Article
Neurosciences
Sara Calafate, Gokhan Ozturan, Nicola Thrupp, Jeroen Vanderlinden, Luisa Santa-Marinha, Rafaela Morais-Ribeiro, Antonella Ruggiero, Ivan Bozic, Thomas Rusterholz, Blanca Lorente-Echeverria, Marcelo Dias, Wei-Ting Chen, Mark Fiers, Ashley Lu, Ine Vlaeminck, Eline Creemers, Katleen Craessaerts, Joris de Wit, Luuk van Boekholdt, Suresh Poovathingal, Kristofer Davie, Dietmar Rudolf Thal, Keimpe Wierda, Tiago Gil Oliveira, Inna Slutsky, Antoine Adamantidis, Bart De Strooper, Joris de Wit
Summary: Early AD is characterized by hippocampal hyperactivity and decreased sleep quality. The MCH system is involved in neuronal homeostasis but fails in the early stages of AD, leading to aberrant excitatory drive and sleep defects that compromise hippocampus-dependent functions.
NATURE NEUROSCIENCE
(2023)
Article
Peripheral Vascular Disease
Rong Ren, Ye Zhang, Linghui Yang, Yuan Shi, Naima Covassin, Xiangdong Tang
Summary: This study aimed to quantify the independent association between arousals during REM/NREM sleep and prevalent hypertension. The results showed a significant dose-response relationship between arousal index during REM sleep and hypertension, while arousal index during NREM sleep was not a significant predictor of hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Luc Masset, Milan Nigam, Anne Ladarre, Marie Vidailhet, Smaranda Leu-Semenescu, Philippe Fossati, Isabelle Arnulf, Jean-Baptiste Maranci
Summary: Dreams during REM sleep can help reduce negative emotions, as shown by the study on emotional dynamics. Previous studies were limited to dream reports, but by studying individuals with REM sleep behavior disorder (RBD), researchers gained direct access to observe emotional dream behaviors. Analysis of 17 participants with RBD and 39.7 hours of REM sleep video revealed that emotional behaviors follow a biphasic temporal course, with an initial increase in frequency followed by a progressive decrease. Negative emotional behaviors occurred earlier than positive and neutral behaviors, and rapid succession of emotions of opposite valence was observed to prevent prolonged periods of negative emotions.
Review
Neurosciences
Liam E. Potter, Christian R. Burgess
Summary: Given the impact of sleep disorders on health, researchers are exploring novel avenues of treatment, including targeting the melanin-concentrating hormone (MCH) system. This system has been implicated in sleep regulation and various physiological functions, but skepticism remains regarding the development of MCH-targeting drugs. Additional research is needed to fully understand the role of the MCH system in sleep regulation and address drug design challenges.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuki Kobayashi, Tomoya Okada, Daisuke Miki, Yuko Sekino, Noriko Koganezawa, Tomoaki Shirao, Giovanne B. Diniz, Yumiko Saito
Summary: The primary cilium is a sensitive signaling hub in cells, capable of changing length to ensure efficient signaling capacity. In hippocampal neurons, MCH triggers cilia length reduction via MCHR1-mediated Gi/o and Akt signaling pathways.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Maria Sotelo, Jean Tyan, Chelsea Markunas, Bibi A. Sulaman, Lorraine Horwitz, Hankyu Lee, Joshua G. Morrow, Gideon Rothschild, Bo Duan, Ada Eban-Rothschild
Summary: The transition from wakefulness to sleep involves specific behaviors, such as nest-building and grooming, which are associated with stereotypic electroencephalogram (EEG) patterns. The ability to build a nest promotes sleep initiation and consolidation, while the lack of nesting material disrupts sleep. Neuronal ensembles in the lateral hypothalamus regulate the motivation to engage in nest-building behavior and control sleep initiation and intensity.
