Synthesis and pre-clinical evaluation of a new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer by PET imaging

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Comprehensive Quality Control of the ITG 68Ge/68Ga Generator and Synthesis of 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC for Clinical Imaging

(2016) A. Amor-Coarasa et al.   JOURNAL OF NUCLEAR MEDICINE

Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent

(2016) Kristell L.S. Chatalic et al.   Theranostics

Design of Internalizing PSMA-specific Glu-ureido-based Radiotherapeuticals

(2016) Till Wüstemann et al.   Theranostics

Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models

(2016) Vincent Bouvet et al.   EJNMMI Research

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

(2015) Rainer Wilcken et al.   ACS Chemical Biology

Seyferth-Gilbert Homologation as a Route to18F-Labeled Building Blocks: Preparation of Radiofluor­inated Phenylacetylenes and Their Application in PET Chemistry

(2015) Philipp Krapf et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II

(2015) Jan Tykvart et al.   JOURNAL OF MEDICINAL CHEMISTRY

18F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer

(2015) S. P. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer

(2015) M. Bene ova et al.   JOURNAL OF NUCLEAR MEDICINE

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Comparison of [18F]DCFPyL and [68Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer

(2015) Markus Dietlein et al.   MOLECULAR IMAGING AND BIOLOGY

Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer

(2015) Zsolt Szabo et al.   MOLECULAR IMAGING AND BIOLOGY

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of [11C]palmitic acid for PET imaging using a single molecular sieve 13X cartridge for reagent trapping, radiolabeling and selective purification

(2015) Alejandro Amor-Coarasa et al.   NUCLEAR MEDICINE AND BIOLOGY

PSMA Ligands for Radionuclide Imaging and Therapy of Prostate Cancer: Clinical Status

(2015) Susanne Lütje et al.   Theranostics

Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery

(2014) Jan Tykvart et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Radiation dosimetry and first therapy results with a 124I/131I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy

(2014) Christian M. Zechmann et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer

(2014) Ali Afshar-Oromieh et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

One-Pot Multi-Tracer Synthesis of Novel 18F-Labeled PET Imaging Agents

(2014) Anna Haslop et al.   MOLECULAR PHARMACEUTICS

99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen for Molecular Imaging of Prostate Cancer

(2013) S. M. Hillier et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of Gallium-68 and Fluorine-18 imaging characteristics in positron emission tomography

(2012) Alejandro Sanchez-Crespo   APPLIED RADIATION AND ISOTOPES

Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-DCFBC, a Low-Molecular-Weight Inhibitor of Prostate-Specific Membrane Antigen, in Patients with Metastatic Prostate Cancer

(2012) S. Y. Cho et al.   JOURNAL OF NUCLEAR MEDICINE

Highly efficient click labeling using 2-[18F]fluoroethyl azide and synthesis of an 18FN-hydroxysuccinimide ester as conjugation agent

(2012) Dong Zhou et al.   NUCLEAR MEDICINE AND BIOLOGY

2-(3- -Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer

(2011) Y. Chen et al.   CLINICAL CANCER RESEARCH

Applications of Click Chemistry in Radiopharmaceutical Development

(2010) Joseph C. Walsh et al.   CHIMIA

A fully automated two-step synthesis of an 18F-labelled tyrosine kinase inhibitor for EGFR kinase activity imaging in tumors

(2009) D. Kobus et al.   APPLIED RADIATION AND ISOTOPES

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Preclinical Evaluation of Novel Glutamate-Urea-Lysine Analogues That Target Prostate-Specific Membrane Antigen as Molecular Imaging Pharmaceuticals for Prostate Cancer

(2009) S. M. Hillier et al.   CANCER RESEARCH

‘Click labelling’ in PET radiochemistry

(2009) Matthias Glaser et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

PET versus SPECT: strengths, limitations and challenges

(2009) Arman Rahmim et al.   NUCLEAR MEDICINE COMMUNICATIONS

Positron Emission Tomography/Computed Tomography: The Current  Technology and Applications

(2009) Erik Mittra et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[18F]Fluorobenzyl-L-Cysteine, [18F]DCFBC: A New Imaging Probe for Prostate Cancer

(2008) R. C. Mease et al.   CLINICAL CANCER RESEARCH

Planar and SPECT imaging in the era of PET and PET–CT: can it survive the test of time?

(2008) Abass Alavi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization†

(2008) Cyril Barinka et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of Halogenated Heterodimeric Inhibitors of Prostate Specific Membrane Antigen (PSMA) as Radiolabeled Probes for Targeting Prostate Cancer

(2008) K. P. Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY