期刊
MOLECULES
卷 26, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules26082380
关键词
nanoparticles; RNA interference; cancer
资金
- Special Project Funding for Science and Technology Talents in Banan District of Chongqing [2020TJZ018]
- Scientific Research Foundation of Chongqing University of Technology
RNA interference (RNAi) is a therapeutic strategy that can mediate gene silencing with high efficiency and targeting for cancer treatment. The use of nanoparticles for efficient delivery of RNAi therapeutics is crucial, and the characteristics of different nanocarriers have been classified and summarized.
RNA interference (RNAi) can mediate gene-silencing by knocking down the expression of a target gene via cellular machinery with much higher efficiency in contrast to other antisense-based approaches which represents an emerging therapeutic strategy for combating cancer. Distinct characters of nanoparticles, such as distinctive size, are fundamental for the efficient delivery of RNAi therapeutics, allowing for higher targeting and safety. In this review, we present the mechanism of RNAi and briefly describe the hurdles and concerns of RNAi as a cancer treatment approach in systemic delivery. Furthermore, the current nanovectors for effective tumor delivery of RNAi therapeutics are classified, and the characteristics of different nanocarriers are summarized.
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