Article
Endocrinology & Metabolism
Meng Wang, Yue Zhai, Xiaowei Lei, Jing Xu, Bopei Jiang, Zhe Kuang, Cong Zhang, Shangyun Liu, Shan Bian, Xiao-Mei Yang, Tao Zan, Li-Na Jin, Qingfeng Li, Chao Zhang
Summary: This study investigated the interaction between MRAP2 and MCHR1, and found that MRAP2 could inhibit the signaling of MCHR1. Functional truncation experiments revealed the importance of the C-terminal domains of MRAP2 in pharmacological modulation. These findings elucidated the broad regulatory profile of MRAP2 in the central nervous system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pao-Huan Chen, Cheng-Chih Chung, Shuen-Hsin Liu, Yu-Hsun Kao, Yi-Jen Chen
Summary: Lithium treatment can improve cardiac dysfunction caused by REM sleep deprivation and alleviate fibrosis. The potential mechanisms may involve the regulation of TGF-β, angiotensin II, and Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Marcus O. Harrington, Jennifer E. Ashton, Hong-Viet V. Ngo, Scott A. Cairney
Summary: This study manipulated theta activity during sleep using auditory closed-loop stimulation, showing that stimulation led to a short-term increase in theta power followed by a prolonged suppression, as well as an increase in beta power. These results highlight the potential of auditory stimulation in investigating REM sleep electrophysiology and its impact on behavior.
Article
Biology
Brittany J. Bush, Caroline Donnay, Eva-Jenee A. Andrews, Darielle Lewis-Sanders, Cloe L. Gray, Zhimei Qiao, Allison J. Brager, Hadiya Johnson, Hamadi C. S. Brewer, Sahil Sood, Talib Saafir, Morris Benveniste, Ketema N. Paul, J. Christopher Ehlen
Summary: Resilience, the ability to overcome stressful conditions, varies significantly among individuals and is influenced by sleep amount and sleep regulation in the prefrontal cortex.
Article
Clinical Neurology
Cole D. Stang, Aidan F. Mullan, Mania Hajeb, Emanuele Camerucci, Pierpaolo Turcano, Peter Martin, Michelle M. Mielke, Keith A. Josephs, James H. Bower, Erik K. St Louis, Bradley F. Boeve, Rodolfo Savica
Summary: The study revealed that the prevalence of rapid eye movement (REM) sleep behavior disorder (RBD) increased over time in patients with alpha-synucleinopathies, with higher likelihood of developing RBD in male patients. However, RBD did not increase mortality risk within the cohort.
ANNALS OF NEUROLOGY
(2021)
Article
Neurosciences
Wedad Alhassen, Yuki Kobayashi, Jessica Su, Brianna Robbins, Henry Nguyen, Thant Myint, Micah Yu, Surya M. Nauli, Yumiko Saito, Amal Alachkar
Summary: The MCH system plays a crucial role in regulating the length of brain neuronal primary cilia, with activation causing cilia shortening and inactivation leading to cilia lengthening. This suggests that MCHR1 at primary cilia could be a potential therapeutic target for conditions associated with impaired primary cilia function.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Cristina Concetti, Denis Burdakov
Summary: The lateral hypothalamus plays a role in sleep-wake control by producing orexin/hypocretin and melanin-concentrating hormone neuropeptides. These neuropeptides can rapidly change their firing in response to external stimuli in awake animals. Optogenetic and chemogenetic manipulations suggest that rapid lateral hypothalamic dynamics shape cognitive and motor processes in the awake brain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Carlos M. O. de Almeida, Manuelina M. C. Brito, Nayanne B. Bosaipo, Angela V. Pimentel, Vitor Tumas, Antonio W. Zuardi, Jose A. S. Crippa, Jaime E. C. Hallak, Alan L. Eckeli
Summary: This study evaluated the efficacy and safety of CBD as an alternative therapy for RBD in patients with Parkinson's disease. While CBD did not show significant differences compared to placebo for primary outcomes, there was a transient improvement in sleep satisfaction observed with a 300mg dose.
MOVEMENT DISORDERS
(2021)
Article
Chemistry, Medicinal
Jozsef Huszar, Eva Bozo, Gyula Beke, Krisztina Katalin Szalai, Peter Kardos, Andras Boros, Istvan Greiner, Janos Eles
Summary: Obesity is a global epidemic associated with severe diseases, and pharmacotherapies including MCHR1 antagonists have been investigated. This study designed and synthesized novel MCHR1 antagonists based on benzofuro-pyridine and pyrazino-indole scaffold, and successfully developed compounds with excellent in vitro parameters that can be considered as valuable tools for further pharmacological investigation.
