monica Lee, Jalees Rehman, Kostandin V. Pajcini, Asrar B. Malik
Summary: We genetically and functionally studied the potential pathways of Notch signalling in mediating vascular regeneration in mouse models. Our findings demonstrate the central role of Notch signalling in vascular endothelial cells and the involvement of SEMA3G as a downstream guidance factor in the reperfusion process mediated by Notch.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Article
Medicine, General & Internal
Florian Simon, Mansur Duran, Waseem Garabet, Hubert Schelzig, Michael Jacobs, Alexander Gombert
Summary: A decade ago, gene therapy was seen as a potential treatment for chronic limb-threatening ischemia, but its safety and clinical feasibility are still in question. Gene therapy can be achieved through transduction and transfection methods, but there are risks involved, such as increased neo-vascularization in undesired tissue, malignant transformation and inflammation, and arterial thrombosis. Clinical trials of gene therapy in vascular occlusive disease have shown mixed results, leaving the role of gene therapy unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Shasha Duan, Chao Wang, Xiangli Xu, Xiaoshan Zhang, Gaofeng Su, You Li, Shuai Fu, Ping Sun, Jiawei Tian
Summary: In this study, we investigated the effect of exosomes extracted from the peripheral serum of patients with acute myocardial infarction (AMI) on angiogenesis and identified the downstream pathways. Our findings suggest that these exosomes promote angiogenesis through the miR-126-3p/TSC1/mTORC1/ HIF-1 alpha signaling pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Environmental
Shu-yi He, Lin-yu Long, Zhi-cun Wang, Wen-qi Liu, Wen Zhang, Cheng Hu, Xiao-feng Wu, Ruiqi Dong, Hong-song Fan, Qing Jiang, Ying-ying Tong, Guang-hua Yang, Li Yang, Yun-bing Wang
Summary: In this study, an injectable self-doping conductive hydrogel was developed for delivering human umbilical cord mesenchymal stem cell secretome to protect cardiac function after myocardial infarction. The conductive hydrogel showed good biocompatibility and conductivity consistent with the natural myocardium, and the secretome was able to promote cell proliferation, migration, and angiogenesis. In a rat MI model, hydrogel injection improved ejection fraction and fraction shortening, and decreased susceptibility to arrhythmia.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Vanessa Nadig, Ken Herrmann, Felix M. Mottaghy, Volkmar Schulz
Summary: This study summarizes the current status and future developments of total-body PET/CT scanners, with three human TB PET/CT systems developed and increasing system sensitivity paving the way for new imaging methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Karl-Josefi Langen, Felix M. Mottaghy
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Bell, Martin Lemos, Felix M. Mottaghy, Oliver Lindner, Alexander Heinzel
Summary: The aim of this study was to evaluate the transfer of an interactive nuclear cardiology teaching module to an online, distance learning setting. The results showed that the teaching module was successfully transferred during the pandemic, but it was perceived to be less efficient in its course didactics, demands and applicability compared to classroom teaching.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ellen Boswijk, Marlies de Ligt, Marie-Fleur J. Habets, Alma M. A. Mingels, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Patrick Schrauwen, Joachim E. Wildberger, Jan Bucerius
Summary: Resveratrol treatment did not significantly attenuate arterial or systemic inflammation as measured by (18) F-FDG PET in subjects at risk of developing type 2 diabetes, although there was a slight increase in (18) F-FDG uptake in visceral adipose tissue. CRP levels were also not significantly affected by resveratrol treatment. Further validation in larger human studies is required.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Oncology
Ramya Ambur Sankaranarayanan, Jennifer Peil, Andreas T. J. Vogg, Carsten Bolm, Steven Terhorst, Arno Classen, Matthias Bauwens, Jochen Maurer, Felix Mottaghy, Agnieszka Morgenroth
Summary: This study presents a promising radiotherapeutic agent for triple negative breast cancer (TNBC) that efficiently induces DNA damage and has therapeutic effects regardless of BRCA mutation status. When combined with chemotherapy, the therapeutic efficacy is further enhanced.
