Article
Biochemistry & Molecular Biology
Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Ruan, Chunjing Zhang, Kai Zhao
Summary: The study found that N-2-Hydroxypropyl trimethyl ammonium chloride chitosan/N, O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) showed good immunogenicity and no toxicity as a universal vaccine adjuvant/delivery system. The prepared N-2-HACC/OVA/CMCS NPs induced higher levels of antibodies and immune responses in mice, suggesting their potential in enhancing humoral, cellular, and mucosal immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin, Kai Zhao
Summary: This report presents the encapsulation of amoxicillin in N-2-Hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles for biomedical applications. The synthesized nanoparticles demonstrated sustained drug release, good cytocompatibility and broad-spectrum antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ling Ding, Zhao Liu, Shen Song, Mohamed Aamer Abubaker, Lele Chen, Jipeng Shi, Zengjie Fan, Ji Zhang
Summary: HACC, synthesized by reacting chitosan with glycidyl trimethylammonium chloride, forms a non-Newtonian pseudoplastic fluid in solution, with thixotropy highly dependent on concentration changes. Dynamic viscoelasticity tests show that HACC exhibits both viscous behavior similar to a fluid and elastic properties of weak gel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Kai Zhao, Beini Sun, Ci Shi, Yanwei Sun, Zheng Jin, Gaowei Hu
Summary: The O-2'-HACC/pFDNA microparticles showed high encapsulation efficiency and loading capacity, promoting immune responses and generating more immune-related cells after intranasal vaccination in chickens, providing better protection compared to commercial live attenuated vaccines.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: This study generated chitosan nanoparticles and examined their effects on dendritic cells, finding that 200kDa NO-CMC-HACC nanoparticles showed strong potential as immunological adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Yang Zhou, Zhenghao Zhai, Yimin Yao, John C. Stant, Sarah L. Landrum, Michael J. Bortner, Charles E. Frazier, Kevin J. Edgar
Summary: Polysaccharide-based Schiff base hydrogels prepared by reacting oxidized hydroxypropyl cellulose (Ox-HPC) with carboxymethyl chitosan (CMCS) exhibit pH-responsive, injectable, and self-healing properties. The reversible nature of the imine bonds allows for an injectable and self-healing hydrogel. The incorporation of the model amine-containing drug phenylalanine within the hydrogel showed pH sensitivity, releasing faster in the extracellular space around tumors (pH 6.8) compared to normal tissues (pH 7.4).
CARBOHYDRATE POLYMERS
(2023)
Article
Immunology
Kai Zhao, Yuan Gao, Gaowei Hu, Lei Wang, Shangjin Cui, Zheng Jin
Summary: The study developed a VP2 protein subunit vaccine against Porcine parvovirus (PPV) using N-2-Hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) as the adjuvant, showing that the vaccine induced higher antibody levels and long-term immune protection in immunized sows. However, the vaccine mainly stimulated humoral immunity rather than cellular immunity, and provided 100% protective efficacy against PPV infection in sows. This suggests that N-2-HACC could be a potential adjuvant for controlling PPV.
Article
Materials Science, Paper & Wood
Mahmoud H. Abu Elella, Heba M. Abdallah, Heba Gamal, Essam B. Moustafa, Emad S. Goda
Summary: Antimicrobial hydrogels are a major focus for repairing soft tissues and preventing bacterial infections, with new hydrogels designed in this study showing high biocompatibility through physical crosslinking reactions. The hydrogels exhibit significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with those containing high TMC content showing superior inhibition zones compared to pure TMC. Additionally, the cytotoxicity testing on normal cell lines VERO and lung (Wi38) cells demonstrates high cell viability at lower concentrations.
Article
Biochemistry & Molecular Biology
Adel Ali Alhowyan, Mohd Abul Kalam, Muzaffar Iqbal, Mohammad Raish, Ahmed M. El-Toni, Musaed Alkholief, Aliyah A. Almomen, Aws Alshamsan
Summary: This study developed amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU). The optimal formulation of AMSN-CMC-FU showed improved corneal permeation and higher bioavailability compared to 5-FU gel. AMSN-CMC-FU gel was minimally irritating to rabbit eyes, suggesting its potential as a topical formulation for ocular cancer treatment.
Article
Biochemistry & Molecular Biology
Li Ming Lim, Kunn Hadinoto
Summary: This study found that hydroxypropyl starch is a suitable mucoadhesive polysaccharide for high-payload buccal film applications, with excellent CUR release characteristics and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Paper & Wood
Shixiong Zhai, Yue Li, Weiwei Dong, Hong Zhao, Kai Ma, Hongguang Zhang, Hai Wang, Yaping Zhao, Xiaoyan Li, Zaisheng Cai
Summary: This study improved the traditional cotton dyeing process, reducing the harm to the ecological environment caused by high-salt wastewater discharge, and achieved a high dye-uptake rate.
Article
Chemistry, Physical
Jialiang Chen, Lirong Fu, Yan Li, Xiaodeng Yang, Beibei Wang, Chunlin Xu, Tianduo Li
Summary: The study revealed that HTCC/CMC/glycerol (PVA and anthocyanin) film-forming solutions exhibited shear-thinning behavior, with a slower decrease in apparent viscosity due to the electrostatic and hydrogen bonding interactions among the biomacromolecules and glycerol, PVA, and anthocyanin, resulting in the formation of three-dimensional networks.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Atefe Sadeghi Lari, Payam Zahedi, Hedayatollah Ghourchian, Alireza Khatibi
Summary: This study successfully synthesized novel crosslinked carboxymethyl chitosan nanoparticles using microfluidics and demonstrated their potential application in diabetes therapy. In the rat experiments, it was found that metformin hydrochloride loaded in these nanoparticles significantly increased body weight and reduced blood glucose levels, with effects on pancreatic islets and beta cells similar to healthy conditions.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Jinhu Liu, Weiwei Mu, Tong Gao, Yuxiao Fang, Na Zhang, Yongjun Liu
Summary: Liver cancer, particularly hepatocellular carcinoma, is a leading cause of cancer-related deaths, and its incidence is increasing globally. Nano drug delivery systems have displayed great potential in cancer treatment. Achieving high drug accumulation and effective release at the tumor site are crucial for improving therapeutic efficacy. In this study, CD13-targeted mesoporous silica nanoparticles coated with NGR-peptide-modified pegylated carboxymethyl chitosan were developed as drug carriers for doxorubicin (DOX). These nanostructures demonstrated responsive release of DOX in acidic environments and efficient internalization through NGR-mediated uptake in vitro. In vivo, they successfully delivered DOX to tumor tissues with prolonged accumulation times and exhibited significant tumor inhibition. This research provides a promising strategy for using DOX/MSN-CPN as a nano-platform for targeted drug delivery in hepatocellular carcinoma treatment.
Article
Chemistry, Multidisciplinary
Rizwan Ahmed, Noor ul ain Hira, Zhinan Fu, Mingwei Wang, Adeel Halepoto, Santosh Khanal, Shahid Iqbal, Hidayatullah Mahar, Martien Abraham Cohen Stuart, Xuhong Guo
Summary: Nanoscale polyelectrolyte complex materials have been extensively studied for their potential applications in protocell, drug carriers, imaging, and catalysis. By utilizing reactive flash nanoprecipitation (RFNP), a more homogeneous mixing and preparation process for these materials has been achieved, resulting in stable nanoscale complexes with controllable size and narrow size distribution. The method allows for continuous and tunable production of these complexes, showing promise for practical translation in the future.