Article
Neurosciences
Anthony N. van den Pol, Claudio Acuna, John N. Davis, Hao Huang, Xiaobing Zhang
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
Carlos Blanco-Centurion, SiWei Luo, Daniel J. Spergel, Aurelio Vidal-Ortiz, Sorinel A. Oprisan, Anthony N. Van den Pol, Meng Liu, Priyattam J. Shiromani
JOURNAL OF NEUROSCIENCE
(2019)
Article
Food Science & Technology
Maria Fernanda Higuera-Hernandez, Elena Reyes-Cuapio, Marissa Gutierrez-Mendoza, Henning Budde, Carlos Blanco-Centurion, Andre Barciela Veras, Nuno Barbosa Rocha, Tetsuya Yamamoto, Diogo Monteiro, Jaime Zaldivar-Rae, Dalila Aldana-Aranda, Sergio Machado, Eric Murillo-Rodriguez
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Biology
Ying Sun, Emmeline Bendell, Meng Liu
Article
Neurosciences
Lily R. Barrett, Jeremiah Nunez, Xiaobing Zhang
Summary: The study reveals a critical role of PVT OT signaling in promoting feeding motivation to attenuate stress-induced hypophagia. OT induces long-lasting excitatory effects on neurons in all PVT regions, especially the middle to posterior PVT.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Carlos Blanco-Centurion, SiWei Luo, Aurelio Vidal-Ortiz, Colby Swank, Priyattam J. Shiromani
Summary: The study found that 60.2% of vGAT GABA neurons in the zona incerta showed activity biased towards sleep, with a subset of neurons becoming active before sleep onset and potentially inducing sleep by inhibiting arousal neurons. Abnormal activation of these neurons may lead to sleep attacks and hypersomnia.
Article
Cell Biology
Longbo Zhang, Xiaobing Zhang, Lawrence S. Hsieh, Tiffany V. Lin, Angelique Bordey
Summary: Decreasing Rab27a levels in late-born pyramidal neurons can increase excitatory synaptic transmission onto L4 neurons and alter responses to sensory stimulation in juvenile mice.
Article
Neurosciences
Qiying Ye, Xiaobing Zhang
Summary: The study reveals that 5-HT regulates PVT neurons through direct excitation and indirect disinhibition, playing a role in controlling feeding behaviors. Chronic high-fat diet impairs the regulatory effect of 5-HT, potentially contributing to overeating and obesity.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Qiying Ye, Jeremiah Nunez, Xiaobing Zhang
Summary: OTR-expressing PVT neurons play a significant role in regulating feeding behavior through modulation of glutamatergic synaptic transmission in the posterior basolateral amygdala (pBLA), nucleus accumbens core (NAcC), and local PVT neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Carlos Blanco-Centurion, Aurelio Vidal-Ortiz, Takashi Sato, Priyattam J. Shiromani
Summary: This study measured the activity of GABA neurons in the zona incerta (ZI) and the ventral lateral periaqueductal grey (vlPAG). The findings showed that most neurons in these regions were most active during REM sleep and there were neurons in ZI that fluoresced 30 seconds before sleep onset. These results suggest that the activity of GABA neurons plays an important role in regulating sleep.
Article
Endocrinology & Metabolism
Qiying Ye, Jeremiah Nunez, Xiaobing Zhang
Summary: This study reveals that raphe-ZIR 5-HT projections dynamically regulate ZIR GABA neurons for feeding control. Photostimulation of 5-HT projections inhibits ZIR neurons while exciting PVT neurons, resulting in decreased motivated food consumption. However, acute food deprivation and high-fat high-sugar diet abolish the inhibitory regulation of raphe-ZIR 5-HT projections on feeding motivation and food intake.
MOLECULAR METABOLISM
(2022)
Article
Behavioral Sciences
Ying Sun, Emmaline Bendell, Carlos Blanco-Centurion, Priyattam J. Shiromani, Meng Liu
HANDBOOK OF SLEEP RESEARCH, VOL 30
(2019)
Article
Neurosciences
Ying Sun, Carlos Blanco-Centurion, Bingyu Zou, Emmaline Bendell, Priyattam J. Shiromani, Meng Liu
Article
Nutrition & Dietetics
Maria Fernanda Higuera-Hernandez, Elena Reyes-Cuapio, Marissa Gutierrez-Mendoza, Nuno Barbosa Rocha, Andre Barciela Veras, Henning Budde, Johanna Jesse, Jaime Zaldivar-Rae, Carlos Blanco-Centurion, Sergio Machado, Eric Murillo-Rodriguez
CLINICAL NUTRITION ESPEN
(2018)
Article
Neurosciences
Carlos Blanco-Centurion, Emmaline Bendell, Bingyu Zou, Ying Sun, Priyattam J. Shiromani, Meng Liu