Article
Chemistry, Multidisciplinary
Prachi Desai, Rahul Rimal, Alexandru Florea, Rustam A. Gumerov, Marta Santi, Anastasia S. Sorokina, Sabri E. M. Sahnoun, Thorsten Fischer, Felix M. Mottaghy, Agnieszka Morgenroth, Ahmed Mourran, Igor I. Potemkin, Martin Moeller, Smriti Singh
Summary: This study demonstrates that by tuning the mechanical properties of nanogels, significant enhancement in their circulation time can be achieved, leading to improved radiation damage to tumor cells. The results show that small changes in the mechanical properties of nanogels influence their fate inside cells, which is confirmed by PET/CT and computer simulations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Betul Altunay, Agnieszka Morgenroth, Felix M. Mottaghy
Summary: Breast cancer is a common and fatal cancer in women worldwide. Noninvasive molecular imaging techniques for hormone receptors have the potential to improve breast cancer diagnosis as an adjunct to conventional imaging, enhancing patient selection and treatment strategies.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Prachi Desai, Rahul Rimal, Sabri E. M. Sahnoun, Felix M. Mottaghy, Martin Moller, Agnieszka Morgenroth, Smriti Singh
Summary: Endogenous targeted radiotherapy has side effects, and the use of nanocarriers can mitigate these effects. Nanocarriers have advantages of prolonging circulation time, increasing tumor retention, and offering multifunctionality for targeting strategies.
Article
Geriatrics & Gerontology
Karin J. C. Sanders, Roel Wierts, Wouter D. Marken Lichtenbelt, Judith Vos-Geelen, Guy Plasqui, Marco C. J. M. Kelders, Vera B. Schrauwen-Hinderling, Jan Bucerius, Anne-Marie C. Dingemans, Felix M. Mottaghy, Annemie M. W. J. Schols
Summary: There is no correlation between basal metabolic rate (BMR), total daily energy expenditure (TDEE), and brown adipose tissue (BAT) activity in patients with chronic obstructive pulmonary disease (COPD). Additionally, BAT activity and gene expression levels of brown adipocyte or beige markers are comparable between COPD patients and controls.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Oncology
Marguerite Mueller, Oliver Winz, Robin Gutsche, Ralph T. H. Leijenaar, Martin Kocher, Christoph Lerche, Christian P. Filss, Gabriele Stoffels, Eike Steidl, Elke Hattingen, Joachim P. Steinbach, Gabriele D. Maurer, Alexander Heinzel, Norbert Galldiks, Felix M. Mottaghy, Karl-Josef Langen, Philipp Lohmann
Summary: This study investigated the potential of radiomics applied to static clinical PET data in differentiating treatment-related changes (TRC) from tumor progression (TP) in patients with gliomas. The results showed that static FET PET scans can be used with high accuracy to differentiate TRC and TP in gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Ahmed Allam Mohamed, Kathrin Risse, Jennifer Stock, Alexander Heinzel, Felix M. Mottaghy, Philipp Bruners, Michael J. Eble
Summary: Obesity and high visceral-to-subcutaneous fat ratio are significantly associated with worsened survival outcomes in patients with anal cancer, highlighting the importance of addressing obesity as a potential factor influencing treatment effectiveness.
Review
Medicine, General & Internal
Prodromos Gavriilidis, Michel Koole, Salvatore Annunziata, Felix M. Mottaghy, Roel Wierts
Summary: This literature review discusses the impact of positron range correction and denoising techniques on the image quality of Ga-68 PET. The results show that these techniques can improve image quality and achieve comparable results to F-18 PET in some cases. However, further validation in clinical studies is needed.
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Article
Cell Biology
Amelie Heesch, Lars Ortmanns, Jochen Maurer, Elmar Stickeler, Sabri E. M. Sahnoun, Felix M. Mottaghy, Agnieszka Morgenroth
Summary: Recent studies have shown that PSMA expression on TNBC cells and adjacent endothelial cells may serve as a new target for therapy. This study analyzed the expression of PSMA and its isoforms in TNBC cells, BCSCs, and tumor-associated endothelial cells. The results demonstrated that PSMA was highly expressed in TNBC cell lines and its isoforms were predominantly found in BCSCs. In addition, tumor-conditioned media had a significant pro-angiogenic effect and all TNBC cell lines induced PSMA expression in HUVEC. These findings suggest the potential of PSMA-targeted therapy in TNBC.
Review
Oncology
Karl-Josef Langen, Norbert Galldiks, Joerg Mauler, Martin Kocher, Christian Peter Filss, Gabriele Stoffels, Claudia Regio Brambilla, Carina Stegmayr, Antje Willuweit, Wieland Alexander Worthoff, Nadim Jon Shah, Christoph Lerche, Felix Manuel Mottaghy, Philipp Lohmann
Summary: Advanced MRI methods and PET using radiolabelled amino acids provide valuable additional information for brain tumour diagnostics. While the hybrid PET/MRI has allowed for the convergence of these methods, simultaneous imaging has limited relevance in clinical neuro-oncology. A multimodal approach that combines PET and MRI shows promising improvement in the diagnosis of cerebral gliomas.