Article
Biochemistry & Molecular Biology
Katherine W. Scangos, Ghassan S. Makhoul, Leo P. Sugrue, Edward F. Chang, Andrew D. Krystal
Summary: Deep brain stimulation shows promise in treating severe depression, but questions about anatomical targeting remain. A study implanting intracranial electrodes in a depressed patient found rapid, reproducible emotional responses that were context and state dependent, providing proof of concept for personalized, circuit-specific medicine in psychiatry.
Review
Psychology, Clinical
Chunliang Feng, Wenhao Huang, Kangli Xu, Julia A. Camilleri, Xiaofeng Yang, Ping Wei, Ruolei Gu, Wenbo Luo, Simon B. Eickhoff, Jennifer L. Stewart
Summary: Motivational dysfunction is a fundamental dimension of psychopathology. This study identifies shared neural alterations related to transdiagnostic motivational deficits, with the ventral striatum playing a key role.
CLINICAL PSYCHOLOGY REVIEW
(2022)
Article
Neurosciences
Madelyn H. Ray, Mahsa Moaddab, Michael A. McDannald
Summary: Appropriate responding to threat and reward is crucial for survival. The nucleus accumbens core (NAcc) plays a significant role in supporting reward behavior and fully discriminating threat and safety cues. The study found that NAcc neurons showed the greatest firing change to danger and uncertainty cues, and there were distinct functional populations within the NAcc that signaled threat and bidirectional valence.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Daniela Jardim Pereira, Alexandre Sayal, Joao Pereira, Sofia Morais, Antonio Macedo, Bruno Direito, Miguel Castelo-Branco
Summary: This study tested the ability to regulate the dorsolateral prefrontal cortex (DLPFC) and explored how feedback contributes to better performance in a single session. The study found that the active group, who received feedback, showed higher and more sustained activity in the target area. Additionally, they also found increased activity in the nucleus accumbens in the active group. This study reinforces the importance of DLPFC as a target for neurofeedback clinical applications and highlights the critical influence of the ventral striatum.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Sameer A. Sheth, Kelly R. Bijanki, Brian Metzger, Anusha Allawala, Victoria Pirtle, Joshua A. Adkinson, John Myers, Raissa K. Mathura, Denise Oswalt, Evangelia Tsolaki, Jiayang Xiao, Angela Noecker, Adriana M. Strutt, Jeffrey F. Cohn, Cameron C. McIntyre, Sanjay J. Mathew, David Borton, Wayne Goodman, Nader Pouratian
Summary: The success of deep brain stimulation (DBS) in treating Parkinson's disease has led to its application in other disorders, including treatment-resistant depression. However, the inconsistent results of DBS for treatment-resistant depression can be attributed to a lack of understanding of the brain networks regulating mood, especially on an individual level. This study reports the results of the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. The findings demonstrate the feasibility of this personalized platform, which has the potential to improve surgical neuromodulation for various neurological and psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Johannes W. de Jong, Kurt M. Fraser, Stephan Lammel
Summary: Ventral tegmental area dopamine neurons encode reward prediction errors, but their release in the nucleus accumbens is involved in reinforcement learning, motivation, aversion, and incentive salience. The contrast between the homogeneous role of dopamine neuron activity and the heterogeneous functions of dopamine release raises questions about how VTA dopamine activity translates into NAc dopamine release.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Judith Gruber, Ruth Hanssen, Mishal Qubad, Aicha Bouzouina, Vivi Schack, Hannah Sochor, Carmen Schiweck, Mareike Aichholzer, Silke Matura, David A. Slattery, Yurdaguel Zopf, Stephanie L. Borgland, Andreas Reif, Sharmili Edwin Thanarajah
Summary: Type 2 diabetes and major depressive disorder (MDD) are highly comorbid and leading causes of disability. This review discusses the potential molecular mechanisms underlying their association by examining the effects of insulin on dopaminergic signaling and behavior in the brain. It also explores the impact of insulin resistance on depressive symptoms and anhedonia, and its relevance for treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Joonyoung Kang, Hyeji Kim, Seong Hwan Hwang, Minjun Han, Sue-Hyun Lee, Hyoung F. Kim
Summary: The ventral striatum is involved in updating reward values for habit learning, while also stably maintaining the value memory for previously rewarded objects. Days after learning, the ventral striatum continues to show increased responses to these objects, indicating a long-term retention of high-valued object memory.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Clinical
A. J. Culbreth, E. K. Schwartz, M. J. Frank, E. C. Brown, Z. Xu, S. Chen, J. M. Gold, J. A. Waltz
Summary: This study found that patients with schizophrenia show reduced reward-seeking behavior and a bias toward loss avoidance learning. However, there was no significant difference in exploratory behavior between patients and controls. Perceptions of relative uncertainty were associated with activity in the rostrolateral prefrontal cortex.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biology
Silina Zaatri, Idan M. Aderka, Uri Hertz
Summary: This study investigates the relationship between social anxiety levels and individual's advice-giving style, and finds that social anxiety levels can influence the strategies and behaviors individuals adopt, such as giving advice similar to rival advisers and refraining from seeking status.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Craig A. A. Taswell, Miriam Janssen, Elisabeth A. A. Murray, Bruno B. B. Averbeck
Summary: This article investigates the contributions of the ventral striatum and amygdala to learning, and finds that learning environments have an impact on motivation. The results show that environmental factors affect animals' learning behavior and effort level. The ventral striatum plays a crucial role in rich deterministic and relatively leaner stochastic learning environments, while the amygdala can learn in stochastic environments and environments with losses.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jerome, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis
Summary: Food odour coding is crucial for food intake, and dopamine plays a regulatory role in food odour information processing in the ventral striatum.
Article
Neurosciences
Alik S. Widge, Fan Zhang, Aishwarya Gosai, George Papadimitrou, Peter Wilson-Braun, Magdalini Tsintou, Senthil Palanivelu, Angela M. Noecker, Cameron C. McIntyre, Lauren O'Donnell, Nicole C. R. McLaughlin, Benjamin D. Greenberg, Nikolaos Makris, Darin D. Dougherty, Yogesh Rathi
Summary: A study investigated the predictive value of patient-specific imaging and statistical models in determining the treatment outcomes of VCVS DBS for OCD and depression, as well as the occurrence of hypomania. The findings suggest that despite some correlation between tract activation and specific symptom responses, no specific tractographic target could be identified with sufficient effect size to drive clinical decision-making or predict individual outcomes. The study highlights the need for caution in interpreting the results of normative connectome studies.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Gina Joue, Karima Chakroun, Janine Bayer, Jan Glaescher, Lei Zhang, Johannes Fuss, Nora Hennies, Tobias Sommer
Summary: The study found that women showed enhanced brain activity related to reward prediction error compared to men, and this effect was further amplified when estrogen levels were elevated in both sexes. However, both female sex and estrogen slowed adaptation to reward prediction errors, resulting in a smaller learning rate.
Article
Neurosciences
Margaret Prenger, Madeline Gilchrist, Kathryne Van Hedger, Ken N. Seergobin, Adrian M. Owen, Penny A. Macdonald
Summary: Humor comprehension and appreciation are cognitive processes involving different brain regions. The dorsal striatum is important for humor comprehension, while the ventral striatum plays a critical role in humor appreciation.
JOURNAL OF NEUROSCIENCE
(2023)